体心立方(body⁃centered cubic,BCC)金属W作为微型化器件中重要的互连材料,其电迁移行为对小尺寸集成电路的稳定性至关重要。本文利用原位透射电子显微(transmission electron microscopy,TEM)技术,在原子尺度下研究了电迁移诱导BCC金属...体心立方(body⁃centered cubic,BCC)金属W作为微型化器件中重要的互连材料,其电迁移行为对小尺寸集成电路的稳定性至关重要。本文利用原位透射电子显微(transmission electron microscopy,TEM)技术,在原子尺度下研究了电迁移诱导BCC金属W表面结构动态演变过程。结果表明,自由表面是主要电迁移路径;而{110}面和<111>方向分别是优选的迁移面迁移方向;电迁移过程中W表面形成特定的原子台阶或锯齿状结构。对于非低能晶面{002},在电流作用下仍能发生定向迁移,形成新的台阶结构。研究结果揭示了电迁移过程中表面结构的演化规律,为优化BCC金属材料的微观结构设计、提高其在高电流密度环境下的结构性能稳定性提供借鉴。展开更多
Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as...Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as a representative case study due to its rich landscape resources and status as a national innovation demonstration zone for implementing the 2030 Agenda for Sustainable Development.This study uses bibliometric visualization tools like CiteSpace and VOSviewer to analyze research trends from 1980 to 2021 in the Chinese Academic Journal Network Publishing Database(CNKI).The results show increasing academic interest over three stages:initiation(1982-1997),exploration(1998-2004),and diversified development(2005-2021).Contributions are predominantly from local academic and tourism sectors,indicating a strong regional influence;however,relatively weak interinstitutional collaboration occurs,suggesting potential for more integrated research efforts.Primary research is also concentrated within economic disciplines,particularly tourism-related ones.The evolution of research frontiers reveals three main paths:urban development strategies,industrial economic theories and empirical validation,and ecosystem analysis and evaluation.A multidisciplinary approach and stronger collaborative efforts are crucial to enhance research on ecological values and empirical models while supporting evidence-based urban development strategies in Guilin City and comparable cities globally.展开更多
In order to further ensure that the 2030 Agenda for Sustainable Development is to be implemented and the action measures of all countries are consistent, the United Nations has put forward a set of indicators to monit...In order to further ensure that the 2030 Agenda for Sustainable Development is to be implemented and the action measures of all countries are consistent, the United Nations has put forward a set of indicators to monitor and evaluate the progress of global sustainable development. This set of evaluation indicators is aimed for global and regional progress. An important feature of the evaluation indicators is that they are internationally comparable, but due to the large differences in the levels of sustainable development among countries, this framework of evaluation indicators has a disadvantage that it does not apply to tracking the progress of sustainable development at the national level. This paper focuses on the analysis of specific issues in the application of the global sustainable development indicators framework to meet the goals and targets of the UN and builds a system of evaluation indicators to assess the progress of sustainable development at the national level in China, and offers a perspective to assess China’s progress as well.展开更多
In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors...In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors that inhibit the BSISO forecast skill in this model.Based on the bivariate anomaly correlation coefficient(ACC)of the BSISO index,defined by the first two EOF modes of outgoing longwave radiation and 850-hPa zonal wind anomalies over the Asian monsoon region,we found that the hindcast skill degraded as the lead time increased.The ACC dropped to below 0.5for lead times of 11 days and longer when the predicted BSISO showed weakened strength and insignificant northward propagation.To identify what causes the weakened forecast skill of BSISO at the forecast lead time of 11 days,we diagnosed the main mechanisms responsible for the BSISO northward propagation.The same analysis was also carried out using the observations and the outputs of the four-day forecast lead that successfully predicted the observed northward-propagating BSISO.We found that the lack of northward propagation at the 11-day forecast lead was due to insufficient increases in low-level cyclonic vorticity,moistening and warm temperature anomalies to the north of the convection,which were induced by the interaction between background mean flows and BSISO-related anomalous fields.The BCC S2S model can predict the background monsoon circulations,such as the low-level southerly and the northerly and easterly vertical shears,but has limited capability in forecasting the distributions of circulation and moisture anomalies.展开更多
