背景与目的肺浸润性黏液腺癌(invasive mucinous adenocarcinoma of the lung,IMA)是肺腺癌中一种少见且特殊的类型,该类肿瘤的特点往往是少有淋巴结转移,因此对于该类肿瘤的预后评估依靠现有的肿瘤原发灶-淋巴结-转移(tumor-node-metas...背景与目的肺浸润性黏液腺癌(invasive mucinous adenocarcinoma of the lung,IMA)是肺腺癌中一种少见且特殊的类型,该类肿瘤的特点往往是少有淋巴结转移,因此对于该类肿瘤的预后评估依靠现有的肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期存在困难。本研究的目的是构建列线图来预测术后淋巴结阴性的IMA患者的预后。方法根据纳入标准和排除标准,回顾性分析2012年7月至2017年5月宁波大学附属李惠利医院(训练队列,n=78)和宁波市第二医院(验证队列,n=66)胸外科收治的术后病理为淋巴结阴性的IMA患者的资料,分析训练队列的临床病理特征的预后价值并建立预后预测模型,并对模型性能进行评价,最后将验证队列的数据代入进行外部验证。结果单因素分析显示肺炎型、较大的肿块、包含黏液和非黏液成分的混合型、较高的总分期是5年无进展生存期(progression-free survival,PFS)及总生存期(overall survival,OS)的影响因素。多因素分析进一步表明,影像学分型、肿块大小、黏液成分是5年PFS及OS的独立预后因素。5年PFS率和OS率分别为62.82%和75.64%,亚组的生存分析显示,肺炎型和包含黏液和非黏液成分的混合型IMA患者的5年PFS及OS分别明显低于孤立型和纯黏液型IMA患者。5年PFS和OS的Harrell’s C指数分别为0.815(95%CI:0.741-0.889)和0.767(95%CI:0.669-0.865),这两个模型的校准曲线及决策曲线分析(decision curve analysis,DCA)在两个队列中显示出良好的预测性能。结论本次基于临床病理特征构建的列线图在一定程度上可以作为IMA切除术后淋巴结阴性患者的一种有效预后预测工具。展开更多
In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was conducted.This research included quantitative mea...In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was conducted.This research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat release.The results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same capacity.Based on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different capacities.Utilizing this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.展开更多
Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the ...Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived mice.CCFM1025 improved the body weight and food and water intake of the mice.It also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related behaviours.CCFM1025 significantly altered the gut microbial composition and genome function.Key microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the serum.Those metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1.Collectively,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites.These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.展开更多
By both the Charpy V-notched impact and the projectile tests, we here investigated the dynamic fracture behavior of a recently developed ultrastrong lightweight steel comprising a hierarchical martensitic matrix, disp...By both the Charpy V-notched impact and the projectile tests, we here investigated the dynamic fracture behavior of a recently developed ultrastrong lightweight steel comprising a hierarchical martensitic matrix, dispersed ultra-fine-retained austenite grains and oriented δ-ferrite lamellas, the latter being due to high Al and Si contents employed for low-density design. This steel shows a superior combination of specific ultimate tensile strength and impact toughness to other ultrastrong steels and has successfully arrested a real steel-cored bullet shot. These are attributed to the densely textured δ-ferrite lamellas that can deflect the propagating cracks until they are trapped and enclosed besides austenite-to-martensite transformation crack closure, leading to more energy consumed before failure. These results suggest a new pathway for toughening ultrastrong lightweight steels.展开更多
Radiation pattern captures the electromagnetic performance of reflector antennas,which is significantly affected by the deformation of the primary reflector due to gravity and the displacement of the secondary reflect...Radiation pattern captures the electromagnetic performance of reflector antennas,which is significantly affected by the deformation of the primary reflector due to gravity and the displacement of the secondary reflector.During the design process of large reflector antennas,a substantial amount of time is often dedicated to iteratively adjusting structural parameters and validating electromagnetic performance.To improve the efficiency of the design process,we first propose an approximate calculation method of optical path difference(OPD)for the deformation of the primary reflector under gravity and the displacement of the secondary reflector.Then an OPD fitting function based on the modified Zernike polynomials is proposed to capture the phase difference of radiation over the aperture plane,based on which the radiation pattern will be obtained quickly by the aperture field integration method.Numerical experiments demonstrate the effectiveness of the proposed quick calculation method for analyzing the radiation pattern of a 10.4 m submillimeter telescope antenna at its highest operating frequency of 856 GHz.In comparison with the numerical simulation method based on GRASP(which is an antenna electromagnetic analysis tool combining physical optics(PO)and physical theory of diffraction(PTD)),the quick calculation method reduces the time for radiation pattern analysis from more than one hour to less than two minutes.Furthermore,the quick calculation method exhibits excellent accuracy for the figure of merit(FOM)of the radiation pattern.Therefore,the proposed quick calculation method can obtain the radiation pattern with high speed and accuracy.Compared to the time-consuming numerical simulation method(PO and PTD),it can be employed for quick analysis of the radiation pattern for the lateral displacement of the secondary reflector and the deformation of the primary reflector under gravity in the design process of a reflector antenna.展开更多
