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肠道菌群和结直肠癌发生发展及治疗的研究进展
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作者 邵雨琪 洪洁 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第17期881-887,共7页
结直肠癌作为全球发病和死亡居首位的消化系统恶性肿瘤,其与肠道菌群的关系越来越受到关注。肠道菌群可以与宿主细胞相互作用,调节包括新陈代谢和免疫反应在内的多种生理过程。近年来,随着研究不断深入,已经揭示了宿主与肠道菌群之间的... 结直肠癌作为全球发病和死亡居首位的消化系统恶性肿瘤,其与肠道菌群的关系越来越受到关注。肠道菌群可以与宿主细胞相互作用,调节包括新陈代谢和免疫反应在内的多种生理过程。近年来,随着研究不断深入,已经揭示了宿主与肠道菌群之间的相互作用在结直肠癌的起源和进展中发挥重要作用。本综述旨在通过描述结直肠癌相关的肠道微生物群以及瘤内微生物群,讨论肠道菌群参与结直肠癌的发生、侵袭、转移过程的具体机制,及其对结直肠癌治疗反应和预后的影响,为深入了解肠道菌群与结直肠癌的关系提供参考,并为开发菌群干预结直肠癌提供治疗思路。 展开更多
关键词 结直肠癌 肠道菌群 肿瘤内菌 免疫治疗 具核梭杆菌
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A review on passenger emergency evacuation from multimodal transportation hubs 被引量:4
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作者 Zhiman Xu Qiang Bai +2 位作者 yuqi shao Aihui Hu Zhi Dong 《Journal of Traffic and Transportation Engineering(English Edition)》 EI CSCD 2022年第4期591-607,共17页
Multimodal transportation hubs serve as transfer points with the function of collecting,transferring,and distributing passengers and play a significant role in the entire multimodal transportation network.In an emerge... Multimodal transportation hubs serve as transfer points with the function of collecting,transferring,and distributing passengers and play a significant role in the entire multimodal transportation network.In an emergency,the development of an effective and efficient emergency evacuation strategy to evacuate passengers from multimodal transportation hubs is very important.This paper aims to conduct a comprehensive review on passenger emergency evacuations from multimodal transportation hubs,summarize the achievements,identify gaps in existing literature,thus to lay a solid foundation for future studies.This paper first reviewed studies on evacuee behavior characteristics in emergency evacuations,including pedestrian characteristics,pedestrian behavior characteristics,and pedestrian flow characteristics.Then evacuation models,including pedestrian evacuation models and multimodal transportation evacuation models,were investigated.In addition,a retrospective analysis was carried out for evacuation simulation.It is found that while many studies have been conducted on passenger emergency evacuations from multimodal transportation hubs,most of them focus more on evacuating pedestrians from inside to outside of hub buildings;the studies on evacuation at multimodal transfer points are limited.It is also found that most existing studies tried to establish a general model to handle all types of emergency evacuations;in fact,a model would be more efficient if it is just established for a specific emergency and for a specific type of hubs.Also,existing data collection methods may collect biased data;new data collection methods need to be explored to increase the accuracy of data collection.Future study directions include the evacuation at multimodal transfer points,interactive effects between individual pedestrian behavior and pedestrian group behavior,more specific types of emergency evacuations,more accurate data collection methods,and tradeoffs between cost and benefit in emergency evacuations. 展开更多
关键词 Multimodal transportation hubs Emergency evacuation PASSENGERS Pedestrian behavior Evacuation simulation
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