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Clinical efficacy of laparoscopic cholecystectomy plus cholangioscopy for the treatment of cholecystolithiasis combined with choledocholithiasis
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作者 Chao-Hui Liu Zhi-Wei Chen +3 位作者 zhe yu Hong-yu Liu Jian-Sheng Pan Shuang-Shuang Qiu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第7期2080-2087,共8页
BACKGROUND Currently,endoscopic retrograde cholangiopancreatography(ERCP)plus laparoscopic cholecystectomy(LC)is the main treatment for cholecystolithiasis combined with choledocholithiasis.However,the treatment is un... BACKGROUND Currently,endoscopic retrograde cholangiopancreatography(ERCP)plus laparoscopic cholecystectomy(LC)is the main treatment for cholecystolithiasis combined with choledocholithiasis.However,the treatment is unsatisfactory,and the development of better therapies is needed.AIM To determine the clinical efficacy of LC plus cholangioscopy for cholecystolithiasis combined with choledocholithiasis.METHODS Patients(n=243)with cholecystolithiasis and choledocholithiasis admitted to The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)between January 2019 and December 2023 were included in the study;111 patients(control group)underwent ERCP+LC and 132 patients(observation group)underwent LC+laparoscopic common bile duct exploration(LCBDE).Surgical success rates,residual stone rates,complications(pancreatitis,hyperamylasemia,biliary tract infection,and bile leakage),surgical indicators[intraoperative blood loss(IBL)and operation time(OT)],recovery indices(postoperative exhaust/defecation time and hospital stay),and serum inflammatory markers[C-reactive protein(CRP)],tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were compared.RESULTS No significant differences in surgical success rates and residual stone rates were detected between the observation and control groups.However,the complication rate,IBL,OT,postoperative exhaust/defecation time,and hospital stays were significantly reduced in the observation group compared with the control group.Furthermore,CRP,TNF-α,and IL-6 Levels after treatment were reduced in the observation group compared with the levels in the control group.CONCLUSION These results indicate that LC+LCBDE is safer than ERCP+LC for the treatment of cholecystolithiasis combined with choledocholithiasis.The surgical risks and postoperative complications were lower in the observation group compared with the control group.Thus,patients may recover quickly with less inflammation after LCBDE. 展开更多
关键词 Laparoscopic common bile duct exploration Endoscopic retrograde cholangiopancreatography Laparoscopic cholecystectomy CHOLECYSTOLITHIASIS CHOLEDOCHOLITHIASIS Clinical efficacy
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Chinese Adaptation and Psychometric Properties of the Belief in a Just World Scale for College Students
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作者 zhe yu Shuping Yang 《International Journal of Mental Health Promotion》 2024年第4期271-278,共8页
This study aims to revise the Belief in a Just World Scale(BJWS)for Chinese college students and test its reliability and validity(construct validity,convergent and divergent validity).Two samples of 546 and 595 colle... This study aims to revise the Belief in a Just World Scale(BJWS)for Chinese college students and test its reliability and validity(construct validity,convergent and divergent validity).Two samples of 546 and 595 college students were selected,respectively,using stratified cluster random sampling.Item analysis,exploratory factor analysis(EFA),confirmatory factor analysis(CFA),reliability analysis and convergent and divergent validity tests were carried out.The results showed that the 13 items of the BJWS have good item discrimination.The corrected item–total correlation in the general belief in a just world subscale was found to range from 0.464 to 0.655,and that in the personal belief in a just world subscale was 0.553 to 0.715.The internal consistency coefficients of the revised version of the BJWS and its subscales are good.The EFA and CFA results show that the structure and items of the revised scale are the same as those of the original scale.Belief in a just world was found to have significant positive correlations with gratitude and empathy,and has a significant negative correlation with anxiety,thereby exhibiting good convergent and divergent validity.Therefore,the Chinese revised version of the BJWS has good reliability and validity. 展开更多