Leighton Chajnantor Telescope(LCT), i.e., the former Caltech Submillimeter Observatory telescope, will be refurbished at the new site in Chajnantor Plateau, Chile in 2023. The environment of LCT will change significan...Leighton Chajnantor Telescope(LCT), i.e., the former Caltech Submillimeter Observatory telescope, will be refurbished at the new site in Chajnantor Plateau, Chile in 2023. The environment of LCT will change significantly after its relocation, and the telescope will be exposed to large wind disturbances directly because its enclosure will be completely open during observation. The wind disturbance is expected to be a challenge for LCT's pointing control since the existing control method cannot reject this disturbance very well. Therefore, it is very necessary to develop a new pointing control method with good capability of disturbance rejection. In this research, a disturbance observer—based composite position controller(DOB-CPC) is designed, in which an H∞feedback controller is employed to compress the disturbance, and a feedforward linear quadratic regulator is employed to compensate the disturbance precisely based on the estimated disturbance signal. Moreover, a controller switching policy is adopted, which applies the proportional controller to the transient process to achieve a quick response and applies the DOB-CPC to the steady state to achieve a small position error. Numerical experiments are conducted to verify the good performance of the proposed pointing controller(i.e., DOB-CPC) for rejecting the disturbance acting on LCT.展开更多
BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving resection.The current globally recognized evaluation method has many drawbacks and its subjectivity ...BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving resection.The current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of LARS.AIM To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of LARS.METHODS We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS score.RESULTS In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of LARS.The comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation methods.There was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.展开更多
Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to...Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to November 2021 were randomly selected,and all samples were manually microscopic examined after the detection of the UN9000 urine analysis line.The intelligent audit rules(including the microscopic review rules and manual verification rules)were validated based on the manual microscopic examination and manual audit,and the rules were adjusted to apply to our laboratory.The laboratory turnaround time(TAT)before and after the application of intelligent audit rules was compared.Result:The microscopic review rate of intelligent rules was 25.63%(292/1139),the true positive rate,false positive rate,true negative rate,and false negative rate were 27.66%(315/1139),6.49%(74/1139),62.34%(710/1139)and 3.51%(40/1139),respectively.The approval consistency rate of manual verification rules was 84.92%(727/856),the approval inconsistency rate was 0%(0/856),the interception consistency rate was 12.61%(108/856),and the interception inconsistency rate was 0%(0/856).Conclusion:The intelligence audit rules for urine analysis by Cui et al.have good clinical applicability in our laboratory.展开更多
In recent years,sEMG(surface electromyography)signals have been increasingly used to operate wearable devices.The development of mechanical lower limbs or exoskeletons controlled by the nervous system requires greater...In recent years,sEMG(surface electromyography)signals have been increasingly used to operate wearable devices.The development of mechanical lower limbs or exoskeletons controlled by the nervous system requires greater accuracy in recognizing lower limb activity.There is less research on devices to assist the human body in uphill movements.However,developing controllers that can accurately predict and control human upward movements in real-time requires the employment of appropriate signal pre-processing methods and prediction algorithms.For this purpose,this