BACKGROUND： Animal experiments and clinical studies about tissue engineering method applied to repair nerve injury mainly focus on seeking ideal artificial nerve grafts, nerve conduit and seed cells. Autologous nerve...BACKGROUND： Animal experiments and clinical studies about tissue engineering method applied to repair nerve injury mainly focus on seeking ideal artificial nerve grafts, nerve conduit and seed cells. Autologous nerve, allogeneic nerve and xenogeneic nerve are used to bridge nerve defects, it is one of the methods to promote the repair of nerve injury by culturing and growing Schwann cells, which can secrete various neurotrophic factor activities, in the grafts. OBJECTIVE ： To observe the effect of acellular nerve grafts co-cultured with Schwann cells in repairing defects of sciatic nerve. DESIGN： An observational comparative study.SETTING： Tissue Engineering Laboratory of China Medical University.MATERIALS： The experiment was carried out in the Tissue Engineering Laboratory of China Medical University between April 2004 and April 2005. Forty neonatal Sprague-Dawley rats of 5-8 days （either males or females） and 24 male Wistar rats of 180-220 g were provided by the experimental animal center of China Medical University. METHODS： ① Culture of Schwann cells： The bilateral sciatic nerves and branchial plexus were isolated from the 40 neonatal SD rats. The sciatic nerves were enzymatically digested with collagenase and dispase, isolatd, purified and cultured with the method of speed-difference adhersion, and identified with the SABC immunohistochemical method. ② Model establishment： In vitro Schwann cells were microinjected into 10-mm long acellular nerve grafts repairing a surgically created gap in the rat sciatic nerve. According to the different grafted methods, the animals were randomly divided into three groups： autografts （n=8）, acellular nerve grafts （n=8）, or acellular nerve grafts with Schwann cells （n=8）. ③ The regenerated nerve fiber number and average diameter of myeline sheath after culture were statistically anlayzed. MAIN OUTCOME MEASURES： ① The regenerated nerve ultrastructure, total number and density of myelinated nerve fibers, and the thickness of myeline sheath were observed under electron microscope. ② The images were processed with the Mias-1000 imaging analytical system to calculate the number of myelinated nerve fibers, and the thickness of myeline sheath. RESULTS： All the 24 Wistar rats were involved in the analysis of results. ① Results observed under transmission electron microscope： The regenerated myelinated nerve fibers in the group of acellular nerve grafts with Schwann cells were more even than those in the group of acellular nerve grafts, the number of myelinated nerve fibers and thickness of myelin sheath were close to those in the allografts group （P 〉 0.05）, but significantly different from those in the group of acellular nerve grafts （P 〈 0.05）. ② Results observed under scanning electron microscope： A great amount of Schwann cells with two polars were observed in the group of grafts with Schwann cells, the feature of cultured Schwann cells showed shoulder by shoulder, head to head. ③ The number of myelinated nerve fibers and thickness of myelin sheath analyzed by Mias-1000 imaging system in the group of acellular nerve grafts with Schwann cells were close to those in the autografts group （P 〉 0.05）, but significantly different from those in the group of acellular nerve grafts （P 〈 0.05）.CONCLUSION： Host axonal regeneration is significantly increased after implant of acellular nerve grafts. Acellular nerve grafts with Schwann cells offers a novel approach for repairing the gap of nerve defect.展开更多
Service-oriented manufacturing is an emerging innovative development model,and its core is the deep integration of products and services.It has become a hot issue in current research.In order to deeply explore the evo...Service-oriented manufacturing is an emerging innovative development model,and its core is the deep integration of products and services.It has become a hot issue in current research.In order to deeply explore the evolution path of servitization transformation of manufacturing enterprises,ShaanGu Group is taken as a case,and discusses practical application of service-oriented manufacturing model in different development processes of ShaanGu Group.Thus,four stages of transformation of ShaanGu Group through servitization are summarized:specialized after-sales service stage,rental service stage,engineering complete service stage and financial service stage.Through comparative research,it is found that general evolution path of manufacturing enterprises to service transformation is:the primary stage(providing product-oriented product service system)→the intermediate stage(providing application-oriented product service system)→the advanced stage(providing utility-oriented product service system)→the completed stage(providing pure service).On this basis,some suggestions are provided for manufacturing enterprises to integrate productive services in the process of transformation.展开更多
文摘体心立方(body⁃centered cubic,BCC)金属W作为微型化器件中重要的互连材料,其电迁移行为对小尺寸集成电路的稳定性至关重要。本文利用原位透射电子显微(transmission electron microscopy,TEM)技术,在原子尺度下研究了电迁移诱导BCC金属W表面结构动态演变过程。结果表明,自由表面是主要电迁移路径;而{110}面和<111>方向分别是优选的迁移面迁移方向;电迁移过程中W表面形成特定的原子台阶或锯齿状结构。对于非低能晶面{002},在电流作用下仍能发生定向迁移,形成新的台阶结构。研究结果揭示了电迁移过程中表面结构的演化规律,为优化BCC金属材料的微观结构设计、提高其在高电流密度环境下的结构性能稳定性提供借鉴。
基金supported by the National Key Research and Development Program of China under the theme“Research on urban sustainable development interactive decision-making and management technologies”[Grant No.2022YFC3802904].
