Accurate prediction of tropical cyclone(TC)intensity is challenging due to the complex physical processes involved.Here,we introduce a new TC intensity prediction scheme for the western North Pacific(WNP)based on a ti...Accurate prediction of tropical cyclone(TC)intensity is challenging due to the complex physical processes involved.Here,we introduce a new TC intensity prediction scheme for the western North Pacific(WNP)based on a time-dependent theory of TC intensification,termed the energetically based dynamical system(EBDS)model,together with the use of a long short-term memory(LSTM)neural network.In time-dependent theory,TC intensity change is controlled by both the internal dynamics of the TC system and various environmental factors,expressed as environmental dynamical efficiency.The LSTM neural network is used to predict the environmental dynamical efficiency in the EBDS model trained using besttrack TC data and global reanalysis data during 1982–2017.The transfer learning and ensemble methods are used to retrain the scheme using the environmental factors predicted by the Global Forecast System(GFS)of the National Centers for Environmental Prediction during 2017–21.The predicted environmental dynamical efficiency is finally iterated into the EBDS equations to predict TC intensity.The new scheme is evaluated for TC intensity prediction using both reanalysis data and the GFS prediction data.The intensity prediction by the new scheme shows better skill than the official prediction from the China Meteorological Administration(CMA)and those by other state-of-art statistical and dynamical forecast systems,except for the 72-h forecast.Particularly at the longer lead times of 96 h and 120 h,the new scheme has smaller forecast errors,with a more than 30%improvement over the official forecasts.展开更多
Artificially controlling the solid-state precipitation in aluminum (Al) alloys is an efficient way to achieve well-performed properties,and the microalloying strategy is the most frequently adopted method for such a p...Artificially controlling the solid-state precipitation in aluminum (Al) alloys is an efficient way to achieve well-performed properties,and the microalloying strategy is the most frequently adopted method for such a purpose.In this paper,recent advances in lengthscale-dependent scandium (Sc) microalloying effects in Al-Cu model alloys are reviewed.In coarse-grained Al-Cu alloys,the Sc-aided Cu/Sc/vacancies complexes that act as heterogeneous nuclei and Sc segregation at the θ′-Al_(2)Cu/matrix interface that reduces interfacial energy contribute significantly to θ′precipitation.By grain size refinement to the fine/ultrafine-grained scale,the strongly bonded Cu/Sc/vacancies complexes inhibit Cu and vacancy diffusing toward grain boundaries,promoting the desired intragranular θ′precipitation.At nanocrystalline scale,the applied high strain producing high-density vacancies results in the formation of a large quantity of (Cu Sc,vacancy)-rich atomic complexes with high thermal stability,outstandingly improving the strength/ductility synergy and preventing the intractable low-temperature precipitation.This review recommends the use of microalloying technology to modify the precipitation behaviors toward better combined mechanical properties and thermal stability in Al alloys.展开更多
Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones(TCs). In this study, with the initial inner-core size(i.e., the radius of...Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones(TCs). In this study, with the initial inner-core size(i.e., the radius of maximum wind—RMW)varied from 20–180 km in idealized simulations using two different numerical models, we found a nonmonotonic dependence of the lifetime maximum intensification rate(LMIR) on the inner-core size. Namely, there is an optimal innercore size for the LMIR of a TC. Tangential wind budget analysis shows that, compared to large TCs, small TCs have large inward flux of absolute vorticity due to large absolute vorticity inside the RMW. However, small TCs also suffer from strong lateral diffusion across the eyewall, which partly offsets the positive contribution from large inward flux of absolute vorticity. These two competing processes ultimately lead to the TC with an intermediate initial inner-core size having the largest LMIR. Results from sensitivity experiments show that the optimal size varies in the range of 40–120 km and increases with higher sea surface temperature, lower latitude, larger horizontal mixing length, and weaker initial TC intensity. The 40–120 km RMW corresponds to the inner-core size most commonly found for intensifying TCs in observations, suggesting the natural selection of initial TC size for intensification. This study highlights the importance of accurate representation of TC inner-core size to TC intensity forecasts by numerical weather prediction models.展开更多
The dynamics model of a 2-degree-of-freedom deep groove ball bearing is established by incorporating the raceway surface waviness model comprising multiple sinusoidal functions superposition.The model is solved using ...The dynamics model of a 2-degree-of-freedom deep groove ball bearing is established by incorporating the raceway surface waviness model comprising multiple sinusoidal functions superposition.The model is solved using the fourth-order Runge-Kutta method to obtain the vibration characteristics including displacement,velocity,acceleration,and frequency of the bearing.Validation of the model is accomplished through comparison with theoretical vibration frequencies.The influence of the amplitude of waviness of the inner and outer ring raceway surfaces of deep groove ball bearings on the vibration displacement,peak-to-peak vibration displacement and root-mean-square vibration acceleration is analyzed,and the results show that as the amplitude of the inner and outer ring raceway surfaces waviness increases,all the vibration characteristic indexes increase,indicating that the vibration amplitude of the bearings as well as the energy of the waviness-induced shock waveforms increase with the increase of the amplitude of the waviness.展开更多
An extraordinary and unprecedented heatwave swept across western North America(i.e.,the Pacific Northwest)in late June of 2021,resulting in hundreds of deaths,a massive die-off of sea creatures off the coast,and horri...An extraordinary and unprecedented heatwave swept across western North America(i.e.,the Pacific Northwest)in late June of 2021,resulting in hundreds of deaths,a massive die-off of sea creatures off the coast,and horrific wildfires.Here,we use observational data to find the atmospheric circulation variabilities of the North Pacific and Arctic-Pacific-Canada patterns that co-occurred with the development and mature phases of the heatwave,as well as the North America pattern,which coincided with the decaying and eastward movement of the heatwave.Climate models from the Coupled Model Intercomparison Project(Phase 6)are not designed to simulate a particular heatwave event like this one.Still,models show that greenhouse gases are the main reason for the long-term increase of average daily maximum temperature in western North America in the past and future.展开更多
Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host d...Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host disease(GVHD)and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life.In addition,GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions(DLIs)and chimeric antigen receptor(CAR)T-cell therapy.Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells,universal immune cell therapy may strongly reduce GVHD,while simultaneously reducing tumor burden.Nevertheless,widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy.Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy,including the use of universal cell lines,signaling regulation and CAR technology.In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives.展开更多
Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate lase...Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate laser irradiation and oxygen(O_(2))are three essential components for PDT,but the hypoxic tumor microenvironment(TME)restricts the O_(2) supply in tumor tissues.Even worse,tumor metastasis and drug resistance frequently happen under hypoxic condition,which further deteriorate the antitumor effect of PDT.To enhance the PDT efficiency,critical attention has been received by relieving tumor hypoxia,and innovative strategies on this topic continue to emerge.Traditionally,the O_(2) supplement strategy is considered as a direct and effective strategy to relieve TME,whereas it is confronted with great challenges for continuous O_(2) supply.Recently,O_(2)-independent PDT provides a brand new strategy to enhance the antitumor efficiency,which can avoid the influence of TME.In addition,PDT can synergize with other antitumor strategies,such as chemotherapy,immunotherapy,photothermal therapy(PTT)and starvation therapy,to remedy the inadequate PDT effect under hypoxia conditions.In this paper,we summarized the latest progresses in the development of innovative strategies to improve PDT efficacy against hypoxic tumor,which were classified into O_(2)-dependent PDT,O_(2)-independent PDT and synergistic therapy.Furthermore,the advantages and deficiencies of various strategies were also discussed to envisage the prospects and challenges in future study.展开更多
WRKY transcription factors play important roles in plant growth,development,and stress responses.Our previous research has shown that the GhWRKY91 gene can delay age-,abscisic acid(ABA)-,and drought-induced leaf senes...WRKY transcription factors play important roles in plant growth,development,and stress responses.Our previous research has shown that the GhWRKY91 gene can delay age-,abscisic acid(ABA)-,and drought-induced leaf senescence when overexpressed in transgenic Arabidopsis plants.To explore in more depth the biological functions of the GhWRKY91 gene,we further observed the root growth of overexpressing transgenic Arabidopsis thaliana under ABA and drought treatment.In this study,we transplanted the germinated seeds of wild-type(WT)and three transgenic lines(OE-12,OE-13 and OE-20)to 1/2 MS solid medium containing ABA and different concentrations of mannitol(simulated drought treatment)for culturing.The results showed that the transgenic plants had dark green leaves and short root lengths when no stress treatment was added.After ABA and mannitol treatment,the root growth of the WT and transgenic Arabidopsis was inhibited to varying degrees,and the root length downregulation of the transgenic plants was higher than that of the WT,indicating that they were more sensitive to ABA and drought.A bimolecular fluorescence complementation(BiFC)assay showed that the GhWRKY91 and GhWRKY3 proteins interact and emit yellow fluorescence in tobacco leaf cells.These results indicate that the GhWRKY91 gene negatively regulates root elongation in transgenic Arabidopsis and provide a basis for further research on the molecular mechanism of its involvement in regulating cotton root development.展开更多
We study a gate-tunable superconducting qubit(gatemon) based on a thin InAs-Al hybrid nanowire.Using a gate voltage to control its Josephson energy,the gatemon can reach the strong coupling regime to a microwave cavit...We study a gate-tunable superconducting qubit(gatemon) based on a thin InAs-Al hybrid nanowire.Using a gate voltage to control its Josephson energy,the gatemon can reach the strong coupling regime to a microwave cavity.In the dispersive regime,we extract the energy relaxation time T_(1)~0.56 μs and the dephasing time T_(2)^(*)~0.38 μs.Since thin In As-Al nanowires can have fewer or single sub-band occupation and recent transport experiment shows the existence of nearly quantized zero-bias conductance peaks,our result holds relevancy for detecting Majorana zero modes in thin InAs-Al nanowires using circuit quantum electrodynamics.展开更多
The grid-point atmospheric model of IAP LASG （GAMIL） was developed in and has been evaluated since early 2004. Although the model shows its ability in simulating the global climate, it suffers from some problems in ...The grid-point atmospheric model of IAP LASG （GAMIL） was developed in and has been evaluated since early 2004. Although the model shows its ability in simulating the global climate, it suffers from some problems in simulating precipitation in the tropics. These biases seem to result mainly from the treatment of the subgrid scale convection, which is parameterized with Tiedtke＇s massflux scheme （or the Zhang-McFarlane scheme, as an option） in the model. In order to reduce the systematic biases, several modifications were made to the Tiedtke scheme used in GAMIL, including （1） an increase in lateral convective entrainment/detrainment rate for shallow convection, （2） inclusion of a relative humidity threshold for the triggering of deep convection, and （3） a reduced efficiency for the conversion of cloud water to rainwater in the convection scheme. Two experiments, one with the original Tiedtke scheme used in GAMIL and the other with the modified scheme, were conducted to evaluate the performance of the modified scheme in this study. The results show that both the climatological mean state, such as precipitation, temperature and specific humidity, and interannual variability in the model simulation are improved with the use of this modified scheme. Results from several additional experiments show that the improvements in the model performance in different regions mainly result from either the introduction of the relative humidity threshold for triggering of the deep convection or the suppressed shallow convection due to enhanced lateral convective entrainment/detrainment rates.展开更多
