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王笑民基于“火水未济”理论辨治乳腺癌类更年期综合征经验 被引量:1
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作者 殷晓辉 张甘霖 +9 位作者 杨永 于明薇 卢泰成 史恩泽 潘元灿 陈栋 李海明 弋润茜 孔维嘉 王笑民 《北京中医药》 2024年第1期27-30,共4页
乳腺癌类更年期综合征包括烦躁易怒、潮热汗出、乏力、失眠多梦、心悸、骨关节异常等症状,在乳腺癌患者中高发,是中医治疗的优势病种。王笑民教授基于“火水未济”理论,提出相火肾水未济、君火肾水未济等是乳腺癌类更年期综合征的重要... 乳腺癌类更年期综合征包括烦躁易怒、潮热汗出、乏力、失眠多梦、心悸、骨关节异常等症状,在乳腺癌患者中高发,是中医治疗的优势病种。王笑民教授基于“火水未济”理论,提出相火肾水未济、君火肾水未济等是乳腺癌类更年期综合征的重要病因病机,同时伴有脾、胃、肝、肺等脏腑功能失调,人体阴阳失衡,辨证施以滋补肾水、引火归元、交通心神、补益脾胃、疏肝宣肺等法,在乳腺癌类更年期综合征治疗过程中取得了显著疗效。 展开更多
关键词 乳腺癌 类更年期综合征 火水未济 王笑民 名家经验
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两样本孟德尔随机化分析炎性因子与前列腺癌因果关系
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作者 曾银 张甘霖 +3 位作者 郭军 杨梦萍 韩强 杨国旺 《中华男科学杂志》 CAS CSCD 2024年第7期588-596,共9页
目的:采用两样本孟德尔随机化方法来评估91种炎性因子与前列腺癌的潜在因果关系。方法:选取91种炎性因子的全基因组关联分析(GWAS)汇总统计数据(n=14824)结合FinnGen最新第9版数据库中选取前列腺癌作为结局进行孟德尔随机化分析。通过... 目的:采用两样本孟德尔随机化方法来评估91种炎性因子与前列腺癌的潜在因果关系。方法:选取91种炎性因子的全基因组关联分析(GWAS)汇总统计数据(n=14824)结合FinnGen最新第9版数据库中选取前列腺癌作为结局进行孟德尔随机化分析。通过逆方差加权法(IVW)、MR-Egger回归、简单中位数法(SM)、加权中位数法(WM)、加权中值法(WME)等回归模型的OR值和95%CI评估炎性因子与前列腺癌的因果关系,其中IVW法得出的因果关系相对稳定,作为本研究的主要统计方法。进一步采用贝叶斯分析法对孟德尔分析结果进行验证。使用Cochran's Q检验评估遗传工具变量的异质性,使用MR-Egger截距检验评估多效性,使用留一法评估作为工具变量的单核苷酸多态性(SNPs)对暴露和结局因果关系影响的敏感性。结果:IVW法结果显示,91种炎性因子中白介素-22受体A1(IL-22RA1)、磺基转移酶1A1(ST1A1)与前列腺癌发病风险呈正向因果关联:IL-22RA1:IVW[OR(95%CI):1.12(1.00~1.25),P=0.04];ST1A1:IVW[OR(95%CI):1.08(1.00~1.16),P=0.03]。趋化因子配体11(CXCL11)、白介素17A(IL-17A)与前列腺癌发病风险呈反向因果关联;CXCL11:IVW[OR(95%CI):0.88(0.81~0.95),P=0.00];IL-17A:IVW[OR(95%CI):0.91(0.84~0.98),P=0.02]。MR-Egger截距分析未检测到潜在的水平多效性(P均>0.05,IL-22RA1=0.885,ST1A1=0.949,CXCL11=0.391,IL-17A=0.884)。MR-PRESSO未检测到偏倚SNPs(P均>0.05,IL-22RA1=0.479,ST1A1=0.629,CXCL11=0.326,IL-17A=0.444),未发现异质性(P均>0.05,IL-22RA1=0.543,ST1A1=0.677,CXCL11=0.336,IL-17A=0.494),留一法敏感性分析结果图提示无个别单核苷酸多态性位点对整体因果关系预测产生明显影响,故分析结果可靠。结论:91种炎性因子中IL-22RA1、ST1A1与前列腺癌有正向因果关系,随着这些因子的水平增加,前列腺癌发病的风险升高;CXCL11、IL-17A与前列腺癌有反向因果关系,即随着这些因子的水平增加,前列腺癌发病风险降低。 展开更多
关键词 炎性因子 前列腺癌 孟德尔随机化分析 敏感性分析 单核苷酸多态性 贝叶斯分析
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基于免疫生态系统探讨中药在三阴性乳腺癌中的治疗策略
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作者 吴桐桐 张甘霖 +1 位作者 李姝蒙 杨国旺 《北京中医药》 2024年第1期31-33,共3页
三阴性乳腺癌(TNBC)是乳腺癌中恶性度最高的亚型,预后较差。研究发现TNBC具有良好的免疫原性,针对TNBC的免疫治疗干预措施具有很大的前景,但临床疗效存在一定争议。通过恢复机体免疫能力来消除肿瘤的机制,与中医“养正积自除”的理念一... 三阴性乳腺癌(TNBC)是乳腺癌中恶性度最高的亚型,预后较差。研究发现TNBC具有良好的免疫原性,针对TNBC的免疫治疗干预措施具有很大的前景,但临床疗效存在一定争议。通过恢复机体免疫能力来消除肿瘤的机制,与中医“养正积自除”的理念一致。中医药应用于TNBC患者疗效较好,其作用与调节机体免疫,参与肿瘤免疫生态系统调控相关。本文总结了目前中医药调控肿瘤免疫生态系统的研究,为进一步机制探索及临床应用提供依据,以优化联合策略。 展开更多
关键词 三阴性乳腺癌 免疫生态系统 免疫微环境 中医药
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王笑民应用大剂量中药治疗肿瘤经验 被引量:10
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作者 程培育 王皓 +4 位作者 韩冬 富琦 于明薇 张甘霖 王笑民(指导) 《北京中医药》 2020年第5期453-456,共4页
王笑民教授认为肿瘤为沉疴之一,结合患者病情与体质,适时应用大剂量中草药抗癌解毒才能力挽狂澜,重剂起沉疴,重剂应包括药物毒性重与应用剂量重两个方面,复法大方为起沉疴之方法,重剂为其手段,复法大方在处方过程中要做到扶正与攻邪主... 王笑民教授认为肿瘤为沉疴之一,结合患者病情与体质,适时应用大剂量中草药抗癌解毒才能力挽狂澜,重剂起沉疴,重剂应包括药物毒性重与应用剂量重两个方面,复法大方为起沉疴之方法,重剂为其手段,复法大方在处方过程中要做到扶正与攻邪主次分明,辨证与辨病统一,并举验案1则,体现王笑民教授重剂起沉疴的肿瘤治疗理念与临床经验。 展开更多
关键词 王笑民 中医 抗肿瘤 名医经验
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Recent progress and future prospect of digital soil mapping: A review 被引量:15
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作者 zhang gan-lin LIU Feng SONG Xiao-dong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第12期2871-2885,共15页
To deal with the global and regional issues including food security, climate change, land degradation, biodiversity loss, water resource management, and ecosystem health, detailed accurate spatial soil information is ... To deal with the global and regional issues including food security, climate change, land degradation, biodiversity loss, water resource management, and ecosystem health, detailed accurate spatial soil information is urgently needed. This drives the worldwide development of digital soil mapping. In recent years, significant progresses have been made in different aspects of digital