Traditional Chinese Medicine(TCM)is one of the most promising programs for disease prevention and treatment.Meanwhile,the quality of TCM has garnered much attention.To ensure the quality of TCM,many works are based on...Traditional Chinese Medicine(TCM)is one of the most promising programs for disease prevention and treatment.Meanwhile,the quality of TCM has garnered much attention.To ensure the quality of TCM,many works are based on the blockchain scheme to design the traceability scheme of TCM to trace its origin.Although these schemes can ensure the integrity,sharability,credibility,and immutability of TCM more effectively,many problems are exposed with the rapid growth of TCM data in blockchains,such as expensive overhead,performance bottlenecks,and the traditional blockchain architecture is unsuitable for TCM data with dynamic growth.Motivated by the aforementioned problems,we propose a novel and lightweight TCM traceability architecture based on the blockchain using sharding(LBS-TCM).Compared to the existing blockchain-based TCM traceability system,our architecture utilizes sharding to develop a novel traceability mechanism that supports more convenient traceability operations for TCM requirements such as uploading,querying,and downloading.Specifically,our architecture consists of a leader shard blockchain layer as its main component,which employs a sharding mechanism to conveniently TCM tracing.Empirical evaluations demonstrated that our architecture showed better performance in many aspects compared to traditional blockchain architectures,such as TCM transaction processing,TCM transaction querying,TCM uploading,etc.In our architecture,tracing TCM has become a very efficient operation,which ensures the quality of TCM and provides great convenience for subsequent TCM analysis and retrospective research.展开更多
Thermoelectric materials can be used to convert heat to electric power through the Seebeck effect. We study magneto-thermoelectric figure of merit(ZT) in three-dimensional Dirac semimetal Cd_3As_2 crystal.It is found ...Thermoelectric materials can be used to convert heat to electric power through the Seebeck effect. We study magneto-thermoelectric figure of merit(ZT) in three-dimensional Dirac semimetal Cd_3As_2 crystal.It is found that enhancement of power factor and reduction of thermal conductivity can be realized at the same time through magnetic field although magnetoresistivity is greatly increased. ZT can be highly enhanced from 0.17 to 1.1 by more than six times around 350 K under a perpendicular magnetic field of 7 T. The huge enhancement of ZT by magnetic field arises from the linear Dirac band with large Fermi velocity and the large electric thermal conductivity in Cd_3As_2. Our work paves a new way to greatly enhance the thermoelectric performance in the quantum topological materials.展开更多
First-principles calculations show that the pulse laser induced graphite-to-diamond phase transition is related to the lattice stress generated by the excited carriers,termed as "quantum electronic stress(QES)&qu...First-principles calculations show that the pulse laser induced graphite-to-diamond phase transition is related to the lattice stress generated by the excited carriers,termed as "quantum electronic stress(QES)".We found that the excited carriers in graphite generate a large anisotropic QES that increases linearly with the increasing carrier density.Using the QES as a guiding parameter,structural relaxation spontaneously transforms the graphite phase into the diamond phase,as the QES is reduced and minimized.Our results suggest that the concept of QES can be generally applied as a good measure to characterize the pulse laser induced phase transitions,in analogy to pressure induced phase transitions.展开更多
The diversity of body plans of mammals accelerates the innovation of lifestyles and the extensive adaptation to different habitats,including terrestrial,aerial and aquatic habitats.However,the genetic basis of those p...The diversity of body plans of mammals accelerates the innovation of lifestyles and the extensive adaptation to different habitats,including terrestrial,aerial and aquatic habitats.However,the genetic basis of those phenotypic modifications,which have occurred during mammalian evolution,remains poorly explored.In the present study,we synthetically surveyed the evolutionary pattern of Hox clusters that played a powerful role in the morphogenesis along the head-tail axis of animal embryos and the main regulatory factors(Mll,Bmi1 and E2f6)that control the expression of Hox genes.A deflected density of repetitive elements and lineage-specific radical mutations of Mll have been determined in marine mammals with morphological changes,suggesting that evolutionary changes may alter Hox gene expression in these lineages,leading to the morphological modification of these lineages.Although no positive selection was detected at certain ancestor nodes of lineages,the increasedωvalues of Hox genes implied the relaxation of functional constraints of these genes during the mammalian evolutionary process.More importantly,49 positively-selected sites were identified in mammalian lineages with phenotypic modifications,indicating adaptive evolution acting on Hox genes and regulatory factors.In addition,3 parallel amino acid substitutions in some Hox genes were examined in marine mammals,which might be responsible for their streamlined body.展开更多
