The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density requirements.Lithium metal ba...The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density requirements.Lithium metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density batteries.In this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in LMBs.Furthermore,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these challenges.The utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing them.This review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid electrolytes.Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal batteries.Based on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.展开更多
The performance of optical interconnection has improved dramatically in recent years.Silicon-based optoelectronic heterogeneous integration is the key enabler to achieve high performance optical interconnection,which ...The performance of optical interconnection has improved dramatically in recent years.Silicon-based optoelectronic heterogeneous integration is the key enabler to achieve high performance optical interconnection,which not only provides the optical gain which is absent from native Si substrates and enables complete photonic functionalities on chip,but also improves the system performance through advanced heterogeneous integrated packaging.This paper reviews recent progress of silicon-based optoelectronic heterogeneous integration in high performance optical interconnection.The research status,development trend and application of ultra-low loss optical waveguides,high-speed detectors,high-speed modulators,lasers and 2D,2.5D,3D and monolithic integration are focused on.展开更多
With the advent of the information security era,it is necessary to guarantee the privacy,accuracy,and dependable transfer of pictures.This study presents a new approach to the encryption and compression of color image...With the advent of the information security era,it is necessary to guarantee the privacy,accuracy,and dependable transfer of pictures.This study presents a new approach to the encryption and compression of color images.It is predicated on 2D compressed sensing(CS)and the hyperchaotic system.First,an optimized Arnold scrambling algorithm is applied to the initial color images to ensure strong security.Then,the processed images are con-currently encrypted and compressed using 2D CS.Among them,chaotic sequences replace traditional random measurement matrices to increase the system’s security.Third,the processed images are re-encrypted using a combination of permutation and diffusion algorithms.In addition,the 2D projected gradient with an embedding decryption(2DPG-ED)algorithm is used to reconstruct images.Compared with the traditional reconstruction algorithm,the 2DPG-ED algorithm can improve security and reduce computational complexity.Furthermore,it has better robustness.The experimental outcome and the performance analysis indicate that this algorithm can withstand malicious attacks and prove the method is effective.展开更多
The ability to overcome the negative effects,induced by obstacles and turbulent atmosphere,is a core challenge of long-distance information transmission,and it is of great significance in free-space optical communicat...The ability to overcome the negative effects,induced by obstacles and turbulent atmosphere,is a core challenge of long-distance information transmission,and it is of great significance in free-space optical communication.The spatial-coherence structure,that characterizes partially coherent fields,provides a new degree of freedom for carrying information.However,due to the influence of the complex transmission environment,the spatial-coherence structure is severely damaged during the propagation path,which undoubtedly limits its ability to transmit information.Here,we realize the robust far-field orbital angular momentum(OAM)transmission and detection by modulating the spatial-coherence structure of a partially coherent vortex beam with the help of the cross-phase.The cross-phase enables the OAM information,quantified by the topological charge,hidden in the spatial-coherence structure can be stably transmitted to the far field and can resist the influence of obstructions and turbulence within the communication link.This is due to the self-reconstruction property of the spatial-coherence structure embedded with the cross-phase.We demonstrate experimentally that the topological charge information can be recognized well by measuring the spatial-coherence structure in the far field,exhibiting a set of distinct and separated dark rings even under amplitude and phase perturbations.Our findings open a door for robust optical signal transmission through the complex environment and may find application in optical communication through a turbulent atmosphere.展开更多
