3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological properties.However,whether these functions are attr...3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological properties.However,whether these functions are attributed to eBAG or additional components in these plants remain unknown.Herein,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer cells.EBAG induced non-apoptotic cell death in hepatocellular carcinoma cells.The eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux inhibitor.We demonstrated that eBAG induced an autophagy-mediated cell death.Application of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of mTOR.Co-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by eBAG.We further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in mice.As a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.展开更多
During oil-gas well drilling and completion,downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works.Downhole tractors have been used to convey tools in complex wellbor...During oil-gas well drilling and completion,downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works.Downhole tractors have been used to convey tools in complex wellbores, however a very large tractive force is needed to carry more downhole tools to accomplish works with high efficiency. A novel serial active helical drive downhole tractor which has significantly improved performance compared with previous work is proposed. All previously reported helical drive downhole tractors need stators to balance the torque generated by the rotator. By contrast, the proposed serial downhole tractor does not need a stator; several rotator-driven units should only be connected to one another to achieve a tractive force multifold higher than that was previously reported. As a result,the length of a single unit is shortened, and the motion flexibility of the downhole tractor is increased. The major performance indicators, namely, gear ratio, velocity, and tractive force, are analyzed. Experimental results show that the maximum tractive force of a single-unit prototype with a length of 900 mm is 165.3 kg or 1620 N. The analysis and experimental results show that the proposed design has considerable potential for downhole works.展开更多
Low-power and low-variability artificial neuronal devices are highly desired for high-performance neuromorphic computing.In this paper,an oscillation neuron based on a low-variability Ag nanodots(NDs)threshold switchi...Low-power and low-variability artificial neuronal devices are highly desired for high-performance neuromorphic computing.In this paper,an oscillation neuron based on a low-variability Ag nanodots(NDs)threshold switching(TS)device with low operation voltage,large on/off ratio and high uniformity is presented.Measurement results indicate that this neuron demonstrates self-oscillation behavior under applied voltages as low as 1 V.The oscillation frequency increases with the applied voltage pulse amplitude and decreases with the load resistance.It can then be used to evaluate the resistive random-access memory(RRAM)synaptic weights accurately when the oscillation neuron is connected to the output of the RRAM crossbar array for neuromorphic computing.Meanwhile,simulation results show that a large RRAM crossbar array(>128×128)can be supported by our oscillation neuron owing to the high on/off ratio(>10^(8))of Ag NDs TS device.Moreover,the high uniformity of the Ag NDs TS device helps improve the distribution of the output frequency and suppress the degradation of neural network recognition accuracy(<1%).Therefore,the developed oscillation neuron based on the Ag NDs TS device shows great potential for future neuromorphic computing applications.展开更多
Ultra-high spectral purity lasers are of considerable research interests in numerous fields such as coherent optical communication,microwave photonics,distributed optical fiber sensing,gravitational wave detection,opt...Ultra-high spectral purity lasers are of considerable research interests in numerous fields such as coherent optical communication,microwave photonics,distributed optical fiber sensing,gravitational wave detection,optical clock,and so on.Herein,to deeply purify laser spectrum with compact size under normal condition,we propose a novel and practical idea to effectively suppress the spontaneous radiation of the laser cavity through weak external distributed perturbation.Subsequently,a laser configuration consisting of a main lasing cavity and an external distributed feedback cavity is proposed.The feedback signal with continuous spatio-temporal phase transition controlled by a distributed feedback structure is injected into the main cavity,which can deeply suppress the coupling rate from the spontaneous radiation to the stimulated emission and extremely purify the laser spectrum.Eventually,an ultra-narrow linewidth on-chip laser system with a side mode suppression ratio greater than 80 dB,an output linewidth of 10 Hz,and a relative intensity noise less than-150 dB/Hz is successfully obtained under normal conditions.The proposed concept in this work provides a new perspective for extreme regulation of laser parameters by using weak external distributed perturbation,which can be valid for various gain-type lasers with wide wavelength bands.展开更多
