目的探讨绝经后骨质疏松症(osteoporosis,OP)患者皮质骨孔率、形态结构、矿化和类骨质密度MRI指标是否受到影响,并探讨MRI指标与绝经后妇女骨密度(BMD)的关系。方法回顾性分析本院于2021年6月到2023年6月期间收治的30名OP患者和38名非O...目的探讨绝经后骨质疏松症(osteoporosis,OP)患者皮质骨孔率、形态结构、矿化和类骨质密度MRI指标是否受到影响,并探讨MRI指标与绝经后妇女骨密度(BMD)的关系。方法回顾性分析本院于2021年6月到2023年6月期间收治的30名OP患者和38名非OP患者的临床资料。在1.5T时,对皮质骨孔率(孔隙水和总水)、类骨质密度(结合水[BW])、形态结构(皮质骨厚度)和矿化(磷[P]密度[31P]和31P/BW浓度比)进行量化,比较OP组和非OP组之间的MRI测量结果,并评估其与BMD的相关性。结果OP组的骨质疏松症患者骨密度明显高于非OP组(11.6mol/L vs 9.5mol/L;P=0.007;P=0.007),总水密度(21.2mol/L vs 19.7mol/L;P=0.03),骨皮质厚度(4.8mm vs 5.6 mm;P<0.001)和31P密度(6.4mol/L vs 7.5mol/L;P=0.01)明显低于非OP组。孔隙密度和总水密度与DXA和外周定量CT骨密度呈负相关(P<0.001),而皮质骨厚度和31P密度与DXA和外周定量CT BMD呈正相关(P=0.01)。BW、31P密度、31P/BW浓度比与DXA呈正相关(P<0.05),与外周定量CT无关。结论:皮质骨的固态MRI能够帮助检测绝经后骨质疏松症中反映孔洞、形态结构和矿化的参数的潜在损害。展开更多
Understanding the physical,mechanical behavior,and seepage characteristics of coal under hydro-mechanical coupling holds significant importance for ensuring the stability of surrounding rock formations and preventing ...Understanding the physical,mechanical behavior,and seepage characteristics of coal under hydro-mechanical coupling holds significant importance for ensuring the stability of surrounding rock formations and preventing gas outbursts.Scanning electron microscopy,uniaxial tests,and triaxial tests were conducted to comprehensively analyze the macroscopic and microscopic physical and mechanical characteristics of coal under different soaking times.Moreover,by restoring the stress path and water injection conditions of the protective layer indoors,we explored the coal mining dynamic behavior and the evolution of permeability.The results show that water causes the micro-surface of coal to peel off and cracks to expand and develop.With the increase of soaking time,the uniaxial and triaxial strengths were gradually decreased with nonlinear trend,and decreased by 63.31%and 30.95%after soaking for 240 h,respectively.Under different water injection pressure conditions,coal permeability undergoes three stages during the mining loading process and ultimately increases to higher values.The peak stress of coal,the deviatoric stress and strain at the permeability surge point all decrease with increasing water injection pressure.The results of this research can help improve the understanding of the coal mechanical properties and seepage evolution law under hydro-mechanical coupling.展开更多
文摘目的探讨绝经后骨质疏松症(osteoporosis,OP)患者皮质骨孔率、形态结构、矿化和类骨质密度MRI指标是否受到影响,并探讨MRI指标与绝经后妇女骨密度(BMD)的关系。方法回顾性分析本院于2021年6月到2023年6月期间收治的30名OP患者和38名非OP患者的临床资料。在1.5T时,对皮质骨孔率(孔隙水和总水)、类骨质密度(结合水[BW])、形态结构(皮质骨厚度)和矿化(磷[P]密度[31P]和31P/BW浓度比)进行量化,比较OP组和非OP组之间的MRI测量结果,并评估其与BMD的相关性。结果OP组的骨质疏松症患者骨密度明显高于非OP组(11.6mol/L vs 9.5mol/L;P=0.007;P=0.007),总水密度(21.2mol/L vs 19.7mol/L;P=0.03),骨皮质厚度(4.8mm vs 5.6 mm;P<0.001)和31P密度(6.4mol/L vs 7.5mol/L;P=0.01)明显低于非OP组。孔隙密度和总水密度与DXA和外周定量CT骨密度呈负相关(P<0.001),而皮质骨厚度和31P密度与DXA和外周定量CT BMD呈正相关(P=0.01)。BW、31P密度、31P/BW浓度比与DXA呈正相关(P<0.05),与外周定量CT无关。结论:皮质骨的固态MRI能够帮助检测绝经后骨质疏松症中反映孔洞、形态结构和矿化的参数的潜在损害。
基金Project(52225403)supported by the National Natural Science Foundation of ChinaProject(2023YFF0615401)supported by the National Key Research and Development Program of China+1 种基金Projects(2023NSFSC0004,2023NSFSC0790)supported by Science and Technology Program of Sichuan Province,ChinaProject(2021-CMCUKFZD001)supported by the Open Fund of State Key Laboratory of Coal Mining and Clean Utilization,China。
文摘Understanding the physical,mechanical behavior,and seepage characteristics of coal under hydro-mechanical coupling holds significant importance for ensuring the stability of surrounding rock formations and preventing gas outbursts.Scanning electron microscopy,uniaxial tests,and triaxial tests were conducted to comprehensively analyze the macroscopic and microscopic physical and mechanical characteristics of coal under different soaking times.Moreover,by restoring the stress path and water injection conditions of the protective layer indoors,we explored the coal mining dynamic behavior and the evolution of permeability.The results show that water causes the micro-surface of coal to peel off and cracks to expand and develop.With the increase of soaking time,the uniaxial and triaxial strengths were gradually decreased with nonlinear trend,and decreased by 63.31%and 30.95%after soaking for 240 h,respectively.Under different water injection pressure conditions,coal permeability undergoes three stages during the mining loading process and ultimately increases to higher values.The peak stress of coal,the deviatoric stress and strain at the permeability surge point all decrease with increasing water injection pressure.The results of this research can help improve the understanding of the coal mechanical properties and seepage evolution law under hydro-mechanical coupling.
