In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro ba...In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro base station(MBS)and the small base station(SBS)transmit their confidential messages to the macro user(MU)and the small user(SU)over their shared spectrum respectively.To enhance the system sum rate(SSR)of MBS-MU and SBS-SU transmission,we propose joint antenna selection combined with optimal power allocation(JAS-OPA)scheme and independent antenna selection combined with optimal power allocation(IAS-OPA)scheme.The JAS-OPA scheme requires to know the channel state information(CSI)of transmission channels and interference channels,while the IAS-OPA scheme only needs to know the CSI of transmission channels.In addition,we carry out the analysis for conventional round-robin antenna selection combined with optimal power allocation(RR-OPA)as a benchmark scheme.We formulate the SSR maximization problem through the power allocation between MBS and SBS and propose iterative OPA algorithms for JAS-OPA,IAS-OPA and RR-OPA schemes,respectively.The results show that the OPA schemes outperform the equal power allocation in terms of SSR.Moreover,we provide the closed-form expression of the system outage probability(SOP)for IAS scheme and RR scheme,it shows the SOP performance can be significantly improved by our proposed IAS scheme compared with RR scheme.展开更多
The concept of community is of great significance in guiding the innovation of the mechanism of industry-education integration,which can promote the integration of industry-education integration from"integration&...The concept of community is of great significance in guiding the innovation of the mechanism of industry-education integration,which can promote the integration of industry-education integration from"integration"to real"integration".We summarize the current situation of the development of industry-teaching integration mode through research,point out the"four deviations"in the development of industry-teaching integration,analyze the causes of deviations,and put forward the research strategy of"four synergistic"innovation mechanism for industry-teaching integration based on the concept of community,i.e.,synergistic development of community planning It proposes the research strategy of"four synergies"innovation mechanism based on the concept of community,namely the synergy of community planning and development,the synergy of community governance concept,the synergy of community multi-party educating mechanism,and the synergy of community fusion effect system,so as to establish collaborative ties,build a new form of cooperation concepts,safeguard the docking of talent supply and demand,and enhance the effect of integration of industry and education.展开更多
Unmanned aerial vehicles(UAVs)are en-visioned as a promising means of providing wireless services for various complex terrains and emergency situations.In this paper,we consider a wireless UAV-enabled cognitive commun...Unmanned aerial vehicles(UAVs)are en-visioned as a promising means of providing wireless services for various complex terrains and emergency situations.In this paper,we consider a wireless UAV-enabled cognitive communication network,where a rotary-wing UAV transmits confidential information to a ground cognitive user over the spectrum assigned to primary users(PUs),while eavesdroppers attempt to wiretap the legitimate transmission.In order to en-hance the secrecy performance of wireless communi-cations,the secrecy rate(SR)of the UAV-enabled cog-nitive communication system is maximized through optimizing UAV three-dimensional(3D)flying trajec-tory while satisfying the requirements of UAV’s initial and final locations and guaranteeing the constraint of maximum speed of UAV and the interference thresh-old of each PU.However,the formulated SR maxi-mization(SRM)problem is non-convex.For the pur-pose of dealing with this intractable problem,we em-ploy the difference of two-convex functions approxi-mation approach to convert the non-convex optimiza-tion problem into a convex one,which is then solved through applying standard convex optimization tech-niques.Moreover,an iterative 3D trajectory opti-mization algorithm for SRM scheme is proposed to achieve the near-optimal 3D trajectory.Simulation re-sults show that our proposed 3D trajectory optimiza-tion based SRM algorithm has good convergence,and the proposed SRM scheme outperforms the bench-mark approach in terms of the SR performance.展开更多
Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 st...Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 stability and activation remains elusive.Here we report that LATS1 is acetylated by acetyltransferase CBP at K751 and is deacetylated by deacetylases SIRT3 and SIRT4.Acetylation at K751 stabilized LATS1 by decreasing LATS1 ubiquitination and inhibited LATS1 activation by reducing its phosphorylation.Mechanistically,LATS1 acetylation resulted in inhibition of YAP phosphorylation and degradation,leading to increased YAP nucleus translocation and promoted target gene expression.Functionally,LATS1-K751 Q,the acetylation mimic mutant potentiated lung cancer cell migration,invasion and tumor growth,whereas LATS1-K751 R,the acetylation deficient mutant inhibited these functions.Taken together,we demonstrated a previously unidentified post-translational modification of LATS1 that converts LATS1 from a tumor suppressor to a tumor promoter by suppression of Hippo signalling through acetylation of LATS1.展开更多
基金supported by National Natural Science Foundation of China(No.62071253)Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX210747).
