Sophora flavescens , which was first recorded in Shen Nong s Herbal Classic , has the functions of clearing away heat, drying dampness, killing parasites and promoting urination. In its long-term application, traditio...Sophora flavescens , which was first recorded in Shen Nong s Herbal Classic , has the functions of clearing away heat, drying dampness, killing parasites and promoting urination. In its long-term application, traditional Chinese medicine has gradually deepened its understanding of the origin and efficacy of S. flavescens . In order to explore changes in the origin and efficacy of traditional Chinese herb S. flavescens in the history of China and Japan, in this paper, the origin and development of S. flavescens in China and Japan were compared from three aspects: the origin, medicinal efficacy, and processing methods of S. flavescens in China and Japan, hoping to provide clear understanding of the medicinal plant S. flavescens .展开更多
In this study,the texture evolutions of two Mg materials during tension are explored.In-situ X-ray synchrotron and Visco-Plastic SelfConsistent(VPSC) modeling are employed to investigate the different deformation mode...In this study,the texture evolutions of two Mg materials during tension are explored.In-situ X-ray synchrotron and Visco-Plastic SelfConsistent(VPSC) modeling are employed to investigate the different deformation modes between pure Mg and Mg-15Gd(wt.%) alloy.These two materials with a strong extrusion texture show large different slip/twinning activity behaviors during tensile deformation.The basal(a) slip has the highest contribution to the initial stage of plastic deformation for pure Mg.During the subsequent plastic deformation,the prismatic slip is dominant due to the strong ED//(100) fiber texture.In contrast,the deformation behavior of Mg-15Gd alloy is more complex.Twinning and basal slip are dominant at the early stage of plastic deformation,but further deformation results in the increased activation of prismatic and pyramidal slips.In comparison to pure Mg,the ratios of the critical resolved shear stress(CRSS) between non-basal slip and basal slip of the Mg-15Gd alloy are much lower.展开更多
In order to improve the ductility of commercial WE43 alloy and reduce its cost,a Mg-3Y-2Gd-1Nd-0.4Zr alloy with a low amount of rare earths was developed and prepared by sand casting with a differential pressure casti...In order to improve the ductility of commercial WE43 alloy and reduce its cost,a Mg-3Y-2Gd-1Nd-0.4Zr alloy with a low amount of rare earths was developed and prepared by sand casting with a differential pressure casting system.Its microstructure,mechanical properties and fracture behaviors in the as-cast,solution-treated and as-aged states were evaluated.It is found that the aged alloy exhibited excellent comprehensive mechanical properties owing to the fine dense plate-shapedβ'precipitates formed on prismatic habits during aging at 200℃for 192 hrs after solution-treated at 500℃for 24 hrs.Its ultimate tensile strength,yield strength,and elongation at ambient temperature reach to 319±10 MPa,202±2 MPa and 8.7±0.3%as well as 230±4 MPa,155±1 MPa and 16.0±0.5%at 250℃.The fracture mode of as-aged alloy was transferred from cleavage at room temperature to quasi-cleavage and ductile fracture at the test temperature 300℃.The properties of large-scale components fabricated using the developed Mg-3Y-2Gd-1Nd-0.4Zr alloy are better than those of commercial WE43 alloy,suggesting that the new developed alloy is a good candidate to fabricate the large complex thin-walled components.展开更多
In this work,a novel bamboo-like carbon nanotubes@Sn4P3@carbon(BLCNTs@Sn_(4)P_(3)@C)coaxial nanotubes are designed and prepared using a newly developed hydrothermal method followed by a phophidation process.The prepar...In this work,a novel bamboo-like carbon nanotubes@Sn4P3@carbon(BLCNTs@Sn_(4)P_(3)@C)coaxial nanotubes are designed and prepared using a newly developed hydrothermal method followed by a phophidation process.The prepared Sn_(4)P_(3) nanoparticles are uniformly coated and wrapped on the one-dimensional(1D)bamboo-like CNTs,which is covered by a uniform carbon layer to form a sandwich-like structure with Sn_(4)P_(3) in between.The inner CNT and outer carbon can effectively maintain the structural stability and serve as the good electron conductors.Additionally,the outer carbon coating layer can effectively keep BLCNTs@Sn_(4)P_(3)@C nanotubes separate each other,preventing aggregation of Sn_(4)P_(3) during charge/discharge when this material is used as anode for sodium ion batteries.The anode of BLCNTs@Sn_(4)P_(3)@C shows excellent reversible capacity and a long cycling of over 2000 cycles.The unique design of coaxial nanotubes is greatly beneficial to the electrochemical performance of Sn_(4)P_(3) for sodium ion storage.展开更多