paper investigates the effects of various sEMG pre-processing methods and algorithms on the prediction results.This investigation involved ten subjects(five males and five females)with normal knee joints.The relevant data of the subjects were collected on a constructed ramp.To obtain feature values that reflect the gait characteristics,an improved PCA algorithm based on the kernel method is proposed for dimensionality reduction to remove redundant information.Then,a new model(CNN+LSTM)was proposed to predict the knee joint angle.Multiple approaches were utilized to validate the superiority of the improved PCA method and CNN-LSTM model.The feasibility of the method was verified by analyzing the gait prediction results of different subjects.Overall,the prediction time of the method was 25 ms,and the prediction error was 1.34±0.25 deg.By comparing with traditional machine learning methods such as BP(backpropagation)neural network,RF(random forest),and SVR(support vector machine),the improved PCA algorithm processed data performed the best in terms of convergence time and prediction accuracy in CNN-LSTM model.The experimental results demonstrate that the proposed method(improved PCA+CNN-LSTM)effectively recognizes lower limb activity from sEMG signals.For the same data input,the EMG signal processed using the improved PCA method performed better in terms of prediction results.This is the first step toward myoelectric control of aided exoskeleton robots using discrete decoding.The study results will lead to the future development of neuro-controlled mechanical exoskeletons that will allow troops or disabled individuals to engage in a greater variety of activities.展开更多
Leaf,spike,stem,and root morphologies are key factors that determine crop growth,development,and productivity.Multiple genes that control these morphological traits have been identified in Arabidopsis,rice,maize,and o...Leaf,spike,stem,and root morphologies are key factors that determine crop growth,development,and productivity.Multiple genes that control these morphological traits have been identified in Arabidopsis,rice,maize,and other plant species.However,little is known about the genomic regions and genes associated with morphological traits in wheat.Here,we identified the ethyl methanesulfonate-derived mutant wheat line M133 that displays multiple morphological changes that include upward-curled leaves,paired spikelets,dwarfism,and delayed heading.Using bulked segregant RNA sequencing(BSR-seq)and a high-resolution genetic map,we identified TraesCS1D02G155200(HBD2)as a potential candidate gene.HB-D2 encodes a class III homeodomain-leucine zipper(HD-ZIP III)transcription factor,and the mutation was located in the miRNA165/166 complementary site,resulting in a resistant allele designated rHb-D2.The relative expression of rHb2 in the mutant plants was significantly higher(P<0.01)than in plants homozygous for the WT allele.Independent resistant mutations that disrupt the miRNA165/166 complementary sites in the A-(rHb-A2)and B-genome(rHb-B2)homoeologs showed similar phenotypic alterations,but the relative intensity of the effects was different.Transgenic plants expressing rHb-D2 gene driven by the maize UBIQUITIN(UBI)promoter showed similar phenotypes to the rHb-D2 mutant.These results confirmed that HB-D2 is the causal gene responsible for the mutant phenotypes.Finally,a survey of 1397 wheat accessions showed that the complementary sites for miRNA165/166 in all three HB2 homoeologs are highly conserved.Our results suggest that HB2 plays an important role in regulating growth and development in wheat.展开更多
Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host d...Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host disease(GVHD)and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life.In addition,GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions(DLIs)and chimeric antigen receptor(CAR)T-cell therapy.Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells,universal immune cell therapy may strongly reduce GVHD,while simultaneously reducing tumor burden.Nevertheless,widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy.Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy,including the use of universal cell lines,signaling regulation and CAR technology.In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives.展开更多
