Objective:To explore the effect of sustained-release recombinant human bone morphogenetic protein-2(rhBMP-2) on ectopic osteogenesis in the muscle pouches of rats through preparing rhBMP-2 sustained-release capsules b...Objective:To explore the effect of sustained-release recombinant human bone morphogenetic protein-2(rhBMP-2) on ectopic osteogenesis in the muscle pouches of rats through preparing rhBMP-2 sustained-release capsules by wrapping morphogenesis protein bones-2(BMP-2)using chitosan nanoparticles,and compositing collagen materials.Methods:Twenty four SpragueDawley rats were randomly divided into four groups with six rats in each group,that is Group A(control group),Group B(only treated with collagen),Group C(rhBMP-2+collagen treated group) and Group D(rhBMP-2/cs+collagen treated group).The composite materials for each group were implanted in the bilateral peroneal muscle pouches in rats.The peroneal muscles were only separated without implanting any materials in control group.Rats were sacrificed 2 weeks and 4 weeks post treatment and samples were cut off for general observation,Micro CT scans and histological observation.Results:General observation showed no new bone formation in Groups A and B mice,while new bones were formed in Groups C and D mice.Two weeks after treatment Micro CT scans showed that The bone volume fraction(BVF),trabecular thickness(Tb. Th),bone mineral density(BMD) in Group C mice were all higher than that in Group D(P<0.05). At the fourth week,the BVK,Tb.Th and BMD were significantly higher than that at the second week(P<0.01).Conclusions:The slow-release effect of rhBMP-2/cs sustained-release capsules can significantly promote ectopic osteogenesis.Its bone formation effect is better than that of rhBMP-2 burst-release group.展开更多
Background Hirschsprung's disease(HSCR)is one of the most common congenital digestive tract malformations and can cause stubborn constipation or gastrointestinal obstruction after birth,causing great physical and ...Background Hirschsprung's disease(HSCR)is one of the most common congenital digestive tract malformations and can cause stubborn constipation or gastrointestinal obstruction after birth,causing great physical and mental pain to patients and their families.Studies have shown that more than 20 genes are involved in HSCR,and most cases of HSCR are sporadic.However,the overall rate of familial recurrence in 4331 cases of HSCR is about 7.6%.Furthermore,familial HSCR patients show incomplete dominance.We still do not know the penetrance and genetic characteristics of these known risk genes due to the rarity of HSCR families.Methods To find published references,we used the title/abstract terms"Hirschsprung"and"familial"in the PubMed data-base and the MeSH terms"Hirschsprung"and"familial"in Web of Science.Finally,we summarized 129 HSCR families over the last 40 years.Results The male-to-female ratio and the percentage of short segment-HSCR in familial HSCR are much lower than in sporadic HSCR.The primary gene factors in the syndromic families are ret proto-oncogene(RET)and endothelin B receptor gene(EDNRB).Most families show incomplete dominance and are relevant to RET,and the RET mutation has 56%pen-etrance in familial HSCR.When one of the parents is a RET mutation carrier in an HSCR family,the offspring's recurrence risk is 28%,and the incidence of the offspring does not depend on whether the parent suffers from HSCR.Conclusion Our findings will help HSCR patients obtain better genetic counseling,calculate the risk of recurrence,and provide new insights for future pedigree studies.展开更多
Design intelligence is an important branch of artificial intelligence(AI),focusing on the intelligent models and algorithms in creativity and design.In the context of AI 2.0,studies on design intelligence have develop...Design intelligence is an important branch of artificial intelligence(AI),focusing on the intelligent models and algorithms in creativity and design.In the context of AI 2.0,studies on design intelligence have developed rapidly.We summarize mainly the current emerging framework of design intelligence and review the state-of-the-art techniques of related topics,including user needs analysis,ideation,content generation,and design evaluation.Specifically,the models and methods of intelligence-generated content are reviewed in detail.Finally,we discuss some open problems and challenges for future research in design intelligence.展开更多
