BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose metabolism.Here,we present fo...BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose metabolism.Here,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed up.All patients were diagnosed with GDM during the second trimester and were treated.The blood glucose level elevated suddenly during the third trimester and then were diagnosed with FT1DM.Two patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before onset.One patient developed ketoacidosis,and three developed ketosis.Two patients had cesarean section deliveries,and two had vaginal deliveries.The growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet function.The frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present study.CONCLUSION In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less acidosis.The pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA genotypes.We speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.展开更多
Information diffusion in complex networks has become quite an active research topic.As an important part of this field,intervention against information diffusion processes is attracting ever-increasing attention from ...Information diffusion in complex networks has become quite an active research topic.As an important part of this field,intervention against information diffusion processes is attracting ever-increasing attention from network and control engineers.In particular,it is urgent to design intervention schemes for the coevolutionary dynamics between information diffusion processes and coupled networks.For this purpose,we comprehensively study the problem of information diffusion intervention over static and temporal coupling networks.First,individual interactions are described by a modified activitydriven network(ADN)model.Then,we establish a novel node-based susceptible-infected-recovered-susceptible(SIRS)model to characterize the information diffusion dynamics.On these bases,three synergetic intervention strategies are formulated.Second,we derive the critical threshold of the controlled-SIRS system via stability analysis.Accordingly,we exploit a spectral optimization scheme to minimize the outbreak risk or the required budget.Third,we develop an optimal control scheme of dynamically allocating resources to minimize both system loss and intervention expense,in which the optimal intervention inputs are obtained through optimal control theory and a forward-backward sweep algorithm.Finally,extensive simulation results validate the accuracy of theoretical derivation and the performance of our proposed intervention schemes.展开更多
A series of naphthyridinone derivatives based on la（a precursor of Voreloxin） were designed and synthesized.Seven compounds having 〉70%inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro...A series of naphthyridinone derivatives based on la（a precursor of Voreloxin） were designed and synthesized.Seven compounds having 〉70%inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro antitumor activity by SRB assay.Results reveal that thiazol-2-yl and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-l-yl groups are optimal at the N-1 and C-7positions of naphthyridinone core,respectively.10 j exhibits broad-spectrum activity（IC_（50）：〈0.5-6.25 μmol/L） against all of the tested cell lines including Etoposide- and/or la-resistant ones,and is 1.3-fold to 〉100-fold more potent than the two references against eight of these cell lines.展开更多
基金Supported by National Natural Science Foundation of China,No.82270864.
文摘BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose metabolism.Here,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed up.All patients were diagnosed with GDM during the second trimester and were treated.The blood glucose level elevated suddenly during the third trimester and then were diagnosed with FT1DM.Two patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before onset.One patient developed ketoacidosis,and three developed ketosis.Two patients had cesarean section deliveries,and two had vaginal deliveries.The growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet function.The frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present study.CONCLUSION In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less acidosis.The pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA genotypes.We speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.
基金the National Natural Science Foundation of China(Grant No.62071248)。
文摘Information diffusion in complex networks has become quite an active research topic.As an important part of this field,intervention against information diffusion processes is attracting ever-increasing attention from network and control engineers.In particular,it is urgent to design intervention schemes for the coevolutionary dynamics between information diffusion processes and coupled networks.For this purpose,we comprehensively study the problem of information diffusion intervention over static and temporal coupling networks.First,individual interactions are described by a modified activitydriven network(ADN)model.Then,we establish a novel node-based susceptible-infected-recovered-susceptible(SIRS)model to characterize the information diffusion dynamics.On these bases,three synergetic intervention strategies are formulated.Second,we derive the critical threshold of the controlled-SIRS system via stability analysis.Accordingly,we exploit a spectral optimization scheme to minimize the outbreak risk or the required budget.Third,we develop an optimal control scheme of dynamically allocating resources to minimize both system loss and intervention expense,in which the optimal intervention inputs are obtained through optimal control theory and a forward-backward sweep algorithm.Finally,extensive simulation results validate the accuracy of theoretical derivation and the performance of our proposed intervention schemes.
基金supported by National Key Research and Development Program (No. 2016YFA0201500)the National S&T Major Special Project on Major New Drug Innovations (Nos.2014ZX09507009-003, 2015ZX09102007)NSFC (Nos. 81373267, 21502237)
文摘A series of naphthyridinone derivatives based on la（a precursor of Voreloxin） were designed and synthesized.Seven compounds having 〉70%inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro antitumor activity by SRB assay.Results reveal that thiazol-2-yl and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-l-yl groups are optimal at the N-1 and C-7positions of naphthyridinone core,respectively.10 j exhibits broad-spectrum activity（IC_（50）：〈0.5-6.25 μmol/L） against all of the tested cell lines including Etoposide- and/or la-resistant ones,and is 1.3-fold to 〉100-fold more potent than the two references against eight of these cell lines.