关键词 Belief in a just world REVISION ANXIETY
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本土社会价值如何融入人工智能论辩系统——结合广义论证理论与基于价值的实践推理 被引量:1
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作者 余喆 《逻辑学研究》 CSSCI 2023年第4期40-54,共15页
现实世界中的论辩必然发生在某种社会文化背景和动态变化的语境之下,其中涉及特定的社会规范和社会价值。对于实践推理决策而言,参与者之间的意见分歧往往不仅在于常识和信念,更在于对社会价值的不同优先排序。本文结合考虑语境的形式... 现实世界中的论辩必然发生在某种社会文化背景和动态变化的语境之下,其中涉及特定的社会规范和社会价值。对于实践推理决策而言,参与者之间的意见分歧往往不仅在于常识和信念,更在于对社会价值的不同优先排序。本文结合考虑语境的形式论辩理论,讨论如何将本土社会价值融入人工智能论辩系统,使得持有不同价值观的参与者之间能够建立有意义的共识。在对论证实例进行分析的基础上,可以将相关建模方法扩展到基于价值的实践推理应用中,探索如何结合形式论辩、广义论证理论等跨学科研究成果,评估考虑社会价值的实践推理论证。 展开更多
关键词 广义论证 论辩系统 实践推理 社会价值
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结构化论辩系统——限制性反驳和非限制性反驳(英文) 被引量:1
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作者 余喆 徐康 廖备水 《逻辑学研究》 CSSCI 2018年第3期3-17,共15页
近年来,形式论辩研究在人工智能领域受到越来越多的关注。形式论辩研究的目标之一是沟通人类推理和机器推理,为实现这一目的,近年来多个结构化论辩系统被提出,如ABA、ASPIC^+、ASPIC^-等。不同的研究在系统设定上有不同的选择,本文关注... 近年来,形式论辩研究在人工智能领域受到越来越多的关注。形式论辩研究的目标之一是沟通人类推理和机器推理,为实现这一目的,近年来多个结构化论辩系统被提出,如ABA、ASPIC^+、ASPIC^-等。不同的研究在系统设定上有不同的选择,本文关注的是对论证间反驳关系定义的两种不同选择:限制性反驳和非限制性反驳。为了验证哪种选择更符合人类推理直觉,本文给出了一个实证研究,研究结果显示非限制性反驳更符合人类直觉。由于非限制性反驳可能导致论辩系统推理结果违反理性公设,这一结论说明目前的结构化论辩形式体系在自然性和合理性的兼顾上还需改进。 展开更多
关键词 非限制性 结构化 论辩 系统 人工智能 实证研究 反理性 推理
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玻璃体腔注射康柏西普联合小梁切除术及全视网膜光凝治疗新生血管性青光眼 被引量:17
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作者 鱼喆 蒲晓莉 +3 位作者 延新年 范强 张萌 秦玲利 《国际眼科杂志》 CAS 北大核心 2018年第5期862-865,共4页
目的:探究玻璃体腔注射康柏西普联合手术及全视网膜光凝治疗新生血管性青光眼(neovascular glaucoma,NVG)的临床疗效。方法:本组探究对象选择2014-06/2016-06于我院治疗的新生血管性青光眼患者90例,对所有患者的病历资料进行回顾性分析... 目的:探究玻璃体腔注射康柏西普联合手术及全视网膜光凝治疗新生血管性青光眼(neovascular glaucoma,NVG)的临床疗效。方法:本组探究对象选择2014-06/2016-06于我院治疗的新生血管性青光眼患者90例,对所有患者的病历资料进行回顾性分析,将采用小梁切除术及全视网膜光凝治疗的42例患者设为对照组,在此基础上术前5~7d加用玻璃体腔注射康柏西普的48例患者设为观察组。比较两组患者治疗前、治疗后1wk,1、3、6mo最佳矫正视力(转换成标准对数视力),各时期通过非接触式眼压计测量眼压,采用前房角镜检查虹膜及房角新生血管消退情况,结合眼压等判断综合疗效,记录术后并发症发生情况。结果:两组治疗前后视力比较差异显著,组间比较观察组术后1mo显著高于对照组,差异有统计学意义(P<0.05),术后1wk,3、6mo无显著性差异(P>0.05);两组治疗前后眼压比较差异显著,组间比较观察组术后1wk,1、3、6mo显著低于对照组,差异有统计学意义(P<0.05);观察组综合治愈率为77%,显著高于对照组(64%),差异有统计学意义(P<0.05);观察组前房出血、浅前房发生率显著低于对照组,差异有统计学意义(P<0.05);低眼压黄斑性病变发生率无显著性差异(P>0.05);观察组术后6mo新生血管复发率显著低于对照组,差异有统计学意义(P<0.05)。结论:新生血管性青光眼在全视网膜光凝治疗术前5~7d加用玻璃体腔注射康柏西普能显著降低眼压,不同程度改善视力,综合治愈率更高。 展开更多
关键词 玻璃体腔 康柏西普 全视网膜光凝 新生血管性青光眼
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康柏西普联合全视网膜激光光凝治疗CRVO继发新生血管性青光眼 被引量:12
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作者 刘小毛 延新年 +3 位作者 范强 张萌 鱼喆 马晓华 《国际眼科杂志》 CAS 北大核心 2018年第6期1077-1080,共4页
目的:探讨康柏西普联合全视网膜激光光凝(panretinal photocoagulation,PRP)治疗视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)继发新生血管性青光眼(neovascular glaucoma,NVG)的疗效。方法:本组观察对象为2014-05/2017-0... 目的:探讨康柏西普联合全视网膜激光光凝(panretinal photocoagulation,PRP)治疗视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)继发新生血管性青光眼(neovascular glaucoma,NVG)的疗效。方法:本组观察对象为2014-05/2017-05于我院眼科治疗的CRVO继发NVG患者100例100眼,现回顾性分析其病历资料,将采用青光眼滤过性手术联合PRP治疗的50例患者设为对照组,在此治疗基础上加用玻璃体腔注射康柏西普的50例患者设为观察组。比较术前、术后7d,1、3、6mo最佳矫正视力(best corrected visual acuity,BCVA),并采用非接触式眼压计比较各时期眼压,裂隙灯检查新生血管消退情况并结合眼压等判断手术效果,随访6mo记录术后复发率及并发症发生情况。结果:两组患者术后1、3、6mo BCVA趋于稳定,术后BCVA与术前比较,组间各时间点比较差异无统计学意义(P>0.05);两组术后7d,1、3、6mo眼压均显著低于术前,术后7d,1mo观察组显著低于对照组,差异有统计学意义(P<0.05),术后3、6mo组间比较差异无统计学意义(P>0.05);观察组手术成功率为100%,与对照组(92%)比较差异具有统计学意义(P<0.05),观察组手术完全成功率为84%,显著高于对照组(66%),差异有统计学意义(P<0.05);观察组前房出血及复发率显著低于对照组,差异有统计学意义(P<0.05),两组患者浅前房、低眼压发生率差异无统计学意义(P>0.05)。结论:术前玻璃体腔注射康柏西普联合PRP治疗CRVO继发NVG眼压恢复时间更短,手术效果更优,能控制前房出血并降低复发率。 展开更多
关键词 康柏西普 全视网膜激光光凝 视网膜中央静脉阻塞 新生血管性青光眼
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Flame-retardant concentrated electrolyte enabling a Li F-rich solid electrolyte interface to improve cycle performance of wide-temperature lithium–sulfur batteries 被引量:7
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作者 zhe yu Jianjun Zhang +9 位作者 Chao Wang Rongxiang Hu Xiaofan Du Ben Tang Hongtao Qu Han Wu Xin Liu Xinhong Zhou Xiaoyan Yang Guanglei Cui 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第12期154-160,共7页