Periodontitis is indeed a chronic inflammatory disease caused by microorganisms, and it is a leading cause of tooth loss in adults worldwide [1–3]. The immune system typically maintains a balance with pathogenic bact...Periodontitis is indeed a chronic inflammatory disease caused by microorganisms, and it is a leading cause of tooth loss in adults worldwide [1–3]. The immune system typically maintains a balance with pathogenic bacteria in the body, and the local mucosal immune system effectively monitors and controls these microorganisms to prevent excessive inflammation.展开更多
Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vi...Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.展开更多
In the second near-infrared channel(NIR-II, 1000–1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and ...In the second near-infrared channel(NIR-II, 1000–1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-II imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-II fluorophores and their impressively biological applications including the NIR-II signal imaging,multimodal imaging and theranostic.展开更多
Peptide-based probes play prominent roles in biomedical research due to their promising properties such as high biocompatibility,fast excretion, favorable pharmacokinetics as well as easy and robust preparation. Consi...Peptide-based probes play prominent roles in biomedical research due to their promising properties such as high biocompatibility,fast excretion, favorable pharmacokinetics as well as easy and robust preparation. Considering the translation of imaging probes into clinical applications, peptide-based probes remain to be the most desirable and optimal candidates. This review summarized the development of peptide-based probes with promising imaging modalities and highlighted the successful applications for in vivo biomedical imaging.展开更多
Purpose： To explore the impact of subtropical maritime monsoon climate on the frequency of ambulance use for trauma patients in a coastal region in China. Method： Statistical analysis of data on ambulance use from t...Purpose： To explore the impact of subtropical maritime monsoon climate on the frequency of ambulance use for trauma patients in a coastal region in China. Method： Statistical analysis of data on ambulance use from the 120 Emergency Command Center in Shantou City, Guangdong Province, from January to December 2012 as well as daily meteorological data from a Shantou observatory was performed to determine how climatic factors （seasons, time, and weather） affect the frequency of ambulance use for trauma patients. Results： The daily ambulance use for trauma patients differed between spring and summer or autumn （p 〈 0.05）, between sunny and rainy days （p 〈 0.05）, and between cloudy and lightly or moderately rainy days （p 〈 0.05）. We found a linear correlation between daily maximum temperature and daily ambulance use for trauma patients （R^2 0.103, p 〈 0.05）. In addition, there was significant difference in ambulance use between good and bad weather （p 〈 0.05）. Conclusion： Frequency of ambulance use for trauma patients is affected by the subtropical maritime monsoon climate in the coastal region. Better weather contributes to increased daily frequency of ambulance use, which is the highest in autumn and lowest in spring.展开更多
基金Supported by Anhui University of Chinese Medicine(2023LCTH18,2021LCTH04)Fuyang Health Commission(FY2023-007)。
文摘Sophora flavescens , which was first recorded in Shen Nong s Herbal Classic , has the functions of clearing away heat, drying dampness, killing parasites and promoting urination. In its long-term application, traditional Chinese medicine has gradually deepened its understanding of the origin and efficacy of S. flavescens . In order to explore changes in the origin and efficacy of traditional Chinese herb S. flavescens in the history of China and Japan, in this paper, the origin and development of S. flavescens in China and Japan were compared from three aspects: the origin, medicinal efficacy, and processing methods of S. flavescens in China and Japan, hoping to provide clear understanding of the medicinal plant S. flavescens .
