BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same patient.In this work,we have provided a detailed description of a patient&...BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same patient.In this work,we have provided a detailed description of a patient's clinical presentation,imaging findings,and treatment.And a retrospective analysis was conducted on 14 published relevant case reports.CASE SUMMARY A 16-year-old male came to our hospital for treatment due to right lower limb swelling.This swelling is already present from birth.The patient’s memory had been progressively declining.Seizures had occurred 1 year prior at an unknown frequency.The patient was diagnosed with TSC combined with PLE through multimodal imaging examination:Computed tomography,magnetic resonance imaging,and lymphoscintigraphy.The patient underwent liposuction.The swelling of the patient's right lower limb significantly improved after surgery.Epilepsy did not occur.after taking antiepileptic drugs and sirolimus.CONCLUSION TSC with PLE is a rare and systemic disease.Imaging can detect lesions of this disease,which are important for diagnosis and treatment.展开更多
In 2009, the Ministry of Culture of China initiated a cooperation mechanism between the central and local levels, with an objective to promote cultural exchanges with the rest of the world. In recent years, several pr...In 2009, the Ministry of Culture of China initiated a cooperation mechanism between the central and local levels, with an objective to promote cultural exchanges with the rest of the world. In recent years, several provinces and municipalities, including Beijing, Shanghai, Zhejiang, Henan, Sichuan, Qinghai, Heilongjiang and Guangxi, joined this mechanism, integrating cultural resources and exploring innovative ways for ever-increasing cultural exchanges and cooperation in a global context. Our magazine will publish articles introducing their efforts and achievements in this regard in following issues.展开更多
AIM To investigate the prevalence and clinical significance of autoimmune liver disease(ALD)-related autoantibodies in patients with biliary atresia(BA).METHODS Sera of 124 BA patients and 140 age-matched non-BA contr...AIM To investigate the prevalence and clinical significance of autoimmune liver disease(ALD)-related autoantibodies in patients with biliary atresia(BA).METHODS Sera of 124 BA patients and 140 age-matched non-BA controls were assayed for detection of the following autoantibodies: ALD profile and specific anti-nuclear antibodies(ANAs), by line-blot assay; ANA and antineutrophil cytoplasmic antibody(ANCA), by indirect immunofluorescence assay; specific ANCAs and antiM2-3 E, by enzyme linked immunosorbent assay. Associations of these autoantibodies with the clinical features of BA(i.e., cytomegalovirus infection, degree of liver fibrosis, and short-term prognosis of Kasai procedure) were evaluated by Spearman's correlation coefficient.RESULTS The overall positive rate of serum autoantibodies in preoperative BA patients was 56.5%. ALD profile assay showed that the positive reaction to primary biliary cholangitis-related autoantibodies in BA patients was higher than that to autoimmune hepatitis-related autoantibodies. Among these autoantibodies, anti-BPO was detected more frequently in the BA patients than in the controls(14.8% vs 2.2%, P < 0.05). Accordingly, 32(25.8%) of the 124 BA patients also showed a high positive reaction for anti-M2-3 E. By comparison, the controls had a remarkably lower frequency of anti-M2-3 E(P < 0.05), with 6/92(8.6%) of patients with other liver diseases and 2/48(4.2%) of healthy controls. The prevalence of ANA in BA patients was 11.3%, which was higher than that in disease controls(3.3%, P < 0.05), but the reactivity to specific ANAs was only 8.2%. The prevalence of ANCAs(ANCA or specific ANCAs) in BA patients was also remarkably higher than that in the healthy controls(37.9% vs 6.3%, P < 0.05), but showed no difference from that in patients with other cholestasis. ANCA positivity was closely associated with the occurrence of postoperative cholangitis(r = 0.61, P < 0.05), whereas none of the autoantibodies showed a correlation to cytomegalovirus infection or the stages of liver fibrosis.CONCLUSION High prevalence of autoantibodies in the BA developmental process strongly reveals the autoimmunemediated pathogenesis. Serological ANCA positivity may be a useful predictive biomarker of postoperative cholangitis.展开更多