Lithium–sulfur batteries have been regarded as the most promising high-energy electrochemical energy storage device owing to the high energy density, low cost and environmental friendliness. However, traditional lith... Lithium–sulfur batteries have been regarded as the most promising high-energy electrochemical energy storage device owing to the high energy density, low cost and environmental friendliness. However, traditional lithium–sulfur batteries using ether-based electrolytes often suffer from severe safety risks(i.e. combustion). Herein, we demonstrated a novel kind of flame-retardant concentrated electrolyte(6.5 M lithium bis(trifluoromethylsulphonyl)imide/fluoroethylene carbonate) for highly-safe and widetemperature lithium–sulfur batteries. It was found that such concentrated electrolyte showed superior flame retardancy, high lithium-ion transference number(0.69) and steady lithium plating/stripping behavior(2.5 m Ah cm^(-2) over 3000 h). Moreover, lithium–sulfur batteries using this flame-retardant concentrated electrolyte delivered outstanding cycle performance in a wide range of temperatures(-10 °C, 25 °C and 90 °C). This superior battery performance is mainly attributed to the LiF-rich solid electrolyte interphase formed on lithium metal anode, which can effectively suppress the continuous growth of lithium dendrites. Above-mentioned fascinating characteristics would endow this flame-retardant concentrated electrolyte a very promising candidate for highly-safe and wide-temperature lithium–sulfur batteries. 展开更多
关键词 Flame retardancy Concentrated electrolyte LiF-rich solid electrolyte interphase Lithium–sulfur batteries Wide temperature
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白内障摘除联合玻璃体切割气体填充术治疗特发性黄斑裂孔 被引量:4
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作者 刘小毛 延新年 +3 位作者 范强 张萌 鱼喆 蒲晓莉 《国际眼科杂志》 CAS 北大核心 2018年第7期1261-1263,共3页
目的:探讨特发性黄斑裂孔(idiopathic macular hole,IMH)不同分期行白内障摘除玻璃体切割气体填充术后视力的恢复情况。方法:选取2014-08/2016-08于我院治疗的IMH合并白内障患者75例75眼,所有患者均行白内障摘除玻璃体切割过氟丙烷(C3F8... 目的:探讨特发性黄斑裂孔(idiopathic macular hole,IMH)不同分期行白内障摘除玻璃体切割气体填充术后视力的恢复情况。方法:选取2014-08/2016-08于我院治疗的IMH合并白内障患者75例75眼,所有患者均行白内障摘除玻璃体切割过氟丙烷(C3F8)气体填充术治疗,按IMH不同Gass分期分为Ⅱ期组(18眼)、Ⅲ期组(36眼)、Ⅳ期组(21眼)。比较术后1、3mo黄斑裂口闭合情况;手术前后进行常规视力检查,比较各组患眼视力提高情况;光学相干断层扫描(optical coherence tomography,OCT)检查手术前后黄斑厚度。结果:术后1mo,Ⅱ期组黄斑裂口闭合率显著高于Ⅲ期与Ⅳ期组,Ⅲ期组显著高于Ⅳ期组,差异有统计学意义(P<0.05);术3moⅡ期组、Ⅲ期组黄斑裂孔闭合率比较,差异无统计学意义(P>0.05)。所有患者手术前后视力数指、0.02~0.08、0.10~0.20、0.25~0.40、≥0.50人数比例比较,差异有统计学意义(P<0.05),Ⅱ期组视力提高率为94%,显著高于Ⅲ期(83%)与Ⅳ期组(67%)。Ⅱ期、Ⅲ期组手术后黄斑厚度较手术前均显著降低,Ⅳ期组手术前后差异无统计学意义(P>0.05),Ⅱ期、Ⅲ期组降低幅度差异无统计学意义(P>0.05),均显著高于Ⅳ期组,差异具有统计学意义(P<0.05)。结论:白内障摘除玻璃体切割气体填充术有助于IMH视力恢复,但不同Gass分期疗效具有差异,应尽早进行手术,有助于黄斑裂孔闭合,改善视力。 展开更多
关键词 特发性黄斑裂孔 不同分期 白内障摘除 玻璃体切割 气体填充
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Effect of suspension training on neuromuscular function, postural control, and knee kinematics in anterior cruciate ligament reconstruction patients 被引量:4
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作者 Dong-Dong Huang Liang-Hua Chen +4 位作者 zhe yu Quan-Jun Chen Jie-Nuan Lai Hai-Hong Li Gang Liu 《World Journal of Clinical Cases》 SCIE 2021年第10期2247-2258,共12页
BACKGROUND Suspension training(SET)is a method of neuromuscular training that enables the body to carry out active training under unstable support through a suspension therapy system.However,there have been few report... BACKGROUND Suspension training(SET)is a method of neuromuscular training that enables the body to carry out active training under unstable support through a suspension therapy system.However,there have been few reports in the literature on the application of SET to anterior cruciate ligament reconstruction(ACLR)patients.It is not clear what aspects of the patient's function are improved after SET.AIM To investigate the effect of SET on the neuromuscular function,postural control,and knee kinematics of patients after ACLR surgery.METHODS Forty participants were randomized to an SET group or a control group.The SET group subjects participated in a SET protocol over 6 wk.The control group subjects participated in a traditional training protocol over 6 wk.Isokinetic muscle strength of the quadriceps and hamstrings,static and dynamic posture stability test,and relative translation of the injured knee were assessed before and after training.RESULTS The relative peak torque of the quadriceps and hamstrings in both groups increased significantly(P<0.001),and the SET group increased by a higher percentage than those in the control group(quadriceps:P=0.004;hamstrings:P=0.011).After training,both groups showed significant improvements in static and dynamic posture stability(P<0.01),and the SET group had a greater change than the control group(P<0.05).No significant improvement on the relative translation of the injured knee was observed after training in either group(P>0.05).CONCLUSION Our findings show that SET promotes great responses in quadriceps and hamstring muscle strength and balance function in ACLR patients. 