基金sponsored by the China Postdoctoral Science Foundation (Grant No. 2020M673156)Shanghai Pujiang Program (Grant No. 20PJ1404900)。
文摘In this study,the texture evolutions of two Mg materials during tension are explored.In-situ X-ray synchrotron and Visco-Plastic SelfConsistent(VPSC) modeling are employed to investigate the different deformation modes between pure Mg and Mg-15Gd(wt.%) alloy.These two materials with a strong extrusion texture show large different slip/twinning activity behaviors during tensile deformation.The basal(a) slip has the highest contribution to the initial stage of plastic deformation for pure Mg.During the subsequent plastic deformation,the prismatic slip is dominant due to the strong ED//(100) fiber texture.In contrast,the deformation behavior of Mg-15Gd alloy is more complex.Twinning and basal slip are dominant at the early stage of plastic deformation,but further deformation results in the increased activation of prismatic and pyramidal slips.In comparison to pure Mg,the ratios of the critical resolved shear stress(CRSS) between non-basal slip and basal slip of the Mg-15Gd alloy are much lower.
基金This work was funded by the National Natural Science Foundation of China(No.U2037601 and No.52074183)The authors appreciate Ge Chen,Wenbin Zou as well as Shiwei Wang for preparing the alloys,Wenyu Liu as well as Xuehao Zheng from ZKKF(Beijing)Science&Technology Co.,Ltd for the TEM measurement,Gert Wiese as well as Petra Fischer for SEM and hardness measurement and Yunting Li from the Instrument Analysis Center of Shanghai Jiao Tong University(China)for SEM measurement.Lixiang Yang also gratefully thanks the China Scholarship Council(201906230111)for awarding a fellowship to support his study stay at Helmholtz-Zentrum Geesthacht.
文摘In order to improve the ductility of commercial WE43 alloy and reduce its cost,a Mg-3Y-2Gd-1Nd-0.4Zr alloy with a low amount of rare earths was developed and prepared by sand casting with a differential pressure casting system.Its microstructure,mechanical properties and fracture behaviors in the as-cast,solution-treated and as-aged states were evaluated.It is found that the aged alloy exhibited excellent comprehensive mechanical properties owing to the fine dense plate-shapedβ'precipitates formed on prismatic habits during aging at 200℃for 192 hrs after solution-treated at 500℃for 24 hrs.Its ultimate tensile strength,yield strength,and elongation at ambient temperature reach to 319±10 MPa,202±2 MPa and 8.7±0.3%as well as 230±4 MPa,155±1 MPa and 16.0±0.5%at 250℃.The fracture mode of as-aged alloy was transferred from cleavage at room temperature to quasi-cleavage and ductile fracture at the test temperature 300℃.The properties of large-scale components fabricated using the developed Mg-3Y-2Gd-1Nd-0.4Zr alloy are better than those of commercial WE43 alloy,suggesting that the new developed alloy is a good candidate to fabricate the large complex thin-walled components.
基金supported by National Natural Science Foundation of China(51772051,51872071)Natural Science Foundation of Guangdong Province(2016A030310127)+3 种基金Support Funding for Innovation Projects for Overseas Students in Anhui Province(2020LCX031)supported by the Foundation of High-level Talents(GB200902-30,No.196100041018)the Foundation of Regular Research Team(TDYB2019007,No.196100043028)the Foundation of Doctor'sWorkstation of MCNAIR NEW POWER CO.,LTD(GC200104-40,No.186100030017)at Dongguan University of Technology.
文摘In this work,a novel bamboo-like carbon nanotubes@Sn4P3@carbon(BLCNTs@Sn_(4)P_(3)@C)coaxial nanotubes are designed and prepared using a newly developed hydrothermal method followed by a phophidation process.The prepared Sn_(4)P_(3) nanoparticles are uniformly coated and wrapped on the one-dimensional(1D)bamboo-like CNTs,which is covered by a uniform carbon layer to form a sandwich-like structure with Sn_(4)P_(3) in between.The inner CNT and outer carbon can effectively maintain the structural stability and serve as the good electron conductors.Additionally,the outer carbon coating layer can effectively keep BLCNTs@Sn_(4)P_(3)@C nanotubes separate each other,preventing aggregation of Sn_(4)P_(3) during charge/discharge when this material is used as anode for sodium ion batteries.The anode of BLCNTs@Sn_(4)P_(3)@C shows excellent reversible capacity and a long cycling of over 2000 cycles.The unique design of coaxial nanotubes is greatly beneficial to the electrochemical performance of Sn_(4)P_(3) for sodium ion storage.