AIM： To study the stability of portal hypertension （PHT） caused by partial ligation of the portal vein ligation （PVL） in a rat model.METHODS： Thirty male adult Wistar rats were divided into two groups： 10 in Gr...AIM： To study the stability of portal hypertension （PHT） caused by partial ligation of the portal vein ligation （PVL） in a rat model.METHODS： Thirty male adult Wistar rats were divided into two groups： 10 in Group Ⅰ received a sham operation; and 20 in Group Ⅱreceived partial PVL. Portal vein pressure （PVP） was measured at four time periods： before ligation, 2 wk, 6 wk and 10 wk postsurgery. Portal venography, blood sampling and liver and spleen pathological examinations were conducted at 10 wk after surgery.RESULTS： The PVP was 9.15± 0.58 cmH2O before ligation, and increased to 17.32 ±0.63 cmH2O 2 wk after PVL. By repeat measurement of the PVP in each rat, it was shown to remain elevated for 10 wk. There were no significant differences in the pressure measurements at 2 wk, 6 wk and 10 wk. Varices were found mainly in the mesenteric vein 2 wk after PVL, which were more obvious later, while these manifestations were similar at week 6 and week 10. Portal venography demonstrated the varices and collaterals. There was no significant change in liver pathology. The volume of the spleen was enlarged 2-fold after ligation, and the sinus of the spleen was enlarged due to congestion. Significant sinus endothelial cell proliferation was observed, but no evidence of hypersplenia was found on hemogram and biochemical examination.CONCLUSION： These findings suggest that a satisfactory prehepatic PHT rat model can be obtained by partial ligation of the portal vein, and this PHT rat model was stable for at least 10 wk.展开更多
The increasing popularity of smart mobile devices and the rise of online services has increased the requirements for efficient dissemination of social video contents. In this paper,we study the problem of distributing...The increasing popularity of smart mobile devices and the rise of online services has increased the requirements for efficient dissemination of social video contents. In this paper,we study the problem of distributing video from cloud server to users in partially connected cooperative D2 D network using network coding. In such a scenario, the transmission conflicts occur from simultaneous transmissions of multiple devices, and the scheduling decision should be made not only on the encoded packets but also on the set of transmitting devices. We analyze the lower bound and give an integer linear formulation of the joint optimization problem over the set of transmitting devices and the packet combinations.We also propose a heuristic solution for this setup using a conflict graph and local graph at every device. Simulation results show that our coding scheme significantly reduces the number of transmission slots, which will increase the efficiency of video delivery.展开更多
Series arcing faults have been recognised as a hazardous phenomenon in the power system of more electric aircraft(MEA),especially with the increasing voltage level and power supply.Instead of the electrical method,the...Series arcing faults have been recognised as a hazardous phenomenon in the power system of more electric aircraft(MEA),especially with the increasing voltage level and power supply.Instead of the electrical method,the optical method can be used as an approach to detect arc fault with the advantages of fast response and immunity to electromagnetic interference.It is the basis of optical arc detection to determine the distribution spectrum range of direct current(DC)arc fault.Aiming at series arc optical detection in the MEA DC system,a DC series arc test platform was established to measure the series arc spectrum.The spectrum was disassembled though empirical mode decomposition to extract characteristic wavelengths of arc light and denoised by means of wavelet decomposition and reconstruction(wavelet transformation)to reduce equipment noise.To resolve the baseline drift,the baseline of the arc spectrum measured was calculated and corrected based on Savitzky−Golay.The experimental results indicate that there are several series arc characteristic spectra of the MEA DC system,including 309.3 and 324.5 nm in the ultraviolet range.Moreover,the arc spectrum with different metals,copper and aluminium,were contrasted,indicating the arc spectral behaviour is related to the melting/boiling point and chemical properties of the anode material.The measurement of the series arc spectrum makes it more effective to apply optical detection in the MEA discharging faults diagnosis.展开更多
基金Supported by National Natural Science Foundation of China,No.61876216.