A new parameterization scheme of sea surface momentum roughness length for all wind regimes, including high winds, under tropical cyclone （TC） conditions is constructed based on measurements from Global Positioning ...A new parameterization scheme of sea surface momentum roughness length for all wind regimes, including high winds, under tropical cyclone （TC） conditions is constructed based on measurements from Global Positioning System （GPS） dropsonde. It reproduces the observed regime transition, namely, an increase of the drag coefficient with an increase in wind speed up to 40 m s-1 , followed by a decrease with a further increase in wind speed. The effect of this parameterization on the structure and intensity of TCs is evaluated using a newly developed numerical model, TCM4. The results show that the final intensity is increased by 10.5% （8.9%） in the maximum surface wind speed and by 8.1 hPa （5.9 hPa） in the minimum sea surface pressure drop with （without） dissipative heating. This intensity increase is found to be due mainly to the reduced frictional dissipation in the surface layer and little to do with either the surface enthalpy flux or latent heat release in the eyewall convection. The effect of the new parameterization on the storm structure is found to be insignificant and occurs only in the inner core region with the increase in tangential winds in the eyewall and the increase in temperature anomalies in the eye. This is because the difference in drag coefficient appears only in a small area under the eyewall. Implications of the results are briefly discussed.展开更多
Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or...Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or Li N_(x)Co_(y)Mn_(z)O_(2) cathode materials will be produced in the very near future,imposing significant pressure for the development of suitable disposal/recycling technologies,in terms of both environmental protection and resource reclaiming.In this review,we firstly do a comprehensive summary of the-state-of-art technologies to recycle Li N_(x)Co_(y)Mn_(z)O_(2) and LiFePO_(4)-based LIBs,in the aspects of pretreatment,hydrometallurgical recycling,and direct regeneration of the cathode materials.This closed-loop strategy for cycling cathode materials has been regarded as an ideal approach considering its economic benefit and environmental friendliness.Afterward,as for the exhausted anode materials,we focus on the utilization of exhausted anode materials to obtain other functional materials,such as graphene.Finally,the existing challenges in recycling the LiFePO_(4) and Li N_(x)Co_(y)Mn_(z)O_(2) cathodes and graphite anodes for industrial-scale application are discussed in detail;and the possible strategies for these issues are proposed.We expect this review can provide a roadmap towards better technologies for recycling LIBs,shed light on the future development of novel battery recycling technologies to promote the environmental benignity and economic viability of the battery industry and pave way for the large-scale application of LIBs in industrial fields in the near future.展开更多
The boundary layer structure and related heavy rainfall of Typhoon Fitow(2013), which made landfall in Zhejiang Province, China, are studied using the Advanced Research version of the Weather Research and Forecasting ...The boundary layer structure and related heavy rainfall of Typhoon Fitow(2013), which made landfall in Zhejiang Province, China, are studied using the Advanced Research version of the Weather Research and Forecasting model, with a focus on the sensitivity of the simulation to the planetary boundary layer parameterization. Two groups of experiments—one with the same surface layer scheme and including the Yonsei University(YSU), Mellor–Yamada–Nakanishi–Niino Level 2.5,and Bougeault and Lacarrere schemes; and the other with different surface layer schemes and including the Mellor–Yamada–Janjic′ and Quasi-Normal Scale Elimination schemes—are investigated. For the convenience of comparative analysis, the simulation with the YSU scheme is chosen as the control run because this scheme successfully reproduces the track, intensity and rainfall as a whole. The maximum deviations in the peak tangential and peak radial winds may account for 11% and 33%of those produced in the control run, respectively. Further diagnosis indicates that the vertical diffusivity is much larger in the first group, resulting in weaker vertical shear of the tangential and radial winds in the boundary layer and a deeper inflow layer therein. The precipitation discrepancies are related to the simulated track deflection and the differences in the simulated low-level convergent flow among all tests. Furthermore, the first group more efficiently transfers moisture and energy and produces a stronger ascending motion than the second, contributing to a deeper moist layer, stronger convection and greater precipitation.展开更多
As a new member in two-dimensional materials family,transition metal carbides(TMCs)have many excellent properties,such as chemical stability,in-plane anisotropy,high conductivity and flexibility,and remarkable energy ...As a new member in two-dimensional materials family,transition metal carbides(TMCs)have many excellent properties,such as chemical stability,in-plane anisotropy,high conductivity and flexibility,and remarkable energy conversation efficiency,which predispose them for promising applications as transparent electrode,flexible electronics,broadband photodetectors and battery electrodes.However,up to now,their device applications are in the early stage,especially because their controllable synthesis is still a great challenge.This review systematically summarized the state-of-the-art research in this rapidly developing field with particular focus on structure,property,synthesis and applicability of TMCs.Finally,the current challenges and future perspectives are outlined for the application of 2D TMCs.展开更多
Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prep...Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prepare CPCs with high conductivity,corrosion resistance,strong interfacial adhesion and high sensitivity.Here,we propose a facile“drop-casting and fluorination”strategy to fabricate superhydrophobic and highly electrically conductive coating by Ag precursor adsorption onto a commercially available elastic tape,subsequent chemical reduction and final fluorination.The Ag nanoparticles could not only construct the electrically conductive network but also greatly enhance the surface roughness.The contact angle and electrical conductivity of the coating can reach as high as 156°and 126 S/cm,respectively.When used for strain sensing,the superhydrophobic and conductive coating shows a high gauger factor(up to 7631 with the strain from 44%to 50%)and outstanding recyclability.The strain sensor could monitor different body joint motions with the stable and reliable sensing signals even after long time treatment in a corrosive solution.展开更多
East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region...East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region,the specific process remains unclear.Here we describe six species of Carpinus,a typical northern hemisphere temperate woody plant,from the early Miocene of the Maguan Basin,southwestern China,southern East Asia.This constitutes the southernmost,and the earliest occurrence that shows a high species diversity of the genus.Together with other Carpinus fossil records from East Asia,we show that the genus had achieved a high diversity in East Asia at least by the middle Miocene.Of the six species here described,three have become extinct,indicating that the genus has experienced apparent species loss during its evolutionary history in East Asia.In contrast,the remaining three species closely resemble extant species,raising the possibility that these species may have persisted in East Asia at least since the early Miocene.These findings indicate that the accumulation of species diversity of Carpinus in East Asia is a complex process involving extinction,persistence,and possible subsequent speciation.展开更多
Although it is well known that the tropical easterly jet(TEJ)has a significant impact on summer weather and climate over India and Africa,whether the TEJ exerts an important impact on tropical cyclone(TC)activity over...Although it is well known that the tropical easterly jet(TEJ)has a significant impact on summer weather and climate over India and Africa,whether the TEJ exerts an important impact on tropical cyclone(TC)activity over the western North Pacific(WNP)remains unknown.In this study,we examined the impact of the TEJ on the interannual variability of TC genesis frequency over the WNP in the TC season(June-September)during 1980-2020.The results show a significant positive correlation between TC genesis frequency over the WNP and the jet intensity in the entrance region of the TEJ over the tropical western Pacific(in brief WP_TEJ),with a correlation coefficient as high as 0.66.The intensified WP_TEJ results in strong ageostrophic northerly winds in the entrance region and thus upper-level divergence to the north of the jet axis over the main TC genesis region in the WNP.This would lead to an increase in upward motion in the troposphere with enhanced low-level convergence,which are the most important factors to the increases in low-level vorticity,mid-level humidity and low-level eddy kinetic energy,and the decreases in sea level pressure and vertical wind shear in the region.All these changes are favorable for TC genesis over the WNP and vice versa.Further analyses indicate that the interannual variability of the WP_TEJ intensity is likely to be linked to the local diabatic heating over the Indian Ocean-western Pacific and the central Pacific El Ni?o-Southern Oscillation.展开更多
Carbon nitride,an emerging polymeric semiconductor,has attracted attention in research ranging from photocatalysis to photodetection due to its favorable visible light response and high physicochemical stability.For i...Carbon nitride,an emerging polymeric semiconductor,has attracted attention in research ranging from photocatalysis to photodetection due to its favorable visible light response and high physicochemical stability.For its practical device application,the fabrication of high-quality carbon nitride films on substrates is essential.However,conventional methodologies to achieve high polymerization of carbon nitride are often accompanied by its decomposition,significantly compromising the film quality.Herein,we report an ultrafast fabrication of carbon nitride film by laser direct writing(LDW).The instantaneous high temperature and pressure during LDW can efficiently boost the polymerization of carbon nitride and suppress its decomposition,resulting in high-quality carbon nitride film with excellent mechanical stability with the substrate.Due to the efficient photon-to-electron conversion,it exhibits an outstanding photoelectrochemical water splitting and optoelectronic detection capability,even under strong acid/alkaline conditions.This study thus offers a facile and efficient LDW strategy for the rapid fabrication of carbon nitride film photoelectrodes,demonstrating its great feasibility in multifunctional photoelectrical applications,including but not limited to photoelectrochemical water splitting and optoelectronic detection.展开更多
基金supported by the National Key R&D Program of China(Grant No.2017YFC1501604)the National Natural Science Foundation of China(Grant Nos.41875114 and 41875057).
文摘Accurate prediction of tropical cyclone(TC)intensity is challenging due to the complex physical processes involved.Here,we introduce a new TC intensity prediction scheme for the western North Pacific(WNP)based on a time-dependent theory of TC intensification,termed the energetically based dynamical system(EBDS)model,together with the use of a long short-term memory(LSTM)neural network.In time-dependent theory,TC intensity change is controlled by both the internal dynamics of the TC system and various environmental factors,expressed as environmental dynamical efficiency.The LSTM neural network is used to predict the environmental dynamical efficiency in the EBDS model trained using besttrack TC data and global reanalysis data during 1982–2017.The transfer learning and ensemble methods are used to retrain the scheme using the environmental factors predicted by the Global Forecast System(GFS)of the National Centers for Environmental Prediction during 2017–21.The predicted environmental dynamical efficiency is finally iterated into the EBDS equations to predict TC intensity.The new scheme is evaluated for TC intensity prediction using both reanalysis data and the GFS prediction data.The intensity prediction by the new scheme shows better skill than the official prediction from the China Meteorological Administration(CMA)and those by other state-of-art statistical and dynamical forecast systems,except for the 72-h forecast.Particularly at the longer lead times of 96 h and 120 h,the new scheme has smaller forecast errors,with a more than 30%improvement over the official forecasts.