soil mapping. The main purpose of this paper is to provide a review for the major progresses of digital soil mapping in the last decade. First, we briefly described the rise of digital soil mapping and outlined important milestones and their influence, and main paradigms in digital soil mapping. Then, we reviewed the progresses in legacy soil data, environmental covariates, soil sampling, predictive models and the applications of digital soil mapping products. Finally, we summarized the main trends and future prospect as revealed by studies up to now. We concluded that although the digital soil mapping is now moving towards mature to meet various demands of soil information, challenges including new theories, methodologies and applications of digital soil mapping, especially for highly heterogeneous and human-affected environments, still exist and need to be addressed in the future. 展开更多
关键词 digital soil mapping soil-landscape model predictive models soil functions spatial variation
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Distribution and Migration of Heavy Metals in Undisturbed Forest Soils:A High Resolution Sampling Method 被引量:13
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作者 RUAN Xin-Ling zhang gan-lin +1 位作者 NI Liu-Jian HE Yue 《Pedosphere》 SCIE CAS CSCD 2008年第3期386-393,共8页
The vertical distribution and migration of Cu,Zn,Pb,and Cd in two forest soil profiles near an industrial emission source were investigated using a high resolution sampling method together with reference element Ti.On... The vertical distribution and migration of Cu,Zn,Pb,and Cd in two forest soil profiles near an industrial emission source were investigated using a high resolution sampling method together with reference element Ti.One-meter soil profile was sectioned horizontally at 2 cm intervals in the first 40 cm,5 cm intervals in the next 40 cm,and 10 cm intervals in the last 20 cm.The migration distance and rate of heavy metals in the soil profiles were calculated according to their relative concentrations in the profiles,as calibrated by the reference element Ti.The enrichment of heavy metals appeared in the uppermost layer of the forest soil,and the soil heavy metal concentrations decreased down the profile until reaching their background values.The calculated average migration rates of Cd,Cu,Pb,and Zn were 0.70,0.33,0.37,and 0.76 cm year-1,respectively,which were comparable to other methods.A simulation model was proposed,which could well describe the distribution of Cu,Zn,Pb,and Cd in natural forest soils. 展开更多
关键词 DISTRIBUTION heavy metals high resolution sampling method migration rate
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An integrated method of selecting environmental covariates for predictive soil depth mapping 被引量:7
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作者 LU Yuan-yuan LIU Feng +2 位作者 ZHAO Yu-guo SONG Xiao-dong zhang gan-lin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第2期301-315,共15页
Environmental covariates are the basis of predictive soil mapping.Their selection determines the performance of soil mapping to a great extent,especially in cases where the number of soil samples is limited but soil s... Environmental covariates are the basis of predictive soil mapping.Their selection determines the performance of soil mapping to a great extent,especially in cases where the number of soil samples is limited but soil spatial heterogeneity is high.In this study,we proposed an integrated method to select environmental covariates for predictive soil depth mapping.First,candidate variables that may influence the development of soil depth were selected based on pedogenetic knowledge.Second,three conventional methods(Pearson correlation analysis(PsCA),generalized additive models(GAMs),and Random Forest(RF))were used to generate optimal combinations of environmental covariates.Finally,three optimal combinations were integrated to produce