Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in a...Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status.展开更多
Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this ...Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy.展开更多
Aiming at predicting ship propeller＇s cavitation low-frequency noise spectrum, a hy- brid method combining the cavitation multi-phase flow unsteady simulation with the pulsating spherical bubble radiated noise theory...Aiming at predicting ship propeller＇s cavitation low-frequency noise spectrum, a hy- brid method combining the cavitation multi-phase flow unsteady simulation with the pulsating spherical bubble radiated noise theory was proposed. Then, both of the NSRDC4383 5-bladed propeller and a 7-bladed highly-skewed propeller＇s cavitation low-frequency noise spectrum sub- jected to the full appended SUBOFF submarine＇s nominal wake were investigated. The effects of thrust loading and cavity extension on the discrete line spectrum frequency and its spectrum source level were analyzed. The improved Sauer cavitation model and modified shear stress transport turbulence models were adopted to simulate the propeller sheet cavitation along with integrated verification. The cavity volume acceleration related to the characteristic length rep- resenting the unsteady sheet cavitation extension, which was more reasonable than the spherical cavity hypothesis, was used to the cavitation low-frequency noise spectrum prediction. Results show that the 7-bladed propeller truly appreciates the advantages of smaller loads, latter cav- itation inception and lower cavitating tonal noise comparing to that of the 5 blades. Under the same cavitation index based on ship speed, the interaction of wake inflow and blades will induce significantly low frequency line spectrums and strengthen their source level. Given the submarine wake, cavitation index and rotating speed condition, the thrust, torque and cavity area of blades will decrease with the decreasing load, but the fluctuated acceleration amplitude of cavity volume and the tonal noise spectrum level increases, and the discrete line spectrum components shift mainly to the even times of the BPF harmonics from the odd. If the cavita- tion extension lightens, the BPF harmonics line spectrums will be depressed, and the spectrum level at 1 kHz reduces 2.54 dB. The numerical method above constructs a numerical system to measure the cavitating hydrodynamics and noise performances of ship propellers, which can be productive for the numerical design of wake adapted low noise submarine propeller.展开更多
The synthetic hallucinogen 3,4-methylenedioxymet hamphetamine （MDMA） is the main psychoactive constituent of the popular recreational drug ＂ecstasy.＂ Whether its neurotoxic effects are fully reversible is unknown....The synthetic hallucinogen 3,4-methylenedioxymet hamphetamine （MDMA） is the main psychoactive constituent of the popular recreational drug ＂ecstasy.＂ Whether its neurotoxic effects are fully reversible is unknown. Here we report a patient with protracted syndrome induced by ecstasy.展开更多
基金"973"National Key Basic Research and Development Program(No.2012CB518202)Project of Qinghai Development of Science and Technology(No.2011-N-150)
文摘Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status.
基金Technical support from the Emory-Georgia Tech Nanotechnology Center for Personalizedsupported by the National High Technology Research and Development Program of China(2006AA02Z485)+2 种基金Specific Prevention and Control Technology for Major Disease of Zhejiang Province(2008C13027-2)Natural Science Foundation of Zhejiang Province(J20060714)Special Foundation for Young Scientists of Zhejiang Province(2009QN009)
文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy.
基金supported by the National Natural Science Foundation of China(51009144)
文摘Aiming at predicting ship propeller＇s cavitation low-frequency noise spectrum, a hy- brid method combining the cavitation multi-phase flow unsteady simulation with the pulsating spherical bubble radiated noise theory was proposed. Then, both of the NSRDC4383 5-bladed propeller and a 7-bladed highly-skewed propeller＇s cavitation low-frequency noise spectrum sub- jected to the full appended SUBOFF submarine＇s nominal wake were investigated. The effects of thrust loading and cavity extension on the discrete line spectrum frequency and its spectrum source level were analyzed. The improved Sauer cavitation model and modified shear stress transport turbulence models were adopted to simulate the propeller sheet cavitation along with integrated verification. The cavity volume acceleration related to the characteristic length rep- resenting the unsteady sheet cavitation extension, which was more reasonable than the spherical cavity hypothesis, was used to the cavitation low-frequency noise spectrum prediction. Results show that the 7-bladed propeller truly appreciates the advantages of smaller loads, latter cav- itation inception and lower cavitating tonal noise comparing to that of the 5 blades. Under the same cavitation index based on ship speed, the interaction of wake inflow and blades will induce significantly low frequency line spectrums and strengthen their source level. Given the submarine wake, cavitation index and rotating speed condition, the thrust, torque and cavity area of blades will decrease with the decreasing load, but the fluctuated acceleration amplitude of cavity volume and the tonal noise spectrum level increases, and the discrete line spectrum components shift mainly to the even times of the BPF harmonics from the odd. If the cavita- tion extension lightens, the BPF harmonics line spectrums will be depressed, and the spectrum level at 1 kHz reduces 2.54 dB. The numerical method above constructs a numerical system to measure the cavitating hydrodynamics and noise performances of ship propellers, which can be productive for the numerical design of wake adapted low noise submarine propeller.
基金This study was supported by the grants from the Science and Technology Bureau of Zhejiang Province Key Science and Technology Innovation Project （No. 2010R50049）, the Education Bureau of Zhejiang Province Grants （No. Y200908102 and No. Y201120182）, the Department of Health Foundation of Zhejiang Province（No. 2013RCB005）, Natural Science Foundation of China （No. 81301158）.Acknowledgements： We are very grateful to the patient for this study.
文摘The synthetic hallucinogen 3,4-methylenedioxymet hamphetamine （MDMA） is the main psychoactive constituent of the popular recreational drug ＂ecstasy.＂ Whether its neurotoxic effects are fully reversible is unknown. Here we report a patient with protracted syndrome induced by ecstasy.
