Plasma technology has widespread applications in many fields, whereas the methods for manipulating plasma transport are limited to magnetic control. In this study, we used a simplified diffusion-migration approach to ...Plasma technology has widespread applications in many fields, whereas the methods for manipulating plasma transport are limited to magnetic control. In this study, we used a simplified diffusion-migration approach to describe plasma transport. The feasibility of the transformation theory for plasma transport was demonstrated.As potential applications, we designed three model devices capable of cloaking, concentrating, and rotating plasmas without disturbing the density profile of plasmas in the background. This research may help advance plasma technology in practical fields, such as medicine and chemistry.展开更多
Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mai...Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and neovasculation.In this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy.Firstly,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker.The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity.In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane.In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.展开更多
基金financial support from the National Natural Science Foundation of China (Grant Nos. 11725521 and 12035004)the Science and Technology Commission of Shanghai Municipality (Grant No. 20JC1414700)。
文摘Plasma technology has widespread applications in many fields, whereas the methods for manipulating plasma transport are limited to magnetic control. In this study, we used a simplified diffusion-migration approach to describe plasma transport. The feasibility of the transformation theory for plasma transport was demonstrated.As potential applications, we designed three model devices capable of cloaking, concentrating, and rotating plasmas without disturbing the density profile of plasmas in the background. This research may help advance plasma technology in practical fields, such as medicine and chemistry.
基金The research was supported by National Key R&D Program of China(2018YFE0201500,2017YFB0309300)National Natural Science Foundation of China(81772317,51973060,82072051,81771964)+5 种基金National Natural Science Foundation of China for Innovative Research Groups(51621002)Natural Science Foundation of Heilongjiang Province(LH2020H076)Shanghai International Cooperation Program(15520721200)Central Universities(WD1714002)The funding grants from Joint research project of important diseases in Xuhui District(XHLHGG201802)Fundamental Research Funds for the Shanghai Municipal Commission of Health and Family Planning(201740034)were also acknowledged.
文摘Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and neovasculation.In this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy.Firstly,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker.The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity.In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane.In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.
