Magnesium alloy is one of the most widely used lightweight structural materials,and the development of high strength-toughness magnesium alloy is an important research field at present and even in the future.The prepa...Magnesium alloy is one of the most widely used lightweight structural materials,and the development of high strength-toughness magnesium alloy is an important research field at present and even in the future.The preparation process parameters of magnesium alloy directly affect the microstructure of the magnesium alloy,and then determine the properties of the magnesium alloy.The cooling rate has important effects on the microstructure and properties of the magnesium alloy,and is an important preparation process parameter that cannot be ignored.Both the cooling rate from liquid phase to solid phase and the cooling rate of the magnesium alloy after heat treatment will change the microstructure of the magnesium alloy.Furthermore,the properties of magnesium alloy will be affected.In this paper,the effects of cooling rate on the solidification behavior,the rheological behavior,the change of microstructure(the solid solution of alloying elements in matrix,the composition,size,distribution and morphology of second phase,the diffusion and segregation of alloying elements,the grain size,the formation and morphology of dendrite,etc.),and the effects of cooling rate of magnesium alloy after heat treatment on the microstructure and stress distribution are reviewed.The reasons for the divergence about the influence of cooling rate on the microstructure of magnesium alloy are analyzed in detail.The effects of cooling rate on the mechanical properties,corrosion resistance and oxidation resistance of magnesium alloy are also analyzed and discussed deeply.Finally,the new methods and approaches to study the effects of cooling rate on the microstructure and properties of magnesium alloy are prospected.展开更多
Due to the scale effect, the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing...Due to the scale effect, the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing efficiency in large-scale channel. A 3D spiral baffle structure(3SBS) was designed and optimized to form microfluidic field disturbed by continuous secondary flow in millimeter scale Y-shaped tube mixer(YSTM). Enhancement effect of the 3SBS in liquid-liquid homogeneous chemical processes was verified and evaluated through the combination of simulation and experiment. Compared with 1 mm YSTM, 10 mm YSTM with 3SBS increased the treatment capacity by 100 times, shortened the basic complete mixing time by 0.85 times, which proves the potential of microfluidic field strategy in enhancement and scale-up of liquid-liquid homogeneous chemical process.展开更多
OBJECTIVE To investigate cyclin D1 expression in peripheral lung cancers and its relationship with CT signs and prognosis. METHODS Cyclin D1 expression in peripheral lung cancers and its relationship with the CT imagi...OBJECTIVE To investigate cyclin D1 expression in peripheral lung cancers and its relationship with CT signs and prognosis. METHODS Cyclin D1 expression in peripheral lung cancers and its relationship with the CT imaging and prognosis were analyzed retrospectively by means of SP immunohistochemistry and spiral CT scanning in 92 patients with peripheral lung cancer verified by pathology. RESULTS Cyclin D1 expression was related to deep lobulation,spiculate protuberance,short thin spinules sign and mediastina lymph node metastasis.Cyclin D1 expression was not related to tumor size,cavity,pleural indentation,histological type,differentiation,tumor TNM stage,age or sex.Cyclin D1 was a negative prognostic factor whose over-expression indicated a poor prognosis. CONCLUSION Cyclin D1 expression may play an important role in the occurrence,progress and CT scan results of lung cancers.Cyclin D1 was a negative factor whose over-expression implied a poor prognosis.Detection of the cyclin D1 and observation of the CT scan can be considered as indexes of clinical diagnosis and prognostic evaluation.展开更多
Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visuali...Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results.Spatial omics technologies include spatial transcriptomics,spatial proteomics,spatial metabolomics,and other technologies,the most widely used of which are spatial transcriptomics and spatial proteomics.The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist,including the surrounding blood vessels,immune cells,fibroblasts,bone marrow-derived inflammatory cells,various signaling molecules,and extracellular matrix.A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment,which can reveal problems that conventional research techniques cannot,potentially leading to the development of novel therapeutic agents for cancer.This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.展开更多
An iron-catalyzed[4+2]annulation of amidines with α,β-unsaturated ketoxime acetates is described.This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted py...An iron-catalyzed[4+2]annulation of amidines with α,β-unsaturated ketoxime acetates is described.This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields,exhibiting good functional group tolerance,scalability and operational simplicity.展开更多