Background Many countries have already banned the use of antibiotics in animal husbandry,making it extremely difficult to maintain animal health in livestock breeding.In the livestock industry,there is an urgent need ...Background Many countries have already banned the use of antibiotics in animal husbandry,making it extremely difficult to maintain animal health in livestock breeding.In the livestock industry,there is an urgent need to develop alternatives to antibiotics which will not lead to drug resistance on prolonged use.In this study,eighteen castrated bulls were randomly divided into two groups.The control group(CK)was fed the basal diet,while the antimicrobial peptide group(AP)was fed the basal diet supplemented with 8 g of antimicrobial peptides in the basal diet for the experimental period of 270 d.They were then slaughtered to measure production performance,and the ruminal contents were isolated for metagenomic and metabolome sequencing analysis.Result The results showed that antimicrobial peptides could improve the daily weight,carcass weight,and net meat weight of the experimental animals.Additionally,the rumen papillae diameter and the micropapillary density in the AP were significantly greater than those in the CK.Furthermore,the determination of digestive enzymes and fermentation parameters showed that the contents of protease,xylanase,andβ-glucoside in the AP were greater than those in the CK.However,lipase content in the CK was greater than that in the AP.Moreover,the content of acetate,propionate,butyrate,and valerate was found to be greater in AP than those in CK.The metagenomic analysis annotated 1993 differential microorganisms at the species level.The KEGG enrichment of these microorganisms revealed that the enrichment of drug resistance-related pathways was dramatically decreased in the AP,whereas the enrichment of immune-related pathways was significantly increased.There was also a significant reduction in the types of viruses in the AP.187 probiotics with significant differences were found,135 of which were higher in AP than in CK.It was also found that the antimicrobial mechanism of the antimicrobial peptides was quite specific.Seven low-abundance microorganisms(Acinetobactersp.Ac1271,Aequorivita soesokkakensis,Bacillus lacisalsi,Haloferax larsenii,Lysinibacillussp.3DF0063,Parabacteroidessp.217,Streptomycessp.So13.3)were found to regulate growth performance of the bull negatively.Metabolome analysis identified 45 differentially differential metabolites that significantly different between the CK and the AP groups.Seven upregulated metabolites(4-pyridoxic acid,Ala-Phe,3-ureidopropionate,hippuric acid,terephthalic acid,L-alanine,uridine 5-monophosphate)improve the growth performance of the experimental animals.To detect the interactions between the rumen microbiome and metabolism,we associated the rumen microbiome with the metabolome and found that negative regulation between the above 7 microorganisms and 7 metabolites.Conclusions This study shows that antimicrobial peptides can improve the growth performance of animals while resisting viruses and harmful bacteria and are expected to become healthy alternatives to antibiotics.We demonstrated a new antimicrobial peptides pharmacological model.We demonstrated low-abundance microorganisms may play a role by regulating the content of metabolites.展开更多
Weighted vertex cover(WVC)is one of the most important combinatorial optimization problems.In this paper,we provide a new game optimization to achieve efficiency and time of solutions for the WVC problem of weighted n...Weighted vertex cover(WVC)is one of the most important combinatorial optimization problems.In this paper,we provide a new game optimization to achieve efficiency and time of solutions for the WVC problem of weighted networks.We first model the WVC problem as a general game on weighted networks.Under the framework of a game,we newly define several cover states to describe the WVC problem.Moreover,we reveal the relationship among these cover states of the weighted network and the strict Nash equilibriums(SNEs)of the game.Then,we propose a game-based asynchronous algorithm(GAA),which can theoretically guarantee that all cover states of vertices converging in an SNE with polynomial time.Subsequently,we improve the GAA by adding 2-hop and 3-hop adjustment mechanisms,termed the improved game-based asynchronous algorithm(IGAA),in which we prove that it can obtain a better solution to the WVC problem than using a the GAA.Finally,numerical simulations demonstrate that the proposed IGAA can obtain a better approximate solution in promising computation time compared with the existing representative algorithms.展开更多