a final combination based on the importance and occurrence frequency of each environmental covariate.We tested this method for soil depth mapping in the upper reaches of the Heihe River Basin in Northwest China.A total of 129 soil sampling sites were collected using a representative sampling strategy,and RF and support vector machine(SVM)models were used to map soil depth.The results showed that compared to the set of environmental covariates selected by the three conventional selection methods,the set of environmental covariates selected by the proposed method achieved higher mapping accuracy.The combination from the proposed method obtained a root mean square error(RMSE)of 11.88 cm,which was 2.25–7.64 cm lower than the other methods,and an R^2 value of 0.76,which was 0.08–0.26 higher than the other methods.The results suggest that our method can be used as an alternative to the conventional methods for soil depth mapping and may also be effective for mapping other soil properties. 展开更多
关键词 ENVIRONMENTAL COVARIATE selection integrated method PREDICTIVE SOIL MAPPING SOIL depth
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Exploring suitability for tropical crop cultivation in Hainan Island by SOTAL methodology 被引量:9
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作者 zhang Xue-lei S.Mantel +1 位作者 zhang gan-lin V.W.P.van Engelen 《Journal of Geographical Sciences》 SCIE CSCD 2001年第4期40-46,共7页
A SOTER-based automatic procedure for qualitative land evaluation is developed. This procedure was created in the automated land evaluation system (ALES). The objective was to design a procedure that allows for a quic... A SOTER-based automatic procedure for qualitative land evaluation is developed. This procedure was created in the automated land evaluation system (ALES). The objective was to design a procedure that allows for a quick separation of potentially suitable from non-suitable SOTER units for the intended land use, indicating constraints to different kinds of land use. Different kinds of land are unequal1y suited to various uses, land eva1uation is the assessment of the suitability of a tract of land for a specified kind of land use. In practice this implicates the comparison (matching) between the requirements of a specified land use and the properties of the land. Land evaluation concepts and definitions are treated in the paper. The ALES is a computer program that allows land evaluators to build their own knowledge-based system with which they can compute the physical and economical suitability of map units in accordance with FAO framework for land evaluation. The ALES program works with so-called decision trees, being hierarchical multiway keys in which the leaves are results (e.g., severity levels of land qualities), and the interior nodes of the tree are decision criteria (e.g., land characteristic values). These trees are traversed by the program to compute an evaluation using actual land data for each map unit. SOTAL is a SOTER-based qualitative model developed in ALES for physical land evaluation in which presently three land utilization types (LUTs) are distinguished, i.e., cultivated banana, coffee and rubber under different input and technological conditions. These LUTs are characterized by 11 landuse requirements and evaluated by matching the land use requirements with the corresponding land qualities. The paper elaborates on the criteria used in SOTAL for land quality assessment and how a final suitability rating is achieved on the basis of the rated land qualities. Results are visualized through G1S-generated maps as products in response to the specific information and data needs of decision and policy makers. 展开更多
关键词 EVALUATION tropical crops HaiSOTER Hainan Island
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Predicting soil depth in a large and complex area using machine learning and environmental correlations
