Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. coli AHAS II in vitro were tested and the results indicated that the hydroxy...Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. coli AHAS II in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS.展开更多
The Qimantag in the East Kunlun Orogenic Belt has widespread Triassic magmatic rocks that have received scant attention,with an unresolved issue relating to its petrogenesis and geodynamics.In this paper,we used zirco...The Qimantag in the East Kunlun Orogenic Belt has widespread Triassic magmatic rocks that have received scant attention,with an unresolved issue relating to its petrogenesis and geodynamics.In this paper,we used zircon U-Pb-Hf isotopes and whole-rock geochemistry to trace the petrogenesis and tectonic settings of the moyite and monzogranite from the Qimantag Alananshan,East Kunlun.The moyite and monzogranite are silicic(SiO_(2-)~69.9-76.41%),highly alkali(Na_(2)O+K_(2)O~7.29 to8.96 wt.%),with Mg^(#)about 10.4-30.34,indicative of a high-K calc-alkaline rock series.The rare earth element patterns diagram is right-leaning,with a negative Eu anomaly(δEu=0.31-0.68).They are enriched in Rb,K,and light rare earth elements but depleted in Nb,Ta,and Ti,with abundant amphibole,typical of I-type granites.U-Pb on zircon constrained the emplacement of the moyite at 223.9±2.6 Ma and monzogranite at 226.9±2.9 Ma.TheεHf(t)values range from-2.8 to+0.1 except for one outlier value of-7.0,corresponding two-stage model age of 1249-1437 Ma.Our combined geochemical and isotopic results indicate that the moyite and monzogranite were derived from partial melting of the lower thicken crust with the contribution from the older basement materials.These rocks formed in a post-collision setting that is transitional between compressive collision and extension orogeny.展开更多
Radiation recall phenomenon is a tissue reaction that develops throughout a previously irradiated area,precipitated by the administration of certain drugs.Radiation recall is uncommon and easily neglected by physician...Radiation recall phenomenon is a tissue reaction that develops throughout a previously irradiated area,precipitated by the administration of certain drugs.Radiation recall is uncommon and easily neglected by physicians;hence,this phenomenon is underreported in literature.This manuscript reports two cases of radiation recall.First,a 44-year-old man with nasopharyngeal carcinoma was treated with radiotherapy in 2010 and subsequently developed multi-site bone metastases.A few days after the docetaxel-based chemotherapy,erythema and papules manifested dermatitis,as well as swallowing pain due to pharyngeal mucositis,developed on the head and neck that strictly corresponded to the previously irradiated areas.Second,a 19-year-old man with recurrent nasal NK/T cell lymphoma initially underwent radiotherapy followed by chemotherapy after five weeks.Erythema and edema appeared only at the irradiated skin.Both cases were considered chemotherapeutic agents that incurred radiation recall reactions.Clinicians should be knowledgeable of and pay attention to such rare phenomenon.展开更多
Dual labeling of an RNA can provide Förster resonance energy transfer(FRET)sensors for studying RNA folding,miRNA maturation,and RNA-protein interactions.Here,we report the development of a highly efficient strat...Dual labeling of an RNA can provide Förster resonance energy transfer(FRET)sensors for studying RNA folding,miRNA maturation,and RNA-protein interactions.Here,we report the development of a highly efficient strategy for direct dual-terminal labeling of any RNA of interest.We explored new Michael cycloaddition for facile labeling of 5′-terminal RNA with improved efficiency.Direct chemical tetrazinylation of RNA at the 3′-terminus was achieved with the highly efficient and catalysis-free tetrazine-cycloalkyne ligation.Both single-terminal labeling methods were combined for dual-terminal labeling of an RNA including short hairpin RNA,pre-miRNA,riboswitch,and noncoding RNA.Notably,these dual-labeled RNA-based FRET sensors were used to monitor RNA-ligand interactions in vitro and in live cells.It is anticipated that these universal RNA labeling strategies will be useful to study RNA structures and functions.展开更多
Strigolactones(SLs)are a new class of phytohormones that not only act as signalling molecules with external rhizospheric fungus and stimulate the seed germination of root parasite weeds,but also regulate many aspects ...Strigolactones(SLs)are a new class of phytohormones that not only act as signalling molecules with external rhizospheric fungus and stimulate the seed germination of root parasite weeds,but also regulate many aspects of plant development,such as regulating root and shoot architecture.These intriguing properties,which in turn,make SLs great potency for applications in agriculture.In this review,we highlight the recent advancements in applying SLs and their agonists or antagonists for agricultural applications,including controlling root parasite weeds,improving plant nutrient availability,and regulating abiotic stress responses.Although many SL agonists or antagonists have been synthesized since the first isolation of SL,strigol,in 1966,there is still no commercial application of this class of molecule.We also present an overview of the possible challenges for the practical application of SL agonists or antagonists.展开更多