Piezocatalysis has attracted unprecedented research interest as a newly emerging catalysis technology.However,the inherent insulating property of ferroelectric materials ultimately leads to the poor vibration-electric...Piezocatalysis has attracted unprecedented research interest as a newly emerging catalysis technology.However,the inherent insulating property of ferroelectric materials ultimately leads to the poor vibration-electricity conversion ability.Herein,this work reports the(K_(0.52)Na_(0.48))NbO_(3) ferroelectric ceramics(KNNFCx),for which the FeCo modification strategy is proposed.The substitution of the moderate amount of FeCo(x=0.015)at Nb site not only optimizes ferroelectricity but also produces beneficial defects,notably increasing Rhodamine B water purification efficiency to 95%.The pinning effect of monovalent oxygen vacancies on ferroelectric domains is responsible for the excellent ferroelectric polarization of KNNFC0.015 through the generation of an internal field to promote charge carriers separation and reduce nonradiative recombination.Importantly,the accompanying electron carriers can easily move to the material surface and participate in redox reactions because they have low activation energy.Therefore,ferroelectric polarization and defects play synergetic roles in enhancing piezocatalytic performance.展开更多
Leighton Chajnantor Telescope(LCT)will be moved from the summit of Maunakea,Hawaii to Chajnantor Plateau,Chile and be refurbished there.Strong wind disturbance at the new site will bring great challenges to the servo ...Leighton Chajnantor Telescope(LCT)will be moved from the summit of Maunakea,Hawaii to Chajnantor Plateau,Chile and be refurbished there.Strong wind disturbance at the new site will bring great challenges to the servo control of LCT.It is necessary and important to develop a simulation platform that behaves as close as possible to the real telescope for testing the performance of the designed servo controller.In this paper,a collaborative simulation platform of LCT based on Adams and Matlab/Simulink is constructed.On this platform,the mechanical structure model of LCT can be integrated with its control system model such that a collaborative simulation of the mechanical structure and the control system of LCT can be conducted.The mechanical structure model of LCT,which contains both rigid body models(i.e.,the mount)and flexible body models(i.e.,the primary reflector),is developed by using Adams.The servo system model and the wind disturbance model are constructed by using Matlab/Simulink.By conducting collaborative simulation,the performances of the servo controller based on the rigid body model and the rigid-flexible coupling model of LCT are compared.The comparison shows that the controller designed based on the rigid body model does not perform well when it is employed to control the rigid-flexible coupling model of LCT.However,by readjusting parameters of the servo controller,its performance can be further improved when applied to the rigid-flexible coupling model.Therefore,an LCT model of integrated mechanical structure and control systems is very helpful for analyzing its performance more accurately and designing a better servo controller.展开更多
基金supported by the New Energy Vehicle Power Battery Life Cycle Testing and Verification Public Service Platform Project[2022-235-224]the Beijing Science and Technology Planning Project[Z221100005222004]+1 种基金the Key Technologies Research and Development Program[2021YFB2012504]the Beijing Goldenbridge Project[ZZ2023002]。
文摘In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was conducted.This research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat release.The results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same capacity.Based on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different capacities.Utilizing this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.
基金the financial support from Natural Science Foundation of Jiangsu Province(BK20210456)the National Natural Science Foundation of China(32201988,31972052,32021005,31820103010)+4 种基金the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501)the China National Postdoctoral Program for Innovative Talents(BX2021114)China Postdoctoral Science Foundation(2021M691290)the Postdoctoral Science Foundation of Jiangsu Province(2021K127B)the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province。
文摘Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived mice.CCFM1025 improved the body weight and food and water intake of the mice.It also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related behaviours.CCFM1025 significantly altered the gut microbial composition and genome function.Key microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the serum.Those metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1.Collectively,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites.These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.
基金financial support from National Natural Science Foundation of China(Grant Nos.51831002,51904028 and 52233018),ChinaFundamental Research Funds for the Central Universities(Grant No.06500151),China.