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global incidence.Unfortunately,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive...BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global incidence.Unfortunately,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive and therapeutic measures.AIM To explore the molecular mechanism of NAFLD.METHODS Whole genome sequencing(WGS)analysis was performed on liver tissues from patients with NAFLD(n=6)and patients with normal metabolic conditions(n=6)to identify the target genes.A NAFLD C57BL6/J mouse model induced by 16 wk of high-fat diet feeding and a hepatocyte-specific F-box only protein 2(FBXO2)overexpression mouse model were used for in vivo studies.Plasmid transfection,co-immunoprecipitation-based mass spectrometry assays,and ubiquitination in HepG2 cells and HEK293T cells were used for in vitro studies.RESULTS A total of 30982 genes were detected in WGS analysis,with 649 up-regulated and 178 down-regulated.Expression of FBXO2,an E3 ligase,was upregulated in the liver tissues of patients with NAFLD.Hepatocyte-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in mice.Overexpression of FBXO2 aggravated odium oleate(OA)-induced lipid accumulation in HepG2 cells,resulting in an abnormal expression of genes related to lipid metabolism,such as fatty acid synthase,peroxisome proliferator-activated receptor alpha,and so on.In contrast,knocking down FBXO2 in HepG2 cells significantly alleviated the OA-induced lipid accumulation and aberrant expression of lipid metabolism genes.The hydroxyl CoA dehydrogenase alpha subunit(HADHA),a protein involved in oxidative stress,was a target of FBXO2-mediated ubiquitination.FBXO2 directly bound to HADHA and facilitated its proteasomal degradation in HepG2 and HEK293T cells.Supplementation with HADHA alleviated lipid accumulation caused by FBXO2 overexpression in HepG2 cells.CONCLUSION FBXO2 exacerbates lipid accumulation by targeting HADHA and is a potential therapeutic target for NAFLD。展开更多
Marigold(Tagetes erecta L., African marigold) is a widely grown ornamental plant and a main source of the carotenoid lutein for the industrial production of pharmaceuticals, food coloring, and feed additives. To gain ...Marigold(Tagetes erecta L., African marigold) is a widely grown ornamental plant and a main source of the carotenoid lutein for the industrial production of pharmaceuticals, food coloring, and feed additives. To gain a deeper understanding of the genetic mechanism of lutein in marigold, a chromosome-scale assembly of the marigold(T. erecta V-01) genome was completed based on Illumina, PacBio, and Hi-C reads. The707.21-Mb assembled genome consisted of 35 834 annotated protein-coding genes, with 97.7% genomic integrity. We anchored 87.8% of the contigs(covering 621.20 Mb) to 12 pseudochromosomes, bringing the scaffold N50 length to 54.15 Mb. Phylogenetic analysis showed that marigold was closely related to the Asteraceae species bitter vine(Mikania micrantha) and sunflower(Helianthus annuus), all three of which originated in the Americas. Marigold diverged from the sunflower clade 23.57 million years ago(MYA) and from M. micrantha 19.59 MYA.Marigold has undergone three whole-genome duplication events, as well as a recent whole-genome duplication event(WGD-2) common to H.annuus and M. micrantha. Marigold gene families were significantly less expanded than those of M. micrantha or H. annuus, and the marigold genome contained significantly fewer interspersed repeats, which might account for its smaller genome. In addition, a range of candidate genes involved in the lutein biosynthetic pathway were identified. The high-quality reference genome obtained in this study provided a valuable genomic resource for studying the evolution of the Asteraceae family and for improving marigold breeding strategies.展开更多
This paper presents the catalytic effect of NaH doped nanocrystalline TiO_(2)(designated as NaTiOxH)in the improvement of MgH_(2)hydrogen storage properties.The catalyst preparation involves ball milling NaH with TiO_...This paper presents the catalytic effect of NaH doped nanocrystalline TiO_(2)(designated as NaTiOxH)in the improvement of MgH_(2)hydrogen storage properties.The catalyst preparation involves ball milling NaH with TiO_(2)for 3 hr.The addition of 5 wt%NaTiOxH powder into MgH_(2)reduces its operating temperature to∼185℃,which is∼110℃lower than the additive-free as-milled MgH_(2).The composite remarkably desorbs∼7.2 wt%H_(2)within 15 min at∼290℃and reabsorbs∼4.5 wt%H_(2)in 45 min at room temperature under 50 bar H_(2).MgH_(2)dehydrogenation is activated at 57 kJ/mol by the catalyst.More importantly,the addition of 2.5 wt%NaTiOxH catalyst aids MgH_(2)to reversibly produce∼6.1 wt%H_(2)upon 100 cycles within 475 hr at 300℃.Microstructural investigation into the catalyzed MgH_(2)composite reveals a firm contact existing between NaTiOxH and MgH_(2)particles.Meanwhile,the NaTiOxH catalyst consists of catalytically active Ti_(3)O_(5),and“rod-like”Na_(2)Ti_(3)O_(7)species liberated in-situ during preparation;these active species could provide multiple hydrogen diffusion pathways for an improved MgH_(2)sorption process.Furthermore,the elemental characterization identifies the reduced valence states of titanium(Ti<4+)which show some sort of reversibility consistent with H_(2)insertion and removal.This phenomenon is believed to enhance the mobility of Mg/MgH_(2)electrons by the creation and elimination of oxygen vacancies in the defective(TiO_(2-x))catalyst.Our findings have therefore moved MgH_(2)closer to practical applications.展开更多