Generally,the topological corner state in two-dimensional(2D)second-order topological insulator(SOTI)is equivalent to the well-known domain wall state,which is originated from the mass-inversion between two adjacent e...Generally,the topological corner state in two-dimensional(2D)second-order topological insulator(SOTI)is equivalent to the well-known domain wall state,which is originated from the mass-inversion between two adjacent edges with phase shift ofπ.In this work,go beyond this conventional physical picture,we report a fractional mass-kink induced 2D SOTI in monolayer FeSe with canted checkerboard antiferromagnetic(AFM)order by analytic model and first-principles calculations.The canted spin associated in-plane Zeeman field can gap out the quantum spin Hall edge state of FeSe,forming a fractional mass-kink with phase shift ofπ/2 at the rectangular corner,and generating an in-gap topological corner state with fractional charge of e/4.Moreover,the topological corner state is robust to a finite perturbation,existing in both naturally and non-naturally cleaved corners,regardless of the edge orientation.Our results not only demonstrate a material system to realize the unique 2D AFM SOTI,but also pave a way to design the higher-order topological states from fractional mass-kink with arbitrary phase shift.展开更多
基金supported by the research and innovation program for graduate students of the Guangzhou University of Traditional Chinese MedicineThis work is also partially supported by the National Key Research and Development Program of China(2019YFC1710402)the research on tracing TCM Electronic Medical Records Based on the Lightweight Blockchain of Guangdong Provincial Bureau of Traditional Chinese Medicine(20222045).
文摘Traditional Chinese Medicine(TCM)is one of the most promising programs for disease prevention and treatment.Meanwhile,the quality of TCM has garnered much attention.To ensure the quality of TCM,many works are based on the blockchain scheme to design the traceability scheme of TCM to trace its origin.Although these schemes can ensure the integrity,sharability,credibility,and immutability of TCM more effectively,many problems are exposed with the rapid growth of TCM data in blockchains,such as expensive overhead,performance bottlenecks,and the traditional blockchain architecture is unsuitable for TCM data with dynamic growth.Motivated by the aforementioned problems,we propose a novel and lightweight TCM traceability architecture based on the blockchain using sharding(LBS-TCM).Compared to the existing blockchain-based TCM traceability system,our architecture utilizes sharding to develop a novel traceability mechanism that supports more convenient traceability operations for TCM requirements such as uploading,querying,and downloading.Specifically,our architecture consists of a leader shard blockchain layer as its main component,which employs a sharding mechanism to conveniently TCM tracing.Empirical evaluations demonstrated that our architecture showed better performance in many aspects compared to traditional blockchain architectures,such as TCM transaction processing,TCM transaction querying,TCM uploading,etc.In our architecture,tracing TCM has become a very efficient operation,which ensures the quality of TCM and provides great convenience for subsequent TCM analysis and retrospective research.
基金supported by the National Key R&D Program of the Ministry of Science and Technology China(2017YFA0303001,2016YFA0300201 and 2017YFA0204904)the National Natural Science Foundation of China(11534010,11774325 and21603210)+4 种基金the Key Research Program of Frontier Sciences CAS(QYZDY-SSW-SLH021)Hefei Science Center CAS(2016HSCIU001)the Fundamental Research Funds for the Central UniversitiesSupercomputing Center at USTC for providing the computing resourcespartially performed on the Superconducting Magnet and PPMS-16T Facilities,High Magnetic Field Laboratory of CAS
文摘Thermoelectric materials can be used to convert heat to electric power through the Seebeck effect. We study magneto-thermoelectric figure of merit(ZT) in three-dimensional Dirac semimetal Cd_3As_2 crystal.It is found that enhancement of power factor and reduction of thermal conductivity can be realized at the same time through magnetic field although magnetoresistivity is greatly increased. ZT can be highly enhanced from 0.17 to 1.1 by more than six times around 350 K under a perpendicular magnetic field of 7 T. The huge enhancement of ZT by magnetic field arises from the linear Dirac band with large Fermi velocity and the large electric thermal conductivity in Cd_3As_2. Our work paves a new way to greatly enhance the thermoelectric performance in the quantum topological materials.