Three species, Macrophya circulotibialis Li, Liu & Heng, sp. nov., M. curvatitheca Li, Liu & Heng, sp. nov. and M. changbaina Li, Liu & Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom(...Three species, Macrophya circulotibialis Li, Liu & Heng, sp. nov., M. curvatitheca Li, Liu & Heng, sp. nov. and M. changbaina Li, Liu & Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom(Hymenoptera, Tenthredinidae) from China are described as new to science. A key to all known species of the imitator-group from China is provided. The specimens examined in this study, including all holotypes and paratypes of the new species, are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China, and the Department of Zoology, National Museum of Nature and Science, Amakubo, Tsukuba, Ibaraki, Japan.展开更多
Macrophya opacifrontalis Li,Lei & Wei,sp.nov.,M.pseudofemorata Li,Wang,& Wei,sp.nov.,and M.huangi Li & Wei,sp.nov.of the sanguinolenta-gxoup of Macrophya(Hymenoptera:Tenthredinidae) from China are describe...Macrophya opacifrontalis Li,Lei & Wei,sp.nov.,M.pseudofemorata Li,Wang,& Wei,sp.nov.,and M.huangi Li & Wei,sp.nov.of the sanguinolenta-gxoup of Macrophya(Hymenoptera:Tenthredinidae) from China are described.M.opacifrontalis and M.pseudofemorata is belong to the tongi-subgroup,whereas M.huangi belongs to the depressinasubgroup.The division of the tongi and depressina subgroups and species inside are briefly discussed.Keys to all known species of the tongi and depressina-subgroups from China are provided respectively.展开更多
Four new species of the sanguinolenta-group of the genus Macrophya from China are described, namely M. cheni sp. nov., M. yichangensis sp. nov., M. elegansoma sp. nov., and M. reni sp. nov. The species M. cheni sp. no...Four new species of the sanguinolenta-group of the genus Macrophya from China are described, namely M. cheni sp. nov., M. yichangensis sp. nov., M. elegansoma sp. nov., and M. reni sp. nov. The species M. cheni sp. nov. and M. yichangensis sp. nov. belong to the koreana-subgroup, while M. elegansoma sp. nov. and M. reni sp. nov. belong to the sanguinolenta-subgroup. The division of the koreana and sanguinolenta-subgroups are briefly discussed. Keys to all known species of the koreana and sanguinolenta-subgroups from China are provided, respectively. The type specimens of new species are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China.展开更多
基金supported by Guangdong Province Science and Technology Foundation,Guangdong,China(No:2011B080701053)
文摘Objective:To explore the effect of sustained-release recombinant human bone morphogenetic protein-2(rhBMP-2) on ectopic osteogenesis in the muscle pouches of rats through preparing rhBMP-2 sustained-release capsules by wrapping morphogenesis protein bones-2(BMP-2)using chitosan nanoparticles,and compositing collagen materials.Methods:Twenty four SpragueDawley rats were randomly divided into four groups with six rats in each group,that is Group A(control group),Group B(only treated with collagen),Group C(rhBMP-2+collagen treated group) and Group D(rhBMP-2/cs+collagen treated group).The composite materials for each group were implanted in the bilateral peroneal muscle pouches in rats.The peroneal muscles were only separated without implanting any materials in control group.Rats were sacrificed 2 weeks and 4 weeks post treatment and samples were cut off for general observation,Micro CT scans and histological observation.Results:General observation showed no new bone formation in Groups A and B mice,while new bones were formed in Groups C and D mice.Two weeks after treatment Micro CT scans showed that The bone volume fraction(BVF),trabecular thickness(Tb. Th),bone mineral density(BMD) in Group C mice were all higher than that in Group D(P<0.05). At the fourth week,the BVK,Tb.Th and BMD were significantly higher than that at the second week(P<0.01).Conclusions:The slow-release effect of rhBMP-2/cs sustained-release capsules can significantly promote ectopic osteogenesis.Its bone formation effect is better than that of rhBMP-2 burst-release group.
基金National Natural Science Foundation of China(82071685 to FJX)Clinical Research Pilot Project of Tongji Hospital(2019YBKY026 to FJX)+2 种基金Provincial Key Research and Development Program(2020BCB008 to FJX)Science and Technology Innovation Base Platform(2020DCD006 to FJX)Project of Shenzhen San Ming(SZSM201812055 to FJX).