Banana is one of the most important crops in tropical and subtropical regions of China. Fenjiao( Musa Spp. ABB,Pisang Awak subgroup) has been grown by small scale famers because of its stable market price and better s...Banana is one of the most important crops in tropical and subtropical regions of China. Fenjiao( Musa Spp. ABB,Pisang Awak subgroup) has been grown by small scale famers because of its stable market price and better sugar-acid blend. However,the traditional Fenjiao variety is susceptible to banana Fusarium wilt,has a high plant height( over 5. 0 m),and farmers lack large-scale planting techniques.Based on the traditional Fenjiao variety,we selected‘Refen 1’variety through mutagenesis technology,which has low temperature resistance,suitable to marginal soils and relatively low plant height( 3. 2-4. 0 m). This paper mainly introduces the major techniques of propagation,cultivation,and post-harvest stages of‘Refen 1’banana,including the selection of explant materials,treatment,disinfection,initial culture,nursery hardening of in vitro-produced banana plants,and transplant of tissue culture seedlings. The major points of the cultivation technology include banana plantation selection and preparation,planting methods,irrigation and fertilizer management,pruning and retaining,and prevention and control of plant diseases and insect pests.展开更多
On the process of power system black start after an accident, it can help to optimize the resources allocation and accelerate the recovery process that decomposing the power system into several independent partitions ...On the process of power system black start after an accident, it can help to optimize the resources allocation and accelerate the recovery process that decomposing the power system into several independent partitions for parallel recovery. On the basis of adequate consideration of fuzziness of black-start zone partitioning, a new algorithm based on fuzzy clustering analysis is presented. Characteristic indexes are extracted fully and accurately. The raw data matrix is made up of the electrical distance between every nodes and blackstart resources. Closure transfer method is utilized to get the dynamic clustering. The availability and feasibility of the proposed algorithm are verified on the New-England 39 bus system at last.展开更多
With the rapid development of data-driven human interaction,advanced datastorage technologies with lower power consumption,larger storage capacity,faster switching speed,and higher integration density have become the ...With the rapid development of data-driven human interaction,advanced datastorage technologies with lower power consumption,larger storage capacity,faster switching speed,and higher integration density have become the goals of future memory electronics.Nevertheless,the physical limitations of conventional Si-based binary storage systems lag far behind the ultrahigh-density requirements of post-Moore information storage.In this regard,the pursuit of alternatives and/or supplements to the existing storage technology has come to the forefront.Recently,organic-based resistive memory materials have emerged as promising candidates for next-generation information storage applications,which provide new possibilities of realizing high-performance organic electronics.Herein,the memory device structure,switching types,mechanisms,and recent advances in organic resistive memory materials are reviewed.In particular,their potential of fulfilling multilevel storage is summarized.Besides,the present challenges and future prospects confronted by organic resistive memory materials and devices are discussed.展开更多
Dissipative solitons emerge as stable pulse solutions of nonintegrable and nonconservative nonlinear physical systems, owing to a balance of nonlinearity, dispersion, and loss/gain. A considerable research effort has ...Dissipative solitons emerge as stable pulse solutions of nonintegrable and nonconservative nonlinear physical systems, owing to a balance of nonlinearity, dispersion, and loss/gain. A considerable research effort has been dedicated to characterizing amplitude and phase evolutions in the spatiotemporal dynamics of dissipative solitons emerging from fiber lasers. Yet, the picture of the buildup process of dissipative solitons in fiber lasers is incomplete in the absence of corresponding information about the polarization evolution. Here, we characterize probabilistic polarization distributions in the buildup of dissipative solitons in a net-normal dispersion fiber laser system, mode-locked by single-wall carbon nanotubes. The output optical spectra under different pump powers are filtered by a tunable filter, and are detected by a polarization state analyzer. The laser system operates from random amplified spontaneous emission into a stable dissipative soliton state as the cavity gain is progressively increased. Correspondingly, the state of polarization of each spectral wavelength converges towards a fixed point.To reveal the invariant polarization relationship among the various wavelength components of the laser output field, the phase diagram of the ellipticity angle and the spherical orientation angle is introduced. We find that,within the central spectral region of the dissipative soliton, the state of polarization evolves with frequency by tracing a uniform arc on the Poincaré sphere, whereas in the edges of the dissipative soliton spectrum, the state of polarization abruptly changes its path. Increasing cavity gain leads to spectral broadening, accompanied by a random scattering of the state of polarization of newly generated frequencies. Further increases of pump power result in dissipative soliton explosions, accompanied by the emergence of a new type of optical polarization rogue waves. These experimental results provide a deeper insight into the transient dynamics of dissipative soliton fiber lasers.展开更多
