Prediction of stock trend has been an intriguing topic and is extensively studied by researchers from diversified fields. Machine learning, a well-established algorithm, has been also studied for its potentials in pre...Prediction of stock trend has been an intriguing topic and is extensively studied by researchers from diversified fields. Machine learning, a well-established algorithm, has been also studied for its potentials in prediction of financial markets. In this paper, seven different techniques of data mining are applied to predict stock price movement of Shanghai Composite Index. The approaches include Support vector machine, Logistic regression, Naive Bayesian, K-nearest neighbor classification, Decision tree, Random forest and Adaboost. Extracting the corresponding comments between April 2017 and May 2018, it shows that: 1) sentiment derived from Eastmoney, a social media platform for the financial community in China, further enhances model performances, 2) for positive and negative sentiments classifications, all classifiers reach at least 75% accuracy and the linear SVC models prove to perform best, 3) according to the strong correlation between the price fluctuation and the bullish index, the approximate overall trend of the closing price can be acquired.展开更多
Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other complications.However,the PP mesh often leads to adhesion formation and does n...Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other complications.However,the PP mesh often leads to adhesion formation and does not promote functional tissue repair.In this study,we synthesized one kind of aldehyde Bletilla striata polysaccharide(BSPA)modified chitosan(CS)hydrogel based on Schiff base reaction.The hydrogel exhibited a porous network structure,a highly hydrophilic surface and good biocompatibility.We wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1×1.5cm abdominal wall defect model in rats.The results of gross observation,histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing effects.Notably,the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo,promoting wound healing by enhancing collagen deposition and capillary rearrangement.This study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion,anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing process.Overall,this work offers a novel approach to the design of abdominal wall repair patches.展开更多
Crop domestication has long been regarded as an evolutionary processbecause the development of new and improvedcultivars isbased on selection.Many domesticated crops possess a suite of selected characteristics such as...Crop domestication has long been regarded as an evolutionary processbecause the development of new and improvedcultivars isbased on selection.Many domesticated crops possess a suite of selected characteristics such as plant architecture,seed shattering,and inflorescence-related traits(Shi and Lai,2015).Alteration of secondary metabolites has also become a common domestication trait.However,it seems to be somewhat overlooked(Alseekh et al.,2021).展开更多
Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly importa...Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop.展开更多
Improving the low-cycle fatigue(LCF)properties of additively manufactured Ti-5.6Al-3.8V alloy is critical in ensuring its service safety and represents a significant research challenge.This work discusses a so-lution ...Improving the low-cycle fatigue(LCF)properties of additively manufactured Ti-5.6Al-3.8V alloy is critical in ensuring its service safety and represents a significant research challenge.This work discusses a so-lution that optimizes the alloy's microstructure and ductility by precisely controlling the over-saturated strengthening elements and heat treatment.This was accomplished using selective laser melting(SLM),heat treatment at 800 ℃ for 2 h,and furnace cooling on a Ti-5.6Al-3.8V alloy with tightly controlled Al,V,and O concentrations in a lower range.The results showed that the SLM-fabricated Ti-5.6Al-3.8V alloy,post-heat treatment,exhibited α laths with a width of~1.4 μm and β columnar grains with a diameter of~126 μm,without experiencing coarsening or variant selection phenomena.The alloy bal-anced strength and ductility post-heat treatment with a UTS of 1015 MPa and an EL of 16.5%relative to the as-deposited state(UTS of 1199 MPa and EL of 11.9%).Notably,the LCF properties of the heat-treated SLM Ti-5.6Al-3.8V alloy are superior to those of other Ti-6Al-4V alloys produced by additive manu-facturing and comparable to traditional forgings.At high strain amplitudes(1-1.5%),the fatigue life of this alloy was twice that of the Ti-6Al-4V forgings.Furthermore,we comprehensively analyzed the mi-crostructure,strength,and ductility of the SLM Ti-5.6Al-3.8V alloy to elucidate the factors influencing its LCF properties.These findings provide a solid foundation for improving the LCF properties of additively manufactured Ti-6Al-4V alloy,thereby contributing to its safe and reliable use in critical applications.展开更多
Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily inv...Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily investigated the relationship between the microstructure and the fracture toughness of DED new Ti-6Al-4V-1Mo alloy.Two types of microstructures were designed via two process strategies:high-line energy density(HE)and low-line energy density(LE).Relative to LE samples,HE samples possess larger-sized microstructural characteristics(coarser grain boundaryα(α_(GB)),largerαcolonies,and coarserαlaths).Lessα/βphase boundaries were formed by coarserαlaths in the HE samples,increasing the movement of dislocations,resulting in tensile strength decreasing from 1007.1 MPa(LE)to 930.8 MPa(HE)and elongation increasing from 10.8%(LE)to 15.7%(HE).Also,HE samples exhibited an excellent fracture toughness of 114.0 MPa m^(1/2),significantly higher than that of LE samples(76.8 MPa m^(1/2)).An analysis of crack propagation paths was conducted to investigate the factors contributing to toughening.The primary factor enhancing toughness is the frequent obstruction of cracks by coarseαGB and largeαcolonies in HE samples.Particularly,the pretty large-angle deflections induced by the superposition effect of coarseαGB and largeαcolonies play a vital of significant role.These factors induced the long and tortuous high-energy pathways,which resulted in ultimately improved fracture toughness.The discovered microstructural toughening mechanisms can serve as a reference for future studies involving titanium alloys,offering insights on how to enhance fracture toughness by achieving similar characteristics.展开更多
Chronic inflammation is a crucial inducerof diabetesvascular complications.Onereason is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist ...Chronic inflammation is a crucial inducerof diabetesvascular complications.Onereason is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist in all human tissues.In pathological vascular,infiltrated macrophages secrete inflammatory factors leading to an increase in plaque stability.?In macrophage polarization,autophagy plays an important role.Enhancement of macrophage autophagy could induce macrophage polarization from the M1 phenotype to M2 phenotype and inhibit inflammatory reactions.3 Our previous research found that high glucose condition promotes miR-32 expression and macrophage M1 polarization,4 but the mechanism of miR-32 promoting macrophage M1 polarization is unclear.In this study,we found that,under a high-glucose condition,miR-32/Mef2d/cAMP signaling promoted M1 macrophage polarization via inhibited autophagy.These results provide a theoretical and experimental basis for the prevention and treatment of T2D vascular inflammation.展开更多
Maca （Lepidium meyenii Walp, 2n = 8x = 64）, belonging to the Brassicaceae family, is an economic plant cultivated in the central Andes sierra in Peru （4000-4500 m）. Considering that the rapid uplift of the central...Maca （Lepidium meyenii Walp, 2n = 8x = 64）, belonging to the Brassicaceae family, is an economic plant cultivated in the central Andes sierra in Peru （4000-4500 m）. Considering that the rapid uplift of the central Andes occurred 5-10 million years ago （Ma）, an evolutionary question arises regarding how plants such as maca acquire high-altitude adaptation within a short geological period. Here, we report the high-quality genome assembly of maca, in which two closely spaced maca-specific whole-genome duplications （WGDs; ~6.7 Ma） were identified. Comparative genomic analysis between maca and closely related Brassicaceae species revealed expansions of maca genes and gene families involved in abiotic stress response, hormone signaling pathway, and secondary metabolite biosynthesis via WGDs. The retention and subsequent functional divergence of many duplicated genes may account for the morphological and physiological changes （i.e., small leaf shape and self-fertility） in maca in a high-altitude environment. In addition, some duplicated maca genes were identified with functions in morphological adaptation （i.e., LEAF CURLING RESPONSIVENESS） and abiotic stress response （i.e., GL YClNE-RICH RNA-BINDING PROTEINS and DNA-DAMAGE-REPAIR/TOLERATION2） under positive selection. Collectively, the maca genome provides use- ful information to understand the important roles of WGDs in the high-altitude adaptation of plants in the Andes.展开更多
This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic...This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic groups,which increased at a more rapidly than the Han population,and population rejuvenation coupled with a population structure that aged.The biological sex structure fluctuated within a balanced range in northwestern China.Urbanization advanced in northwestern China,throughout this period,but the area’s level of urbanization is still significantly lower than the average level of urbanization nationally.展开更多
文摘Prediction of stock trend has been an intriguing topic and is extensively studied by researchers from diversified fields. Machine learning, a well-established algorithm, has been also studied for its potentials in prediction of financial markets. In this paper, seven different techniques of data mining are applied to predict stock price movement of Shanghai Composite Index. The approaches include Support vector machine, Logistic regression, Naive Bayesian, K-nearest neighbor classification, Decision tree, Random forest and Adaboost. Extracting the corresponding comments between April 2017 and May 2018, it shows that: 1) sentiment derived from Eastmoney, a social media platform for the financial community in China, further enhances model performances, 2) for positive and negative sentiments classifications, all classifiers reach at least 75% accuracy and the linear SVC models prove to perform best, 3) according to the strong correlation between the price fluctuation and the bullish index, the approximate overall trend of the closing price can be acquired.