文摘By both the Charpy V-notched impact and the projectile tests, we here investigated the dynamic fracture behavior of a recently developed ultrastrong lightweight steel comprising a hierarchical martensitic matrix, dispersed ultra-fine-retained austenite grains and oriented δ-ferrite lamellas, the latter being due to high Al and Si contents employed for low-density design. This steel shows a superior combination of specific ultimate tensile strength and impact toughness to other ultrastrong steels and has successfully arrested a real steel-cored bullet shot. These are attributed to the densely textured δ-ferrite lamellas that can deflect the propagating cracks until they are trapped and enclosed besides austenite-to-martensite transformation crack closure, leading to more energy consumed before failure. These results suggest a new pathway for toughening ultrastrong lightweight steels.
基金supported by Open Fund of State Key Laboratory of Infrared Physics,Shanghai Institute of Technical Physics,Chinese Academy of Sciences。
文摘Radiation pattern captures the electromagnetic performance of reflector antennas,which is significantly affected by the deformation of the primary reflector due to gravity and the displacement of the secondary reflector.During the design process of large reflector antennas,a substantial amount of time is often dedicated to iteratively adjusting structural parameters and validating electromagnetic performance.To improve the efficiency of the design process,we first propose an approximate calculation method of optical path difference(OPD)for the deformation of the primary reflector under gravity and the displacement of the secondary reflector.Then an OPD fitting function based on the modified Zernike polynomials is proposed to capture the phase difference of radiation over the aperture plane,based on which the radiation pattern will be obtained quickly by the aperture field integration method.Numerical experiments demonstrate the effectiveness of the proposed quick calculation method for analyzing the radiation pattern of a 10.4 m submillimeter telescope antenna at its highest operating frequency of 856 GHz.In comparison with the numerical simulation method based on GRASP(which is an antenna electromagnetic analysis tool combining physical optics(PO)and physical theory of diffraction(PTD)),the quick calculation method reduces the time for radiation pattern analysis from more than one hour to less than two minutes.Furthermore,the quick calculation method exhibits excellent accuracy for the figure of merit(FOM)of the radiation pattern.Therefore,the proposed quick calculation method can obtain the radiation pattern with high speed and accuracy.Compared to the time-consuming numerical simulation method(PO and PTD),it can be employed for quick analysis of the radiation pattern for the lateral displacement of the secondary reflector and the deformation of the primary reflector under gravity in the design process of a reflector antenna.
文摘Leighton Chajnantor Telescope(LCT), i.e., the former Caltech Submillimeter Observatory telescope, will be refurbished at the new site in Chajnantor Plateau, Chile in 2023. The environment of LCT will change significantly after its relocation, and the telescope will be exposed to large wind disturbances directly because its enclosure will be completely open during observation. The wind disturbance is expected to be a challenge for LCT's pointing control since the existing control method cannot reject this disturbance very well. Therefore, it is very necessary to develop a new pointing control method with good capability of disturbance rejection. In this research, a disturbance observer—based composite position controller(DOB-CPC) is designed, in which an H∞feedback controller is employed to compress the disturbance, and a feedforward linear quadratic regulator is employed to compensate the disturbance precisely based on the estimated disturbance signal. Moreover, a controller switching policy is adopted, which applies the proportional controller to the transient process to achieve a quick response and applies the DOB-CPC to the steady state to achieve a small position error. Numerical experiments are conducted to verify the good performance of the proposed pointing controller(i.e., DOB-CPC) for rejecting the disturbance acting on LCT.
文摘BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving resection.The current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of LARS.AIM To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of LARS.METHODS We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS score.RESULTS In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of LARS.The comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation methods.There was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.
