China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China....China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously.展开更多
In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type Ⅰ alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristi...In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type Ⅰ alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G > C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC + CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was > 3. In addition, the rs42524 G > C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type Ⅰ alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.展开更多
目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结...目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结果研究发现,仅15.8%的GBM患者接受了与Stupp方案一致的治疗。治疗方案的不一致主要是由于同步放化疗阶段替莫唑胺剂量>75 mg/m^(2)(58/120;48.3%)和治疗持续时间<42 d(84/120;70.0%),以及辅助治疗阶段替莫唑胺剂量<150 mg/m^(2)(89/101;88.1%)。接受符合Stupp方案治疗的患者的中位总生存期(27.09 vs 18.21个月)和无进展生存期(14.27 vs 12.10个月)更长。结论需要提高中国GBM患者实际接受的治疗方案与Stupp方案的一致性。展开更多
[b,T] denotes the commutator of generalized Calderon-Zygmund operators T with Lipschitz function b, where b∈Lip_β(R^n),(0 <β≤1) and T is aθ(t)-type Calderón-Zygmund operator. The commutator [b,T] generate...[b,T] denotes the commutator of generalized Calderon-Zygmund operators T with Lipschitz function b, where b∈Lip_β(R^n),(0 <β≤1) and T is aθ(t)-type Calderón-Zygmund operator. The commutator [b,T] generated by b and T is defined by[b,T]f(x)=b(x)Tf(x)-T(bf)(x)=∫k(x,y)(b(x)-b(y))f(y)dy.In this paper, the authors discuss the boundedness of the commutator [b, T] on weighted Hardy spaces and weighted Herz type Hardy spaces and prove that [b,T] is bounded from H^p(ω~p) to L^q(ω~q), and from HK_(q1)^(α,p)(ω_1,ω_2^(q1)) to K_(q2)^(α,p)(ω_1,ω_2^(q2)). The results extend and generalize the well-known ones in [7].展开更多
Faba bean (Vicia faba L) seeds are an important source of plant protein for humans and animals. A total of 15,697 Differentially Expressed Genes (DEGs) with pathway annotation were discovered in RNA-Seq of the faba be...Faba bean (Vicia faba L) seeds are an important source of plant protein for humans and animals. A total of 15,697 Differentially Expressed Genes (DEGs) with pathway annotation were discovered in RNA-Seq of the faba bean seeds. A total of 75 significant KEGG pathways abundance were discovered and 9 pathways were conserved within all genotypes. 41 significant pathways were found to be partially conserved within comparisons of 2 to 6 pairs of genotypes and 25 significant pathways were unique to single pairs of genotypes. There were 8 specific significant pathways discovered related to the faba bean seed Hydration Capacity trait and 9 specific significant pathways discovered related to the PSbMV seeds staining trait. The DEGs demonstrated the genetic distance between these varieties was confirmed by the breeding pedigree selection information and a PCA graph clearly illustrated the genetic distance within these genotypes.展开更多
Background To investigate the classification and microsurgical treatment of foramen magnum meningioma(FMM).Methods We retrospectively analyzed 76 patients with FMM and classified them into two classifications,classifi...Background To investigate the classification and microsurgical treatment of foramen magnum meningioma(FMM).Methods We retrospectively analyzed 76 patients with FMM and classified them into two classifications,classification ABS according to the relationship between the FMM and the brainstem and classification SIM according to the relationship between the FMM and the vertebral artery(VA).All patients underwent either the far lateral approach(54 cases)or the suboccipital midline approach(22 cases).Results Of the 76 cases,47 cases were located ahead of the brainstem(A),16 cases at the back of the brainstem(B),and 13 cases were located laterally to the brainstem(S).There were 15 cases located superior to the VA(S),49 cases were inferior(I),and 12 cases were mixed type(M).Among 76 cases,71 cases were resected with Simpson grade 2(93.42%),3 with Simpson grade 3(3.95%),and 2 with Simpson grade 4(2.63%).We summarized four anatomical triangles:triangles SOT,VOT,JVV,and TVV.The mean postoperative Karnofsky performance score was improved in all patients(p<0.05).However,several complications occurred,including hoarseness and CSF leak.Conclusion ABS and SIM classifications are objective indices for choosing the surgical approach and predicting the difficulty of FMMs,and it is of great importance to master the content,position relationship with the tumor,and variable anatomical structures in the four"triangles"for the success of the operation.展开更多
With the development of electric helicopters' motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rot...With the development of electric helicopters' motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rotor, the wake of the main rotor influences the tail rotor's inflow and wake.In the procedure of controlling, crosswind will also cause changes to the tail disk load. This paper describes requirements and design principles of an electric motor drive and variable pitch tail rotor system. A particular spoke-type architecture of the motor is designed, and the performance of blades is analyzed by the CFD method. The demand for simplicity of moving parts and strict constraints on the weight of a helicopter makes the design of electrical and mechanical components challenging. Different solutions have been investigated to propose an effective alternative to the mechanical actuation system. A test platform is constructed which can collect the dynamic response of the thrust control. The enhancement of the response speed due to an individual motor speed control and variable-pitch system is validated.展开更多
