Objective:To analyze the effect of continuity of care in the cardiac intensive care unit(CICU)on improving cognitive function and psychological state in patients with heart failure(HF).Methods:A total of 112 chronic H...Objective:To analyze the effect of continuity of care in the cardiac intensive care unit(CICU)on improving cognitive function and psychological state in patients with heart failure(HF).Methods:A total of 112 chronic HF patients admitted to the CICU of Xuzhou Traditional Chinese Medicine Hospital from July 2022 to August 2024 were selected and randomly divided into two groups using the red and blue ball method:a control group(n=56)and a study group(n=56).The control group received routine CICU nursing management,while the study group received routine CICU nursing combined with continuity of care management.Cognitive function(using the Montreal Cognitive Assessment,MoCA),psychological state(using the Self-Rating Depression Scale,SDS,and Self-Rating Anxiety Scale,SAS),and quality of life(using the Minnesota Living with Heart Failure Questionnaire,MLHFQ)were compared between the two groups.Results:After the intervention,the cognitive function scores of the study group were significantly higher than those of the control group(P<0.05).The SDS and SAS scores of the study group were significantly lower than those of the control group after the intervention(P<0.05).The quality of life in the study group was also significantly better than in the control group(P<0.05).Conclusion:CICU continuity of care can effectively improve cognitive function and psychological state in patients with HF,while also enhancing their quality of life.展开更多
A simple method is proposed to optimize the thickness parameter of the boundary layer of the saturation function in the Complementary Sliding Mode Control (CSMC). A pair of complementary sliding surfaces are construct...A simple method is proposed to optimize the thickness parameter of the boundary layer of the saturation function in the Complementary Sliding Mode Control (CSMC). A pair of complementary sliding surfaces are constructed. And the Taylor series is used to estimate the steady state error of CSMC system to optimize the parameter value for the boundary layer of the saturation function without artificial settings. This proposed CSMC strategy is applied to the speed regulation in permanent magnet synchronous motor with lump uncertainties. The experimental results show that the proposed CSMC strategy can obtain an optimal value for the boundary layer parameter effectively suppressing the chattering and keep an excellent system performance.展开更多
Conjunctival melanoma(CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B(CuB). We found that CuB remarkably in...Conjunctival melanoma(CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B(CuB). We found that CuB remarkably inhibited the proliferation of CM cells including CM-AS16,CRMM1, CRMM2 and CM2005.1, without toxicity to normal cells. CuB can also induce CM cells G2/M cell cycle arrest. RNA-seq screening identified KIF20A, a key downstream effector of FOXM1 pathway, was abolished by CuB treatment. Further target identification by activity-based protein profiling chemoproteomic approach revealed that GRP78 is a potential target of CuB. Several lines of evidence demonstrated that CuB interacted with GRP78 and bound with a Kdvalue of0.11 μmol/L. Furthermore, ATPase activity evaluation showed that CuB suppressed GRP78 both in human recombinant GRP78 protein and cellular lysates. Knockdown of the GRP78 gene significantly induced the downregulation of FOXM1 and related pathway proteins including KIF20A, underlying an interesting therapeutic perspective. Finally, CuB significantly inhibited tumor progression in NCG mice without causing obvious side effects in vivo. Taken together, our current work proved that GRP78-FOXM1-KIF20A as a promising pathway for CM therapy, and the traditional medicine CuB as a candidate drug to hinder this pathway.展开更多
A new type of X-ray fiber dosimeters is proposed that is based on the X-ray response of CsPbBr_(3) perovskite-quantum-dots[PQDs]activated silica fiber.Such a fiber sensor is constructed by covering a multimode silica ...A new type of X-ray fiber dosimeters is proposed that is based on the X-ray response of CsPbBr_(3) perovskite-quantum-dots[PQDs]activated silica fiber.Such a fiber sensor is constructed by covering a multimode silica fiber with PQDs embedded glass powders using a transparent high-temperature glue.Under X-ray irradiation,the fiber sensor emits bright green light at 525 nm,which can be readily recorded by a CCD spectrometer.The integrated radioluminescence intensity has an excellent linear response to the X-ray dose.Study is given to the fiber sensor concerning its thermal stability in a temperature range of room temperature up to 300℃,resistance to water erosion,and prolonged X-ray irradiation.The results verify that the proposed fiber sensor has the advantages of good thermal stability,chemical durability,and radiation hardness.The studied X-ray fiber sensor holds promise to be used in a real-time,in-situ,and remote radiation dose monitoring.展开更多