文摘Periodontitis is indeed a chronic inflammatory disease caused by microorganisms, and it is a leading cause of tooth loss in adults worldwide [1–3]. The immune system typically maintains a balance with pathogenic bacteria in the body, and the local mucosal immune system effectively monitors and controls these microorganisms to prevent excessive inflammation.
基金supported by National Natural Science Foundation of China(22022404,22074050,21904103)the Fundamental Research Funds for the Central Universities(CCNU22QN007)+4 种基金the Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics(2021005)the Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University(KLSAOFM2111)the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University(JDGD-202209)the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education(FS2202)supported by the CRI project of National Research Foundation of Republic of Korea(2018R1A3B1052702,JSK)。
文摘Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.
基金partially supported by grants from NKR&DPC (No. 2016YFD0200902)National Natural Science Foundation of China (No. 21708012)+3 种基金111 Project (No. B17019)NSFHP (No. 2017CFB151)self-determined research funds of CCNU from the colleges, basic research and operation of MOE for the Central Universities (No. 110030106190234)Wuhan Morning Light Plan of Youth Science and Technology (No. 201705304010321)
文摘In the second near-infrared channel(NIR-II, 1000–1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-II imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-II fluorophores and their impressively biological applications including the NIR-II signal imaging,multimodal imaging and theranostic.
基金partially supported by grants from the National Natural Science Foundation of China(NSFC Nos. 21708012,81773674, 81573383,21390402, 81725009, 21788102, 81425015)111 Project (No. B17019)+6 种基金NKR&DPC (No. 2016YFA00900)NSFHP(Nos. 2017CFB151, 2017CFA024, 2017CFB711, 2016ACA126)ABRPSTCS (No. SYG201521)NSFJP (No. BK20160387)Shenzhen Science and Technology Research Grant (No. JCYJ20170303170809222)self-determined research funds of CCNU from the colleges, basic research and operation of MOE for the Central Universities (No. 23020205170469)Wuhan Morning Light Plan of Youth Science and Technology (No. 201705304010321)
文摘Peptide-based probes play prominent roles in biomedical research due to their promising properties such as high biocompatibility,fast excretion, favorable pharmacokinetics as well as easy and robust preparation. Considering the translation of imaging probes into clinical applications, peptide-based probes remain to be the most desirable and optimal candidates. This review summarized the development of peptide-based probes with promising imaging modalities and highlighted the successful applications for in vivo biomedical imaging.
基金This study was supported by a grant from National Natural Science Foundation of China （NO. 81372084）.Acknowledgments The authors are grateful to the Shantou Observatory and the 120 Emergency Command Center of Shantou City for providing related data.
文摘Purpose： To explore the impact of subtropical maritime monsoon climate on the frequency of ambulance use for trauma patients in a coastal region in China. Method： Statistical analysis of data on ambulance use from the 120 Emergency Command Center in Shantou City, Guangdong Province, from January to December 2012 as well as daily meteorological data from a Shantou observatory was performed to determine how climatic factors （seasons, time, and weather） affect the frequency of ambulance use for trauma patients. Results： The daily ambulance use for trauma patients differed between spring and summer or autumn （p 〈 0.05）, between sunny and rainy days （p 〈 0.05）, and between cloudy and lightly or moderately rainy days （p 〈 0.05）. We found a linear correlation between daily maximum temperature and daily ambulance use for trauma patients （R^2 0.103, p 〈 0.05）. In addition, there was significant difference in ambulance use between good and bad weather （p 〈 0.05）. Conclusion： Frequency of ambulance use for trauma patients is affected by the subtropical maritime monsoon climate in the coastal region. Better weather contributes to increased daily frequency of ambulance use, which is the highest in autumn and lowest in spring.
