The effect of Gd,Ce and Y elements on texture,recrystallization and mechanical properties of Mg–1.5Zn alloys was investigated.The results show that the addition of Gd,Ce and Y elements in Mg–1.5Zn alloy,which rolled...The effect of Gd,Ce and Y elements on texture,recrystallization and mechanical properties of Mg–1.5Zn alloys was investigated.The results show that the addition of Gd,Ce and Y elements in Mg–1.5Zn alloy,which rolled at 450℃ and subsequently annealed at 350℃ for 1h,can effectively weaken and modify the basal texture,characterized by the splitting basal pole toward to transverse direction,leading to the yield and tensile strength,the highest along the rolling direction and the lowest along the transverse direction.Besides,the unique basal texture contributes to the significant improvement of elongation at room temperature.Electron back scattering diffraction(EBSD)analysis indicated that the non-basal texture in Mg–1.5Zn–0.2RE alloys can be attributed to obstructive effect of static recrystallization and the non-basal orientation grains nucleation near pre-existing grain boundaries during annealing.Specially,the Mg–1.5Zn–0.2Gd sheet exhibits much excellent plasticity with the elongation of 27%than Mg–1.5Zn–0.2Ce and Mg–1.5Zn–0.2Y alloys,resulting from the less and smaller second phase of MgZnGd.展开更多
BACKGROUND:Gastrointestinal motility dysfunction in multiple organ dysfunction syndrome(MODS) has been reported to be related to damage to interstitial cells of Cajal(ICC).In the enteric nervous system,ICC and smooth ...BACKGROUND:Gastrointestinal motility dysfunction in multiple organ dysfunction syndrome(MODS) has been reported to be related to damage to interstitial cells of Cajal(ICC).In the enteric nervous system,ICC and smooth muscle cells are connected in a network to form a special functional unit.Many gastrointestinal motility dysfunction diseases are associated with damage to this network.OBJECTIVE:To investigate the morphological changes of intestinal ICC,and to explore the mechanisms underlying gastrointestinal motility dysfunction in rats with MODS.DESIGN,TIME AND SETTING:The randomized,controlled,experiment was performed at the Central Laboratory of the First Affiliated Hospital of Dalian Medical University of China between June 2007 and March 2009.MATERIALS:Escherichia coli(E.coli strain O127 H6) and bovine serum albumin were purchased from Sigma,USA.METHODS:A total of 40 Wistar rats were equally and randomly divided into MODS group and control group.Suspension of E.coli strain O127 H6 containing BaSO4 and saline were sterilely injected into the abdominal cavity of rats in the MODS and control groups,respectively.MAIN OUTCOME MEASURES:Immunohistochemical double-staining and confocal laser scanning microscopy were used to observe the morphological changes in intestinal cholinergic nerves and ICC in the deep muscular plexus network.Electron microscopy was employed to evaluate the ultrastructural features of ICC in the deep muscular plexus of rats with MODS.RESULTS:Compared with the control group,the distributions and densities of cholinergic/nitrergic nerves and ICC in the deep muscular plexus were significantly decreased in the MODS group(P < 0.01).The enteric nerve-ICC network were disrupted.CONCLUSION:There is ultrastructural injury in the ICC in the deep muscular plexus and enteric nerves of the intestine in rats with MODS,which may be associated with the dysmotility of the gastrointestinal tract in MODS.展开更多
Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve ...Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve the penetration depth for bioimaging.However,the design of red persistent RTP materials is still challenging.In this study,a fused-ring structure has been proposed to effectively decrease the triplet energy level,thus extending the emission wavelength of phosphorescence.In addition,the fused-ring structure exhibits a high molar extinction coefficient(ɛ)and high luminescence efficiency due to the rigid structure.A new class of crystalline hosts(iminodibenzyl,IDB)are developed to stabilize the triplet excitons that are generated from the fused-ring molecules.The maximum RTP wavelength of doping materials can reach 635 nm with a lifetime of 9.35 ms.Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging,which eliminates the background fluorescence interference from biological tissues.These reveal a delicate design strategy for the construction of long-wavelength emissive RTP materials for high-resolution bioimaging.展开更多