展开更多
关键词 Anterior cruciate ligament reconstruction Suspension training Neuromuscular function Postural control Knee kinematics REHABILITATION
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STRASS Dehazing:Spatio-Temporal Retinex-Inspired Dehazing by an Averaging of Stochastic Samples 被引量:4
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作者 zhe yu Bangyong Sun +3 位作者 Di Liu Vincent Whannou de Dravo Margarita Khokhlova Siyuan Wu 《Journal of Renewable Materials》 SCIE EI 2022年第5期1381-1395,共15页
In this paper,we propose a neoteric and high-efficiency single image dehazing algorithm via contrast enhancement which is called STRASS(Spatio-Temporal Retinex-Inspired by an Averaging of Stochastic Samples)dehazing,i... In this paper,we propose a neoteric and high-efficiency single image dehazing algorithm via contrast enhancement which is called STRASS(Spatio-Temporal Retinex-Inspired by an Averaging of Stochastic Samples)dehazing,it is realized by constructing an efficient high-pass filter to process haze images and taking the influence of human vision system into account in image dehazing principles.The novel high-pass filter works by getting each pixel using RSR and computes the average of the samples.Then the low-pass filter resulting from the minimum envelope in STRESS framework has been replaced by the average of the samples.The final dehazed image is yielded after iterations of the high-pass filter.STRASS can be run directly without any machine learning.Extensive experimental results on datasets prove that STRASS surpass the state-of-the-arts.Image dehazing can be applied in the field of printing and packaging,our method is of great significance for image pre-processing before printing. 展开更多
关键词 Image dehazing contrast enhancement high-pass filter image reconstruction
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Characteristics of DBD micro-discharge at different pressure and its effect on the performance of oxygen plasma reactor 被引量:1
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作者 Rui LIU zhe yu +2 位作者 Huijuan CAO Pu LIU Zhitao ZHANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2019年第5期5-13,共9页
The oxygen plasma reactor based on dielectric barrier discharge principle can produce a high concentration of reactive oxygen species,which can cooperate with hydraulic cavitation gas-liquid mixer to realize the appli... The oxygen plasma reactor based on dielectric barrier discharge principle can produce a high concentration of reactive oxygen species,which can cooperate with hydraulic cavitation gas-liquid mixer to realize the application of advanced oxidation technology in water treatment.In this technology,the work pressure of the oxygen plasma reactor is decreased by the vacuum suction effect generated in the snap-back section of the gas-liquid mixed container.In this paper,the characteristics of single micro-discharge at different pressures were investigated with the methods of discharge image,electrical characteristics and spectral diagnosis,in order to analyze the electrical characteristics and reactive oxygen species generation efficiency of oxygen plasma reactor at the pressure range from 60 kPa to 100 kPa.The study indicated that,when the pressure decreases,the duty ratio of ionization in the discharge gap and number of electrons with high energy increases,leading to a rise in reactive oxygen species production.When the oxygen reaches the maximum ionization,the concentration of reactive oxygen species is the highest.Then,the discharge intensity continues to increase,producing more heat,which will decompose the ozone and lower the production of reactive oxygen species.The oxygen plasma reactor has an optimum working pressure at different input powers,which makes the oxygen plasma reactor the most efficient in generating reactive oxygen species. 展开更多
