目的探讨Nd∶YAG激光照射联合iROOT BP Plus材料行直接盖髓术治疗龋源性牙髓炎的临床效果。方法前瞻性选取2018年7月至2019年12月在合肥市第二人民医院治疗的龋源性牙髓炎患者95例107颗患牙,以随机数字表法将患者分为观察组(47例54颗牙...目的探讨Nd∶YAG激光照射联合iROOT BP Plus材料行直接盖髓术治疗龋源性牙髓炎的临床效果。方法前瞻性选取2018年7月至2019年12月在合肥市第二人民医院治疗的龋源性牙髓炎患者95例107颗患牙,以随机数字表法将患者分为观察组(47例54颗牙)和对照组(48例53颗牙)。观察组给予Nd∶YAG激光照射联合iRoot BP Plus材料行直接盖髓术,对照组给予Nd∶YAG激光照射联合MTA材料行直接盖髓术。观察两组治疗成功率、手术前后龈沟液炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8、IL-1β和IL-6]、根尖根管改善、牙髓活力、咀嚼功能和咬合功能等差异。结果观察组治疗成功率为96.30%,高于对照组(88.67%),但差异无统计学意义(P>0.05)。术后1周,观察组龈沟液TNF-α、IL-8、IL-1β和IL-6分别为(20.20±6.22)mg/mL、(8.11±3.02)pg/mL、(19.22±5.56)mg/L和(10.21±2.54)pg/mL,明显低于对照组[(39.40±5.82)mg/mL、(19.20±5.58)pg/mL、(30.20±8.12)mg/L和(16.60±3.10)pg/mL],差异均有统计学意义(P<0.05)。观察组术后12个月根管长度、根管壁厚度分别为(16.40±1.52)、(2.79±0.74)mm,明显高于对照组[(14.89±1.62)、(2.44±0.81)mm],差异均有统计学意义(P<0.05)。观察组术后1、3个月的牙髓电活力(EPT)分别为(18.52±3.08)和(18.10±4.01),明显低于对照组[(20.10±3.10)、(20.83±4.88)],差异均有统计学意义(P<0.05)。观察组和对照组术后12个月咀嚼功能和咬合功能比较,差异无统计学意义(P>0.05)。结论Nd∶YAG激光照射联合iRoot BP Plus材料行直接盖髓术治疗龋源性牙髓炎有较好的效果,可明显降低炎症水平,改善近期牙髓活力。展开更多
Forty-eight male Lezhi black goat kids with similar body weight((12.09±1.70)kg)and age((60±5)d)were used to determine the effect of dietary copper(Cu),in the form of reagent grade Cu sulfate(CuSO4∙5H2O),on p...Forty-eight male Lezhi black goat kids with similar body weight((12.09±1.70)kg)and age((60±5)d)were used to determine the effect of dietary copper(Cu),in the form of reagent grade Cu sulfate(CuSO4∙5H2O),on performance,serum lipid profile,and the relative mRNA abundance of genes involved in lipid metabolism.Goat kids were stratified by body weight and randomly assigned to one of 4 treatment groups.Each treatment consisted of 12 replicate pens with each pen containing one goat kid.Treatment groups received the basal diet with no supplemental Cu(control),basal diet plus 10 mg of Cu kg^(-1)of dry matter(DM),basal diet plus 20 mg of Cu kg^(-1)of DM,or basal diet plus 30 mg of Cu kg^(-1)of DM.Goats were housed individually in pens and fed a high-concentrate pelleted diet for 60 d.Average daily gain,average daily feed intake and feed:gain of goats were not affected by dietary Cu supplementation(P>0.10).No differences were detected in serum total cholesterol,triglyceride,and high density lipoprotein cholesterol concentrations of goat kids fed with different Cu concentrations(P>0.05).However,serum low density lipoprotein cholesterol concentrations decreased linearly(P=0.01)as the concentration of dietary Cu increased.Intramuscular fat content of longissimus muscle increased(P=0.002)quadratically and liver Cu concentrations increased(P<0.001)linearly as dietary Cu concentration increased.Compared with the control,dietary supplementation of 20 mg Cu kg^(-1)DM decreased the relative mRNA abundance of fatty acid-binding protein 4(P=0.01)and lipoprotein lipase(P=0.05),and tended to decrease the relative mRNA abundance of carnitine palmitoyltransferase I(P=0.06)in longissimus muscle of goats.The relative mRNA abundance of peroxisome proliferator-activated receptor alpha(P<0.001),carnitine acetyltransferase(P=0.001),and carnitine palmitoyltransferase Ⅰ(P=0.001)were also decreased in liver by Cu supplementation.These results indicate that dietary supplementation of Cu modified lipid metabolism by increasing muscular fat and decreasing serum low density lipoprotein cholesterol,and the modification might be associated with the reduction of relative mRNA abundance of genes for oxidation of long-chain fatty acid in muscle and liver of Lezhi black goat kids.展开更多