Bloodebrain barrier(BBB)damage after ischemia significantly influences stroke outcome.Compound LFHP-1 c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of ...Bloodebrain barrier(BBB)damage after ischemia significantly influences stroke outcome.Compound LFHP-1 c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after stroke remains unknown.Here,we show that LFHP-1 c,as a direct PGAM5 inhibitor,prevented BBB disruption after transient middle cerebral artery occlusion(tMCAO)in rats.Mechanistically,LFHP-1 c binding with endothelial PGAM5 not only inhibited the PGAM5 phosphatase activity,but also reduced the interaction of PGAM5 with NRF2,which facilitated nuclear translocation of NRF2 to prevent BBB disruption from ischemia.Furthermore,LFHP-1 c administration by targeting PGAM5 shows a trend toward reduced infarct volume,brain edema and neurological deficits in nonhuman primate Macaca fascicularis model with t MCAO.Thus,our study identifies compound LFHP-1 c as a firstly direct PGAM5 inhibitor showing amelioration of ischemia-induced BBB disruption in vitro and in vivo,and provides a potentially therapeutics for brain ischemic stroke.展开更多
The Unsteady Vortex Lattice Method(UVLM) is a medium-fidelity aerodynamic tool that has been widely used in aeroelasticity and flight dynamics simulations. The most timeconsuming step is the evaluation of the induced ...The Unsteady Vortex Lattice Method(UVLM) is a medium-fidelity aerodynamic tool that has been widely used in aeroelasticity and flight dynamics simulations. The most timeconsuming step is the evaluation of the induced velocity. Supposing that the number of bound and wake lattices is N and the computational cost is O (N2), we present an OeNT Dipole Panel Fast Multipole Method(DPFMM) for the rapid evaluation of the induced velocity in UVLM. The multipole expansion coefficients of a quadrilateral dipole panel have been derived in spherical coordinates, whose accuracy is the same as that of the Biot-Savart kernel at the same truncation degree P.Two methods(the loosening method and the shrinking method) are proposed and tested for space partitioning volumetric panels. Compared with FMM for vortex filaments(with three harmonics),DPFMM is approximately two times faster for N2 [103,106]. The simulation time of a multirotor(N~104) is reduced from 100 min(with unaccelerated direct solver) to 2 min(with DPFMM).展开更多
基金the National Key Research Development Program of China(2016YFC0208901 and 2017YFC0212100)the National Natural Science Foundation of China(71722003 and 71690244)。
文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously.
文摘In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type Ⅰ alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G > C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC + CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was > 3. In addition, the rs42524 G > C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type Ⅰ alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.
基金This study was approved by the Ethics Committee of the Peking Union Medical College Hospital,China(EC No.:S-473).Written informed consent was obtained from all patients prior to enrollment.
文摘目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结果研究发现,仅15.8%的GBM患者接受了与Stupp方案一致的治疗。治疗方案的不一致主要是由于同步放化疗阶段替莫唑胺剂量>75 mg/m^(2)(58/120;48.3%)和治疗持续时间<42 d(84/120;70.0%),以及辅助治疗阶段替莫唑胺剂量<150 mg/m^(2)(89/101;88.1%)。接受符合Stupp方案治疗的患者的中位总生存期(27.09 vs 18.21个月)和无进展生存期(14.27 vs 12.10个月)更长。结论需要提高中国GBM患者实际接受的治疗方案与Stupp方案的一致性。
文摘[b,T] denotes the commutator of generalized Calderon-Zygmund operators T with Lipschitz function b, where b∈Lip_β(R^n),(0 <β≤1) and T is aθ(t)-type Calderón-Zygmund operator. The commutator [b,T] generated by b and T is defined by[b,T]f(x)=b(x)Tf(x)-T(bf)(x)=∫k(x,y)(b(x)-b(y))f(y)dy.In this paper, the authors discuss the boundedness of the commutator [b, T] on weighted Hardy spaces and weighted Herz type Hardy spaces and prove that [b,T] is bounded from H^p(ω~p) to L^q(ω~q), and from HK_(q1)^(α,p)(ω_1,ω_2^(q1)) to K_(q2)^(α,p)(ω_1,ω_2^(q2)). The results extend and generalize the well-known ones in [7].
文摘Faba bean (Vicia faba L) seeds are an important source of plant protein for humans and animals. A total of 15,697 Differentially Expressed Genes (DEGs) with pathway annotation were discovered in RNA-Seq of the faba bean seeds. A total of 75 significant KEGG pathways abundance were discovered and 9 pathways were conserved within all genotypes. 41 significant pathways were found to be partially conserved within comparisons of 2 to 6 pairs of genotypes and 25 significant pathways were unique to single pairs of genotypes. There were 8 specific significant pathways discovered related to the faba bean seed Hydration Capacity trait and 9 specific significant pathways discovered related to the PSbMV seeds staining trait. The DEGs demonstrated the genetic distance between these varieties was confirmed by the breeding pedigree selection information and a PCA graph clearly illustrated the genetic distance within these genotypes.
