目的探讨输尿管软镜联合负压吸引治疗感染性肾结石的有效性与安全性。方法检索中国知网(CNKI)、维普(VIP)、中国生物医学数据库(CBM)、万方、PubMed、Web ofScience、Embase、the Cochrane Central Trial Register of Controlled Trial...目的探讨输尿管软镜联合负压吸引治疗感染性肾结石的有效性与安全性。方法检索中国知网(CNKI)、维普(VIP)、中国生物医学数据库(CBM)、万方、PubMed、Web ofScience、Embase、the Cochrane Central Trial Register of Controlled Trials等数据库从建库至2020年11月19日的关于输尿管软镜联合负压吸引治疗感染性肾结石的临床研究。由两位研究者独立进行文献筛选和资料提取,采用Cochrane协作网提供的偏倚风险评价表对随机对照实验进行质量评估,采用纽卡斯尔-渥太华量表对纳入的回顾性队列研究进行风险偏倚评估,RevMan 5.3软件进行Meta分析。结果共纳入7篇文献,660例感染性肾结石患者(观察组336例,对照组324例)。Meta分析表明,观察组结石清除率较对照组高(O^R=7.01,95%CI:3.70~13.27,P=0.000);观察组术后发热发生率较对照组低(O^R=0.17,95%CI:0.07~0.41,P=0.000);观察组手术时间较对照组短(MD=-26.73,95%CI:-27.45~-26.02,P=0.000);两组患者结石大小比较,差异无统计学意义(MD=-0.07,95%CI:-0.57~0.42,P=0.770)。结论与常规输尿管软镜相比,输尿管软镜联合负压吸引治疗感染性肾结石能够提高结石清除率,减少术后发热等并发症的发生。展开更多
Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties.We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury.In this study,r...Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties.We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury.In this study,rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1,7,and 14 days after cavernous nerve injury.Serum superoxide dismutase and glutathione peroxidase activities significantly increased at 1 and 2 weeks post-injury.Serum malondialdehyde levels decreased at 2 and 4 weeks.At 12 weeks,peak intracavernous pressure,the number of myelinated axons and nicotinamide adenine dinucleotide phosphate-diaphorase-positive nerve fibers,levels of phospho-endothelial nitric oxide synthase protein and 3-nitrotyrosine were higher in rats administered at 1 day post-injury compared with rats administered at 7 and 14 days post-injury.These findings suggest that application of Lycium barbarum polysaccharides following cavernous nerve crush injury effectively promotes nerve regeneration and erectile functional recovery.This neuroregenerative effect was most effective in rats orally administered Lycium barbarum polysaccharides at 1 day after cavernous nerve crush injury.展开更多
Amorphous powder cores based on spherical （Fe0.76Si0.09B0.1P0.05）99Nb1 amorphous powder and their SiO2 layer prepared by in situ coating insulation process were investigated in detAll. These cores were characterized...Amorphous powder cores based on spherical （Fe0.76Si0.09B0.1P0.05）99Nb1 amorphous powder and their SiO2 layer prepared by in situ coating insulation process were investigated in detAll. These cores were characterized by scanning electron microscopy and X-ray diffraction analyses, and the results revealed that the surface layer of the amorphous powder was composed of SiO2 with uniform surface coverage. The thickness of the SiO2 insulating layer could be controlled by adjusting the tetraethyl orthosilicate （TEOS） content. By cold-pressing with epoxy resin under a pressure of 1800 MPa, a ring powder core with an outer diameter of 20.3 ram, inner diameter of 12.7 mm, and height of 5.3 mm was prepared. The FeSiBPNb composite core showed its best properties when the TEOS content was 2 mL/g （the volume of TEOS for each gram of （Fe0.76Si0.09B0.1P0.05）99Nb1 amorphous powder, mL/g）, which showed good relative permeability in the high-frequency range of up to 10 MHz and a low core loss of 320 W/kg under the maximum magnetic flux density of 0.1 T and frequency of 100 kHz.展开更多