文摘In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro base station(MBS)and the small base station(SBS)transmit their confidential messages to the macro user(MU)and the small user(SU)over their shared spectrum respectively.To enhance the system sum rate(SSR)of MBS-MU and SBS-SU transmission,we propose joint antenna selection combined with optimal power allocation(JAS-OPA)scheme and independent antenna selection combined with optimal power allocation(IAS-OPA)scheme.The JAS-OPA scheme requires to know the channel state information(CSI)of transmission channels and interference channels,while the IAS-OPA scheme only needs to know the CSI of transmission channels.In addition,we carry out the analysis for conventional round-robin antenna selection combined with optimal power allocation(RR-OPA)as a benchmark scheme.We formulate the SSR maximization problem through the power allocation between MBS and SBS and propose iterative OPA algorithms for JAS-OPA,IAS-OPA and RR-OPA schemes,respectively.The results show that the OPA schemes outperform the equal power allocation in terms of SSR.Moreover,we provide the closed-form expression of the system outage probability(SOP)for IAS scheme and RR scheme,it shows the SOP performance can be significantly improved by our proposed IAS scheme compared with RR scheme.
基金this paper is supposed by National Natural Science Foundation of China(12074289)Zhejiang Provincial Natural Science Foundation of China(Y23A040004)+2 种基金Teaching Reform Project of Zhejiang Province(jg20220509)Scientific Research Project of Zhejiang Graduate Education Association(2023-016)The 14th Five-year Teaching Reform Project of Zhejiang Province(jg20220522)。
文摘The concept of community is of great significance in guiding the innovation of the mechanism of industry-education integration,which can promote the integration of industry-education integration from"integration"to real"integration".We summarize the current situation of the development of industry-teaching integration mode through research,point out the"four deviations"in the development of industry-teaching integration,analyze the causes of deviations,and put forward the research strategy of"four synergistic"innovation mechanism for industry-teaching integration based on the concept of community,i.e.,synergistic development of community planning It proposes the research strategy of"four synergies"innovation mechanism based on the concept of community,namely the synergy of community planning and development,the synergy of community governance concept,the synergy of community multi-party educating mechanism,and the synergy of community fusion effect system,so as to establish collaborative ties,build a new form of cooperation concepts,safeguard the docking of talent supply and demand,and enhance the effect of integration of industry and education.
基金National Natural Sci-ence Foundation of China(Nos.61631020,61671253,62071253 and 91738201)the Key Project of Nat-ural Science Research of Higher Education Institu-tions of Jiangsu Province(Grant No.18KJB510031).
文摘Unmanned aerial vehicles(UAVs)are en-visioned as a promising means of providing wireless services for various complex terrains and emergency situations.In this paper,we consider a wireless UAV-enabled cognitive communication network,where a rotary-wing UAV transmits confidential information to a ground cognitive user over the spectrum assigned to primary users(PUs),while eavesdroppers attempt to wiretap the legitimate transmission.In order to en-hance the secrecy performance of wireless communi-cations,the secrecy rate(SR)of the UAV-enabled cog-nitive communication system is maximized through optimizing UAV three-dimensional(3D)flying trajec-tory while satisfying the requirements of UAV’s initial and final locations and guaranteeing the constraint of maximum speed of UAV and the interference thresh-old of each PU.However,the formulated SR maxi-mization(SRM)problem is non-convex.For the pur-pose of dealing with this intractable problem,we em-ploy the difference of two-convex functions approxi-mation approach to convert the non-convex optimiza-tion problem into a convex one,which is then solved through applying standard convex optimization tech-niques.Moreover,an iterative 3D trajectory opti-mization algorithm for SRM scheme is proposed to achieve the near-optimal 3D trajectory.Simulation re-sults show that our proposed 3D trajectory optimiza-tion based SRM algorithm has good convergence,and the proposed SRM scheme outperforms the bench-mark approach in terms of the SR performance.
基金supported by the National Natural Science Foundation of China(81730071,81972616,81230051,81472734,31170711 and 81773199)the Ministry of Science and Technology of China(2016YFC1302103 and 2015CB553906)+1 种基金Beijing Natural Science Foundation(7120002 and 7171005)Peking University(BMU2018JC004,BMU20120314 and BMU20130364)。
文摘Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 stability and activation remains elusive.Here we report that LATS1 is acetylated by acetyltransferase CBP at K751 and is deacetylated by deacetylases SIRT3 and SIRT4.Acetylation at K751 stabilized LATS1 by decreasing LATS1 ubiquitination and inhibited LATS1 activation by reducing its phosphorylation.Mechanistically,LATS1 acetylation resulted in inhibition of YAP phosphorylation and degradation,leading to increased YAP nucleus translocation and promoted target gene expression.Functionally,LATS1-K751 Q,the acetylation mimic mutant potentiated lung cancer cell migration,invasion and tumor growth,whereas LATS1-K751 R,the acetylation deficient mutant inhibited these functions.Taken together,we demonstrated a previously unidentified post-translational modification of LATS1 that converts LATS1 from a tumor suppressor to a tumor promoter by suppression of Hippo signalling through acetylation of LATS1.