基金supported by the National Natural Science Foundation of China(Grant No.21603210)Chinese Youth 1000 Talents Program+1 种基金the Fundamental Research Funds for the Central Universitiesthe United States Department of Energy Basic Energy Sciences(Grant No.DE-FG0204ER46148)
文摘First-principles calculations show that the pulse laser induced graphite-to-diamond phase transition is related to the lattice stress generated by the excited carriers,termed as "quantum electronic stress(QES)".We found that the excited carriers in graphite generate a large anisotropic QES that increases linearly with the increasing carrier density.Using the QES as a guiding parameter,structural relaxation spontaneously transforms the graphite phase into the diamond phase,as the QES is reduced and minimized.Our results suggest that the concept of QES can be generally applied as a good measure to characterize the pulse laser induced phase transitions,in analogy to pressure induced phase transitions.
基金This work was supported by the National Natural Science Funds for Distinguished Young Scholars to G.Y.(grant number 31325025)the State Key Program of National Natural Science Foundation of China(NSFC)(grant number 31630071)+2 种基金the NSFC(grant numbers 31570379 to S.X.,31370401 to W.R.)the Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y.and S.X.the Natural Science Foundation of Jiangsu Province of China(grant number BK20141449)to S.X.
文摘The diversity of body plans of mammals accelerates the innovation of lifestyles and the extensive adaptation to different habitats,including terrestrial,aerial and aquatic habitats.However,the genetic basis of those phenotypic modifications,which have occurred during mammalian evolution,remains poorly explored.In the present study,we synthetically surveyed the evolutionary pattern of Hox clusters that played a powerful role in the morphogenesis along the head-tail axis of animal embryos and the main regulatory factors(Mll,Bmi1 and E2f6)that control the expression of Hox genes.A deflected density of repetitive elements and lineage-specific radical mutations of Mll have been determined in marine mammals with morphological changes,suggesting that evolutionary changes may alter Hox gene expression in these lineages,leading to the morphological modification of these lineages.Although no positive selection was detected at certain ancestor nodes of lineages,the increasedωvalues of Hox genes implied the relaxation of functional constraints of these genes during the mammalian evolutionary process.More importantly,49 positively-selected sites were identified in mammalian lineages with phenotypic modifications,indicating adaptive evolution acting on Hox genes and regulatory factors.In addition,3 parallel amino acid substitutions in some Hox genes were examined in marine mammals,which might be responsible for their streamlined body.
基金This work was supported by NSFC(Grant No.12174369,11774325,and 21603210)National Key Research and Development Program of China(Grant No.2017YFA0204904)Fundamental Research Funds for the Central Universities.
文摘Generally,the topological corner state in two-dimensional(2D)second-order topological insulator(SOTI)is equivalent to the well-known domain wall state,which is originated from the mass-inversion between two adjacent edges with phase shift ofπ.In this work,go beyond this conventional physical picture,we report a fractional mass-kink induced 2D SOTI in monolayer FeSe with canted checkerboard antiferromagnetic(AFM)order by analytic model and first-principles calculations.The canted spin associated in-plane Zeeman field can gap out the quantum spin Hall edge state of FeSe,forming a fractional mass-kink with phase shift ofπ/2 at the rectangular corner,and generating an in-gap topological corner state with fractional charge of e/4.Moreover,the topological corner state is robust to a finite perturbation,existing in both naturally and non-naturally cleaved corners,regardless of the edge orientation.Our results not only demonstrate a material system to realize the unique 2D AFM SOTI,but also pave a way to design the higher-order topological states from fractional mass-kink with arbitrary phase shift.