文摘目的探讨输尿管软镜联合负压吸引治疗感染性肾结石的有效性与安全性。方法检索中国知网(CNKI)、维普(VIP)、中国生物医学数据库(CBM)、万方、PubMed、Web ofScience、Embase、the Cochrane Central Trial Register of Controlled Trials等数据库从建库至2020年11月19日的关于输尿管软镜联合负压吸引治疗感染性肾结石的临床研究。由两位研究者独立进行文献筛选和资料提取,采用Cochrane协作网提供的偏倚风险评价表对随机对照实验进行质量评估,采用纽卡斯尔-渥太华量表对纳入的回顾性队列研究进行风险偏倚评估,RevMan 5.3软件进行Meta分析。结果共纳入7篇文献,660例感染性肾结石患者(观察组336例,对照组324例)。Meta分析表明,观察组结石清除率较对照组高(O^R=7.01,95%CI:3.70~13.27,P=0.000);观察组术后发热发生率较对照组低(O^R=0.17,95%CI:0.07~0.41,P=0.000);观察组手术时间较对照组短(MD=-26.73,95%CI:-27.45~-26.02,P=0.000);两组患者结石大小比较,差异无统计学意义(MD=-0.07,95%CI:-0.57~0.42,P=0.770)。结论与常规输尿管软镜相比,输尿管软镜联合负压吸引治疗感染性肾结石能够提高结石清除率,减少术后发热等并发症的发生。
基金supported by grants from the National Natural Science Foundation of China,No.81100492,81402119 and 81500517the Natural Science Foundation of Shandong Province of China,No.ZR2014HP055 and ZR2014HL071
文摘Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties.We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury.In this study,rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1,7,and 14 days after cavernous nerve injury.Serum superoxide dismutase and glutathione peroxidase activities significantly increased at 1 and 2 weeks post-injury.Serum malondialdehyde levels decreased at 2 and 4 weeks.At 12 weeks,peak intracavernous pressure,the number of myelinated axons and nicotinamide adenine dinucleotide phosphate-diaphorase-positive nerve fibers,levels of phospho-endothelial nitric oxide synthase protein and 3-nitrotyrosine were higher in rats administered at 1 day post-injury compared with rats administered at 7 and 14 days post-injury.These findings suggest that application of Lycium barbarum polysaccharides following cavernous nerve crush injury effectively promotes nerve regeneration and erectile functional recovery.This neuroregenerative effect was most effective in rats orally administered Lycium barbarum polysaccharides at 1 day after cavernous nerve crush injury.
基金The work was with the support from the National Key Research and Development Program of China （Grant No. 2017YFB0903902）, National Natural Science Foundation of China （Grant Nos. 51601205, 51671035, 51071034, and 51671206）, and Ningbo Municipal Nature Science Foundation （Grant No. 2017A610036）.
文摘Amorphous powder cores based on spherical （Fe0.76Si0.09B0.1P0.05）99Nb1 amorphous powder and their SiO2 layer prepared by in situ coating insulation process were investigated in detAll. These cores were characterized by scanning electron microscopy and X-ray diffraction analyses, and the results revealed that the surface layer of the amorphous powder was composed of SiO2 with uniform surface coverage. The thickness of the SiO2 insulating layer could be controlled by adjusting the tetraethyl orthosilicate （TEOS） content. By cold-pressing with epoxy resin under a pressure of 1800 MPa, a ring powder core with an outer diameter of 20.3 ram, inner diameter of 12.7 mm, and height of 5.3 mm was prepared. The FeSiBPNb composite core showed its best properties when the TEOS content was 2 mL/g （the volume of TEOS for each gram of （Fe0.76Si0.09B0.1P0.05）99Nb1 amorphous powder, mL/g）, which showed good relative permeability in the high-frequency range of up to 10 MHz and a low core loss of 320 W/kg under the maximum magnetic flux density of 0.1 T and frequency of 100 kHz.