Acousto-optic interactions, employed in the ultrafast laser regulation,possess remarkable advantages for fast tuning performance in a wide spectral range. Here, we propose an ultrafast fiber laser whose wideband tunab...Acousto-optic interactions, employed in the ultrafast laser regulation,possess remarkable advantages for fast tuning performance in a wide spectral range. Here, we propose an ultrafast fiber laser whose wideband tunability is provided by an acousto-optic structure fabricated with an etched single-mode fiber. Because of the laser polarization conversion induced by the coupling between the core and cladding vector modes in the etched fiber,a band-pass characteristic of the acousto-optic interaction is achieved to effectively regulate the inner-cavity gain range. Cooperating with a saturable absorber based on single-wall carbon nanotubes (SWCNTs) with polarization robustness,a soliton operating state is achieved in the tunable erbium-doped fiber laser.By controlling the acoustical wave frequency from 1.039 to 1.069 MHz, this soliton laser can be conveniently tuned in a wide spectral range from 1571.52 to 1539.26nm.Meanwhile, the laser pulses have near-transform-limited durations stably maintaining less than 2 ps at different wavelength channels,owing to the broadband nonlinear absorption of SWCNTs.展开更多
Data factors have become one of the five essential production factors,but their role in economic growth has always been ambiguous.Starting from AI technologies,this paper establishes an endogenous growth model of data...Data factors have become one of the five essential production factors,but their role in economic growth has always been ambiguous.Starting from AI technologies,this paper establishes an endogenous growth model of data factors affecting economic growth,constructs the generation path and value path of data factors,and estimates the value of new data factors at the provincial level in China from 1999 to 2018 accordingly.Based on theoretical analyses and empirical tests,it clarifes that data factors have a“two-dimensional driving effect”on China's economic growth,that is,data factors can drive growth both directly through its own economic growth effect and indirectly by promoting technological progress.Furthermore,this paper makes three extended discussions,aiming to make a trial study on the impacts of local government big data transaction platforms on data factors and their growth effects,discuss whether it is possible to reduce the uncertainties of local economic policy based on the nature of data factors,and make a preliminary survey of the output elasticity of data factors between 1999 and 2018.展开更多
Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is bec...Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the liver, contribute to HBV infection in various aspects. These cells play an important role not only in the anti-HBV immunity including virus recognition, cytokine production to directly inhibit viral replication and recruitment and activation of other immune cells involved in virus clearance but also in HBV outcome and progression, such as persistent infection and development of end-stage liver diseases. Since liver macrophages play multiple roles in HBV infection, they are directly targeted by HBV to benefit its life cycle. In the present review, we briefly outline the current advances of research of macrophages, especially the studies of their phenotypes, in chronic HBV infection.展开更多
基金supported by Henan Provincial Science and Technology Research Project (212102310355)the National Natural Science Foundation of China (82020108024 and 32161143021)。
文摘3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological properties.However,whether these functions are attributed to eBAG or additional components in these plants remain unknown.Herein,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer cells.EBAG induced non-apoptotic cell death in hepatocellular carcinoma cells.The eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux inhibitor.We demonstrated that eBAG induced an autophagy-mediated cell death.Application of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of mTOR.Co-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by eBAG.We further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in mice.As a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.
基金Supported by Sichuan Provincial Science and Technology Program of China(Grant Nos.2013GZ0150,2014GZ0121)Research Project of Key Laboratory of Fluid and Power Machinery of Ministry of Education,Xihua University,China
文摘During oil-gas well drilling and completion,downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works.Downhole tractors have been used to convey tools in complex wellbores, however a very large tractive force is needed to carry more downhole tools to accomplish works with high efficiency. A novel serial active helical drive downhole tractor which has significantly improved performance compared with previous work is proposed. All previously reported helical drive downhole tractors need stators to balance the torque generated by the rotator. By contrast, the proposed serial downhole tractor does not need a stator; several rotator-driven units should only be connected to one another to achieve a tractive force multifold higher than that was previously reported. As a result,the length of a single unit is shortened, and the motion flexibility of the downhole tractor is increased. The major performance indicators, namely, gear ratio, velocity, and tractive force, are analyzed. Experimental results show that the maximum tractive force of a single-unit prototype with a length of 900 mm is 165.3 kg or 1620 N. The analysis and experimental results show that the proposed design has considerable potential for downhole works.
