[Objective]The aim is to provide data support for the prevention and control of pollution of exogenous chemical in pig breeding industry.[Methods]Solid-phase extraction(SPE)and tandem mass(LC-MS/MS)were used for deter...[Objective]The aim is to provide data support for the prevention and control of pollution of exogenous chemical in pig breeding industry.[Methods]Solid-phase extraction(SPE)and tandem mass(LC-MS/MS)were used for determining four classes(tetracyclines,quinolones,macrolides and sulfonamides)of 10 common veterinary antibiotics in groundwater of an important pig breeding base in the Yangtze River Delta region of China.[Results]Results revealed the total concentration of the ten antibiotics in urban rivers ranged from 20.1 ng /L to 61.2 ng /L.The highest proportion was taken by tetracyclines,account for 95%,the concentration was up to 44.0 ng /L.Quinolones shared the second largest proportion of total concentration,about 29%,the concentration was up to 21.6 ng /L,while concentration of sulfonamides and macrolides were respectively below 2.7 ng /L and 6.3 ng /L.The highest total concentration of the ten antibiotics in rural rivers was up to 467 ng /L,60% of which was shared by tetracyclines,the highest concentration of tetracyclines was 253 ng /L.Sulfonamides share 20% of the total concentration,the highest concentration of it was 165 ng /L.The highest concentration of macrolides and quinolones was 14.6 ng /L and 14.5 ng /L,respectively.[Conclusion] Antibiotics' pollution in town rivers is more serious than urban rivers' pollution caused by antibiotics.展开更多
目的对比氟比洛芬酯注射液和/或罗哌卡因注射液用于腹腔镜胆囊切除(LC)术后镇痛的临床疗效及安全性。方法将120例腹腔镜胆囊切除术患者随机分为A、B、C和D组,每组30例。A组于手术结束前不输注氟比洛芬酯和罗哌卡因,结束时也不在切口处...目的对比氟比洛芬酯注射液和/或罗哌卡因注射液用于腹腔镜胆囊切除(LC)术后镇痛的临床疗效及安全性。方法将120例腹腔镜胆囊切除术患者随机分为A、B、C和D组,每组30例。A组于手术结束前不输注氟比洛芬酯和罗哌卡因,结束时也不在切口处进行局部麻醉;B组于手术结束前5 min给予静脉输注氟比洛芬酯50 mg,结束时不在切口处进行局部麻醉;C组于手术结束前不输注氟比洛芬酯和罗哌卡因,结束时用罗哌卡因10 mL在腹壁4个切口处进行均匀局部麻醉;D组于手术结束前静脉输注氟比洛芬酯50 mg,结束时用罗哌卡因10 mL在腹壁4个切口处进行均匀局部麻醉。比较4组患者的术后视觉模拟评分(VAS)、补救镇痛,以及药物不良反应的发生情况。结果A、B、C和D组的术后3 h VAS评分分别为(6.07±1.82),(3.20±1.40),(3.23±1.10)和(3.13±1.17),术后6 h VAS评分分别为(6.23±1.81),(4.63±1.69),(4.77±1.81)和(3.63±1.43),哌替啶使用率分别为50.00%(15例/30例),13.33%(4例/30例),16.67%(5例/30例)和16.67%(5例/30例),B、C和D组患者的上述指标与A组比较,差异均有统计学意义(均P<0.05),且D组的术后6 h VAS评分与B、C组比较,差异均有统计学意义(均P<0.05)。4组患者的药物不良反应主要有恶心呕吐,此外D组还有皮肤瘙痒的发生。A、B、C和D组的总药物不良反应发生率分别为10.00%,13.33%,10.00%和16.67%,差异均无统计学意义(均P>0.05)。结论氟比洛芬酯注射液和罗哌卡因注射液在LC术后3 h和6 h内对患者镇痛的效果确切,而且术后6 h时两药的联合镇痛效果更佳。展开更多
基金Supported by the Public Welfare Technology Research Project of Zhejiang Province(2014C31042)National Natural Science Foundation of China(51569035)+2 种基金the Natural Science Foundation of Zhejiang province,China(LY15E080014)preparatory funds of School of Architecture and TransportationNingbo university of technology,Open Research Fund Program of State key Laboratory of Hydroscience and Engineering
文摘[Objective]The aim is to provide data support for the prevention and control of pollution of exogenous chemical in pig breeding industry.[Methods]Solid-phase extraction(SPE)and tandem mass(LC-MS/MS)were used for determining four classes(tetracyclines,quinolones,macrolides and sulfonamides)of 10 common veterinary antibiotics in groundwater of an important pig breeding base in the Yangtze River Delta region of China.[Results]Results revealed the total concentration of the ten antibiotics in urban rivers ranged from 20.1 ng /L to 61.2 ng /L.The highest proportion was taken by tetracyclines,account for 95%,the concentration was up to 44.0 ng /L.Quinolones shared the second largest proportion of total concentration,about 29%,the concentration was up to 21.6 ng /L,while concentration of sulfonamides and macrolides were respectively below 2.7 ng /L and 6.3 ng /L.The highest total concentration of the ten antibiotics in rural rivers was up to 467 ng /L,60% of which was shared by tetracyclines,the highest concentration of tetracyclines was 253 ng /L.Sulfonamides share 20% of the total concentration,the highest concentration of it was 165 ng /L.The highest concentration of macrolides and quinolones was 14.6 ng /L and 14.5 ng /L,respectively.[Conclusion] Antibiotics' pollution in town rivers is more serious than urban rivers' pollution caused by antibiotics.
文摘目的对比氟比洛芬酯注射液和/或罗哌卡因注射液用于腹腔镜胆囊切除(LC)术后镇痛的临床疗效及安全性。方法将120例腹腔镜胆囊切除术患者随机分为A、B、C和D组,每组30例。A组于手术结束前不输注氟比洛芬酯和罗哌卡因,结束时也不在切口处进行局部麻醉;B组于手术结束前5 min给予静脉输注氟比洛芬酯50 mg,结束时不在切口处进行局部麻醉;C组于手术结束前不输注氟比洛芬酯和罗哌卡因,结束时用罗哌卡因10 mL在腹壁4个切口处进行均匀局部麻醉;D组于手术结束前静脉输注氟比洛芬酯50 mg,结束时用罗哌卡因10 mL在腹壁4个切口处进行均匀局部麻醉。比较4组患者的术后视觉模拟评分(VAS)、补救镇痛,以及药物不良反应的发生情况。结果A、B、C和D组的术后3 h VAS评分分别为(6.07±1.82),(3.20±1.40),(3.23±1.10)和(3.13±1.17),术后6 h VAS评分分别为(6.23±1.81),(4.63±1.69),(4.77±1.81)和(3.63±1.43),哌替啶使用率分别为50.00%(15例/30例),13.33%(4例/30例),16.67%(5例/30例)和16.67%(5例/30例),B、C和D组患者的上述指标与A组比较,差异均有统计学意义(均P<0.05),且D组的术后6 h VAS评分与B、C组比较,差异均有统计学意义(均P<0.05)。4组患者的药物不良反应主要有恶心呕吐,此外D组还有皮肤瘙痒的发生。A、B、C和D组的总药物不良反应发生率分别为10.00%,13.33%,10.00%和16.67%,差异均无统计学意义(均P>0.05)。结论氟比洛芬酯注射液和罗哌卡因注射液在LC术后3 h和6 h内对患者镇痛的效果确切,而且术后6 h时两药的联合镇痛效果更佳。