基金supported by the National Natural Science Foundation of China(Nos.52201135,52271115,U23A6013,92360301,and U2330203)the 111 Project of China(No.BP2018008)+1 种基金the Shaanxi Province Innovation Team Project,China(No.2024RS-CXTD-58)supported by the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies and by the open research fund of Suzhou Laboratory。
文摘Artificially controlling the solid-state precipitation in aluminum (Al) alloys is an efficient way to achieve well-performed properties,and the microalloying strategy is the most frequently adopted method for such a purpose.In this paper,recent advances in lengthscale-dependent scandium (Sc) microalloying effects in Al-Cu model alloys are reviewed.In coarse-grained Al-Cu alloys,the Sc-aided Cu/Sc/vacancies complexes that act as heterogeneous nuclei and Sc segregation at the θ′-Al_(2)Cu/matrix interface that reduces interfacial energy contribute significantly to θ′precipitation.By grain size refinement to the fine/ultrafine-grained scale,the strongly bonded Cu/Sc/vacancies complexes inhibit Cu and vacancy diffusing toward grain boundaries,promoting the desired intragranular θ′precipitation.At nanocrystalline scale,the applied high strain producing high-density vacancies results in the formation of a large quantity of (Cu Sc,vacancy)-rich atomic complexes with high thermal stability,outstandingly improving the strength/ductility synergy and preventing the intractable low-temperature precipitation.This review recommends the use of microalloying technology to modify the precipitation behaviors toward better combined mechanical properties and thermal stability in Al alloys.
基金supported by the National Natural Science Foundation of China (Grant No.41730960)Wuxi University Research Start-up Fund for Introduced Talents (2024r037)Yuqing WANG was supported by the NSF (Grant No. AGS-1834300)。
文摘Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones(TCs). In this study, with the initial inner-core size(i.e., the radius of maximum wind—RMW)varied from 20–180 km in idealized simulations using two different numerical models, we found a nonmonotonic dependence of the lifetime maximum intensification rate(LMIR) on the inner-core size. Namely, there is an optimal innercore size for the LMIR of a TC. Tangential wind budget analysis shows that, compared to large TCs, small TCs have large inward flux of absolute vorticity due to large absolute vorticity inside the RMW. However, small TCs also suffer from strong lateral diffusion across the eyewall, which partly offsets the positive contribution from large inward flux of absolute vorticity. These two competing processes ultimately lead to the TC with an intermediate initial inner-core size having the largest LMIR. Results from sensitivity experiments show that the optimal size varies in the range of 40–120 km and increases with higher sea surface temperature, lower latitude, larger horizontal mixing length, and weaker initial TC intensity. The 40–120 km RMW corresponds to the inner-core size most commonly found for intensifying TCs in observations, suggesting the natural selection of initial TC size for intensification. This study highlights the importance of accurate representation of TC inner-core size to TC intensity forecasts by numerical weather prediction models.
文摘The dynamics model of a 2-degree-of-freedom deep groove ball bearing is established by incorporating the raceway surface waviness model comprising multiple sinusoidal functions superposition.The model is solved using the fourth-order Runge-Kutta method to obtain the vibration characteristics including displacement,velocity,acceleration,and frequency of the bearing.Validation of the model is accomplished through comparison with theoretical vibration frequencies.The influence of the amplitude of waviness of the inner and outer ring raceway surfaces of deep groove ball bearings on the vibration displacement,peak-to-peak vibration displacement and root-mean-square vibration acceleration is analyzed,and the results show that as the amplitude of the inner and outer ring raceway surfaces waviness increases,all the vibration characteristic indexes increase,indicating that the vibration amplitude of the bearings as well as the energy of the waviness-induced shock waveforms increase with the increase of the amplitude of the waviness.
基金supported by the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (GML2019ZD0306)National Natural Science Foundation of China (Grant Nos. 41731173 and 42192564)+5 种基金National Key R&D Program of China (2019YFA0606701)Strategic Priority Research Program of Chinese Academy of Sciences (XDB42000000 and XDA20060502)Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences (ISEE2021ZD01)Independent Research Project Program of State Key Laboratory of Tropical Oceanography (Grand No. LTOZZ2004)Leading Talents of Guangdong Province Programsupported by the High Performance Computing Division in the South China Sea Institute of Oceanology
文摘An extraordinary and unprecedented heatwave swept across western North America(i.e.,the Pacific Northwest)in late June of 2021,resulting in hundreds of deaths,a massive die-off of sea creatures off the coast,and horrific wildfires.Here,we use observational data to find the atmospheric circulation variabilities of the North Pacific and Arctic-Pacific-Canada patterns that co-occurred with the development and mature phases of the heatwave,as well as the North America pattern,which coincided with the decaying and eastward movement of the heatwave.Climate models from the Coupled Model Intercomparison Project(Phase 6)are not designed to simulate a particular heatwave event like this one.Still,models show that greenhouse gases are the main reason for the long-term increase of average daily maximum temperature in western North America in the past and future.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1103300)the National Natural Science Foundation of China(Grant No.82020108004)+3 种基金the Natural Science Foundation of Chongqing Innovation Group Science Program(Grant No.cstc2021jcyjcxttX0001)the Natural Science Foundation of Chongqing(Grant No.CSTB2022NSCQ-MSX1060)the Special Project for Talent Construction in Xinqiao Hospital(Grant No.2022XKRC001)the National College Student Innovation and Entrepreneurship Training Program(Grant No.202190035001).
文摘Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host disease(GVHD)and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life.In addition,GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions(DLIs)and chimeric antigen receptor(CAR)T-cell therapy.Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells,universal immune cell therapy may strongly reduce GVHD,while simultaneously reducing tumor burden.Nevertheless,widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy.Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy,including the use of universal cell lines,signaling regulation and CAR technology.In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives.