基金supported in part by China Key Research and Development Program(2016YFA0201800)the National Natural Science Foundation of China(91964104,61974081)。
文摘Low-power and low-variability artificial neuronal devices are highly desired for high-performance neuromorphic computing.In this paper,an oscillation neuron based on a low-variability Ag nanodots(NDs)threshold switching(TS)device with low operation voltage,large on/off ratio and high uniformity is presented.Measurement results indicate that this neuron demonstrates self-oscillation behavior under applied voltages as low as 1 V.The oscillation frequency increases with the applied voltage pulse amplitude and decreases with the load resistance.It can then be used to evaluate the resistive random-access memory(RRAM)synaptic weights accurately when the oscillation neuron is connected to the output of the RRAM crossbar array for neuromorphic computing.Meanwhile,simulation results show that a large RRAM crossbar array(>128×128)can be supported by our oscillation neuron owing to the high on/off ratio(>10^(8))of Ag NDs TS device.Moreover,the high uniformity of the Ag NDs TS device helps improve the distribution of the output frequency and suppress the degradation of neural network recognition accuracy(<1%).Therefore,the developed oscillation neuron based on the Ag NDs TS device shows great potential for future neuromorphic computing applications.
基金supported by the National Natural Science Foundation of China(NSFC)(61635004)the National Science Fund for Distinguished Young Scholars(61825501)the Chongqing Natural Science Foundation of Innovative Research Groups under Grant(CSTC2020JCYJ,CXTTX0005)。
文摘Ultra-high spectral purity lasers are of considerable research interests in numerous fields such as coherent optical communication,microwave photonics,distributed optical fiber sensing,gravitational wave detection,optical clock,and so on.Herein,to deeply purify laser spectrum with compact size under normal condition,we propose a novel and practical idea to effectively suppress the spontaneous radiation of the laser cavity through weak external distributed perturbation.Subsequently,a laser configuration consisting of a main lasing cavity and an external distributed feedback cavity is proposed.The feedback signal with continuous spatio-temporal phase transition controlled by a distributed feedback structure is injected into the main cavity,which can deeply suppress the coupling rate from the spontaneous radiation to the stimulated emission and extremely purify the laser spectrum.Eventually,an ultra-narrow linewidth on-chip laser system with a side mode suppression ratio greater than 80 dB,an output linewidth of 10 Hz,and a relative intensity noise less than-150 dB/Hz is successfully obtained under normal conditions.The proposed concept in this work provides a new perspective for extreme regulation of laser parameters by using weak external distributed perturbation,which can be valid for various gain-type lasers with wide wavelength bands.
基金Supported by the Earmarked Fund for China Agriculture Research System(CARS-31-02)Key R&D project in Hainan Province(ZDYF2019060)Agricultural Science and Technology Innovation Program of CAAS "Evaluation and Regulation of Nutritional Quality of Major Agricultural Products"
文摘Banana is one of the most important crops in tropical and subtropical regions of China. Fenjiao( Musa Spp. ABB,Pisang Awak subgroup) has been grown by small scale famers because of its stable market price and better sugar-acid blend. However,the traditional Fenjiao variety is susceptible to banana Fusarium wilt,has a high plant height( over 5. 0 m),and farmers lack large-scale planting techniques.Based on the traditional Fenjiao variety,we selected‘Refen 1’variety through mutagenesis technology,which has low temperature resistance,suitable to marginal soils and relatively low plant height( 3. 2-4. 0 m). This paper mainly introduces the major techniques of propagation,cultivation,and post-harvest stages of‘Refen 1’banana,including the selection of explant materials,treatment,disinfection,initial culture,nursery hardening of in vitro-produced banana plants,and transplant of tissue culture seedlings. The major points of the cultivation technology include banana plantation selection and preparation,planting methods,irrigation and fertilizer management,pruning and retaining,and prevention and control of plant diseases and insect pests.