文摘Objective:To analyze the effect of continuity of care in the cardiac intensive care unit(CICU)on improving cognitive function and psychological state in patients with heart failure(HF).Methods:A total of 112 chronic HF patients admitted to the CICU of Xuzhou Traditional Chinese Medicine Hospital from July 2022 to August 2024 were selected and randomly divided into two groups using the red and blue ball method:a control group(n=56)and a study group(n=56).The control group received routine CICU nursing management,while the study group received routine CICU nursing combined with continuity of care management.Cognitive function(using the Montreal Cognitive Assessment,MoCA),psychological state(using the Self-Rating Depression Scale,SDS,and Self-Rating Anxiety Scale,SAS),and quality of life(using the Minnesota Living with Heart Failure Questionnaire,MLHFQ)were compared between the two groups.Results:After the intervention,the cognitive function scores of the study group were significantly higher than those of the control group(P<0.05).The SDS and SAS scores of the study group were significantly lower than those of the control group after the intervention(P<0.05).The quality of life in the study group was also significantly better than in the control group(P<0.05).Conclusion:CICU continuity of care can effectively improve cognitive function and psychological state in patients with HF,while also enhancing their quality of life.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61174051)the Natural Science Foundation of Fujian Province(Grant No.2017J05101)the Technology Project of Fujian Province(Grant No.2019H0007)
文摘A simple method is proposed to optimize the thickness parameter of the boundary layer of the saturation function in the Complementary Sliding Mode Control (CSMC). A pair of complementary sliding surfaces are constructed. And the Taylor series is used to estimate the steady state error of CSMC system to optimize the parameter value for the boundary layer of the saturation function without artificial settings. This proposed CSMC strategy is applied to the speed regulation in permanent magnet synchronous motor with lump uncertainties. The experimental results show that the proposed CSMC strategy can obtain an optimal value for the boundary layer parameter effectively suppressing the chattering and keep an excellent system performance.
基金supported by the National Mega-project for Innovative Drugs of China(2019ZX09721001-004-003)the National Natural Science Foundation of China(82003603 and 81872747)+1 种基金the Innovative Research Team of High-level Local Universities in Shanghai,the National Special Fund for State Key Laboratory of Bioreactor Engineering(2060204,China)Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03-28,China).
文摘Conjunctival melanoma(CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B(CuB). We found that CuB remarkably inhibited the proliferation of CM cells including CM-AS16,CRMM1, CRMM2 and CM2005.1, without toxicity to normal cells. CuB can also induce CM cells G2/M cell cycle arrest. RNA-seq screening identified KIF20A, a key downstream effector of FOXM1 pathway, was abolished by CuB treatment. Further target identification by activity-based protein profiling chemoproteomic approach revealed that GRP78 is a potential target of CuB. Several lines of evidence demonstrated that CuB interacted with GRP78 and bound with a Kdvalue of0.11 μmol/L. Furthermore, ATPase activity evaluation showed that CuB suppressed GRP78 both in human recombinant GRP78 protein and cellular lysates. Knockdown of the GRP78 gene significantly induced the downregulation of FOXM1 and related pathway proteins including KIF20A, underlying an interesting therapeutic perspective. Finally, CuB significantly inhibited tumor progression in NCG mice without causing obvious side effects in vivo. Taken together, our current work proved that GRP78-FOXM1-KIF20A as a promising pathway for CM therapy, and the traditional medicine CuB as a candidate drug to hinder this pathway.
基金supported by the National Natural Science Foundation of China(No.51872055)the Fundamental Research Funds for the Central Universities,the State Key Laboratory of Particle Detection and Electronics(No.SKLPDE-KF-202108)the 111 Project(No.B13015)to the Harbin Engineering University。
文摘A new type of X-ray fiber dosimeters is proposed that is based on the X-ray response of CsPbBr_(3) perovskite-quantum-dots[PQDs]activated silica fiber.Such a fiber sensor is constructed by covering a multimode silica fiber with PQDs embedded glass powders using a transparent high-temperature glue.Under X-ray irradiation,the fiber sensor emits bright green light at 525 nm,which can be readily recorded by a CCD spectrometer.The integrated radioluminescence intensity has an excellent linear response to the X-ray dose.Study is given to the fiber sensor concerning its thermal stability in a temperature range of room temperature up to 300℃,resistance to water erosion,and prolonged X-ray irradiation.The results verify that the proposed fiber sensor has the advantages of good thermal stability,chemical durability,and radiation hardness.The studied X-ray fiber sensor holds promise to be used in a real-time,in-situ,and remote radiation dose monitoring.