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作者 LIU Feng YANG Fei +2 位作者 ZHAO Yu-guo zhang gan-lin LI De-cheng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2022年第8期2422-2434,共13页
Soil depth is critical for eco-hydrological modeling,carbon storage calculation and land evaluation.However,its spatial variation is poorly understood and rarely mapped.With a limited number of sparse samples,how to p... Soil depth is critical for eco-hydrological modeling,carbon storage calculation and land evaluation.However,its spatial variation is poorly understood and rarely mapped.With a limited number of sparse samples,how to predict soil depth in a large area of complex landscapes is still an issue.This study constructed an ensemble machine learning model,i.e.,quantile regression forest,to quantify the relationship between soil depth and environmental conditions.The model was then combined with a rich set of environmental covariates to predict spatial variation of soil depth and straightforwardly estimate the associated predictive uncertainty in the 140000 km^(2)Heihe River basin of northwestern China.A total of 275 soil depth observation points and 26 covariates were used.The results showed a model predictive accuracy with coefficient of determination(R)of 0.587 and root mean square error(RMSE)of 2.98 cm(square root scale),i.e.,almost 60% of soil depth variation explained.The resulting soil depth map clearly exhibited regional patterns as well as local details.Relatively deep soils occurred in low lying landscape positions such as valley bottoms and plains while shallow soils occurred in high and steep landscape positions such as hillslopes,ridges and terraces.The oases had much deeper soils than outside semi-desert areas,the middle of an alluvial plain had deeper soils than its margins,and the middle of a lacustrine plain had shallower soils than its margins.Large predictive uncertainty mainly occurred in areas with a lack of soil survey points.Both pedogenic and geomorphic processes contributed to the shaping of soil depth pattern of this basin but the latter was dominant.This findings may be applicable to other similar basins in cold and arid regions around the world. 展开更多
关键词 digital soil mapping spatial variation UNCERTAINTY machine learning soil-landscape model soil depth
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GubenyiliuⅡ inhibits breast tumor growth and metastasis associated with decreased heparanase expression and Akt phosphorylation
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作者 zhang Yi zhang gan-lin +9 位作者 SUN Xu CAO Ke-xin SHANG Ya-wen GONG Mu-xin MA Cong NAN Nan LI Jin-ping YU Ming-wei YANG Guo-wang WANG Xiao-min 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2016年第10期1076-1076,共1页
OBJECTIVE GubenyiliuⅡ(GYⅡ),a traditional Chinese medicine(TCM)formula used in our hospital,has shown beneficial effects in cancer patients.In this study,we investigated the molecular mechanisms underlying the benefi... OBJECTIVE GubenyiliuⅡ(GYⅡ),a traditional Chinese medicine(TCM)formula used in our hospital,has shown beneficial effects in cancer patients.In this study,we investigated the molecular mechanisms underlying the beneficial effects of GYⅡon murine breast cancer models.METHODS Inhibition of tumor growth and metastasis was evaluated by assessment of tumor weight and analysis of bioluminescent signal after a homograft inoculation.Viability of cultured breast cancer cells was determined using MTT assay andreal-time cell analysis(RTCA).Cell migratory ability was evaluated by Transwell?assay and wound healing assay.Subsequently,the potential anti-tumor and anti-metastatic mechanism was investigated by Western blotting and Immunohistochemistry.RESULTS GYⅡshowed significant inhibitory effects on tumor growth and metastasis in the murine breast cancer model.And GYⅡsuppressed theproliferation of 4T1 and MCF-7 cells in a dose-dependent manner.A better inhibitory effect on 4T1 cells