文摘Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as a representative case study due to its rich landscape resources and status as a national innovation demonstration zone for implementing the 2030 Agenda for Sustainable Development.This study uses bibliometric visualization tools like CiteSpace and VOSviewer to analyze research trends from 1980 to 2021 in the Chinese Academic Journal Network Publishing Database(CNKI).The results show increasing academic interest over three stages:initiation(1982-1997),exploration(1998-2004),and diversified development(2005-2021).Contributions are predominantly from local academic and tourism sectors,indicating a strong regional influence;however,relatively weak interinstitutional collaboration occurs,suggesting potential for more integrated research efforts.Primary research is also concentrated within economic disciplines,particularly tourism-related ones.The evolution of research frontiers reveals three main paths:urban development strategies,industrial economic theories and empirical validation,and ecosystem analysis and evaluation.A multidisciplinary approach and stronger collaborative efforts are crucial to enhance research on ecological values and empirical models while supporting evidence-based urban development strategies in Guilin City and comparable cities globally.
文摘In order to further ensure that the 2030 Agenda for Sustainable Development is to be implemented and the action measures of all countries are consistent, the United Nations has put forward a set of indicators to monitor and evaluate the progress of global sustainable development. This set of evaluation indicators is aimed for global and regional progress. An important feature of the evaluation indicators is that they are internationally comparable, but due to the large differences in the levels of sustainable development among countries, this framework of evaluation indicators has a disadvantage that it does not apply to tracking the progress of sustainable development at the national level. This paper focuses on the analysis of specific issues in the application of the global sustainable development indicators framework to meet the goals and targets of the UN and builds a system of evaluation indicators to assess the progress of sustainable development at the national level in China, and offers a perspective to assess China’s progress as well.
基金supported by the National Basic Research Program of China (973 Program) (Grant No.2015CB453200)
文摘In this study,we evaluate the forecast skill of the subseasonal-to-seasonal(S2S)prediction model of the Beijing Climate Center(BCC)for the boreal summer intraseasonal oscillation(BSISO).We also discuss the key factors that inhibit the BSISO forecast skill in this model.Based on the bivariate anomaly correlation coefficient(ACC)of the BSISO index,defined by the first two EOF modes of outgoing longwave radiation and 850-hPa zonal wind anomalies over the Asian monsoon region,we found that the hindcast skill degraded as the lead time increased.The ACC dropped to below 0.5for lead times of 11 days and longer when the predicted BSISO showed weakened strength and insignificant northward propagation.To identify what causes the weakened forecast skill of BSISO at the forecast lead time of 11 days,we diagnosed the main mechanisms responsible for the BSISO northward propagation.The same analysis was also carried out using the observations and the outputs of the four-day forecast lead that successfully predicted the observed northward-propagating BSISO.We found that the lack of northward propagation at the 11-day forecast lead was due to insufficient increases in low-level cyclonic vorticity,moistening and warm temperature anomalies to the north of the convection,which were induced by the interaction between background mean flows and BSISO-related anomalous fields.The BCC S2S model can predict the background monsoon circulations,such as the low-level southerly and the northerly and easterly vertical shears,but has limited capability in forecasting the distributions of circulation and moisture anomalies.