文摘BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same patient.In this work,we have provided a detailed description of a patient's clinical presentation,imaging findings,and treatment.And a retrospective analysis was conducted on 14 published relevant case reports.CASE SUMMARY A 16-year-old male came to our hospital for treatment due to right lower limb swelling.This swelling is already present from birth.The patient’s memory had been progressively declining.Seizures had occurred 1 year prior at an unknown frequency.The patient was diagnosed with TSC combined with PLE through multimodal imaging examination:Computed tomography,magnetic resonance imaging,and lymphoscintigraphy.The patient underwent liposuction.The swelling of the patient's right lower limb significantly improved after surgery.Epilepsy did not occur.after taking antiepileptic drugs and sirolimus.CONCLUSION TSC with PLE is a rare and systemic disease.Imaging can detect lesions of this disease,which are important for diagnosis and treatment.
文摘In 2009, the Ministry of Culture of China initiated a cooperation mechanism between the central and local levels, with an objective to promote cultural exchanges with the rest of the world. In recent years, several provinces and municipalities, including Beijing, Shanghai, Zhejiang, Henan, Sichuan, Qinghai, Heilongjiang and Guangxi, joined this mechanism, integrating cultural resources and exploring innovative ways for ever-increasing cultural exchanges and cooperation in a global context. Our magazine will publish articles introducing their efforts and achievements in this regard in following issues.
基金the Guangdong Provincial Science and Technology Planning Project,No.2014A020212520the Guangzhou Science and Technology Project,No.201707010014
文摘AIM To investigate the prevalence and clinical significance of autoimmune liver disease(ALD)-related autoantibodies in patients with biliary atresia(BA).METHODS Sera of 124 BA patients and 140 age-matched non-BA controls were assayed for detection of the following autoantibodies: ALD profile and specific anti-nuclear antibodies(ANAs), by line-blot assay; ANA and antineutrophil cytoplasmic antibody(ANCA), by indirect immunofluorescence assay; specific ANCAs and antiM2-3 E, by enzyme linked immunosorbent assay. Associations of these autoantibodies with the clinical features of BA(i.e., cytomegalovirus infection, degree of liver fibrosis, and short-term prognosis of Kasai procedure) were evaluated by Spearman's correlation coefficient.RESULTS The overall positive rate of serum autoantibodies in preoperative BA patients was 56.5%. ALD profile assay showed that the positive reaction to primary biliary cholangitis-related autoantibodies in BA patients was higher than that to autoimmune hepatitis-related autoantibodies. Among these autoantibodies, anti-BPO was detected more frequently in the BA patients than in the controls(14.8% vs 2.2%, P < 0.05). Accordingly, 32(25.8%) of the 124 BA patients also showed a high positive reaction for anti-M2-3 E. By comparison, the controls had a remarkably lower frequency of anti-M2-3 E(P < 0.05), with 6/92(8.6%) of patients with other liver diseases and 2/48(4.2%) of healthy controls. The prevalence of ANA in BA patients was 11.3%, which was higher than that in disease controls(3.3%, P < 0.05), but the reactivity to specific ANAs was only 8.2%. The prevalence of ANCAs(ANCA or specific ANCAs) in BA patients was also remarkably higher than that in the healthy controls(37.9% vs 6.3%, P < 0.05), but showed no difference from that in patients with other cholestasis. ANCA positivity was closely associated with the occurrence of postoperative cholangitis(r = 0.61, P < 0.05), whereas none of the autoantibodies showed a correlation to cytomegalovirus infection or the stages of liver fibrosis.CONCLUSION High prevalence of autoantibodies in the BA developmental process strongly reveals the autoimmunemediated pathogenesis. Serological ANCA positivity may be a useful predictive biomarker of postoperative cholangitis.
