目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型...目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型,采取改良多平台睡眠剥夺法实施睡眠剥夺,用旷场实验和强迫游泳实验对大鼠的行为变化进行测试,免疫组化法检测海马环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)、磷酸化环磷腺苷反应元件结合蛋白(phosphorylation cyclic adenosinemonophosphate response element binding protein,p-CREB)的含量。结果:与抑郁模型组相比,睡眠剥夺组大鼠的旷场实验水平运动得分与垂直运动得分均明显升高,潜伏期明显缩短,强迫游泳实验不动时间明显减少(P<0.05或P<0.01)。抑郁模型组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著低于正常对照组(P<0.05),睡眠剥夺组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著高于抑郁模型组(P<0.05)。结论:睡眠剥夺可明显改善大鼠的抑郁样行为,其快速抗抑郁作用可能与海马部位CREB含量及活性的增高有关,可为海港地区抑郁症治疗提供依据。展开更多
Noise characteristic is one of the important factors to be considered during the design of a launch vehicle system.In this paper,the acceptance conditions for the external noise environment of the instrument cabin are...Noise characteristic is one of the important factors to be considered during the design of a launch vehicle system.In this paper,the acceptance conditions for the external noise environment of the instrument cabin are given based on multi-source data,including the measured data of the launch vehicle lift-off noise,the mechanical environment of the launch vehicle equipment,and the external noise environment of the instrument cabin deduced from empirical formula.Then an acoustic and vibration transfer model is established based on the response data of the instrument equipment used to conduct measurements in the noise test reverberation room.By using an external noise environment and a transfer model,the response of the instrument and equipment for the acceptance condition can be obtained.The acoustic and vibration prediction technology introduced in this paper can provide technical support in the environmental prediction analysis of heavy launch vehicles for the future.展开更多
目的探讨集训新兵觉察压力特点、认知情绪调节策略和应激性失眠之间的关系。方法采用便利抽样法,选取某部集训1个月的新兵486名,采用自编一般资料问卷、福特应激失眠反应量表中文版(Ford insomnia response to stress test Chinese vers...目的探讨集训新兵觉察压力特点、认知情绪调节策略和应激性失眠之间的关系。方法采用便利抽样法,选取某部集训1个月的新兵486名,采用自编一般资料问卷、福特应激失眠反应量表中文版(Ford insomnia response to stress test Chinese version,FIRST-C)、觉察压力量表(perceived stress scale,PSS)和认知情绪调节问卷中文版(cognitive emotion regulation questionnaire-Chinese version,CERQ-C)进行调查,应用FIRST-C把调查新兵划分成应激性失眠高风险组(n=145)和低风险组(n=341)。结果①与低风险组比较,高风险组城镇户口比例(52.41%vs.41.64%)和独生子女比例(68.97%vs.57.18%)偏高,组间比较差异有统计学意义(P<0.05);高风险组PSS总分及各因子分、非适应性调节策略分高于低风险组,适应性调节策略分低于低风险组,组间比较差异有统计学意义(P<0.05或0.01)。②集训新兵FIRST-C总分与新兵来源(城镇)、独生子女(是)、PSS总分、预测感因子分、控制感因子分、超载感因子分、非适应性调节策略因子分呈正相关,而与适应性调节策略呈显著负相关(P<0.05或0.01)。③独生子女、预测感和非适应性调节策略能有效预测集训新兵应激性失眠的易患性(F=7.358,P<0.05)。结论既往的成长环境是集训新兵易患应激性失眠的重要因素,觉察压力水平和不良的压力调节策略加剧了失眠症的发展。展开更多
文摘目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型,采取改良多平台睡眠剥夺法实施睡眠剥夺,用旷场实验和强迫游泳实验对大鼠的行为变化进行测试,免疫组化法检测海马环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)、磷酸化环磷腺苷反应元件结合蛋白(phosphorylation cyclic adenosinemonophosphate response element binding protein,p-CREB)的含量。结果:与抑郁模型组相比,睡眠剥夺组大鼠的旷场实验水平运动得分与垂直运动得分均明显升高,潜伏期明显缩短,强迫游泳实验不动时间明显减少(P<0.05或P<0.01)。抑郁模型组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著低于正常对照组(P<0.05),睡眠剥夺组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著高于抑郁模型组(P<0.05)。结论:睡眠剥夺可明显改善大鼠的抑郁样行为,其快速抗抑郁作用可能与海马部位CREB含量及活性的增高有关,可为海港地区抑郁症治疗提供依据。
文摘Noise characteristic is one of the important factors to be considered during the design of a launch vehicle system.In this paper,the acceptance conditions for the external noise environment of the instrument cabin are given based on multi-source data,including the measured data of the launch vehicle lift-off noise,the mechanical environment of the launch vehicle equipment,and the external noise environment of the instrument cabin deduced from empirical formula.Then an acoustic and vibration transfer model is established based on the response data of the instrument equipment used to conduct measurements in the noise test reverberation room.By using an external noise environment and a transfer model,the response of the instrument and equipment for the acceptance condition can be obtained.The acoustic and vibration prediction technology introduced in this paper can provide technical support in the environmental prediction analysis of heavy launch vehicles for the future.
文摘目的探讨集训新兵觉察压力特点、认知情绪调节策略和应激性失眠之间的关系。方法采用便利抽样法,选取某部集训1个月的新兵486名,采用自编一般资料问卷、福特应激失眠反应量表中文版(Ford insomnia response to stress test Chinese version,FIRST-C)、觉察压力量表(perceived stress scale,PSS)和认知情绪调节问卷中文版(cognitive emotion regulation questionnaire-Chinese version,CERQ-C)进行调查,应用FIRST-C把调查新兵划分成应激性失眠高风险组(n=145)和低风险组(n=341)。结果①与低风险组比较,高风险组城镇户口比例(52.41%vs.41.64%)和独生子女比例(68.97%vs.57.18%)偏高,组间比较差异有统计学意义(P<0.05);高风险组PSS总分及各因子分、非适应性调节策略分高于低风险组,适应性调节策略分低于低风险组,组间比较差异有统计学意义(P<0.05或0.01)。②集训新兵FIRST-C总分与新兵来源(城镇)、独生子女(是)、PSS总分、预测感因子分、控制感因子分、超载感因子分、非适应性调节策略因子分呈正相关,而与适应性调节策略呈显著负相关(P<0.05或0.01)。③独生子女、预测感和非适应性调节策略能有效预测集训新兵应激性失眠的易患性(F=7.358,P<0.05)。结论既往的成长环境是集训新兵易患应激性失眠的重要因素,觉察压力水平和不良的压力调节策略加剧了失眠症的发展。