文摘Photodynamic therapy(PDT)is applied as a robust therapeutic option for tumor,which exhibits some advantages of unique selectivity and irreversible damage to tumor cells.Among which,photosensitizer(PS),appropriate laser irradiation and oxygen(O_(2))are three essential components for PDT,but the hypoxic tumor microenvironment(TME)restricts the O_(2) supply in tumor tissues.Even worse,tumor metastasis and drug resistance frequently happen under hypoxic condition,which further deteriorate the antitumor effect of PDT.To enhance the PDT efficiency,critical attention has been received by relieving tumor hypoxia,and innovative strategies on this topic continue to emerge.Traditionally,the O_(2) supplement strategy is considered as a direct and effective strategy to relieve TME,whereas it is confronted with great challenges for continuous O_(2) supply.Recently,O_(2)-independent PDT provides a brand new strategy to enhance the antitumor efficiency,which can avoid the influence of TME.In addition,PDT can synergize with other antitumor strategies,such as chemotherapy,immunotherapy,photothermal therapy(PTT)and starvation therapy,to remedy the inadequate PDT effect under hypoxia conditions.In this paper,we summarized the latest progresses in the development of innovative strategies to improve PDT efficacy against hypoxic tumor,which were classified into O_(2)-dependent PDT,O_(2)-independent PDT and synergistic therapy.Furthermore,the advantages and deficiencies of various strategies were also discussed to envisage the prospects and challenges in future study.
基金supported by the Hebei Agricultural University Introduced Talents Scientific Research Project(No.YJ2021011).
文摘WRKY transcription factors play important roles in plant growth,development,and stress responses.Our previous research has shown that the GhWRKY91 gene can delay age-,abscisic acid(ABA)-,and drought-induced leaf senescence when overexpressed in transgenic Arabidopsis plants.To explore in more depth the biological functions of the GhWRKY91 gene,we further observed the root growth of overexpressing transgenic Arabidopsis thaliana under ABA and drought treatment.In this study,we transplanted the germinated seeds of wild-type(WT)and three transgenic lines(OE-12,OE-13 and OE-20)to 1/2 MS solid medium containing ABA and different concentrations of mannitol(simulated drought treatment)for culturing.The results showed that the transgenic plants had dark green leaves and short root lengths when no stress treatment was added.After ABA and mannitol treatment,the root growth of the WT and transgenic Arabidopsis was inhibited to varying degrees,and the root length downregulation of the transgenic plants was higher than that of the WT,indicating that they were more sensitive to ABA and drought.A bimolecular fluorescence complementation(BiFC)assay showed that the GhWRKY91 and GhWRKY3 proteins interact and emit yellow fluorescence in tobacco leaf cells.These results indicate that the GhWRKY91 gene negatively regulates root elongation in transgenic Arabidopsis and provide a basis for further research on the molecular mechanism of its involvement in regulating cotton root development.
基金supported by the Tsinghua University Initiative Scientific Research Programthe Alibaba Innovative Research Program+1 种基金the National Natural Science Foundation of China (Grant Nos.12204047,92065106,and 61974138)the support from Youth Innovation Promotion Association,Chinese Academy of Sciences (Grant Nos.2017156 and Y2021043)。
文摘We study a gate-tunable superconducting qubit(gatemon) based on a thin InAs-Al hybrid nanowire.Using a gate voltage to control its Josephson energy,the gatemon can reach the strong coupling regime to a microwave cavity.In the dispersive regime,we extract the energy relaxation time T_(1)~0.56 μs and the dephasing time T_(2)^(*)~0.38 μs.Since thin In As-Al nanowires can have fewer or single sub-band occupation and recent transport experiment shows the existence of nearly quantized zero-bias conductance peaks,our result holds relevancy for detecting Majorana zero modes in thin InAs-Al nanowires using circuit quantum electrodynamics.
基金This work is jointly supported by CAS International Partnership Creative Group ＂The Climate System Model Development and Application Studies＂, the 973 Project （Grant No. 2005CB321703） the Fund for Innovative Research Groups （Grant No. 40221503） the National Natural Science Foundation of China （Grant No. 40233031）.
文摘The grid-point atmospheric model of IAP LASG （GAMIL） was developed in and has been evaluated since early 2004. Although the model shows its ability in simulating the global climate, it suffers from some problems in simulating precipitation in the tropics. These biases seem to result mainly from the treatment of the subgrid scale convection, which is parameterized with Tiedtke＇s massflux scheme （or the Zhang-McFarlane scheme, as an option） in the model. In order to reduce the systematic biases, several modifications were made to the Tiedtke scheme used in GAMIL, including （1） an increase in lateral convective entrainment/detrainment rate for shallow convection, （2） inclusion of a relative humidity threshold for the triggering of deep convection, and （3） a reduced efficiency for the conversion of cloud water to rainwater in the convection scheme. Two experiments, one with the original Tiedtke scheme used in GAMIL and the other with the modified scheme, were conducted to evaluate the performance of the modified scheme in this study. The results show that both the climatological mean state, such as precipitation, temperature and specific humidity, and interannual variability in the model simulation are improved with the use of this modified scheme. Results from several additional experiments show that the improvements in the model performance in different regions mainly result from either the introduction of the relative humidity threshold for triggering of the deep convection or the suppressed shallow convection due to enhanced lateral convective entrainment/detrainment rates.