关键词 atmospheric PRESSURE plasma REACTOR PRESSURE active oxygen particle dielectric BARRIER DISCHARGE
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Research on resonance parameters matching based on partitioned operation method of atmospheric pressure plasma reactor array
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作者 zhe yu Jialin ZHAO +3 位作者 Rui LIU Huijuan CAO Pu LIU Zhitao ZHANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2019年第5期34-42,共9页
Matching optimization of resonant parameters among the high power inverters,low power transformers and plasma reactors have significant effects on the performance and output of the reactor array when applying the part... Matching optimization of resonant parameters among the high power inverters,low power transformers and plasma reactors have significant effects on the performance and output of the reactor array when applying the partitioned operation method.In this paper,the Matlab/Simulink electrical model was established based on the method of partitioned operation.The matching relation between resonant parameters is analyzed on the basis of experimental result.As a consequence,transformer leakage inductance and working frequency are the important parameters influencing the operational efficiency of system,leakage inductance of transformer should be adjusted based on the equivalent capacitance of plasma reactor to realize the matching optimization of resonant parameters. 展开更多
关键词 ATMOSPHERIC pressure plasma reactor dielectric BARRIER DISCHARGE MATLAB/SIMULINK RESONANCE parameters partitioned operation method
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Repeated platelet-rich plasma injections improve erectile dysfunction in a rat model of hyperhomocysteinemia
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作者 zhe yu yuan-Zhi Xie +3 位作者 Xiao-Lan Huang Su-zhen Huang Xiang-Min Luo Jin-Xiang Wu 《Asian Journal of Andrology》 SCIE CAS CSCD 2024年第6期622-627,共6页
Platelet-rich plasma (PRP) shows promise as a regenerative modality for mild-to-moderate erectile dysfunction (ED). However, its efficacy in treating severe ED remains unknown. Blood samples from 8-week-old male rats ... Platelet-rich plasma (PRP) shows promise as a regenerative modality for mild-to-moderate erectile dysfunction (ED). However, its efficacy in treating severe ED remains unknown. Blood samples from 8-week-old male rats were used to prepare PRP through a two-step centrifugation procedure, followed by chitosan activation and freeze thaw cycle. A hyperhomocysteinemia (HHcy)-related ED model was established using a methionine-enriched diet, and an apomorphine (APO) test was conducted during the 4th week. APO-negative rats were divided into two groups and were injected with PRP or saline every 2 weeks. Erectile function and histological analyses of the corpus cavernosum were performed during the 16th week. The results revealed that erectile function was significantly impaired in rats with HHcy-related ED compared to that in age-matched rats but was improved by repeated PRP injections. Immunofluorescence staining revealed a reduction in reactive oxygen species and additional benefits on the recovery of structures within the corpus cavernosum in rats that received PRP treatment compared to those in the saline-injected control group. Therefore, PRP could enhance functional and structural recovery in a severe HHcy-related ED model. A notable strength of the present study lies in the use of a repeated intracavernous injection method, mirroring protocols used in human studies, which offers more reliable results for translating the findings to humans. 展开更多
关键词 erectile dysfunction growth factor HYPERHOMOCYSTEINEMIA platelet-rich plasma
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Targeting lipid metabolism overcomes BTK inhibitor resistance in diffuse large B-cell lymphoma
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作者 Zhuojun Liu Chenyue Wu +3 位作者 Zhaohua Yao yuxuan Wang zhe yu Jian yu 《Medicine in Novel Technology and Devices》 2024年第2期9-14,共6页
