Sterol o-acyltransferase1(SOAT1)is an enzyme that regulates lipid metabolism.Nevertheless,the predictive value of SOAT1 regarding immune responses in cancer is not fully understood.Herein,we aimed to expound the predi...Sterol o-acyltransferase1(SOAT1)is an enzyme that regulates lipid metabolism.Nevertheless,the predictive value of SOAT1 regarding immune responses in cancer is not fully understood.Herein,we aimed to expound the predictive value and the potential biological functions of SOAT1 in pan-cancer.Raw data related to SOAT1 expression in 33 different types of cancer were acquired from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)databases.SOAT1 expression was significantly increased in most cancers and showed a distinct correlation with prognosis.This enhanced expression of the SOAT1 gene was confirmed by evaluating SOAT1 protein expression using tissue microarrays.In addition,we found significant positive associations between SOAT1 expression levels and infiltrating immune cells,including T cells,neutrophils,and macrophages.Moreover,the co-expression analysis between SOAT1 and immune genes showed that many immune-related genes were increased with enhanced SOAT1 expression.A gene set enrichment analysis(GSEA)revealed that the expression of SOAT1 correlated with the tumor microenvironment,adaptive immune response,interferon signaling,and cytokine signaling.These findings indicate that SOAT1 is a potential candidate marker for predicting prognosis and a promising target for tumor immunotherapy in cancers.展开更多
The k·p method is significant in condensed matter physics for the compact and analytical Hamiltonian.In the presence of magnetic field,it is described by the effective Zeeman's coupling Hamiltonian with Land&...The k·p method is significant in condensed matter physics for the compact and analytical Hamiltonian.In the presence of magnetic field,it is described by the effective Zeeman's coupling Hamiltonian with Landég-factors.Here,we develop an open-source package VASP2KP(including two parts:vasp2mat and mat2kp)to compute k·p parameters and Landég-factors directly from the wavefunctions provided by the density functional theory(DFT)as implemented in Vienna ab initio Simulation Package(VASP).First,we develop a VASP patch vasp2mat to compute matrix representations of the generalized momentum operatorπ=p+1/2mc^(2)[s×■V(r)],spin operator s,time reversal operatorT,and crystalline symmetry operatorsR on the DFT wavefunctions.Second,we develop a python code mat2kp to obtain the unitary transformation U that rotates the degenerate DFT basis towards the standard basis,and then automatically compute the k·p parameters and g-factors.The theory and the methodology behind VASP2KP are described in detail.The matrix elements of the operators are derived comprehensively and computed correctly within the projector augmented wave method.We apply this package to some materials,e.g.,Bi2Se3,Na3Bi,Te,InAs and 1H-TMD monolayers.The obtained effective model's dispersions are in good agreement with the DFT data around the specific wave vector,and the g-factors are consistent with experimental data.The VASP2KP package is available at https://github.com/zjwang11/VASP2KP.展开更多
目的探讨自我管理程序干预对首发脑卒中患者康复自我效能、创伤后成长、心理韧性的影响。方法选取2019-09—2020-02郑州大学第二附属医院收治的90例首发脑卒中患者,采用随机数字表法分为干预组45例和对照组45例。对照组采用常规的护理...目的探讨自我管理程序干预对首发脑卒中患者康复自我效能、创伤后成长、心理韧性的影响。方法选取2019-09—2020-02郑州大学第二附属医院收治的90例首发脑卒中患者,采用随机数字表法分为干预组45例和对照组45例。对照组采用常规的护理模式和健康教育,干预组在此基础上进行自我管理程序干预,比较2组患者干预3个月后康复自我效能、创伤后成长及心理韧性得分。结果干预后干预组患者康复自我效能(总分77.02±8.656 vs 71.33±10.187)、创伤后成长(总分55.11±5.457 vs 51.00±5.800)及心理韧性(总分50.29±5.550 vs 46.13±5.421)各维度得分及总分较对照组显著提高,差异有统计学意义(P<0.05)。结论在首发脑卒中患者中实施自我管理程序干预,可明显提高患者的康复自我效能水平,增强患者的心理韧性,促进创伤后成长,加快康复进程。展开更多
基金This work was mainly supported by the Science and Technology Innovation Fund Project of Shanghai Jinshan District Science and Technology Commission(No.2021-3-55)All sponsors or funders played no roles in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