基金support from the National Basic Research Program of China (973 Program) (No. 2009CB421500)the National Natural Science Foundation of China (GrantNos. 40875039 and 40730948)+3 种基金the Typhoon Research Foundation of Shanghai Typhoon Institute/China Mete-orological Administration (Grant Nos. 2006STB07 and2008ST11)support from the Knowledge Innovation Program of theChinese Academy of Sciences (IAP09318)support from the US Office of Naval Research (Grant No. N00014-021-0532)the National Science Foundation (Grant No. ATM-0427128)
文摘A new parameterization scheme of sea surface momentum roughness length for all wind regimes, including high winds, under tropical cyclone （TC） conditions is constructed based on measurements from Global Positioning System （GPS） dropsonde. It reproduces the observed regime transition, namely, an increase of the drag coefficient with an increase in wind speed up to 40 m s-1 , followed by a decrease with a further increase in wind speed. The effect of this parameterization on the structure and intensity of TCs is evaluated using a newly developed numerical model, TCM4. The results show that the final intensity is increased by 10.5% （8.9%） in the maximum surface wind speed and by 8.1 hPa （5.9 hPa） in the minimum sea surface pressure drop with （without） dissipative heating. This intensity increase is found to be due mainly to the reduced frictional dissipation in the surface layer and little to do with either the surface enthalpy flux or latent heat release in the eyewall convection. The effect of the new parameterization on the storm structure is found to be insignificant and occurs only in the inner core region with the increase in tangential winds in the eyewall and the increase in temperature anomalies in the eye. This is because the difference in drag coefficient appears only in a small area under the eyewall. Implications of the results are briefly discussed.
基金supported by the National Natural Science Foundation of China(Nos.51072130,51502045 and 21905202)the Australian Research Council(ARC)through Discovery Early Career Researcher Award(DECRA,No.DE170100871)program。
文摘Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or Li N_(x)Co_(y)Mn_(z)O_(2) cathode materials will be produced in the very near future,imposing significant pressure for the development of suitable disposal/recycling technologies,in terms of both environmental protection and resource reclaiming.In this review,we firstly do a comprehensive summary of the-state-of-art technologies to recycle Li N_(x)Co_(y)Mn_(z)O_(2) and LiFePO_(4)-based LIBs,in the aspects of pretreatment,hydrometallurgical recycling,and direct regeneration of the cathode materials.This closed-loop strategy for cycling cathode materials has been regarded as an ideal approach considering its economic benefit and environmental friendliness.Afterward,as for the exhausted anode materials,we focus on the utilization of exhausted anode materials to obtain other functional materials,such as graphene.Finally,the existing challenges in recycling the LiFePO_(4) and Li N_(x)Co_(y)Mn_(z)O_(2) cathodes and graphite anodes for industrial-scale application are discussed in detail;and the possible strategies for these issues are proposed.We expect this review can provide a roadmap towards better technologies for recycling LIBs,shed light on the future development of novel battery recycling technologies to promote the environmental benignity and economic viability of the battery industry and pave way for the large-scale application of LIBs in industrial fields in the near future.
基金supported by the National Natural Science Foundation of China (Grant No. 41375056)the National Basic Research and Development Project (973 program) of China under contract no. 2015CB452805+2 种基金the National Key Technology R&D Program (Grant No. 2012BAC03)the Social Welfare Technology Development Projects of the Science and Technology Department of Zhejiang Province (Grant No. 2014C33056)the Key Project of Science and Technology Plan of Zhejiang Meteorological Provincial Bureau (2017ZD04)
文摘The boundary layer structure and related heavy rainfall of Typhoon Fitow(2013), which made landfall in Zhejiang Province, China, are studied using the Advanced Research version of the Weather Research and Forecasting model, with a focus on the sensitivity of the simulation to the planetary boundary layer parameterization. Two groups of experiments—one with the same surface layer scheme and including the Yonsei University(YSU), Mellor–Yamada–Nakanishi–Niino Level 2.5,and Bougeault and Lacarrere schemes; and the other with different surface layer schemes and including the Mellor–Yamada–Janjic′ and Quasi-Normal Scale Elimination schemes—are investigated. For the convenience of comparative analysis, the simulation with the YSU scheme is chosen as the control run because this scheme successfully reproduces the track, intensity and rainfall as a whole. The maximum deviations in the peak tangential and peak radial winds may account for 11% and 33%of those produced in the control run, respectively. Further diagnosis indicates that the vertical diffusivity is much larger in the first group, resulting in weaker vertical shear of the tangential and radial winds in the boundary layer and a deeper inflow layer therein. The precipitation discrepancies are related to the simulated track deflection and the differences in the simulated low-level convergent flow among all tests. Furthermore, the first group more efficiently transfers moisture and energy and produces a stronger ascending motion than the second, contributing to a deeper moist layer, stronger convection and greater precipitation.
基金This research was supported by grants from by the National Natural Science Foundation of China(52002254)Sichuan Science and Technology Program(2020YJ0262,2021YFH0127)+2 种基金Chunhui plan of Ministry of Education of China,Fundamental Research Funds for the Central Universities,China(YJ201893)State Key Lab of Advanced Metals and Materials,China(Grant No.2019-Z03)the Danish National Research Foundation and EU H2020RISE 2016-MNR4S Cell project.