With the development of China’s crewed space mission,the space radiation risk for astronauts is increasingly prominent.This paper describes a simulation of the radiation doses experienced by a Chinese female voxel ph...With the development of China’s crewed space mission,the space radiation risk for astronauts is increasingly prominent.This paper describes a simulation of the radiation doses experienced by a Chinese female voxel phantom on board the Chinese Space Station(CSS)performed using the Monte Carlo N-Particle(MCNP)software.The absorbed dose,equivalent dose,and effective dose experienced by the voxel phantom and its critical organs are discussed for different levels of shielding of the Tianhe core module.The risk of space-radiation exposure is then assessed by comparing these doses with the current risk limits in China(the skin dose limit for short-term low-earth-orbit missions)and the NASA figures(National Council on Radiation Protection and Measurements Report No.98)for female astronauts.The results obtained can be used to guide and optimize the radiation protection provided for manned space missions.展开更多
The secure dominating set(SDS),a variant of the dominating set,is an important combinatorial structure used in wireless networks.In this paper,we apply algorithmic game theory to study the minimum secure dominating se...The secure dominating set(SDS),a variant of the dominating set,is an important combinatorial structure used in wireless networks.In this paper,we apply algorithmic game theory to study the minimum secure dominating set(Min SDS) problem in a multi-agent system.We design a game framework for SDS and show that every Nash equilibrium(NE) is a minimal SDS,which is also a Pareto-optimal solution.We prove that the proposed game is an exact potential game,and thus NE exists,and design a polynomial-time distributed local algorithm which converges to an NE in O(n) rounds of interactions.Extensive experiments are done to test the performance of our algorithm,and some interesting phenomena are witnessed.展开更多
High-performance phase-locked loops(PLL)are widely used in modern system-on chips(So C)including the ultrahigh-speed wireless/wireline communication(e.g.5G/6G transceivers,over-100-Gbps Ser Des transceivers),high reso...High-performance phase-locked loops(PLL)are widely used in modern system-on chips(So C)including the ultrahigh-speed wireless/wireline communication(e.g.5G/6G transceivers,over-100-Gbps Ser Des transceivers),high resolution mm-wave radars,ultra-low power internet-of-thing(Io T),and high-sampling-rate data converters.In the 2023 IEEE International Solid-State Circuits Conference(ISSCC 2023).展开更多
<div style="text-align:justify;"> In view of the serious lack and lag of the test and evaluation technology of non-metallic composite continuous pipe, and focusing on the characteristics of the applica...<div style="text-align:justify;"> In view of the serious lack and lag of the test and evaluation technology of non-metallic composite continuous pipe, and focusing on the characteristics of the application of non-metallic composite continuous pipe in oil field, this paper discusses a series of new full-scale test and evaluation technologies for accurately evaluating the product quality and practical application performance of non-metallic composite continuous pipe, which effectively solves the major technical problem that the new products of non-metallic pipe cannot be accurately evaluated. Based on the characteristics of the application of non-metallic composite continuous pipe in oil field, a series of new full-scale test evaluation technologies which can accurately evaluate the product quality and practical application performance of non-metallic pipe are designed through a large number of tests. The test and evaluation technology can accurately evaluate the key performance of high and low pressure cycle, high and low temperature cycle, gas permeability resistance, minimum bending radius etc. It provides a scientific evaluation basis for the standardized application of non-metallic continuous pipe and a reliable quality control method for the selection of products in oil field. </div>展开更多
基金This work is supported by the Technologies R&D Program of Huzhou City(No.2022JB01)the Key Research and Development Program of Zhejiang Province(No.2023C01127)the Highstar Corporation HSD20210118.
文摘The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density requirements.Lithium metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density batteries.In this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in LMBs.Furthermore,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these challenges.The utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing them.This review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid electrolytes.Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal batteries.Based on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.
基金Project supported in part by the National Key Research and Development Program of China(Grant No.2021YFB2206504)the National Natural Science Foundation of China(Grant No.62235017)the China Postdoctoral Science Foundation(Grant No.2021M703125).