文摘Sterol o-acyltransferase1(SOAT1)is an enzyme that regulates lipid metabolism.Nevertheless,the predictive value of SOAT1 regarding immune responses in cancer is not fully understood.Herein,we aimed to expound the predictive value and the potential biological functions of SOAT1 in pan-cancer.Raw data related to SOAT1 expression in 33 different types of cancer were acquired from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)databases.SOAT1 expression was significantly increased in most cancers and showed a distinct correlation with prognosis.This enhanced expression of the SOAT1 gene was confirmed by evaluating SOAT1 protein expression using tissue microarrays.In addition,we found significant positive associations between SOAT1 expression levels and infiltrating immune cells,including T cells,neutrophils,and macrophages.Moreover,the co-expression analysis between SOAT1 and immune genes showed that many immune-related genes were increased with enhanced SOAT1 expression.A gene set enrichment analysis(GSEA)revealed that the expression of SOAT1 correlated with the tumor microenvironment,adaptive immune response,interferon signaling,and cytokine signaling.These findings indicate that SOAT1 is a potential candidate marker for predicting prognosis and a promising target for tumor immunotherapy in cancers.
基金supported by the National Key R&D Program of Chain(Grant No.2022YFA1403800)the National Natural Science Foundation of China(Grant Nos.11974395,12188101,11925408,12274436,and 11921004)+5 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB33000000)the Center for Materials Genomesupported by the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302403)the National Natural Science Foundation of China(Grant No.12274005)the National Key Research and Development Program of China(Grant No.2021YFA1401900)supported by the Informatization Plan of the Chinese Academy of Sciences(Grant No.CASWX2021SF0102)。
文摘The k·p method is significant in condensed matter physics for the compact and analytical Hamiltonian.In the presence of magnetic field,it is described by the effective Zeeman's coupling Hamiltonian with Landég-factors.Here,we develop an open-source package VASP2KP(including two parts:vasp2mat and mat2kp)to compute k·p parameters and Landég-factors directly from the wavefunctions provided by the density functional theory(DFT)as implemented in Vienna ab initio Simulation Package(VASP).First,we develop a VASP patch vasp2mat to compute matrix representations of the generalized momentum operatorπ=p+1/2mc^(2)[s×■V(r)],spin operator s,time reversal operatorT,and crystalline symmetry operatorsR on the DFT wavefunctions.Second,we develop a python code mat2kp to obtain the unitary transformation U that rotates the degenerate DFT basis towards the standard basis,and then automatically compute the k·p parameters and g-factors.The theory and the methodology behind VASP2KP are described in detail.The matrix elements of the operators are derived comprehensively and computed correctly within the projector augmented wave method.We apply this package to some materials,e.g.,Bi2Se3,Na3Bi,Te,InAs and 1H-TMD monolayers.The obtained effective model's dispersions are in good agreement with the DFT data around the specific wave vector,and the g-factors are consistent with experimental data.The VASP2KP package is available at https://github.com/zjwang11/VASP2KP.
文摘目的探讨自我管理程序干预对首发脑卒中患者康复自我效能、创伤后成长、心理韧性的影响。方法选取2019-09—2020-02郑州大学第二附属医院收治的90例首发脑卒中患者,采用随机数字表法分为干预组45例和对照组45例。对照组采用常规的护理模式和健康教育,干预组在此基础上进行自我管理程序干预,比较2组患者干预3个月后康复自我效能、创伤后成长及心理韧性得分。结果干预后干预组患者康复自我效能(总分77.02±8.656 vs 71.33±10.187)、创伤后成长(总分55.11±5.457 vs 51.00±5.800)及心理韧性(总分50.29±5.550 vs 46.13±5.421)各维度得分及总分较对照组显著提高,差异有统计学意义(P<0.05)。结论在首发脑卒中患者中实施自我管理程序干预,可明显提高患者的康复自我效能水平,增强患者的心理韧性,促进创伤后成长,加快康复进程。