Exploring novel therapeutic targets of Diffuse large B cell lymphoma(DLBCL)to overcome its resistance to Bruton's Tyrosine Kinase(BTK)inhibitors is a key topic.Lipid metabolism,crucial in the resistance landscape ... Exploring novel therapeutic targets of Diffuse large B cell lymphoma(DLBCL)to overcome its resistance to Bruton's Tyrosine Kinase(BTK)inhibitors is a key topic.Lipid metabolism,crucial in the resistance landscape of various cancers,may unlock new aspects of BTK inhibitor resistance in DLBCL.Despite the known importance of lipid metabolism in oncological resistance patterns,its intricate role in DLBCL and its resistance to BTK inhibitor therapies remains largely uncharted.This review will explore the complex relationship between lipid metabolism and BTK inhibitor resistance,giving new insights for improving the effectiveness of BTK inhibitors and developing innovative combination treatment methods for DLBCL.This review holds the potential for guiding future research directions,optimizing existing therapeutic processes,and inspiring the development of innovative combinatorial therapeutic strategies that improve outcomes in patients with DLBCL. 展开更多
关键词 Diffuse large B-Cell lymphoma BTK inhibitor resistance Lipid metabolism Fatty acid CHOLESTEROL
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用于锂二次电池的类三明治结构电解质的研究进展与展望 被引量:5
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作者 刘亭亭 张建军 +4 位作者 于喆 吴瀚 张津宁 唐犇 崔光磊 《高分子学报》 SCIE CAS CSCD 北大核心 2020年第7期710-727,I0003,共19页
设计和开发高性能电解质对于提升锂二次电池的安全使用性能和电化学性能十分必要.类三明治结构电解质是一类新兴的,具有特殊两层、三层或多层对称或非对称结构的电解质体系,可实现不同材料的性能优势互补,同“刚柔并济”电解质设计理念... 设计和开发高性能电解质对于提升锂二次电池的安全使用性能和电化学性能十分必要.类三明治结构电解质是一类新兴的,具有特殊两层、三层或多层对称或非对称结构的电解质体系,可实现不同材料的性能优势互补,同“刚柔并济”电解质设计理念相吻合.基于此,本综述详细梳理了类三明治结构电解质在高电压锂电池、固态锂电池、锂金属电池和锂硫电池等方面展现出的多功能应用:(1)提高离子电导率;(2)提高负极界面相容性,抑制锂枝晶生长;(3)提高正极界面抗氧化性能;(4)防止过渡金属离子溶出游弋到负极;(5)防止多硫化物穿梭.并从类三明治结构电解质特定应用方面出发,重点论述了类三明治结构电解质的类型、制备、功能以及在高性能锂二次电池中的研究进展.文末还对类三明治结构电解质未来可能的发展趋势及存在的挑战进行了深入分析和阐释.本综述将会对锂二次电池高性能电解质的设计、开发和研究工作起到非常好的理论指导和思路借鉴作用.“刚柔并济”类三明治结构电解质必将在未来高性能二次电池开发过程中发挥重要作用. 展开更多
关键词 类三明治结构 电解质 锂二次电池 界面相容性 展望
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Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability 被引量:6
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作者 Jinfeng Yang Min Zhang +8 位作者 zheng Chen Xiaofan Du Suqi Huang Ben Tang Tiantian Dong Han Wu zhe yu Jianjun Zhang Guanglei Cui 《Nano Research》 SCIE EI CAS CSCD 2019年第9期2230-2237,共8页
Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!on.Herein,we report a flame-retardant quasi-s... Con ventio nal liquid electrolytes based sodium metal batteries suffer from severe safety hazards owing to electrolyte leakage,in flammability and dendritic sodium deposit!on.Herein,we report a flame-retardant quasi-solid polymer electrolyte with poly(methyl vinyl ether-alt-maleic an hydride)(P(MVE-alt-MA))as host,bacterial cellulose(BC)as reinforceme nt,and triethyl phosphate/vinyle ne carb on ate/sodium perchlorate(TEP/VC/NaClO4)as plasticizer for highly safe sodium metal batteries.The as-obtained quasi-solid polymer electrolyte exhibits superior flame retardancy(self-extinguish within 1 s),complete non-leakage property and wide electrochemical windows(4.4 V).More importantly,Na3V2(PO4)3/Na metal batteries using such polymer electrolyte delivers superior I on g-term cycli ng stability(84.4%capacity rete ntion after 1000 cycles)which is significantly better than that(only 2%after 240 cycles)of liquid electrolyte.In addition,this flame-retardant quasi-solid polymer electrolyte provides favorable cycle performance(80.2%capacity retention after 70 cycles at 50°C and 84.8%capacity retention after 50 cycles at-10°C)for Na3V2(PO4)3/Na metal batteries.And this battery also displayed a normal charge/discharge property even at-15°C.These fascinating cycle properties are mainly ascribed to the effective pro怕ctive layers formed on Na3V2(PC>4)3 cathode and sodium metal ano de.More thorough in vestigati on elucidates that such flame-retardant quasi-solid polymer electrolyte plays a multif unctional role in the adva need sodium metal batteries:(1)being in volved in the formatio n of a favorable cathode electrolyte in terface(CEI)to inhibit the dissolutio n of van adium and maintai n the structure integrity of the Na3V2(PO4)3;(2)participati ng in