文摘The performance of optical interconnection has improved dramatically in recent years.Silicon-based optoelectronic heterogeneous integration is the key enabler to achieve high performance optical interconnection,which not only provides the optical gain which is absent from native Si substrates and enables complete photonic functionalities on chip,but also improves the system performance through advanced heterogeneous integrated packaging.This paper reviews recent progress of silicon-based optoelectronic heterogeneous integration in high performance optical interconnection.The research status,development trend and application of ultra-low loss optical waveguides,high-speed detectors,high-speed modulators,lasers and 2D,2.5D,3D and monolithic integration are focused on.
基金This work was supported in part by the National Natural Science Foundation of China under Grants 71571091,71771112the State Key Laboratory of Synthetical Automation for Process Industries Fundamental Research Funds under Grant PAL-N201801the Excellent Talent Training Project of University of Science and Technology Liaoning under Grant 2019RC05.
文摘With the advent of the information security era,it is necessary to guarantee the privacy,accuracy,and dependable transfer of pictures.This study presents a new approach to the encryption and compression of color images.It is predicated on 2D compressed sensing(CS)and the hyperchaotic system.First,an optimized Arnold scrambling algorithm is applied to the initial color images to ensure strong security.Then,the processed images are con-currently encrypted and compressed using 2D CS.Among them,chaotic sequences replace traditional random measurement matrices to increase the system’s security.Third,the processed images are re-encrypted using a combination of permutation and diffusion algorithms.In addition,the 2D projected gradient with an embedding decryption(2DPG-ED)algorithm is used to reconstruct images.Compared with the traditional reconstruction algorithm,the 2DPG-ED algorithm can improve security and reduce computational complexity.Furthermore,it has better robustness.The experimental outcome and the performance analysis indicate that this algorithm can withstand malicious attacks and prove the method is effective.
基金National Key Research and Development Program of China (2022YFA1404800,2019YFA0705000)National Natural Science Foundation of China (12104264,12192254,92250304,and 12374311)+2 种基金China Postdoctoral Science Foundation (2022T150392)Natural Science Foundation of Shandong Province (ZR2021QA014 and ZR2023YQ006)Qingchuang Science and Technology Plan of Shandong Province (2022KJ246).
文摘The ability to overcome the negative effects,induced by obstacles and turbulent atmosphere,is a core challenge of long-distance information transmission,and it is of great significance in free-space optical communication.The spatial-coherence structure,that characterizes partially coherent fields,provides a new degree of freedom for carrying information.However,due to the influence of the complex transmission environment,the spatial-coherence structure is severely damaged during the propagation path,which undoubtedly limits its ability to transmit information.Here,we realize the robust far-field orbital angular momentum(OAM)transmission and detection by modulating the spatial-coherence structure of a partially coherent vortex beam with the help of the cross-phase.The cross-phase enables the OAM information,quantified by the topological charge,hidden in the spatial-coherence structure can be stably transmitted to the far field and can resist the influence of obstructions and turbulence within the communication link.This is due to the self-reconstruction property of the spatial-coherence structure embedded with the cross-phase.We demonstrate experimentally that the topological charge information can be recognized well by measuring the spatial-coherence structure in the far field,exhibiting a set of distinct and separated dark rings even under amplitude and phase perturbations.Our findings open a door for robust optical signal transmission through the complex environment and may find application in optical communication through a turbulent atmosphere.