proliferation and migration was found in sub-fractions(SF)of GYⅡ.Moreover,heparanase expression and degree of angiogenesis were reduced in tumor tissues.Western blotting analysis showed decreased expression of heparanase and growth factors in the cells treated with GYⅡand its sub-fractions(SF2 and SF3),there by a reduction in phosphorylation of ERK and AKT.CONCLUSION GYⅡexerts anti-tumor growth and anti-metastatic effects on murine breast cancer model.Sub-fractions 2 and 3 exhibits higher potency of the anti-tumor activity that is,at least partly,associated with decreased heparanase and growth factor sexpression,which subsequently sup-pressed activation of ERK and AKT pathways. 展开更多
关键词 Gubenyiliu breast tumor HEPARANASE growth factors ERK AKT pathways
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Numerical Approaches to Identification of Characteristic Soil Layers in an Urban Environment
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作者 YUAN Da-Gang zhang gan-lin GONG Zi-Tong 《Pedosphere》 SCIE CAS CSCD 2008年第3期335-343,共9页
Pedogenetic soil horizons are one of the fundamental building blocks of modern soil classification; however, in soils of urban areas which are often strongly disturbed by human activities, horizons are difficult to di... Pedogenetic soil horizons are one of the fundamental building blocks of modern soil classification; however, in soils of urban areas which are often strongly disturbed by human activities, horizons are difficult to distinguish but substitutive morphological layers may be identified. To identify the characteristic soil layers in an urban environment, 224 soil layers of 36 in-situ pedons were examined and described in urban and suburban Nanjing, and 27 variables were extracted for multivariate analysis. Three groups and six subdivisions were identified by TwoStep cluster analysis combined with hierarchical cluster analysis based on factor scores. Soil forming factors and soil forming processes could be interpreted from the principal component analysis (PCA) of variables, cluster analysis of soil layers, and discriminant analysis of soil layer groups and their subdivisions. Parent materials, moisture regimes, organic matter accumulation, and especially nutrient accumulation were the main causes of characteristic soil layer formations. The numerical approaches used in this study were useful tools for characteristic soil layer identification of urban soils. 展开更多
关键词 characteristic soil layer multivariate analysis numerical soil classification urban soils
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Spatholobus suberectus column extract inhibit estrogen receptor positive breast cancer
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作者 SUN Jia-qi zhang Yi +5 位作者 NAN Nan SUN Xu zhang gan-lin YU Ming-wei WANG Xiao-min LI Jin-ping 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2016年第10期1070-1070,共1页
OBJECTIVE To investigate the inhibitory effects of Spatholobus Suberectus Column Extract(SSCE)on estrogen receptor positive(ER+)breast cancer cel MCF-7and its possible molecular mechanism.METHODS MCF-7cells were cultu... OBJECTIVE To investigate the inhibitory effects of Spatholobus Suberectus Column Extract(SSCE)on estrogen receptor positive(ER+)breast cancer cel MCF-7and its possible molecular mechanism.METHODS MCF-7cells were cultured without estrogen and with 17-β-estrogen(10-8mol·L-1),respectively,then treated with SSCE(0,40,80,160,320μg·m L-1).MTT assay was employed to evaluate cell viability.Flow cytometry assays were performed to underlying apoptosis and detecting cel cycle of MCF-7 cells treated with SSCE(0,80,160,320μg·mL-1).Wound healing assays was conducted to detect the migration ability.Dual luciferase reporter system was used to detect the activity of p-ERα,p-ERβpresented in intra-nuclear estrogen response element(ERE).Western blotting assay was employed to identify the expression of protein such as