Cyclic dinucleotides(CDNs)play important physiological roles in bacteria,mammals and insects as a novel class of signaling molecules.However,the application of CDNs in agricultural pest control has not been reported y...Cyclic dinucleotides(CDNs)play important physiological roles in bacteria,mammals and insects as a novel class of signaling molecules.However,the application of CDNs in agricultural pest control has not been reported yet.To explore the potential bioactivity of CDNs on agricultural pests,we synthesized ten kinds of CDNs containing adenine and guanine bases with different internucleotide linkages(30,30;20,30;20,20).The target CDNs were used to determine the antifeedant and insecticidal activity against common Lepidoptera pests including S.frugiperda,M.separata,and H.armigera.The bioassay tests indicated that 30,30-c-di-AMP showed the highest antifeedant activity(EC50?0.59 mg/L)against M.separata larvae among all the tested CDNs.Regarding insecticidal activity,20,30-c-di-AMP showed higher insecticidal activity against M.separata larvae with LC50 of 55.4 mg/L.RNA-seq further revealed that 30,30-c-di-AMP and 20,30-c-di-AMP exhibited a significant effect on the growth and development process of insects.More importantly,the bioactivity of 30,30-c-di-AMP was also closely correlated with the stimulation of insect immune inflammation.These results indicated that cyclic dinucleotides can affect the normal physiological process of insects,providing a new direction for managing pests.展开更多
A new skeleton bisabolane-type sesquiterpene curcuminoid,bisabocurcumin（1）,along with 5 known compounds,curcumin（2）, demethoxycurcumin（3）,bidemethoxycurcumin（4）,（1E,4E）-1,5-bis（4-hydroxy-3-methoxyphenyl）-p...A new skeleton bisabolane-type sesquiterpene curcuminoid,bisabocurcumin（1）,along with 5 known compounds,curcumin（2）, demethoxycurcumin（3）,bidemethoxycurcumin（4）,（1E,4E）-1,5-bis（4-hydroxy-3-methoxyphenyl）-penta-1,4-dien-3-one（5）,and （1E,4E）-1-（4-hydroxy-3-methoxyphenyl）-5-（4-hydroxy phenyl-）-penta-1,4-dien-3-one（6）were isolated from the rhizomes of Curcuma longa L.Their structures were determined on the basis of spectroscopic analysis.Bisabocurcumin（1） is firstly obtained from nature with a new skeleton combined by a bisabolane-type sesquiterpene and a 1,7-diphenylheptanoid through a C-C bond.展开更多
文摘Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. coli AHAS II in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS.
基金co-financed by the"Xinjiang Uygur Autonomous Region Central Government Returns the Price of Two Rights(K15-1-LQ06)"the National Natural Science Foundations of China(No.42101005)the Research Foundation of Education Department of Hunan Province for Excellent Young Scholars(No.19B097)。
文摘The Qimantag in the East Kunlun Orogenic Belt has widespread Triassic magmatic rocks that have received scant attention,with an unresolved issue relating to its petrogenesis and geodynamics.In this paper,we used zircon U-Pb-Hf isotopes and whole-rock geochemistry to trace the petrogenesis and tectonic settings of the moyite and monzogranite from the Qimantag Alananshan,East Kunlun.The moyite and monzogranite are silicic(SiO_(2-)~69.9-76.41%),highly alkali(Na_(2)O+K_(2)O~7.29 to8.96 wt.%),with Mg^(#)about 10.4-30.34,indicative of a high-K calc-alkaline rock series.The rare earth element patterns diagram is right-leaning,with a negative Eu anomaly(δEu=0.31-0.68).They are enriched in Rb,K,and light rare earth elements but depleted in Nb,Ta,and Ti,with abundant amphibole,typical of I-type granites.U-Pb on zircon constrained the emplacement of the moyite at 223.9±2.6 Ma and monzogranite at 226.9±2.9 Ma.TheεHf(t)values range from-2.8 to+0.1 except for one outlier value of-7.0,corresponding two-stage model age of 1249-1437 Ma.Our combined geochemical and isotopic results indicate that the moyite and monzogranite were derived from partial melting of the lower thicken crust with the contribution from the older basement materials.These rocks formed in a post-collision setting that is transitional between compressive collision and extension orogeny.
文摘Radiation recall phenomenon is a tissue reaction that develops throughout a previously irradiated area,precipitated by the administration of certain drugs.Radiation recall is uncommon and easily neglected by physicians;hence,this phenomenon is underreported in literature.This manuscript reports two cases of radiation recall.First,a 44-year-old man with nasopharyngeal carcinoma was treated with radiotherapy in 2010 and subsequently developed multi-site bone metastases.A few days after the docetaxel-based chemotherapy,erythema and papules manifested dermatitis,as well as swallowing pain due to pharyngeal mucositis,developed on the head and neck that strictly corresponded to the previously irradiated areas.Second,a 19-year-old man with recurrent nasal NK/T cell lymphoma initially underwent radiotherapy followed by chemotherapy after five weeks.Erythema and edema appeared only at the irradiated skin.Both cases were considered chemotherapeutic agents that incurred radiation recall reactions.Clinicians should be knowledgeable of and pay attention to such rare phenomenon.