基金financially supported by Research and application of corn straw forage and beef cattle high-efficiency and quality production technology (Provincial Education Science and Technology Innovation Project) (GSSYLXM-02)the Gansu beef cattle quality fattening project (GSAXMLZ-2021-01)+1 种基金the Application of Pingliang Red Bull Planting and Breeding Combined with High-efficiency Circular Production System Construction Technology Application (2020C-08)the local funding (GSSLCSX-2020-1)。
文摘Background Many countries have already banned the use of antibiotics in animal husbandry,making it extremely difficult to maintain animal health in livestock breeding.In the livestock industry,there is an urgent need to develop alternatives to antibiotics which will not lead to drug resistance on prolonged use.In this study,eighteen castrated bulls were randomly divided into two groups.The control group(CK)was fed the basal diet,while the antimicrobial peptide group(AP)was fed the basal diet supplemented with 8 g of antimicrobial peptides in the basal diet for the experimental period of 270 d.They were then slaughtered to measure production performance,and the ruminal contents were isolated for metagenomic and metabolome sequencing analysis.Result The results showed that antimicrobial peptides could improve the daily weight,carcass weight,and net meat weight of the experimental animals.Additionally,the rumen papillae diameter and the micropapillary density in the AP were significantly greater than those in the CK.Furthermore,the determination of digestive enzymes and fermentation parameters showed that the contents of protease,xylanase,andβ-glucoside in the AP were greater than those in the CK.However,lipase content in the CK was greater than that in the AP.Moreover,the content of acetate,propionate,butyrate,and valerate was found to be greater in AP than those in CK.The metagenomic analysis annotated 1993 differential microorganisms at the species level.The KEGG enrichment of these microorganisms revealed that the enrichment of drug resistance-related pathways was dramatically decreased in the AP,whereas the enrichment of immune-related pathways was significantly increased.There was also a significant reduction in the types of viruses in the AP.187 probiotics with significant differences were found,135 of which were higher in AP than in CK.It was also found that the antimicrobial mechanism of the antimicrobial peptides was quite specific.Seven low-abundance microorganisms(Acinetobactersp.Ac1271,Aequorivita soesokkakensis,Bacillus lacisalsi,Haloferax larsenii,Lysinibacillussp.3DF0063,Parabacteroidessp.217,Streptomycessp.So13.3)were found to regulate growth performance of the bull negatively.Metabolome analysis identified 45 differentially differential metabolites that significantly different between the CK and the AP groups.Seven upregulated metabolites(4-pyridoxic acid,Ala-Phe,3-ureidopropionate,hippuric acid,terephthalic acid,L-alanine,uridine 5-monophosphate)improve the growth performance of the experimental animals.To detect the interactions between the rumen microbiome and metabolism,we associated the rumen microbiome with the metabolome and found that negative regulation between the above 7 microorganisms and 7 metabolites.Conclusions This study shows that antimicrobial peptides can improve the growth performance of animals while resisting viruses and harmful bacteria and are expected to become healthy alternatives to antibiotics.We demonstrated a new antimicrobial peptides pharmacological model.We demonstrated low-abundance microorganisms may play a role by regulating the content of metabolites.
基金partly supported by the National Natural Science Foundation of China(61751303,U20A2068,11771013)the Zhejiang Provincial Natural Science Foundation of China(LD19A010001)the Fundamental Research Funds for the Central Universities。
文摘Weighted vertex cover(WVC)is one of the most important combinatorial optimization problems.In this paper,we provide a new game optimization to achieve efficiency and time of solutions for the WVC problem of weighted networks.We first model the WVC problem as a general game on weighted networks.Under the framework of a game,we newly define several cover states to describe the WVC problem.Moreover,we reveal the relationship among these cover states of the weighted network and the strict Nash equilibriums(SNEs)of the game.Then,we propose a game-based asynchronous algorithm(GAA),which can theoretically guarantee that all cover states of vertices converging in an SNE with polynomial time.Subsequently,we improve the GAA by adding 2-hop and 3-hop adjustment mechanisms,termed the improved game-based asynchronous algorithm(IGAA),in which we prove that it can obtain a better solution to the WVC problem than using a the GAA.Finally,numerical simulations demonstrate that the proposed IGAA can obtain a better approximate solution in promising computation time compared with the existing representative algorithms.
基金the National Natural Science Foundation of China,No.82070869 and 82270914.