building a stable solid electrolyte in terface(SEI)to suppress the growth of Na dendrites;(3)integrating flame-retardanee into polymer sodium batteries to enhance flame-resistanee,eliminate electrolyte leakage,and thus improve safety of sodium batteries.Based on these results,we further assembled Na3V2(PO4)3/MoS2 pouch cell which can withsta nd harsh conditions(be nded or cut off a corn er),confirming the obtai ned polymer electrolyte with superior non-leakage property.In all,these outstanding characteristics would endow this flame-retardant quasi-solid polymer electrolyte a very promising can didate for highly-safe sodium metal batteries. 展开更多
关键词 flame-retarda nt quasi-solid polymer electrolyte HIGHLY SAFE CHARACTERISTIC SODIUM metal BATTERIES long-term cycling stability
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Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation 被引量:3
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作者 Sen yu zhe yu +6 位作者 Dagang Guo Hui Zhu Minghua Zhang Jianye Han zhentao yu Yemin Cao Gui Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第5期137-149,共13页
The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte cont... The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte containing calcium and phosphate,a hydrothermal treatment enabled secondary microporous hydroxyapatite(HA)coating,and a further bone morphogenetic protein-2(BMP-2)loading treatment through immersion and freeze-drying.The treatment led to an orderly secondary microporous coating containing HA nano-particles and evenly distributed BMP-2 in the porous coatings.As a result,osteoblasts could adhere and grow well on the coatings with a high cell adhesion rate and cell functional activity.The in-situ shear testing indicated that the interfacial strength had been enhanced significantly.Improvement of the bond formation and osseointegration with the titanium implant is attributed to increased surface area for the cell to attach,creating voids for the cell to grow in,and activating titanium surface by introducing bioactive ingredients such as HA and BMP-2. 展开更多
关键词 Graded porosity titanium Secondary microporous Bioactivity Ti3Zr2Sn3Mo25Nb alloy Interface binding strength
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Neural-network-based Power System State Estimation with Extended Observability 被引量:3
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作者 Guanyu Tian Yingzhong Gu +3 位作者 Di Shi Jing Fu zhe yu Qun Zhou 《Journal of Modern Power Systems and Clean Energy》 SCIE EI CSCD 2021年第5期1043-1053,共11页
This paper proposes a neural-network-based state estimation(NNSE)method that aims to achieve higher time efficiency,improved robustness against noise,and extended observability when compared with the conventional weig... This paper proposes a neural-network-based state estimation(NNSE)method that aims to achieve higher time efficiency,improved robustness against noise,and extended observability when compared with the conventional weighted least squares(WLS)state estimation method.NNSE consists of two parts,the linear state estimation neural network(LSE-net)and the unobservable state estimation neural network(USE-net).The LSE-net functions as an adaptive approximator of linear state estimation(LSE)equations to estimate the nominally observable states.The inputs of LSE-net are the vectors of synchrophasors while the outputs are the estimated states.The USE-net operates as the complementary estimator on the nominally unobservable states.The inputs are the estimated observable states from LSE-net while the outputs are the estimation of nominally unobservable states.USE-net is trained off-line to approximate the veiled relationship between observable states and unobservable states.Two test cases are conducted to validate the performance of the proposed approach.The first case,which is based on the IEEE 118-bus system,shows the comprehensive performance of convergence,accuracy,and robustness of the proposed approach.The second case study adopts real-world synchrophasor measurements,and is based on the Jiangsu power grid,which is one of the largest provincial power systems in China. 展开更多
关键词 State estimation linear state estimation stochastic gradient descent neural network wide area management system(WAMS).