基金supported by the Scientific Research Fund of Liaoning Provincial Education Department(CN)(FWZR2020006)
文摘Background To investigate the classification and microsurgical treatment of foramen magnum meningioma(FMM).Methods We retrospectively analyzed 76 patients with FMM and classified them into two classifications,classification ABS according to the relationship between the FMM and the brainstem and classification SIM according to the relationship between the FMM and the vertebral artery(VA).All patients underwent either the far lateral approach(54 cases)or the suboccipital midline approach(22 cases).Results Of the 76 cases,47 cases were located ahead of the brainstem(A),16 cases at the back of the brainstem(B),and 13 cases were located laterally to the brainstem(S).There were 15 cases located superior to the VA(S),49 cases were inferior(I),and 12 cases were mixed type(M).Among 76 cases,71 cases were resected with Simpson grade 2(93.42%),3 with Simpson grade 3(3.95%),and 2 with Simpson grade 4(2.63%).We summarized four anatomical triangles:triangles SOT,VOT,JVV,and TVV.The mean postoperative Karnofsky performance score was improved in all patients(p<0.05).However,several complications occurred,including hoarseness and CSF leak.Conclusion ABS and SIM classifications are objective indices for choosing the surgical approach and predicting the difficulty of FMMs,and it is of great importance to master the content,position relationship with the tumor,and variable anatomical structures in the four"triangles"for the success of the operation.
文摘With the development of electric helicopters' motor technology and the widespread use of electric drive rotors, more aircraft use electric rotors to provide thrust and directional control.For a helicopter tail rotor, the wake of the main rotor influences the tail rotor's inflow and wake.In the procedure of controlling, crosswind will also cause changes to the tail disk load. This paper describes requirements and design principles of an electric motor drive and variable pitch tail rotor system. A particular spoke-type architecture of the motor is designed, and the performance of blades is analyzed by the CFD method. The demand for simplicity of moving parts and strict constraints on the weight of a helicopter makes the design of electrical and mechanical components challenging. Different solutions have been investigated to propose an effective alternative to the mechanical actuation system. A test platform is constructed which can collect the dynamic response of the thrust control. The enhancement of the response speed due to an individual motor speed control and variable-pitch system is validated.
基金supported by the National Natural Science Foundation of China(81973512,81822041,21977116,and 81673305)National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”(No.2018ZX09711002006-013,China)+7 种基金Science&Technology Major Project of Zhongshan City(No.2019A4020,China)Double First-Class Project of China Pharmaceutical University(CPU2018GY06,CPU2018GY18,and CPU2018GY20,China)the Open Project of State Key Laboratory of Natural Medicines(SKLNMZZCX 201824 and SKLNMZZ202029,China)the Open Project Program of the State Key Laboratory of Drug Research(SIMM2004KF-08,China)the Open Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University(Traditional Chinese Pharmacology,China)Zhejiang Chinese Medical University(No.ZYAOX2018001,China)State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia Fund(SKL-HIDCA-2018-1,China)supported by the Six Talent Peaks Project of Jiangsu Province to Tao Pang
文摘Bloodebrain barrier(BBB)damage after ischemia significantly influences stroke outcome.Compound LFHP-1 c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after stroke remains unknown.Here,we show that LFHP-1 c,as a direct PGAM5 inhibitor,prevented BBB disruption after transient middle cerebral artery occlusion(tMCAO)in rats.Mechanistically,LFHP-1 c binding with endothelial PGAM5 not only inhibited the PGAM5 phosphatase activity,but also reduced the interaction of PGAM5 with NRF2,which facilitated nuclear translocation of NRF2 to prevent BBB disruption from ischemia.Furthermore,LFHP-1 c administration by targeting PGAM5 shows a trend toward reduced infarct volume,brain edema and neurological deficits in nonhuman primate Macaca fascicularis model with t MCAO.Thus,our study identifies compound LFHP-1 c as a firstly direct PGAM5 inhibitor showing amelioration of ischemia-induced BBB disruption in vitro and in vivo,and provides a potentially therapeutics for brain ischemic stroke.
文摘The Unsteady Vortex Lattice Method(UVLM) is a medium-fidelity aerodynamic tool that has been widely used in aeroelasticity and flight dynamics simulations. The most timeconsuming step is the evaluation of the induced velocity. Supposing that the number of bound and wake lattices is N and the computational cost is O (N2), we present an OeNT Dipole Panel Fast Multipole Method(DPFMM) for the rapid evaluation of the induced velocity in UVLM. The multipole expansion coefficients of a quadrilateral dipole panel have been derived in spherical coordinates, whose accuracy is the same as that of the Biot-Savart kernel at the same truncation degree P.Two methods(the loosening method and the shrinking method) are proposed and tested for space partitioning volumetric panels. Compared with FMM for vortex filaments(with three harmonics),DPFMM is approximately two times faster for N2 [103,106]. The simulation time of a multirotor(N~104) is reduced from 100 min(with unaccelerated direct solver) to 2 min(with DPFMM).