文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global incidence.Unfortunately,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive and therapeutic measures.AIM To explore the molecular mechanism of NAFLD.METHODS Whole genome sequencing(WGS)analysis was performed on liver tissues from patients with NAFLD(n=6)and patients with normal metabolic conditions(n=6)to identify the target genes.A NAFLD C57BL6/J mouse model induced by 16 wk of high-fat diet feeding and a hepatocyte-specific F-box only protein 2(FBXO2)overexpression mouse model were used for in vivo studies.Plasmid transfection,co-immunoprecipitation-based mass spectrometry assays,and ubiquitination in HepG2 cells and HEK293T cells were used for in vitro studies.RESULTS A total of 30982 genes were detected in WGS analysis,with 649 up-regulated and 178 down-regulated.Expression of FBXO2,an E3 ligase,was upregulated in the liver tissues of patients with NAFLD.Hepatocyte-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in mice.Overexpression of FBXO2 aggravated odium oleate(OA)-induced lipid accumulation in HepG2 cells,resulting in an abnormal expression of genes related to lipid metabolism,such as fatty acid synthase,peroxisome proliferator-activated receptor alpha,and so on.In contrast,knocking down FBXO2 in HepG2 cells significantly alleviated the OA-induced lipid accumulation and aberrant expression of lipid metabolism genes.The hydroxyl CoA dehydrogenase alpha subunit(HADHA),a protein involved in oxidative stress,was a target of FBXO2-mediated ubiquitination.FBXO2 directly bound to HADHA and facilitated its proteasomal degradation in HepG2 and HEK293T cells.Supplementation with HADHA alleviated lipid accumulation caused by FBXO2 overexpression in HepG2 cells.CONCLUSION FBXO2 exacerbates lipid accumulation by targeting HADHA and is a potential therapeutic target for NAFLD。
基金supported by the National Natural Science Foundation of China (Grant Nos. 31572166, 31772344, 31871691 and 31972444)。
文摘Marigold(Tagetes erecta L., African marigold) is a widely grown ornamental plant and a main source of the carotenoid lutein for the industrial production of pharmaceuticals, food coloring, and feed additives. To gain a deeper understanding of the genetic mechanism of lutein in marigold, a chromosome-scale assembly of the marigold(T. erecta V-01) genome was completed based on Illumina, PacBio, and Hi-C reads. The707.21-Mb assembled genome consisted of 35 834 annotated protein-coding genes, with 97.7% genomic integrity. We anchored 87.8% of the contigs(covering 621.20 Mb) to 12 pseudochromosomes, bringing the scaffold N50 length to 54.15 Mb. Phylogenetic analysis showed that marigold was closely related to the Asteraceae species bitter vine(Mikania micrantha) and sunflower(Helianthus annuus), all three of which originated in the Americas. Marigold diverged from the sunflower clade 23.57 million years ago(MYA) and from M. micrantha 19.59 MYA.Marigold has undergone three whole-genome duplication events, as well as a recent whole-genome duplication event(WGD-2) common to H.annuus and M. micrantha. Marigold gene families were significantly less expanded than those of M. micrantha or H. annuus, and the marigold genome contained significantly fewer interspersed repeats, which might account for its smaller genome. In addition, a range of candidate genes involved in the lutein biosynthetic pathway were identified. The high-quality reference genome obtained in this study provided a valuable genomic resource for studying the evolution of the Asteraceae family and for improving marigold breeding strategies.
基金The authors acknowledge the Project supported by the National Key R&D Program of China(2019YFE0103600,2018YFB1502101)the Key R&D Program of Shandong Province,China(2020CXGC010402)+4 种基金the National Natural Science Foundation of China(51801197)the Liaoning Revitalization Talents Program(XLYC2002076)the Dalian High-level Talents Program(2019RD09)the Youth Innovation Promotion Association CAS(2019189)K.C.Wong Education Foundation(GJTD-2018–06).
文摘This paper presents the catalytic effect of NaH doped nanocrystalline TiO_(2)(designated as NaTiOxH)in the improvement of MgH_(2)hydrogen storage properties.The catalyst preparation involves ball milling NaH with TiO_(2)for 3 hr.The addition of 5 wt%NaTiOxH powder into MgH_(2)reduces its operating temperature to∼185℃,which is∼110℃lower than the additive-free as-milled MgH_(2).The composite remarkably desorbs∼7.2 wt%H_(2)within 15 min at∼290℃and reabsorbs∼4.5 wt%H_(2)in 45 min at room temperature under 50 bar H_(2).MgH_(2)dehydrogenation is activated at 57 kJ/mol by the catalyst.More importantly,the addition of 2.5 wt%NaTiOxH catalyst aids MgH_(2)to reversibly produce∼6.1 wt%H_(2)upon 100 cycles within 475 hr at 300℃.Microstructural investigation into the catalyzed MgH_(2)composite reveals a firm contact existing between NaTiOxH and MgH_(2)particles.Meanwhile,the NaTiOxH catalyst consists of catalytically active Ti_(3)O_(5),and“rod-like”Na_(2)Ti_(3)O_(7)species liberated in-situ during preparation;these active species could provide multiple hydrogen diffusion pathways for an improved MgH_(2)sorption process.Furthermore,the elemental characterization identifies the reduced valence states of titanium(Ti<4+)which show some sort of reversibility consistent with H_(2)insertion and removal.This phenomenon is believed to enhance the mobility of Mg/MgH_(2)electrons by the creation and elimination of oxygen vacancies in the defective(TiO_(2-x))catalyst.Our findings have therefore moved MgH_(2)closer to practical applications.