文摘On the process of power system black start after an accident, it can help to optimize the resources allocation and accelerate the recovery process that decomposing the power system into several independent partitions for parallel recovery. On the basis of adequate consideration of fuzziness of black-start zone partitioning, a new algorithm based on fuzzy clustering analysis is presented. Characteristic indexes are extracted fully and accurately. The raw data matrix is made up of the electrical distance between every nodes and blackstart resources. Closure transfer method is utilized to get the dynamic clustering. The availability and feasibility of the proposed algorithm are verified on the New-England 39 bus system at last.
基金This work was supported by the National Natural Science Foundation of China （Nos. 21476039 and 21076030）. M. T. thanks the Marie S~odowska-Curie Individual Fellowship for a postdoctoral grant. A. J. H. and O. K. F. gratefully acknowledge funding from the U.S. Dept. of F.nerg~ Office of Science, Basic Energy Sciences Program （No. DE-FG02-08ER15967）. The authors also thank Professor Huanting Wang from Monash University for further revising the manuscript.
基金Jiangsu Key Disciplines of the Thirteenth Five-Year Plan,Grant/Award Number:20168765Six Talent Peaks Project of Jiangsu Province,Grant/Award Number:XCL-078+4 种基金NSF of Jiangsu Higher Education Institutions,Grant/Award Number:17KJA140001National Excellent Doctoral Dissertation funds of China,Grant/Award Number:201455National Natural Science Foundation of China,Grant/Award Numbers:21878199,21938006Undergraduate Innovation and Entrepreneurship Training Program of Jiangsu Province,Grant/Award Number:201910332067YNatural Science Foundation of the Jiangsu Higher。
文摘With the rapid development of data-driven human interaction,advanced datastorage technologies with lower power consumption,larger storage capacity,faster switching speed,and higher integration density have become the goals of future memory electronics.Nevertheless,the physical limitations of conventional Si-based binary storage systems lag far behind the ultrahigh-density requirements of post-Moore information storage.In this regard,the pursuit of alternatives and/or supplements to the existing storage technology has come to the forefront.Recently,organic-based resistive memory materials have emerged as promising candidates for next-generation information storage applications,which provide new possibilities of realizing high-performance organic electronics.Herein,the memory device structure,switching types,mechanisms,and recent advances in organic resistive memory materials are reviewed.In particular,their potential of fulfilling multilevel storage is summarized.Besides,the present challenges and future prospects confronted by organic resistive memory materials and devices are discussed.
基金National Natural Science Foundation of China(61405023,61635004)National Postdoctoral Program for Innovative Talents(BX201600200)+6 种基金Postdoctoral Science Foundation of China(2017M610589)Postdoctoral Science Foundation of Chongqing(Xm2017047)Science Foundation of Chongqing(CSTC2017JCYJA0651)Fundamental Research Funds for the Central Universities(106112017CDJXY120004)National Science Fund for Distinguished Young Scholars(61825501)H2020 Marie Sklodowska-Curie Actions(691051)Russian Ministry of Science and Education(14.Y26.31.0017)
文摘Dissipative solitons emerge as stable pulse solutions of nonintegrable and nonconservative nonlinear physical systems, owing to a balance of nonlinearity, dispersion, and loss/gain. A considerable research effort has been dedicated to characterizing amplitude and phase evolutions in the spatiotemporal dynamics of dissipative solitons emerging from fiber lasers. Yet, the picture of the buildup process of dissipative solitons in fiber lasers is incomplete in the absence of corresponding information about the polarization evolution. Here, we characterize probabilistic polarization distributions in the buildup of dissipative solitons in a net-normal dispersion fiber laser system, mode-locked by single-wall carbon nanotubes. The output optical spectra under different pump powers are filtered by a tunable filter, and are detected by a polarization state analyzer. The laser system operates from random amplified spontaneous emission into a stable dissipative soliton state as the cavity gain is progressively increased. Correspondingly, the state of polarization of each spectral wavelength converges towards a fixed point.To reveal the invariant polarization relationship among the various wavelength components of the laser output field, the phase diagram of the ellipticity angle and the spherical orientation angle is introduced. We find that,within the central spectral region of the dissipative soliton, the state of polarization evolves with frequency by tracing a uniform arc on the Poincaré sphere, whereas in the edges of the dissipative soliton spectrum, the state of polarization abruptly changes its path. Increasing cavity gain leads to spectral broadening, accompanied by a random scattering of the state of polarization of newly generated frequencies. Further increases of pump power result in dissipative soliton explosions, accompanied by the emergence of a new type of optical polarization rogue waves. These experimental results provide a deeper insight into the transient dynamics of dissipative soliton fiber lasers.