基金the National Natural Science Foundation of China(No.32171345)the Hebei Provincial Natural Science Foundation of China(No.C2022104003)+4 种基金the Beijing Nova Programme Interdisciplinary Cooperation Project(No.20230484464)the Fok Ying Tung Education Foundation(No.141039)the Fund of Key Laboratory of Advanced Materials of Ministry of Education(No.AdvMat-2023-10)the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of Chinathe 111 Project(No.B13003).
文摘Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other complications.However,the PP mesh often leads to adhesion formation and does not promote functional tissue repair.In this study,we synthesized one kind of aldehyde Bletilla striata polysaccharide(BSPA)modified chitosan(CS)hydrogel based on Schiff base reaction.The hydrogel exhibited a porous network structure,a highly hydrophilic surface and good biocompatibility.We wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1×1.5cm abdominal wall defect model in rats.The results of gross observation,histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing effects.Notably,the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo,promoting wound healing by enhancing collagen deposition and capillary rearrangement.This study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion,anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing process.Overall,this work offers a novel approach to the design of abdominal wall repair patches.
基金This work was supported by the National Natural Science Foundation of China(32301813,32161143005)the Project of Sanya Yazhou Bay Science and Technology City(SCKJ-JYRC-2022-22)Hainan Yazhou Bay Seed Laboratory(B21Y10212).
文摘Crop domestication has long been regarded as an evolutionary processbecause the development of new and improvedcultivars isbased on selection.Many domesticated crops possess a suite of selected characteristics such as plant architecture,seed shattering,and inflorescence-related traits(Shi and Lai,2015).Alteration of secondary metabolites has also become a common domestication trait.However,it seems to be somewhat overlooked(Alseekh et al.,2021).
基金the National Key R&D Program of China(2022YFE0140800)the European Union Horizon 2020 project ECOBREED(771367)+4 种基金the Youth Innovation Program of Chinese Academy of Agricultural Sciences(No.Y2022QC02)Project of Sanya Yazhou Bay Science and Technology City(SCKJ-JYRC-2022-22)National Natural Science Foundation of China(32161143005,31911530772,32111540258)PlantaSYST(SGA No 739582 under FPA No.664620)the BG05M2OP001-1.003-001-C01 project,financed by the European Regional Development Fund through the“Science and Education for Smart Growth”Operational Programme and Slovenian Research Agency,program P4-0077“Genetics and Modern Technologies of Crops”.
文摘Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop.
基金Key Research and Development Projects of Shaanxi Province(No.2023-YBGY-359)China CEEC University Joint Education Project(2021108)+2 种基金Science and Technology Plan of Xi'an City(Nos.21ZCZZHXJS-QCY6-0001,21CXLHTJSGG-QCY8-0003)Open Fund of Key Laboratory of Plasma Dynamics of Air Force Engineering University(No.6142202210203)“Qin Chuang Yuan”Project of Shaanxi Province(No.2023KXJ-272).
文摘Improving the low-cycle fatigue(LCF)properties of additively manufactured Ti-5.6Al-3.8V alloy is critical in ensuring its service safety and represents a significant research challenge.This work discusses a so-lution that optimizes the alloy's microstructure and ductility by precisely controlling the over-saturated strengthening elements and heat treatment.This was accomplished using selective laser melting(SLM),heat treatment at 800 ℃ for 2 h,and furnace cooling on a Ti-5.6Al-3.8V alloy with tightly controlled Al,V,and O concentrations in a lower range.The results showed that the SLM-fabricated Ti-5.6Al-3.8V alloy,post-heat treatment,exhibited α laths with a width of~1.4 μm and β columnar grains with a diameter of~126 μm,without experiencing coarsening or variant selection phenomena.The alloy bal-anced strength and ductility post-heat treatment with a UTS of 1015 MPa and an EL of 16.5%relative to the as-deposited state(UTS of 1199 MPa and EL of 11.9%).Notably,the LCF properties of the heat-treated SLM Ti-5.6Al-3.8V alloy are superior to those of other Ti-6Al-4V alloys produced by additive manu-facturing and comparable to traditional forgings.At high strain amplitudes(1-1.5%),the fatigue life of this alloy was twice that of the Ti-6Al-4V forgings.Furthermore,we comprehensively analyzed the mi-crostructure,strength,and ductility of the SLM Ti-5.6Al-3.8V alloy to elucidate the factors influencing its LCF properties.These findings provide a solid foundation for improving the LCF properties of additively manufactured Ti-6Al-4V alloy,thereby contributing to its safe and reliable use in critical applications.
