目的系统评价促红细胞生成素(EPO)治疗急性颅脑损伤的有效性和安全性。方法计算机检索The Cochrane Li brary、Clinical Trials、Web of Science、PubMed、EMbase、中国生物医学文献数据库、中国知网数据库和万方数据库,检索年限均从建...目的系统评价促红细胞生成素(EPO)治疗急性颅脑损伤的有效性和安全性。方法计算机检索The Cochrane Li brary、Clinical Trials、Web of Science、PubMed、EMbase、中国生物医学文献数据库、中国知网数据库和万方数据库,检索年限均从建库至2018年5月。搜集EPO治疗急性颅脑损伤的临床随机对照试验,试验组采用EPO治疗,对照组采用安慰剂或空白对照。采用RevMan 5.3软件进行meta分析。结果纳入7项临床随机对照研究,共计1101例,试验组564例,对照组537例。meta分析显示:EPO显著降低病死率(RR=0.69;95%CI 0.51~0.94;P=0.02),不能改善神经功能(RR=1.28;95%CI 0.90~1.81;P=0.17),不增加深静脉血栓形成发生率(RR=1.00;95%CI=0.74~1.35;P=0.99)。结论EPO治疗急性颅脑损伤可以降低死亡率,无明显严重的不良反应,但不能改善神经功能。展开更多
To the editor: Ventral spinal schwannoma is not a frequently encountered disease and its surgical treatment is difficult.1,2 It has not been reported that the arachnoid adhesions caused by SURGICEL after operation fo...To the editor: Ventral spinal schwannoma is not a frequently encountered disease and its surgical treatment is difficult.1,2 It has not been reported that the arachnoid adhesions caused by SURGICEL after operation for ventral spinal schwannoma.A 45-year-old man was admitted to our clinic with complaints of intermittent lumbar pain for 12 months. Physical examination: The patient's lower extremity muscle strength was Ⅲ-Ⅳ grade, the bilateral knee tendon reflexes was hyperactive, the bilateral Babinski sign was positive, the sensory dysfunction level was at T11, the anal reflex was positive, the bilateral cremasteric reflex was positive.展开更多
文摘目的系统评价促红细胞生成素(EPO)治疗急性颅脑损伤的有效性和安全性。方法计算机检索The Cochrane Li brary、Clinical Trials、Web of Science、PubMed、EMbase、中国生物医学文献数据库、中国知网数据库和万方数据库,检索年限均从建库至2018年5月。搜集EPO治疗急性颅脑损伤的临床随机对照试验,试验组采用EPO治疗,对照组采用安慰剂或空白对照。采用RevMan 5.3软件进行meta分析。结果纳入7项临床随机对照研究,共计1101例,试验组564例,对照组537例。meta分析显示:EPO显著降低病死率(RR=0.69;95%CI 0.51~0.94;P=0.02),不能改善神经功能(RR=1.28;95%CI 0.90~1.81;P=0.17),不增加深静脉血栓形成发生率(RR=1.00;95%CI=0.74~1.35;P=0.99)。结论EPO治疗急性颅脑损伤可以降低死亡率,无明显严重的不良反应,但不能改善神经功能。
文摘To the editor: Ventral spinal schwannoma is not a frequently encountered disease and its surgical treatment is difficult.1,2 It has not been reported that the arachnoid adhesions caused by SURGICEL after operation for ventral spinal schwannoma.A 45-year-old man was admitted to our clinic with complaints of intermittent lumbar pain for 12 months. Physical examination: The patient's lower extremity muscle strength was Ⅲ-Ⅳ grade, the bilateral knee tendon reflexes was hyperactive, the bilateral Babinski sign was positive, the sensory dysfunction level was at T11, the anal reflex was positive, the bilateral cremasteric reflex was positive.