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Doubly-fed Deep Learning Method for Bad Data Identification in Linear State Estimation 被引量:3
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作者 Yingzhong Gu zhe yu +1 位作者 Ruisheng Diao Di Shi 《Journal of Modern Power Systems and Clean Energy》 SCIE EI CSCD 2020年第6期1140-1150,共11页
With more data-driven applications introduced in wide-area monitoring systems(WAMS),data quality of phasor measurement units(PMUs)becomes one of the fundamental requirements for ensuring reliable WAMS applications.Thi... With more data-driven applications introduced in wide-area monitoring systems(WAMS),data quality of phasor measurement units(PMUs)becomes one of the fundamental requirements for ensuring reliable WAMS applications.This paper proposes a doubly-fed deep learning method for bad data identification in linear state estimation,which can:(1)identify bad data under both steady states and contingencies;(2)achieve higher accuracy than conventional pre-filtering approaches;(3)reduce iteration burden for linear state estimation;(4)efficiently identify bad data in a parallelizable scheme.The proposed method consists of four key steps:(1)preprocessing filter;(2)online training of short-term deep neural network;(3)offline training of long-term deep neural network;(4)a decision merger.Through delicate design and comprehensive training,the proposed method can effectively differentiate the bad data from event data without relying on real-time topology information.An IEEE 39-bus system simulated by DSATools TSAT and a provincial electric power system with real PMU data collected are used to verify the proposed method.Multiple test scenarios are applied,which include steady states,three-phase-to-ground faults with(un)successful auto-reclosing,low-frequency oscillation,and low-frequency oscillation with simultaneous threephase-to-ground faults.The proposed method demonstrates satisfactory performance during both the training session and the testing session. 展开更多
关键词 Bad data identification linear state estimation PREPROCESSING deep neural network wide-area monitoring system(WAMS)
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A Robust Real-time Low-frequency Oscillation Detection and Analysis (LFODA) System with Innovative Ensemble Filtering 被引量:3
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作者 Desong Bian zhe yu +3 位作者 Di Shi Senior Ruisheng Diao Zhiwei Wang 《CSEE Journal of Power and Energy Systems》 SCIE CSCD 2020年第1期174-183,共10页
Low-frequency oscillations are hazardous to power system operation,and can lead to cascading failures if not detected and mitigated in a timely manner.This paper presents a robust and automated real-time monitoring sy... Low-frequency oscillations are hazardous to power system operation,and can lead to cascading failures if not detected and mitigated in a timely manner.This paper presents a robust and automated real-time monitoring system for detecting grid oscillations and analyzing their mode shapes using PMU measurements.A novel Extended Kalman Filtering(EKF)based approach is introduced to detect and analyze oscillations.To further improve the accuracy and efficiency of the presented software system,the EKF approach takes advantages of three effective signal processing methods(including Prony’s Method,Hankel Total Least Square(HTLS)Method,EKF)and adopts a novel voting schema to significantly reduce the computation cost.Results from these methods are processed through a timeseries filter to ensure the consistency of detected oscillations and reduce the number of false alarms.The Density-based Spatial Clustering of Applications with Noise(DBSCAN)method is used to accurately classify oscillation modes and the PMU measurement channels.The LFODA system has been functioning well in the State Grid Jiangsu Electric Power Company with 176 PMUs and 1000+channels since February 2018,demonstrating outstanding performance in reducing false alarms with much less computational cost. 展开更多
关键词 Extended Kalman filter HTLS low frequency oscillation PMU PRONY
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