An improved method for the preparation of pentafluoroethylating reagent pentafluoroethyl-substituted benzio- doxole （BIX-C2Fs） was described. Under mild conditions, BIX-C2F5 was able to react with β-ketoesters or a...An improved method for the preparation of pentafluoroethylating reagent pentafluoroethyl-substituted benzio- doxole （BIX-C2Fs） was described. Under mild conditions, BIX-C2F5 was able to react with β-ketoesters or aryl/ heteroaryl boronic acids to generate pentafluoroethylated compounds in good yields.展开更多
Masking is one of the most commonly used Side-Channel Attack （SCA） countermeasures and is built on a security framework, such as the ISW framework, and ensures theoretical security through secret sharing. Unfortunat...Masking is one of the most commonly used Side-Channel Attack （SCA） countermeasures and is built on a security framework, such as the ISW framework, and ensures theoretical security through secret sharing. Unfortunately, the theoretical security cannot guarantee practical security, because several possible weaknesses may exist in the actual implementation. These weaknesses likely come from the masking schemes or are introduced by the implementation methods. Finding the possible weakness of the masking scheme is an interesting and important issue for real applications. In this paper, the possible weaknesses for masking schemes in Field- Programmable Gate Array （FPGA） design are discussed. It was found that the combinational circuit is the key to the security of masking schemes. The Toggle Count （TC） method and its extension are utilized to evaluate the security of masking schemes in the design phase and the implementation phase separately. Comparing different logic-level simulators for the Xilinx FPGA platform, the behavioral and post-translate simulations are considered as the analysis method in the design phase, while the post-map and the post-route simulations are used to find the weakness during the implementation phase. Moreover, a Standard Delay Format （SDF） based improvement scheme is proposed to significantly increase the effectiveness of the TC model.展开更多
基金supports from the Natural Science Foundation of Inner Mongolia Autonomous Region of china(2024MS05009)National Natural Science Foundation of China(51661025)+1 种基金Research Program of science and technology at Universities of Inner Mongolia Autonomous Region(NJZY21315)Scientific research project of Inner Mongolia University of Technology(ZY202001 and BS2020003).
文摘Magnesium alloy is one of the most widely used lightweight structural materials,and the development of high strength-toughness magnesium alloy is an important research field at present and even in the future.The preparation process parameters of magnesium alloy directly affect the microstructure of the magnesium alloy,and then determine the properties of the magnesium alloy.The cooling rate has important effects on the microstructure and properties of the magnesium alloy,and is an important preparation process parameter that cannot be ignored.Both the cooling rate from liquid phase to solid phase and the cooling rate of the magnesium alloy after heat treatment will change the microstructure of the magnesium alloy.Furthermore,the properties of magnesium alloy will be affected.In this paper,the effects of cooling rate on the solidification behavior,the rheological behavior,the change of microstructure(the solid solution of alloying elements in matrix,the composition,size,distribution and morphology of second phase,the diffusion and segregation of alloying elements,the grain size,the formation and morphology of dendrite,etc.),and the effects of cooling rate of magnesium alloy after heat treatment on the microstructure and stress distribution are reviewed.The reasons for the divergence about the influence of cooling rate on the microstructure of magnesium alloy are analyzed in detail.The effects of cooling rate on the mechanical properties,corrosion resistance and oxidation resistance of magnesium alloy are also analyzed and discussed deeply.Finally,the new methods and approaches to study the effects of cooling rate on the microstructure and properties of magnesium alloy are prospected.
基金supported by the National Key Research and Development Program of China (2021YFC2101900 and 2019YFA0905000)National Natural Science Foundation of China (21908094, 21776130 and 22078150)+1 种基金Nanjing International Joint Research and Development Project (202002037)Top-notch Academic Programs Project of Jiangsu Higher Education Institutions。
文摘Due to the scale effect, the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing efficiency in large-scale channel. A 3D spiral baffle structure(3SBS) was designed and optimized to form microfluidic field disturbed by continuous secondary flow in millimeter scale Y-shaped tube mixer(YSTM). Enhancement effect of the 3SBS in liquid-liquid homogeneous chemical processes was verified and evaluated through the combination of simulation and experiment. Compared with 1 mm YSTM, 10 mm YSTM with 3SBS increased the treatment capacity by 100 times, shortened the basic complete mixing time by 0.85 times, which proves the potential of microfluidic field strategy in enhancement and scale-up of liquid-liquid homogeneous chemical process.