文摘Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to November 2021 were randomly selected,and all samples were manually microscopic examined after the detection of the UN9000 urine analysis line.The intelligent audit rules(including the microscopic review rules and manual verification rules)were validated based on the manual microscopic examination and manual audit,and the rules were adjusted to apply to our laboratory.The laboratory turnaround time(TAT)before and after the application of intelligent audit rules was compared.Result:The microscopic review rate of intelligent rules was 25.63%(292/1139),the true positive rate,false positive rate,true negative rate,and false negative rate were 27.66%(315/1139),6.49%(74/1139),62.34%(710/1139)and 3.51%(40/1139),respectively.The approval consistency rate of manual verification rules was 84.92%(727/856),the approval inconsistency rate was 0%(0/856),the interception consistency rate was 12.61%(108/856),and the interception inconsistency rate was 0%(0/856).Conclusion:The intelligence audit rules for urine analysis by Cui et al.have good clinical applicability in our laboratory.
文摘In recent years,sEMG(surface electromyography)signals have been increasingly used to operate wearable devices.The development of mechanical lower limbs or exoskeletons controlled by the nervous system requires greater accuracy in recognizing lower limb activity.There is less research on devices to assist the human body in uphill movements.However,developing controllers that can accurately predict and control human upward movements in real-time requires the employment of appropriate signal pre-processing methods and prediction algorithms.For this purpose,this paper investigates the effects of various sEMG pre-processing methods and algorithms on the prediction results.This investigation involved ten subjects(five males and five females)with normal knee joints.The relevant data of the subjects were collected on a constructed ramp.To obtain feature values that reflect the gait characteristics,an improved PCA algorithm based on the kernel method is proposed for dimensionality reduction to remove redundant information.Then,a new model(CNN+LSTM)was proposed to predict the knee joint angle.Multiple approaches were utilized to validate the superiority of the improved PCA method and CNN-LSTM model.The feasibility of the method was verified by analyzing the gait prediction results of different subjects.Overall,the prediction time of the method was 25 ms,and the prediction error was 1.34±0.25 deg.By comparing with traditional machine learning methods such as BP(backpropagation)neural network,RF(random forest),and SVR(support vector machine),the improved PCA algorithm processed data performed the best in terms of convergence time and prediction accuracy in CNN-LSTM model.The experimental results demonstrate that the proposed method(improved PCA+CNN-LSTM)effectively recognizes lower limb activity from sEMG signals.For the same data input,the EMG signal processed using the improved PCA method performed better in terms of prediction results.This is the first step toward myoelectric control of aided exoskeleton robots using discrete decoding.The study results will lead to the future development of neuro-controlled mechanical exoskeletons that will allow troops or disabled individuals to engage in a greater variety of activities.
基金supported by the Provincial Natural Science Foundation of Shandong(ZR2021MC056 and ZR2021ZD30)the Open Project Funding of the State Key Laboratory of Crop Stress Adaptation and Improvementfunded by Competitive Grant 202268013-36439(WheatCAP)from the USDA National Institute of Food and Agriculture。
文摘Leaf,spike,stem,and root morphologies are key factors that determine crop growth,development,and productivity.Multiple genes that control these morphological traits have been identified in Arabidopsis,rice,maize,and other plant species.However,little is known about the genomic regions and genes associated with morphological traits in wheat.Here,we identified the ethyl methanesulfonate-derived mutant wheat line M133 that displays multiple morphological changes that include upward-curled leaves,paired spikelets,dwarfism,and delayed heading.Using bulked segregant RNA sequencing(BSR-seq)and a high-resolution genetic map,we identified TraesCS1D02G155200(HBD2)as a potential candidate gene.HB-D2 encodes a class III homeodomain-leucine zipper(HD-ZIP III)transcription factor,and the mutation was located in the miRNA165/166 complementary site,resulting in a resistant allele designated rHb-D2.The relative expression of rHb2 in the mutant plants was significantly higher(P<0.01)than in plants homozygous for the WT allele.Independent resistant mutations that disrupt the miRNA165/166 complementary sites in the A-(rHb-A2)and B-genome(rHb-B2)homoeologs showed similar phenotypic alterations,but the relative intensity of the effects was different.Transgenic plants expressing rHb-D2 gene driven by the maize UBIQUITIN(UBI)promoter showed similar phenotypes to the rHb-D2 mutant.These results confirmed that HB-D2 is the causal gene responsible for the mutant phenotypes.Finally,a survey of 1397 wheat accessions showed that the complementary sites for miRNA165/166 in all three HB2 homoeologs are highly conserved.Our results suggest that HB2 plays an important role in regulating growth and development in wheat.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1103300)the National Natural Science Foundation of China(Grant No.82020108004)+3 种基金the Natural Science Foundation of Chongqing Innovation Group Science Program(Grant No.cstc2021jcyjcxttX0001)the Natural Science Foundation of Chongqing(Grant No.CSTB2022NSCQ-MSX1060)the Special Project for Talent Construction in Xinqiao Hospital(Grant No.2022XKRC001)the National College Student Innovation and Entrepreneurship Training Program(Grant No.202190035001).