基金National Natural Science Foundation of China(NSFC)(61635004,61705023,61705024)Key Research and Development Project of Ministry of Science and Technology(2016YFC0801200)+4 种基金Chongqing Postdoctoral Program for Innovative Talents(CQBX201703)Postdoctoral Science Foundation of Chongqing(Xm2017047)Natural Science Foundation of Chongqing(cstc2018jcyjAX0644)Science and Technology on Plasma Physics Laboratory(6142A0403050817)National Science Fund for Distinguished Young Scholars(61825501)
文摘Acousto-optic interactions, employed in the ultrafast laser regulation,possess remarkable advantages for fast tuning performance in a wide spectral range. Here, we propose an ultrafast fiber laser whose wideband tunability is provided by an acousto-optic structure fabricated with an etched single-mode fiber. Because of the laser polarization conversion induced by the coupling between the core and cladding vector modes in the etched fiber,a band-pass characteristic of the acousto-optic interaction is achieved to effectively regulate the inner-cavity gain range. Cooperating with a saturable absorber based on single-wall carbon nanotubes (SWCNTs) with polarization robustness,a soliton operating state is achieved in the tunable erbium-doped fiber laser.By controlling the acoustical wave frequency from 1.039 to 1.069 MHz, this soliton laser can be conveniently tuned in a wide spectral range from 1571.52 to 1539.26nm.Meanwhile, the laser pulses have near-transform-limited durations stably maintaining less than 2 ps at different wavelength channels,owing to the broadband nonlinear absorption of SWCNTs.
基金“Research on System Regulation on High-quality Supply of Data Factors under the Framework of‘Market+Government+Community’Collaborative Governance”,a National Social Science Fund Project for 2022.(22BJL033).
文摘Data factors have become one of the five essential production factors,but their role in economic growth has always been ambiguous.Starting from AI technologies,this paper establishes an endogenous growth model of data factors affecting economic growth,constructs the generation path and value path of data factors,and estimates the value of new data factors at the provincial level in China from 1999 to 2018 accordingly.Based on theoretical analyses and empirical tests,it clarifes that data factors have a“two-dimensional driving effect”on China's economic growth,that is,data factors can drive growth both directly through its own economic growth effect and indirectly by promoting technological progress.Furthermore,this paper makes three extended discussions,aiming to make a trial study on the impacts of local government big data transaction platforms on data factors and their growth effects,discuss whether it is possible to reduce the uncertainties of local economic policy based on the nature of data factors,and make a preliminary survey of the output elasticity of data factors between 1999 and 2018.
基金Some of the studies summarized in this review were financially supported by grants from the Chinese Academy of Medical Sciences(CAMS)Initiative for Innovative Medicine(CAMS-2016-I2M-3-025 and CAMS-2017-I2M-B&R-15)the National Key Research Development Program of China(2018YFE0107500 to Professor Limin Chen)the Science&Technology Department of Sichuan Province(2020YFH0070 to Yujia Li).
文摘Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the liver, contribute to HBV infection in various aspects. These cells play an important role not only in the anti-HBV immunity including virus recognition, cytokine production to directly inhibit viral replication and recruitment and activation of other immune cells involved in virus clearance but also in HBV outcome and progression, such as persistent infection and development of end-stage liver diseases. Since liver macrophages play multiple roles in HBV infection, they are directly targeted by HBV to benefit its life cycle. In the present review, we briefly outline the current advances of research of macrophages, especially the studies of their phenotypes, in chronic HBV infection.