基金This work was supported by the Key Research and Development Projects of Shaanxi Province(2023-YBGY-359)the China CEEC University Joint Education Project(2021108)+1 种基金the Science and Technology Plan of Xi'an City(21ZCZZHXJS-QCY6-0001,21CXLHTJSGG-QCY8-0003)the Open Fund of Key Laboratory of Plasma Dynamics of Air Force Engineering University(6142202210203).
文摘Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily investigated the relationship between the microstructure and the fracture toughness of DED new Ti-6Al-4V-1Mo alloy.Two types of microstructures were designed via two process strategies:high-line energy density(HE)and low-line energy density(LE).Relative to LE samples,HE samples possess larger-sized microstructural characteristics(coarser grain boundaryα(α_(GB)),largerαcolonies,and coarserαlaths).Lessα/βphase boundaries were formed by coarserαlaths in the HE samples,increasing the movement of dislocations,resulting in tensile strength decreasing from 1007.1 MPa(LE)to 930.8 MPa(HE)and elongation increasing from 10.8%(LE)to 15.7%(HE).Also,HE samples exhibited an excellent fracture toughness of 114.0 MPa m^(1/2),significantly higher than that of LE samples(76.8 MPa m^(1/2)).An analysis of crack propagation paths was conducted to investigate the factors contributing to toughening.The primary factor enhancing toughness is the frequent obstruction of cracks by coarseαGB and largeαcolonies in HE samples.Particularly,the pretty large-angle deflections induced by the superposition effect of coarseαGB and largeαcolonies play a vital of significant role.These factors induced the long and tortuous high-energy pathways,which resulted in ultimately improved fracture toughness.The discovered microstructural toughening mechanisms can serve as a reference for future studies involving titanium alloys,offering insights on how to enhance fracture toughness by achieving similar characteristics.
基金supported by the National Natural Science Foundation of China(No.81873651)Natural Science Foundation of Hunan Province,China(No.2021JJ40490,2021JJ70113)Scientific Research Fund Project of Hunan Provincial Health Commission,China(No.20201981,20201901)。
文摘Chronic inflammation is a crucial inducerof diabetesvascular complications.Onereason is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist in all human tissues.In pathological vascular,infiltrated macrophages secrete inflammatory factors leading to an increase in plaque stability.?In macrophage polarization,autophagy plays an important role.Enhancement of macrophage autophagy could induce macrophage polarization from the M1 phenotype to M2 phenotype and inhibit inflammatory reactions.3 Our previous research found that high glucose condition promotes miR-32 expression and macrophage M1 polarization,4 but the mechanism of miR-32 promoting macrophage M1 polarization is unclear.In this study,we found that,under a high-glucose condition,miR-32/Mef2d/cAMP signaling promoted M1 macrophage polarization via inhibited autophagy.These results provide a theoretical and experimental basis for the prevention and treatment of T2D vascular inflammation.
文摘Maca （Lepidium meyenii Walp, 2n = 8x = 64）, belonging to the Brassicaceae family, is an economic plant cultivated in the central Andes sierra in Peru （4000-4500 m）. Considering that the rapid uplift of the central Andes occurred 5-10 million years ago （Ma）, an evolutionary question arises regarding how plants such as maca acquire high-altitude adaptation within a short geological period. Here, we report the high-quality genome assembly of maca, in which two closely spaced maca-specific whole-genome duplications （WGDs; ~6.7 Ma） were identified. Comparative genomic analysis between maca and closely related Brassicaceae species revealed expansions of maca genes and gene families involved in abiotic stress response, hormone signaling pathway, and secondary metabolite biosynthesis via WGDs. The retention and subsequent functional divergence of many duplicated genes may account for the morphological and physiological changes （i.e., small leaf shape and self-fertility） in maca in a high-altitude environment. In addition, some duplicated maca genes were identified with functions in morphological adaptation （i.e., LEAF CURLING RESPONSIVENESS） and abiotic stress response （i.e., GL YClNE-RICH RNA-BINDING PROTEINS and DNA-DAMAGE-REPAIR/TOLERATION2） under positive selection. Collectively, the maca genome provides use- ful information to understand the important roles of WGDs in the high-altitude adaptation of plants in the Andes.
基金supported by China’s National Social Science Foundation(Grant No:20ARK007).
文摘This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic groups,which increased at a more rapidly than the Han population,and population rejuvenation coupled with a population structure that aged.The biological sex structure fluctuated within a balanced range in northwestern China.Urbanization advanced in northwestern China,throughout this period,but the area’s level of urbanization is still significantly lower than the average level of urbanization nationally.