文摘Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host disease(GVHD)and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life.In addition,GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions(DLIs)and chimeric antigen receptor(CAR)T-cell therapy.Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells,universal immune cell therapy may strongly reduce GVHD,while simultaneously reducing tumor burden.Nevertheless,widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy.Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy,including the use of universal cell lines,signaling regulation and CAR technology.In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives.
基金supported by the National Natural Science Foundation of China (Nos.52172116 and 62171214)the Natural Science Basic Research Program of Shaanxi (Nos.2021JQ-655,2020JQ-828,2021JQ-188,2021JM-442,and 2020JQ-822)+2 种基金the Shaanxi Provincial Association of Science and Technology Youth Talents Lifting Plan (No.20180418)the Scientific Research Foundation for Ph.D.of Xi’an Polytechnic University (No.BS201877)the Special Scientific Research Project in Shaanxi Province Department of Education (No.21JK0653).
文摘Piezocatalysis has attracted unprecedented research interest as a newly emerging catalysis technology.However,the inherent insulating property of ferroelectric materials ultimately leads to the poor vibration-electricity conversion ability.Herein,this work reports the(K_(0.52)Na_(0.48))NbO_(3) ferroelectric ceramics(KNNFCx),for which the FeCo modification strategy is proposed.The substitution of the moderate amount of FeCo(x=0.015)at Nb site not only optimizes ferroelectricity but also produces beneficial defects,notably increasing Rhodamine B water purification efficiency to 95%.The pinning effect of monovalent oxygen vacancies on ferroelectric domains is responsible for the excellent ferroelectric polarization of KNNFC0.015 through the generation of an internal field to promote charge carriers separation and reduce nonradiative recombination.Importantly,the accompanying electron carriers can easily move to the material surface and participate in redox reactions because they have low activation energy.Therefore,ferroelectric polarization and defects play synergetic roles in enhancing piezocatalytic performance.
文摘Leighton Chajnantor Telescope(LCT)will be moved from the summit of Maunakea,Hawaii to Chajnantor Plateau,Chile and be refurbished there.Strong wind disturbance at the new site will bring great challenges to the servo control of LCT.It is necessary and important to develop a simulation platform that behaves as close as possible to the real telescope for testing the performance of the designed servo controller.In this paper,a collaborative simulation platform of LCT based on Adams and Matlab/Simulink is constructed.On this platform,the mechanical structure model of LCT can be integrated with its control system model such that a collaborative simulation of the mechanical structure and the control system of LCT can be conducted.The mechanical structure model of LCT,which contains both rigid body models(i.e.,the mount)and flexible body models(i.e.,the primary reflector),is developed by using Adams.The servo system model and the wind disturbance model are constructed by using Matlab/Simulink.By conducting collaborative simulation,the performances of the servo controller based on the rigid body model and the rigid-flexible coupling model of LCT are compared.The comparison shows that the controller designed based on the rigid body model does not perform well when it is employed to control the rigid-flexible coupling model of LCT.However,by readjusting parameters of the servo controller,its performance can be further improved when applied to the rigid-flexible coupling model.Therefore,an LCT model of integrated mechanical structure and control systems is very helpful for analyzing its performance more accurately and designing a better servo controller.