基金grants from Natural Science Foundation of Guangdong,China (No.06301077)Administration of Tradi-tional Chinese Medicine of Guangdong,China (No.2060134)+1 种基金the Health Department Foun-dation of Guangdong,China (No.A2007421)the Shantou Technology Bureau Science Foundation of China (No.Shantou Govern-ment Technology[2006]85)
文摘OBJECTIVE To investigate cyclin D1 expression in peripheral lung cancers and its relationship with CT signs and prognosis. METHODS Cyclin D1 expression in peripheral lung cancers and its relationship with the CT imaging and prognosis were analyzed retrospectively by means of SP immunohistochemistry and spiral CT scanning in 92 patients with peripheral lung cancer verified by pathology. RESULTS Cyclin D1 expression was related to deep lobulation,spiculate protuberance,short thin spinules sign and mediastina lymph node metastasis.Cyclin D1 expression was not related to tumor size,cavity,pleural indentation,histological type,differentiation,tumor TNM stage,age or sex.Cyclin D1 was a negative prognostic factor whose over-expression indicated a poor prognosis. CONCLUSION Cyclin D1 expression may play an important role in the occurrence,progress and CT scan results of lung cancers.Cyclin D1 was a negative factor whose over-expression implied a poor prognosis.Detection of the cyclin D1 and observation of the CT scan can be considered as indexes of clinical diagnosis and prognostic evaluation.
基金supported by Basic and Applied Basic Research Foundation of Guangdong Province(No.2022A1111220217)Medical Scientific Research Foundation of Guangdong Province(Nos.A2023216,A2022124)+3 种基金Science and Technology Program of Guangzhou(Nos.202201010840,202201010810,202102080132,202002030032,202002020023)Health Commission Program of Guangzhou(20212A010021,20201A010081,20211A011116)Science and Technology Project of Panyu,Guangzhou(2022-Z04-009,2022-Z04-090,2022-Z04-072,2021-Z04-013,2020-Z04-026,2019-Z04-02)Scientific Research Project of Guangzhou Panyu Central Hospital(Nos.2022Y002,2021Y004,2021Y002).
文摘Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results.Spatial omics technologies include spatial transcriptomics,spatial proteomics,spatial metabolomics,and other technologies,the most widely used of which are spatial transcriptomics and spatial proteomics.The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist,including the surrounding blood vessels,immune cells,fibroblasts,bone marrow-derived inflammatory cells,various signaling molecules,and extracellular matrix.A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment,which can reveal problems that conventional research techniques cannot,potentially leading to the development of novel therapeutic agents for cancer.This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.
基金the National Natural Science Foundation of China(No.22078150)the National Key R&D Program of China(No.2021YFC2101904)+1 种基金the Jiangsu Province Industrial Prospects and Key Core Technologies-Competitive Projects(No.BE2021083)the Nanjing International Joint R&D Project(No.202002037)for their financial support。
文摘An iron-catalyzed[4+2]annulation of amidines with α,β-unsaturated ketoxime acetates is described.This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields,exhibiting good functional group tolerance,scalability and operational simplicity.
基金National Basic Research Program of China （No. 2012CB821600）, National Natural Science Foundation of China （Nos. 21372247, 21572258, 21421002） and SIOC.
文摘An improved method for the preparation of pentafluoroethylating reagent pentafluoroethyl-substituted benzio- doxole （BIX-C2Fs） was described. Under mild conditions, BIX-C2F5 was able to react with β-ketoesters or aryl/ heteroaryl boronic acids to generate pentafluoroethylated compounds in good yields.
基金supported in part by the National Natural Science Foundation of China under Grant (No. 61472292)the key technology research of new-generation high-speed and high-level security chip for smart grid (No. 526816160015)in part by the Technological Innovation of Hubei Province (Major Special Project, No. 2018AAA046)
文摘Masking is one of the most commonly used Side-Channel Attack （SCA） countermeasures and is built on a security framework, such as the ISW framework, and ensures theoretical security through secret sharing. Unfortunately, the theoretical security cannot guarantee practical security, because several possible weaknesses may exist in the actual implementation. These weaknesses likely come from the masking schemes or are introduced by the implementation methods. Finding the possible weakness of the masking scheme is an interesting and important issue for real applications. In this paper, the possible weaknesses for masking schemes in Field- Programmable Gate Array （FPGA） design are discussed. It was found that the combinational circuit is the key to the security of masking schemes. The Toggle Count （TC） method and its extension are utilized to evaluate the security of masking schemes in the design phase and the implementation phase separately. Comparing different logic-level simulators for the Xilinx FPGA platform, the behavioral and post-translate simulations are considered as the analysis method in the design phase, while the post-map and the post-route simulations are used to find the weakness during the implementation phase. Moreover, a Standard Delay Format （SDF） based improvement scheme is proposed to significantly increase the effectiveness of the TC model.