文摘Background Hirschsprung's disease(HSCR)is one of the most common congenital digestive tract malformations and can cause stubborn constipation or gastrointestinal obstruction after birth,causing great physical and mental pain to patients and their families.Studies have shown that more than 20 genes are involved in HSCR,and most cases of HSCR are sporadic.However,the overall rate of familial recurrence in 4331 cases of HSCR is about 7.6%.Furthermore,familial HSCR patients show incomplete dominance.We still do not know the penetrance and genetic characteristics of these known risk genes due to the rarity of HSCR families.Methods To find published references,we used the title/abstract terms"Hirschsprung"and"familial"in the PubMed data-base and the MeSH terms"Hirschsprung"and"familial"in Web of Science.Finally,we summarized 129 HSCR families over the last 40 years.Results The male-to-female ratio and the percentage of short segment-HSCR in familial HSCR are much lower than in sporadic HSCR.The primary gene factors in the syndromic families are ret proto-oncogene(RET)and endothelin B receptor gene(EDNRB).Most families show incomplete dominance and are relevant to RET,and the RET mutation has 56%pen-etrance in familial HSCR.When one of the parents is a RET mutation carrier in an HSCR family,the offspring's recurrence risk is 28%,and the incidence of the offspring does not depend on whether the parent suffers from HSCR.Conclusion Our findings will help HSCR patients obtain better genetic counseling,calculate the risk of recurrence,and provide new insights for future pedigree studies.
基金the National Science and Technology Innovation 2030 Major Project of the Ministry of Science and Technology of China(No.2018AAA0100703)the National Natural Science Foundation of China(Nos.61773336 and 91748127)+2 种基金the Chinese Academy of Engineering Consulting Project(No.2018-ZD-12-06)the Provincial Key Research and Development Plan of Zhejiang Province,China(No.2019C03137)the Ng Teng Fong Charitable Foundation in the form of ZJU-SUTD IDEA Grant。
文摘Design intelligence is an important branch of artificial intelligence(AI),focusing on the intelligent models and algorithms in creativity and design.In the context of AI 2.0,studies on design intelligence have developed rapidly.We summarize mainly the current emerging framework of design intelligence and review the state-of-the-art techniques of related topics,including user needs analysis,ideation,content generation,and design evaluation.Specifically,the models and methods of intelligence-generated content are reviewed in detail.Finally,we discuss some open problems and challenges for future research in design intelligence.
基金supported by the National Natural Science Foundation of China(31201736,31172142)
文摘Three species, Macrophya circulotibialis Li, Liu & Heng, sp. nov., M. curvatitheca Li, Liu & Heng, sp. nov. and M. changbaina Li, Liu & Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom(Hymenoptera, Tenthredinidae) from China are described as new to science. A key to all known species of the imitator-group from China is provided. The specimens examined in this study, including all holotypes and paratypes of the new species, are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China, and the Department of Zoology, National Museum of Nature and Science, Amakubo, Tsukuba, Ibaraki, Japan.
基金supported by the National Natural Science Foundation of China(31201736)Hunan Provincial Natural Science Foundation of China(12JJ3029)the Municipal Science and Technology Raise Project ofLishui City(2013ZC036)
文摘Macrophya opacifrontalis Li,Lei & Wei,sp.nov.,M.pseudofemorata Li,Wang,& Wei,sp.nov.,and M.huangi Li & Wei,sp.nov.of the sanguinolenta-gxoup of Macrophya(Hymenoptera:Tenthredinidae) from China are described.M.opacifrontalis and M.pseudofemorata is belong to the tongi-subgroup,whereas M.huangi belongs to the depressinasubgroup.The division of the tongi and depressina subgroups and species inside are briefly discussed.Keys to all known species of the tongi and depressina-subgroups from China are provided respectively.
基金supported by the National Natural Science Foundation of China(31172142)Key Agricultural Program of Major Science and Technology Projects of Zhejiang Province(2010C02004-3)the Municipal Science and Technology Raise Project of Lishui City(2013ZC036)
文摘Four new species of the sanguinolenta-group of the genus Macrophya from China are described, namely M. cheni sp. nov., M. yichangensis sp. nov., M. elegansoma sp. nov., and M. reni sp. nov. The species M. cheni sp. nov. and M. yichangensis sp. nov. belong to the koreana-subgroup, while M. elegansoma sp. nov. and M. reni sp. nov. belong to the sanguinolenta-subgroup. The division of the koreana and sanguinolenta-subgroups are briefly discussed. Keys to all known species of the koreana and sanguinolenta-subgroups from China are provided, respectively. The type specimens of new species are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China.