Bax,Bcl-2,p-ERα,p-ERβ,ERK1/2,p-ERK1/2,AKT,p-AKT,m TOR,p-m TOR,PI3K,p-PI3K.RESULTS It showed that SSCE(80,160and 320μg·mL-1)significantly decreased the viability of MCF-7.SSCE also triggered apoptosis,arrested cell cycle at G0/G1phase,inhibited migration.Dual luciferase reporter system showed that SSCE suppressed intra-nuclear p-ER activity,Western blotting analysis confirmed that SSCE did repress the expression of phosphorylated-ER alpha(p-ERα),ERK1/2,p-ERK1/2,AKT,p-AKT,pmT OR,PI3K,p-PI3K,which indicate that SSCE suppress MAPK PI3K/AKT signal pathway.CONCLUSION Our result showed that SSCE cause ER+MCF-7 cells apoptosis,G0/G1phase arresting,migration decreasing,via hypo-active of ER,suppress MAPK PI3K/AKT pathway. 展开更多
关键词 Caulis Spatholobi breast neoplasms estrogen receptor PROLIFERATION
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离子型稀土矿原地浸矿场地分类及人体健康风险预测 被引量:1
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作者 孙正 曹亚非 +3 位作者 刘峰 王德彩 张甘霖 吴华勇 《土壤通报》 CAS CSCD 北大核心 2023年第5期1186-1195,共10页
【目的】建立离子型稀土矿原地浸矿场地分类及人体健康风险预测模型,为稀土矿浸矿场地生态恢复和污染治理提供参考。【方法】以江西省龙南县为研究区,使用人机交互解译方法获取稀土矿原地浸矿场地空间分布信息;建立浸矿场地分类的模糊... 【目的】建立离子型稀土矿原地浸矿场地分类及人体健康风险预测模型,为稀土矿浸矿场地生态恢复和污染治理提供参考。【方法】以江西省龙南县为研究区,使用人机交互解译方法获取稀土矿原地浸矿场地空间分布信息;建立浸矿场地分类的模糊层次分析模型;结合分类结果,建立浸矿场地人体健康风险预测的随机森林、提升回归树、C5.0决策树及加权集成模型,运用反距离加权插值法对浸矿场地周边人体健康风险概率进行空间制图。【结果】龙南县稀土矿原地浸矿场地主要集中在县域东北部坡度小于25°的山地丘陵地区;浸矿场地面积是利用模糊层次分析模型开展场地分类的最重要变量;浸矿场地类型在场地集中分布区自东北向西南逐渐由第二类(较低风险)过渡至第四类(高风险);随机森林模型对浸矿场地人体健康风险预测的精度高于提升回归树模型和C5.0决策树模型,模型的决定系数为0.744,使用简单的加权集成方法,可进一步提升预测的精度;浸矿场地人体健康风险在场地集中分布区的中部风险较高、东西两侧风险较低;浸矿场地周边约3500 m范围内人体健康风险较高,3500 m之外风险较低。【结论】模糊层次分析模型是离子型稀土矿原地浸矿场地分类的适用模型;随机森林模型是离子型稀土矿原地浸矿场地人体健康风险预测的最优单一模型。 展开更多
关键词 污染场地 人体健康风险 模糊层次分析法 机器学习模型 空间插值
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半枝莲和白花蛇舌草药对的研究现状 被引量:32
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作者 马婷婷 张甘霖 +4 位作者 张博然 曹可心 代存芳 李光达 王笑民 《中华中医药杂志》 CAS CSCD 北大核心 2021年第6期3491-3494,共4页
半枝莲和白花蛇舌草是癌症治疗当中常用的清热解毒中药,在中医临床遣方用药当中常相须配伍使用。近些年,陆续有中医药研究团队展开对此药对的研究,随着现代研究手段的进步,研究内容也从临床病案的总结观察逐步深入到基础实验机制的挖掘... 半枝莲和白花蛇舌草是癌症治疗当中常用的清热解毒中药,在中医临床遣方用药当中常相须配伍使用。近些年,陆续有中医药研究团队展开对此药对的研究,随着现代研究手段的进步,研究内容也从临床病案的总结观察逐步深入到基础实验机制的挖掘和探讨,在主治功效、剂型和成分、比例和用量、作用机制以及中医理论探讨等方面均有涉及。现将所报道的研究进行综述,旨在梳理半枝莲和白花蛇舌草药对研究现状,为更加深入的研究和探讨做铺垫。 展开更多
关键词 半枝莲 白花蛇舌草 药对 研究现状 癌症
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青海省表层土壤属性数字制图 被引量:15
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作者 庞龙辉 刘峰 +6 位作者 赵霞 宋效东 李德成 张甘霖 石平超 王欣烨 代子俊 《土壤通报》 CAS CSCD 北大核心 2019年第3期505-513,共9页
对于土壤景观复杂的大区域,样点往往较为稀疏,如何准确地进行土壤预测制图仍是一个需要研究的问题。本文以青海省为研究区,基于近年采集205个土系调查点数据,采用随机森林模型,分别建立了表层(0~20 cm)土壤全氮、有机碳、粉粒含量和pH... 对于土壤景观复杂的大区域,样点往往较为稀疏,如何准确地进行土壤预测制图仍是一个需要研究的问题。本文以青海省为研究区,基于近年采集205个土系调查点数据,采用随机森林模型,分别建立了表层(0~20 cm)土壤全氮、有机碳、粉粒含量和pH四个基本土壤属性与环境协同变量(海拔、坡度、地形湿度指数、年降水量、年平均气温、归一化植被指数、地表温度和地表反射率)之间的定量关系模型,对该地区进行了土壤多要素预测制图,分析了影响土壤空间变异的控制性因素。交叉验证结果显示,全氮、有机碳、粉粒含量和pH的R^2分别是0.61、0.53、0.47和0.54,这说明随机森林模型可解释47%以上的土壤空间变异。表层土壤全氮和有机碳空间分布趋势东南高,西北低,pH呈现出相反的空间模式;粉粒含量东高西低,预测结果高值出现在柴达木盆地和南部玉树、果洛地区。环境变量的重要性分析表明,年降水量对表层土壤全氮、有机碳、pH空间分布模式具有控制性影响,夜间地表温度与表层土壤粉粒含量空间变异具有较强的协同关系。 展开更多
关键词 土壤表层属性 环境变量 随机森林 青海省 数字土壤制图
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固本消瘤胶囊加减方联合吉非替尼对非小细胞肺癌PC9与PC9GR细胞生物学行为的影响 被引量:4
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作者 李光达 马云飞 +6 位作者 张甘霖 于明薇 马婷婷 陈欣洁 李冰雪 程培育 王笑民 《中华中医药杂志》 CAS CSCD 北大核心 2021年第6期3568-3571,共4页
目的:观察固本消瘤胶囊加减方及其联合吉非替尼对非小细胞肺癌PC9及吉非替尼耐药株PC9GR细胞的增殖、迁移、凋亡及细胞周期的影响。方法:应用MTT法检测细胞增殖能力;细胞划痕实验检测细胞的迁移能力;流式细胞术观察细胞的凋亡和周期。结... 目的:观察固本消瘤胶囊加减方及其联合吉非替尼对非小细胞肺癌PC9及吉非替尼耐药株PC9GR细胞的增殖、迁移、凋亡及细胞周期的影响。方法:应用MTT法检测细胞增殖能力;细胞划痕实验检测细胞的迁移能力;流式细胞术观察细胞的凋亡和周期。结果:固本消瘤胶囊加减方与吉非替尼可呈浓度依赖性抑制PC9及PC9GR细胞的增殖,且联合用药后具有显著的增效作用(P<0.05);两药均可减弱两种细胞的划痕修复能力,联合用药同样具有显著的增效作用(P<0.05);两药均可显著增加细胞的凋亡率,且联合用药组细胞凋亡率显著高于两个单药组(P<0.05),同时各组用药对两种细胞的G0/G1期均产生了不同程度的抑制,但联合用药的抑制作用弱于单用吉非替尼(P<0.05)。结论:固本消瘤胶囊加减方可以显著抑制PC9及PC9GR细胞的增殖、迁移,其作用机制与诱导细胞凋亡、阻滞细胞周期有关;同时该方与吉非替尼联合应用在抑制细胞增殖、迁移,诱导细胞凋亡方面具有明显的增效作用。 展开更多
关键词 固本消瘤胶囊加减方 吉非替尼 非小细胞肺癌细胞 耐药 生物学行为 联合用药 增效