基金the National Natural Science Foundation of China, No. 30070775 a grant from the Scientific Research Foundation of Liaoning Department of Education, No. 2005L5371
文摘BACKGROUND： Animal experiments and clinical studies about tissue engineering method applied to repair nerve injury mainly focus on seeking ideal artificial nerve grafts, nerve conduit and seed cells. Autologous nerve, allogeneic nerve and xenogeneic nerve are used to bridge nerve defects, it is one of the methods to promote the repair of nerve injury by culturing and growing Schwann cells, which can secrete various neurotrophic factor activities, in the grafts. OBJECTIVE ： To observe the effect of acellular nerve grafts co-cultured with Schwann cells in repairing defects of sciatic nerve. DESIGN： An observational comparative study.SETTING： Tissue Engineering Laboratory of China Medical University.MATERIALS： The experiment was carried out in the Tissue Engineering Laboratory of China Medical University between April 2004 and April 2005. Forty neonatal Sprague-Dawley rats of 5-8 days （either males or females） and 24 male Wistar rats of 180-220 g were provided by the experimental animal center of China Medical University. METHODS： ① Culture of Schwann cells： The bilateral sciatic nerves and branchial plexus were isolated from the 40 neonatal SD rats. The sciatic nerves were enzymatically digested with collagenase and dispase, isolatd, purified and cultured with the method of speed-difference adhersion, and identified with the SABC immunohistochemical method. ② Model establishment： In vitro Schwann cells were microinjected into 10-mm long acellular nerve grafts repairing a surgically created gap in the rat sciatic nerve. According to the different grafted methods, the animals were randomly divided into three groups： autografts （n=8）, acellular nerve grafts （n=8）, or acellular nerve grafts with Schwann cells （n=8）. ③ The regenerated nerve fiber number and average diameter of myeline sheath after culture were statistically anlayzed. MAIN OUTCOME MEASURES： ① The regenerated nerve ultrastructure, total number and density of myelinated nerve fibers, and the thickness of myeline sheath were observed under electron microscope. ② The images were processed with the Mias-1000 imaging analytical system to calculate the number of myelinated nerve fibers, and the thickness of myeline sheath. RESULTS： All the 24 Wistar rats were involved in the analysis of results. ① Results observed under transmission electron microscope： The regenerated myelinated nerve fibers in the group of acellular nerve grafts with Schwann cells were more even than those in the group of acellular nerve grafts, the number of myelinated nerve fibers and thickness of myelin sheath were close to those in the allografts group （P 〉 0.05）, but significantly different from those in the group of acellular nerve grafts （P 〈 0.05）. ② Results observed under scanning electron microscope： A great amount of Schwann cells with two polars were observed in the group of grafts with Schwann cells, the feature of cultured Schwann cells showed shoulder by shoulder, head to head. ③ The number of myelinated nerve fibers and thickness of myelin sheath analyzed by Mias-1000 imaging system in the group of acellular nerve grafts with Schwann cells were close to those in the autografts group （P 〉 0.05）, but significantly different from those in the group of acellular nerve grafts （P 〈 0.05）.CONCLUSION： Host axonal regeneration is significantly increased after implant of acellular nerve grafts. Acellular nerve grafts with Schwann cells offers a novel approach for repairing the gap of nerve defect.
基金Western and Frontier Region Project of Humanities and Social Sciences Research of the Ministry of Education(20XJA630001)Research project of Shaanxi Provincial Key Think Tank on Major Theoretical and Practical issues of Philosophy and Social Sciences(2021ZD1011)+2 种基金Research Project on Major Theoretical and Practical Problems in Social Science Circles of Shaanxi Province(2020Z394)Soft Science Project of Xi'an Science and Technology Plan(2019111713RKX001SF005-3)Key Scientific Research Program of Shaanxi Provincial Department of Education(new think tank project)(20JT025).
文摘Service-oriented manufacturing is an emerging innovative development model,and its core is the deep integration of products and services.It has become a hot issue in current research.In order to deeply explore the evolution path of servitization transformation of manufacturing enterprises,ShaanGu Group is taken as a case,and discusses practical application of service-oriented manufacturing model in different development processes of ShaanGu Group.Thus,four stages of transformation of ShaanGu Group through servitization are summarized:specialized after-sales service stage,rental service stage,engineering complete service stage and financial service stage.Through comparative research,it is found that general evolution path of manufacturing enterprises to service transformation is:the primary stage(providing product-oriented product service system)→the intermediate stage(providing application-oriented product service system)→the advanced stage(providing utility-oriented product service system)→the completed stage(providing pure service).On this basis,some suggestions are provided for manufacturing enterprises to integrate productive services in the process of transformation.
