Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic res...Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue engineering.Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors.In this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel constructs.The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.展开更多
基金Areas of Excellence Scheme(AoE/M402/20)Theme-based Research Scheme(T13-402/17 N)under the Research Grant Council of Hong Kong,Mainland-Hong Kong Joint Funding Scheme(MHP/030/20)+4 种基金National Natural Science Foundation of China(81802152 and 32171332)Natural Science Foundation of Guangdong Province(2019A1515012224)Research Grants Council Collaborative Research Fund(C4026-17WF)General Research Fund(14121918 and 14173917)Innovation and Technology Commission Funding(Ref No.ITS/208/18FX).
文摘Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue engineering.Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors.In this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel constructs.The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.