文摘As a new member in two-dimensional materials family,transition metal carbides(TMCs)have many excellent properties,such as chemical stability,in-plane anisotropy,high conductivity and flexibility,and remarkable energy conversation efficiency,which predispose them for promising applications as transparent electrode,flexible electronics,broadband photodetectors and battery electrodes.However,up to now,their device applications are in the early stage,especially because their controllable synthesis is still a great challenge.This review systematically summarized the state-of-the-art research in this rapidly developing field with particular focus on structure,property,synthesis and applicability of TMCs.Finally,the current challenges and future perspectives are outlined for the application of 2D TMCs.
基金Natural Science Foundation of China(No.51873178)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(No.sklpme2020-4-03)+1 种基金Qing Lan Project of Yangzhou University and Jiangsu Province,High-end Talent Project of Yangzhou University,the Priority Academic Program Development of Jiangsu Higher Education Institutions,Postgraduate Research&Practice Innovation Program of Jiangsu province(No.KYCX18_2364,No.KYCX20_2977)Outstanding Doctoral Dissertation Fund of Yangzhou University.
文摘Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prepare CPCs with high conductivity,corrosion resistance,strong interfacial adhesion and high sensitivity.Here,we propose a facile“drop-casting and fluorination”strategy to fabricate superhydrophobic and highly electrically conductive coating by Ag precursor adsorption onto a commercially available elastic tape,subsequent chemical reduction and final fluorination.The Ag nanoparticles could not only construct the electrically conductive network but also greatly enhance the surface roughness.The contact angle and electrical conductivity of the coating can reach as high as 156°and 126 S/cm,respectively.When used for strain sensing,the superhydrophobic and conductive coating shows a high gauger factor(up to 7631 with the strain from 44%to 50%)and outstanding recyclability.The strain sensor could monitor different body joint motions with the stable and reliable sensing signals even after long time treatment in a corrosive solution.
基金the National Natural Science Foundation of China(No.31670216,No.31900194)the Foundation of the State Key Laboratory of Palaeobiology and Stratigraphy,Nanjing Institute of Geology and Palaeontology,Chinese Academy of Sciences(No.183112)。
文摘East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region,the specific process remains unclear.Here we describe six species of Carpinus,a typical northern hemisphere temperate woody plant,from the early Miocene of the Maguan Basin,southwestern China,southern East Asia.This constitutes the southernmost,and the earliest occurrence that shows a high species diversity of the genus.Together with other Carpinus fossil records from East Asia,we show that the genus had achieved a high diversity in East Asia at least by the middle Miocene.Of the six species here described,three have become extinct,indicating that the genus has experienced apparent species loss during its evolutionary history in East Asia.In contrast,the remaining three species closely resemble extant species,raising the possibility that these species may have persisted in East Asia at least since the early Miocene.These findings indicate that the accumulation of species diversity of Carpinus in East Asia is a complex process involving extinction,persistence,and possible subsequent speciation.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(Grant No.2020B0301030004)the National Natural Science Foundation of China(Grant Nos.42075015,41775060,41875114)+1 种基金the Science and Technology Commission of Shanghai MunicipalityChina(Grant No.20dz1200700)。
文摘Although it is well known that the tropical easterly jet(TEJ)has a significant impact on summer weather and climate over India and Africa,whether the TEJ exerts an important impact on tropical cyclone(TC)activity over the western North Pacific(WNP)remains unknown.In this study,we examined the impact of the TEJ on the interannual variability of TC genesis frequency over the WNP in the TC season(June-September)during 1980-2020.The results show a significant positive correlation between TC genesis frequency over the WNP and the jet intensity in the entrance region of the TEJ over the tropical western Pacific(in brief WP_TEJ),with a correlation coefficient as high as 0.66.The intensified WP_TEJ results in strong ageostrophic northerly winds in the entrance region and thus upper-level divergence to the north of the jet axis over the main TC genesis region in the WNP.This would lead to an increase in upward motion in the troposphere with enhanced low-level convergence,which are the most important factors to the increases in low-level vorticity,mid-level humidity and low-level eddy kinetic energy,and the decreases in sea level pressure and vertical wind shear in the region.All these changes are favorable for TC genesis over the WNP and vice versa.Further analyses indicate that the interannual variability of the WP_TEJ intensity is likely to be linked to the local diabatic heating over the Indian Ocean-western Pacific and the central Pacific El Ni?o-Southern Oscillation.
基金Australian Research Council,Grant/Award Number:DP200100365National Natural Science Foundation of China,Grant/Award Numbers:21905144,21905202,22002107,22179093+1 种基金Qinghai Provincial Department of Science and Technology,Grant/Award Number:2021-zj-702Tianjin University,Grant/Award Number:2021XZC-0052。
文摘Carbon nitride,an emerging polymeric semiconductor,has attracted attention in research ranging from photocatalysis to photodetection due to its favorable visible light response and high physicochemical stability.For its practical device application,the fabrication of high-quality carbon nitride films on substrates is essential.However,conventional methodologies to achieve high polymerization of carbon nitride are often accompanied by its decomposition,significantly compromising the film quality.Herein,we report an ultrafast fabrication of carbon nitride film by laser direct writing(LDW).The instantaneous high temperature and pressure during LDW can efficiently boost the polymerization of carbon nitride and suppress its decomposition,resulting in high-quality carbon nitride film with excellent mechanical stability with the substrate.Due to the efficient photon-to-electron conversion,it exhibits an outstanding photoelectrochemical water splitting and optoelectronic detection capability,even under strong acid/alkaline conditions.This study thus offers a facile and efficient LDW strategy for the rapid fabrication of carbon nitride film photoelectrodes,demonstrating its great feasibility in multifunctional photoelectrical applications,including but not limited to photoelectrochemical water splitting and optoelectronic detection.