文摘目的探讨Nd∶YAG激光照射联合iROOT BP Plus材料行直接盖髓术治疗龋源性牙髓炎的临床效果。方法前瞻性选取2018年7月至2019年12月在合肥市第二人民医院治疗的龋源性牙髓炎患者95例107颗患牙,以随机数字表法将患者分为观察组(47例54颗牙)和对照组(48例53颗牙)。观察组给予Nd∶YAG激光照射联合iRoot BP Plus材料行直接盖髓术,对照组给予Nd∶YAG激光照射联合MTA材料行直接盖髓术。观察两组治疗成功率、手术前后龈沟液炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8、IL-1β和IL-6]、根尖根管改善、牙髓活力、咀嚼功能和咬合功能等差异。结果观察组治疗成功率为96.30%,高于对照组(88.67%),但差异无统计学意义(P>0.05)。术后1周,观察组龈沟液TNF-α、IL-8、IL-1β和IL-6分别为(20.20±6.22)mg/mL、(8.11±3.02)pg/mL、(19.22±5.56)mg/L和(10.21±2.54)pg/mL,明显低于对照组[(39.40±5.82)mg/mL、(19.20±5.58)pg/mL、(30.20±8.12)mg/L和(16.60±3.10)pg/mL],差异均有统计学意义(P<0.05)。观察组术后12个月根管长度、根管壁厚度分别为(16.40±1.52)、(2.79±0.74)mm,明显高于对照组[(14.89±1.62)、(2.44±0.81)mm],差异均有统计学意义(P<0.05)。观察组术后1、3个月的牙髓电活力(EPT)分别为(18.52±3.08)和(18.10±4.01),明显低于对照组[(20.10±3.10)、(20.83±4.88)],差异均有统计学意义(P<0.05)。观察组和对照组术后12个月咀嚼功能和咬合功能比较,差异无统计学意义(P>0.05)。结论Nd∶YAG激光照射联合iRoot BP Plus材料行直接盖髓术治疗龋源性牙髓炎有较好的效果,可明显降低炎症水平,改善近期牙髓活力。
基金supported by the National Natural Science Foundation of China(31501977)the Sichuan Provincial Key R&D Project,China(22ZDYF0194)+1 种基金the Fundamental Research Funds for the Central Universities of Southwest Minzu University(2021PTJS20)the Innovation Team Development Funds for Sichuan Mutton Sheep,China(cxtd2019–14).
文摘Forty-eight male Lezhi black goat kids with similar body weight((12.09±1.70)kg)and age((60±5)d)were used to determine the effect of dietary copper(Cu),in the form of reagent grade Cu sulfate(CuSO4∙5H2O),on performance,serum lipid profile,and the relative mRNA abundance of genes involved in lipid metabolism.Goat kids were stratified by body weight and randomly assigned to one of 4 treatment groups.Each treatment consisted of 12 replicate pens with each pen containing one goat kid.Treatment groups received the basal diet with no supplemental Cu(control),basal diet plus 10 mg of Cu kg^(-1)of dry matter(DM),basal diet plus 20 mg of Cu kg^(-1)of DM,or basal diet plus 30 mg of Cu kg^(-1)of DM.Goats were housed individually in pens and fed a high-concentrate pelleted diet for 60 d.Average daily gain,average daily feed intake and feed:gain of goats were not affected by dietary Cu supplementation(P>0.10).No differences were detected in serum total cholesterol,triglyceride,and high density lipoprotein cholesterol concentrations of goat kids fed with different Cu concentrations(P>0.05).However,serum low density lipoprotein cholesterol concentrations decreased linearly(P=0.01)as the concentration of dietary Cu increased.Intramuscular fat content of longissimus muscle increased(P=0.002)quadratically and liver Cu concentrations increased(P<0.001)linearly as dietary Cu concentration increased.Compared with the control,dietary supplementation of 20 mg Cu kg^(-1)DM decreased the relative mRNA abundance of fatty acid-binding protein 4(P=0.01)and lipoprotein lipase(P=0.05),and tended to decrease the relative mRNA abundance of carnitine palmitoyltransferase I(P=0.06)in longissimus muscle of goats.The relative mRNA abundance of peroxisome proliferator-activated receptor alpha(P<0.001),carnitine acetyltransferase(P=0.001),and carnitine palmitoyltransferase Ⅰ(P=0.001)were also decreased in liver by Cu supplementation.These results indicate that dietary supplementation of Cu modified lipid metabolism by increasing muscular fat and decreasing serum low density lipoprotein cholesterol,and the modification might be associated with the reduction of relative mRNA abundance of genes for oxidation of long-chain fatty acid in muscle and liver of Lezhi black goat kids.