基金Supported by National 10th 5-year Science Research Plan of China,No.2001BA705B10-15
文摘AIM： To study the stability of portal hypertension （PHT） caused by partial ligation of the portal vein ligation （PVL） in a rat model.METHODS： Thirty male adult Wistar rats were divided into two groups： 10 in Group Ⅰ received a sham operation; and 20 in Group Ⅱreceived partial PVL. Portal vein pressure （PVP） was measured at four time periods： before ligation, 2 wk, 6 wk and 10 wk postsurgery. Portal venography, blood sampling and liver and spleen pathological examinations were conducted at 10 wk after surgery.RESULTS： The PVP was 9.15± 0.58 cmH2O before ligation, and increased to 17.32 ±0.63 cmH2O 2 wk after PVL. By repeat measurement of the PVP in each rat, it was shown to remain elevated for 10 wk. There were no significant differences in the pressure measurements at 2 wk, 6 wk and 10 wk. Varices were found mainly in the mesenteric vein 2 wk after PVL, which were more obvious later, while these manifestations were similar at week 6 and week 10. Portal venography demonstrated the varices and collaterals. There was no significant change in liver pathology. The volume of the spleen was enlarged 2-fold after ligation, and the sinus of the spleen was enlarged due to congestion. Significant sinus endothelial cell proliferation was observed, but no evidence of hypersplenia was found on hemogram and biochemical examination.CONCLUSION： These findings suggest that a satisfactory prehepatic PHT rat model can be obtained by partial ligation of the portal vein, and this PHT rat model was stable for at least 10 wk.
基金supported by Fundamental Research Funds for the Central Universities(No.SWU115002,No.XDJK2015C104)
文摘The increasing popularity of smart mobile devices and the rise of online services has increased the requirements for efficient dissemination of social video contents. In this paper,we study the problem of distributing video from cloud server to users in partially connected cooperative D2 D network using network coding. In such a scenario, the transmission conflicts occur from simultaneous transmissions of multiple devices, and the scheduling decision should be made not only on the encoded packets but also on the set of transmitting devices. We analyze the lower bound and give an integer linear formulation of the joint optimization problem over the set of transmitting devices and the packet combinations.We also propose a heuristic solution for this setup using a conflict graph and local graph at every device. Simulation results show that our coding scheme significantly reduces the number of transmission slots, which will increase the efficiency of video delivery.
基金This work was supported in part by the National Natural Science Foundation of China(grant no.51807088)the Natural Science Foundation of Jiangsu Province(BK20170786)+1 种基金the Fundamental Research Funds for the Central Universities(no.XCA17003-04)the Postgraduate Research and Practice Innovation Program of Jiangsu Province(no.SJCX18_0099).
文摘Series arcing faults have been recognised as a hazardous phenomenon in the power system of more electric aircraft(MEA),especially with the increasing voltage level and power supply.Instead of the electrical method,the optical method can be used as an approach to detect arc fault with the advantages of fast response and immunity to electromagnetic interference.It is the basis of optical arc detection to determine the distribution spectrum range of direct current(DC)arc fault.Aiming at series arc optical detection in the MEA DC system,a DC series arc test platform was established to measure the series arc spectrum.The spectrum was disassembled though empirical mode decomposition to extract characteristic wavelengths of arc light and denoised by means of wavelet decomposition and reconstruction(wavelet transformation)to reduce equipment noise.To resolve the baseline drift,the baseline of the arc spectrum measured was calculated and corrected based on Savitzky−Golay.The experimental results indicate that there are several series arc characteristic spectra of the MEA DC system,including 309.3 and 324.5 nm in the ultraviolet range.Moreover,the arc spectrum with different metals,copper and aluminium,were contrasted,indicating the arc spectral behaviour is related to the melting/boiling point and chemical properties of the anode material.The measurement of the series arc spectrum makes it more effective to apply optical detection in the MEA discharging faults diagnosis.