基金Project supported by the Open Project Funds for the Key Laboratory of Space Photoelectric Detection and Perception(Nanjing University of Aeronautics and Astronautics),the Ministry of Industry and Information Technology of China(Grant No.NJ2022025-7)the Fundamental Research Funds for the Central Universities(Grant No.NJ2022025).
文摘With the development of China’s crewed space mission,the space radiation risk for astronauts is increasingly prominent.This paper describes a simulation of the radiation doses experienced by a Chinese female voxel phantom on board the Chinese Space Station(CSS)performed using the Monte Carlo N-Particle(MCNP)software.The absorbed dose,equivalent dose,and effective dose experienced by the voxel phantom and its critical organs are discussed for different levels of shielding of the Tianhe core module.The risk of space-radiation exposure is then assessed by comparing these doses with the current risk limits in China(the skin dose limit for short-term low-earth-orbit missions)and the NASA figures(National Council on Radiation Protection and Measurements Report No.98)for female astronauts.The results obtained can be used to guide and optimize the radiation protection provided for manned space missions.
基金supported in part by the National Natural Science Foundation of China(U20A2068, 11771013)Zhejiang Provincial Natural Science Foundation of China (LD19A010001)。
文摘The secure dominating set(SDS),a variant of the dominating set,is an important combinatorial structure used in wireless networks.In this paper,we apply algorithmic game theory to study the minimum secure dominating set(Min SDS) problem in a multi-agent system.We design a game framework for SDS and show that every Nash equilibrium(NE) is a minimal SDS,which is also a Pareto-optimal solution.We prove that the proposed game is an exact potential game,and thus NE exists,and design a polynomial-time distributed local algorithm which converges to an NE in O(n) rounds of interactions.Extensive experiments are done to test the performance of our algorithm,and some interesting phenomena are witnessed.
基金supported by the National Natural Science Foundation of China(Grant Nos.62222409 and62174153)Beijing Municipal Science and Technology Project(Grant No.Z211100007921019)。
文摘High-performance phase-locked loops(PLL)are widely used in modern system-on chips(So C)including the ultrahigh-speed wireless/wireline communication(e.g.5G/6G transceivers,over-100-Gbps Ser Des transceivers),high resolution mm-wave radars,ultra-low power internet-of-thing(Io T),and high-sampling-rate data converters.In the 2023 IEEE International Solid-State Circuits Conference(ISSCC 2023).
基金Project(2017YFB0305601) supported by the National Key R&D Program of ChinaProjects(51874368,51274246) supported by the National Natural Science Foundation of China
文摘<div style="text-align:justify;"> In view of the serious lack and lag of the test and evaluation technology of non-metallic composite continuous pipe, and focusing on the characteristics of the application of non-metallic composite continuous pipe in oil field, this paper discusses a series of new full-scale test and evaluation technologies for accurately evaluating the product quality and practical application performance of non-metallic composite continuous pipe, which effectively solves the major technical problem that the new products of non-metallic pipe cannot be accurately evaluated. Based on the characteristics of the application of non-metallic composite continuous pipe in oil field, a series of new full-scale test evaluation technologies which can accurately evaluate the product quality and practical application performance of non-metallic pipe are designed through a large number of tests. The test and evaluation technology can accurately evaluate the key performance of high and low pressure cycle, high and low temperature cycle, gas permeability resistance, minimum bending radius etc. It provides a scientific evaluation basis for the standardized application of non-metallic continuous pipe and a reliable quality control method for the selection of products in oil field. </div>