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探地雷达地波法测定红壤区土壤水分的参数律定研究 被引量:6
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作者 曹棋 宋效东 +2 位作者 吴华勇 张甘霖 杨顺华 《土壤通报》 CAS CSCD 北大核心 2020年第2期332-342,共11页
探地雷达地波法是一种农田尺度快速测量土壤体积含水量的有效技术,能够弥补传统方法和卫星遥感方法在含水量监测上的不足。但地波法在红壤地区进行含水量反演的最佳参数仍未确定,相关研究鲜有报道。本研究以位于南方红壤区江西省鹰潭市... 探地雷达地波法是一种农田尺度快速测量土壤体积含水量的有效技术,能够弥补传统方法和卫星遥感方法在含水量监测上的不足。但地波法在红壤地区进行含水量反演的最佳参数仍未确定,相关研究鲜有报道。本研究以位于南方红壤区江西省鹰潭市孙家流域为例,采用地波法对区域土壤体积含水量进行了探测:先使用共中心点法确定所用雷达的系统延时、有效反演深度,并利用Topp、Roth、Ferre和朱安宁四种常用的经验模型由介电常数ε反演土壤含水量;然后通过固定间距法进行区域性的土壤体积含水量测量,确定雷达测量时的最佳天线间距。这一系列过程中,土壤含水量实测值是用烘干法校正的管式时域反射仪(time domain reflectometry,TDR)测定的土壤体积含水量。研究的目的是为了律定地波法在红壤区测定土壤含水量的有效反演深度、最优模型和最佳天线间距等参数。结果表明:60 MHz探地雷达地波法反演0~40 cm土层的土壤体积含水量时精度最高,误差最小;Roth经验模型更适合于红壤地区0~40 cm土层土壤含水量的反演,均方根误差(root mean square error,RMSE)为0.022 m3m-3;地波法的最佳天线间距为1.0 m,能够准确地反演土壤体积含水量;土地利用类型对雷达的探测精度具有一定影响,在1.0 m天线间距下,旱地上的反演精度优于果园,旱地和果园的RMSE分别为0.004和0.020 m3m-3。 展开更多
关键词 探地雷达 土壤含水量 地波法 共中心点法 固定间距法
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Progress in Significant Soil Science Fields of China over the Last Three Decades: A Review 被引量:12
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作者 ZHAO Qi-Guo HE Ji-Zheng +3 位作者 YAN Xiao-Yuan zhang Bin zhang gan-lin CAI Zu-Cong 《Pedosphere》 SCIE CAS CSCD 2011年第1期1-10,共10页
Due to continuous decreases in arable land area and continuous population increases,Chinese soil scientists face great challenges in meeting food demands,mitigating adverse environmental impacts,and sustaining or enha... Due to continuous decreases in arable land area and continuous population increases,Chinese soil scientists face great challenges in meeting food demands,mitigating adverse environmental impacts,and sustaining or enhancing soil productivity under intensive agriculture.With the aim of promoting the application of soil science knowledge,this paper reviews the achievements of Chinese scientists in soil resource use and management,soil fertility,global change mitigation and soil biology over the last 30 years.During this period,soil resource science has provided essential support for the use and exploitation of Chinese soil resources,and has itself developed through introduction of new theories such as Soil Taxonomy and new technologies such as remote sensing.Soil fertility science has contributed to the alleviation and elimination of impeding physical and chemical factors that constrain availability of essential nutrients and water in soils,the understanding of nutrient cycling in agroecosystems,and the increase in nutrient use efficiency for sustainable crop production.Chinese soil scientists have contributed to the understanding of the cropland's role in global change,particularly to the understanding of methane and nitrous oxide emission from rice fields and the effect of elevated carbon dioxide and ozone on rice-wheat system.Soil biology research has progressed in biological N fixation,distribution of fauna in Chinese soils,and bioremediation of polluted soils.A new generation of soil scientists has arisen in the last three decades.The gaps between research and application in these soil science fields are also discussed. 展开更多
关键词 global change soil biology soil fertility soil resources
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Mapping Soil Texture of a Plain Area Using Fuzzy-c-Means Clustering Method Based on Land Surface Diurnal Temperature Difference 被引量:7
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作者 WANG De-Cai zhang gan-lin +3 位作者 PAN Xian-zhang ZHAO Yu-Guo ZHAO Ming-Song WANG Gai-Fen 《Pedosphere》 SCIE CAS CSCD 2012年第3期394-403,共10页
