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c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses 被引量:3
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作者 Xu-Yan Wang Yuan Wei +12 位作者 Bo Hu Yuan Liao Xiaodong Wang Wen-Hua Wan Chun-Xiang Huang Mahepali Mahabati zheng-yu liu Jing-Rui Qu Xiao-Dan Chen Dong-Ping Chen Dong-Ming Kuang Xue-Hao Wang Yun Chen 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第5期1735-1745,共11页
B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)... B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)cells in humans is still lacking.Here,we demonstrate that,although IL-10 itself is anti-inflammatory,IL-10+functional B_(reg)cells in patients with systemic lupus erythematosus(SLE)display aggressive inflammatory features;these features shift their functions away from inducing CD8^(+)T cell tolerance and cause them to induce a pathogenic CD4^(+)T cell response. 展开更多
关键词 INFLAMMATORY clinical FUNCTIONAL
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