基金This research was made possible as a result of a generous grant from the National Nature Science Foundation of China(grant nos.21877008,32070670,and 22177010)the Zhejiang Provincial Natural Science Foundation of China(grant no.LY21C060003).
文摘Dual labeling of an RNA can provide Förster resonance energy transfer(FRET)sensors for studying RNA folding,miRNA maturation,and RNA-protein interactions.Here,we report the development of a highly efficient strategy for direct dual-terminal labeling of any RNA of interest.We explored new Michael cycloaddition for facile labeling of 5′-terminal RNA with improved efficiency.Direct chemical tetrazinylation of RNA at the 3′-terminus was achieved with the highly efficient and catalysis-free tetrazine-cycloalkyne ligation.Both single-terminal labeling methods were combined for dual-terminal labeling of an RNA including short hairpin RNA,pre-miRNA,riboswitch,and noncoding RNA.Notably,these dual-labeled RNA-based FRET sensors were used to monitor RNA-ligand interactions in vitro and in live cells.It is anticipated that these universal RNA labeling strategies will be useful to study RNA structures and functions.
基金funding support by the National Natural Science Foundation of China(No.22077072 and 21837001)the Frontiers Science Center for New Organic Matter of Nankai University(No.63181206)the Haihe Laboratory of Sustainable Chemical Transformations(No.YYJC202102).
文摘Strigolactones(SLs)are a new class of phytohormones that not only act as signalling molecules with external rhizospheric fungus and stimulate the seed germination of root parasite weeds,but also regulate many aspects of plant development,such as regulating root and shoot architecture.These intriguing properties,which in turn,make SLs great potency for applications in agriculture.In this review,we highlight the recent advancements in applying SLs and their agonists or antagonists for agricultural applications,including controlling root parasite weeds,improving plant nutrient availability,and regulating abiotic stress responses.Although many SL agonists or antagonists have been synthesized since the first isolation of SL,strigol,in 1966,there is still no commercial application of this class of molecule.We also present an overview of the possible challenges for the practical application of SL agonists or antagonists.
基金supported by National Key Research and Development Program of China(Grant Number:2023YFD1700502)Frontiers Science Center for New Organic Matter,Nankai University,(Grant Number:63181206)the Haihe Laboratory of Sustainable Chemical Transformations,China(Grant Number:YYJC202102).
文摘Cyclic dinucleotides(CDNs)play important physiological roles in bacteria,mammals and insects as a novel class of signaling molecules.However,the application of CDNs in agricultural pest control has not been reported yet.To explore the potential bioactivity of CDNs on agricultural pests,we synthesized ten kinds of CDNs containing adenine and guanine bases with different internucleotide linkages(30,30;20,30;20,20).The target CDNs were used to determine the antifeedant and insecticidal activity against common Lepidoptera pests including S.frugiperda,M.separata,and H.armigera.The bioassay tests indicated that 30,30-c-di-AMP showed the highest antifeedant activity(EC50?0.59 mg/L)against M.separata larvae among all the tested CDNs.Regarding insecticidal activity,20,30-c-di-AMP showed higher insecticidal activity against M.separata larvae with LC50 of 55.4 mg/L.RNA-seq further revealed that 30,30-c-di-AMP and 20,30-c-di-AMP exhibited a significant effect on the growth and development process of insects.More importantly,the bioactivity of 30,30-c-di-AMP was also closely correlated with the stimulation of insect immune inflammation.These results indicated that cyclic dinucleotides can affect the normal physiological process of insects,providing a new direction for managing pests.
文摘A new skeleton bisabolane-type sesquiterpene curcuminoid,bisabocurcumin（1）,along with 5 known compounds,curcumin（2）, demethoxycurcumin（3）,bidemethoxycurcumin（4）,（1E,4E）-1,5-bis（4-hydroxy-3-methoxyphenyl）-penta-1,4-dien-3-one（5）,and （1E,4E）-1-（4-hydroxy-3-methoxyphenyl）-5-（4-hydroxy phenyl-）-penta-1,4-dien-3-one（6）were isolated from the rhizomes of Curcuma longa L.Their structures were determined on the basis of spectroscopic analysis.Bisabocurcumin（1） is firstly obtained from nature with a new skeleton combined by a bisabolane-type sesquiterpene and a 1,7-diphenylheptanoid through a C-C bond.