The use of landscape covariates to variability of soil properties in similar estimate soil properties is not suitable topographic and vegetation conditions. for the areas of low relief due to the high A new method wa... The use of landscape covariates to variability of soil properties in similar estimate soil properties is not suitable topographic and vegetation conditions. for the areas of low relief due to the high A new method was implemented to map regional soil texture (in terms of sand, silt and clay contents) by hypothesizing that the change in the land surface diurnal temperature difference (DTD) is related to soil texture in case of a relatively homogeneous rainfall input. To examine this hypothesis, the DTDs from moderate resolution imagine spectroradiometer (MODIS) during a selected time period, i.e., after a heavy rainfall between autumn harvest and autumn sowing, were classified using fuzzy-c-means (FCM) clustering. Six classes were generated, and for each class, the sand (〉 0.05 mm), silt (0.002-0.05 mm) and clay (〈 0.002 mm) contents at the location of maximum membership value were considered as the typical values of that class. A weighted average model was then used to digitally map soil texture. The results showed that the predicted map quite accurately reflected the regional soil variation. A validation dataset produced estimates of error for the predicted maps of sand, silt and clay contents at root mean of squared error values of 8.4%, 7.8% and 2.3%, respectively, which is satisfactory in a practical context. This study thus provided a methodology that can help improve the accuracy and efficiency of soil texture mapping in plain areas using easily available data sources. 展开更多
关键词 digital soil mapping land surface temperature low relief area MODIS remote sensing
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Grain Size Evidence of Multiple Origins of Red Clays in the Jinhua-Quzhou Basin, South China 被引量:5
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作者 LI Jian-Wu YE Wei +3 位作者 zhang gan-lin ZHU Li-Dong JIANG Yong-Jian GONG Zi-Tong 《Pedosphere》 SCIE CAS CSCD 2013年第5期686-695,共10页
Six typical red clay profiles were sampled from Tangxi (TX), Langyaz (LYZ), South Shangshanwen (SSW), Xianqiao (XQ), Qijian (Q J) and Huhaitang (HHT) of Jinhua-Quzhou Basin, Zhejiang Province of China to e... Six typical red clay profiles were sampled from Tangxi (TX), Langyaz (LYZ), South Shangshanwen (SSW), Xianqiao (XQ), Qijian (Q J) and Huhaitang (HHT) of Jinhua-Quzhou Basin, Zhejiang Province of China to evaluate the characteristics of grain size composition, distribution and parameters of red clays and to reveal the origin of red clays and interpret possible implications for paleoclimate in subtropical China. The results showed that red clays in TX, LYZ and SSW were fine and uniform, with no 〉 2 mm gravels and little 〉 63μm fraction. They had a high content of 10-50 μm fraction, so-called "basic dust fraction", and showed unimodal distributions, which were very comparable to those of the Xiashu Loess in southeastern China and the loess in North China. All these features reflected marked aeolian characteristics of the red clays in these areas. Red clays in XQ and QJ were much coarser than those in TjjX, LYZ and SSW, with high contents of 〉 63μm fraction and even containing 〉 2 mm gravels in some layers. The grain size distribution patterns showed significantly progressive trends from the lower profile to the upmost layer and could not be compared with those of the loess in North China or the Xiashu Loess, implying they might be derived from underlying parent rocks and had some inherited properties from bedrock. Red clays in HHT had high contents of 〉 63μm fraetion and contain many 〉 2 mm gravels in each layer. The grain size frequency curves showed multiple-peaks and some abrupt variations were also observed on the profile, revealing its alluvial or diluvial origin in HHT. The multiple origins of red clays reflected the diversity and complexity of the Quaternary environment in South China. It can be concluded that grain size is an effective proxy indicator for the origin of most deposits. 展开更多
关键词 aeolian characteristics grain size distribution LOESS PALEOCLIMATE QUATERNARY
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