Buckybowl structures as non-uniform electrostatic potential distributions of poly-cyclic aromatic materials show a unique photoelectric performance.In this work,OTC was utilized for dynamic modulation of triplet excit...Buckybowl structures as non-uniform electrostatic potential distributions of poly-cyclic aromatic materials show a unique photoelectric performance.In this work,OTC was utilized for dynamic modulation of triplet exciton transition processes.Five host molecules with different functional units were selected,thus providing dif-ferent intermolecular interactions in the host/guest systems.Therefore,the delayed emissions were regulated from 536 to 624 nm via the tuning of the triplet exciton transition processes of OTC in different hosts.Experimental data and theoretical calculations revealed that the varied triplet transition behaviors resulted from the competition between the intersystem crossing(ISC)process of OTC-monomer and the reverse intersystem crossing(RISC)process of OTC-aggregates.This work proves the superior structure of buckybowl-based luminophore for controlling triplet exciton transition processes and supplies a new perspective for persistent afterglow luminophore design.展开更多
Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming t...Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming to address this challenge,we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers.Among these multi-arylpyrrole derivatives,MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%)when they are encapsulated by an amphiphilic polymer.As a result,the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic signals.The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.展开更多
Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we repor...Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we report red-emissive RTP materials via integration of the ring-fusing effect and host–guest interaction.展开更多
Organic dyes with conformational sensitivity can be used to probe weak interactions at the molecular level.Here,three molecules based on tetraphenyl-1,3-butadienes(TPBs)were synthesized and studied with respect to the...Organic dyes with conformational sensitivity can be used to probe weak interactions at the molecular level.Here,three molecules based on tetraphenyl-1,3-butadienes(TPBs)were synthesized and studied with respect to their synthesis,structural characterization and potential application.All TPBs showed aggregation-induced emission(AIE)characteristics and sensitive conformational properties,in which the emission wavelengths could be changed in different states.The TPBs single crystals revealed that the phenyl groups at the 4-position of the 1,3-butadienes contributed to their conformational sensitivity.Furthermore,the potential application for monitoring the interactions among polyelectrolyte complexes and metal ions was explored,and the results showed that TPBs could be used for sensitively probing some weak interactions by changing the emission wavelengths due to their conformation-sensitive properties.TPBs may become a new star in AIE research fields.展开更多
In this paper,we report the design,synthesis and semiconducting behavior of two conjugated D-A polymers BPDDTE and BPDBDTE which entail BPD,a Pechmann dye framework,as electron accepting moieties and(E)-1,2-di(thiophe...In this paper,we report the design,synthesis and semiconducting behavior of two conjugated D-A polymers BPDDTE and BPDBDTE which entail BPD,a Pechmann dye framework,as electron accepting moieties and(E)-1,2-di(thiophen-2-yl)ethane with and without alkyl chains as electron donating moieties.They both show very narrow bandgaps below 1.3 eV.Based on the characterization of the field-effect transistors,thin film of BPDDT exhibits ambipolar semiconducting properties with hole and electron mobilities reaching 0.245 and 0.095 cm^(2)•V^(−1)•s^(−1),respectively,after thermal annealing.Similarly,BPDBDTE with more alkylchains shows ambipolar semiconducting behavior with hole mobility and electron mobilities reaching 0.109 and 0.081 cm^(2)•V^(−1)•s^(−1).Furthermore,BPDBDTE shows good solubilities in several common organic solvents and thus is easily solution-processible.Thus,BPDBDTE is potentially processible with inkjet printing and roll-to-roll printing techniques.展开更多
文摘The effect of Gd,Ce and Y elements on texture,recrystallization and mechanical properties of Mg–1.5Zn alloys was investigated.The results show that the addition of Gd,Ce and Y elements in Mg–1.5Zn alloy,which rolled at 450℃ and subsequently annealed at 350℃ for 1h,can effectively weaken and modify the basal texture,characterized by the splitting basal pole toward to transverse direction,leading to the yield and tensile strength,the highest along the rolling direction and the lowest along the transverse direction.Besides,the unique basal texture contributes to the significant improvement of elongation at room temperature.Electron back scattering diffraction(EBSD)analysis indicated that the non-basal texture in Mg–1.5Zn–0.2RE alloys can be attributed to obstructive effect of static recrystallization and the non-basal orientation grains nucleation near pre-existing grain boundaries during annealing.Specially,the Mg–1.5Zn–0.2Gd sheet exhibits much excellent plasticity with the elongation of 27%than Mg–1.5Zn–0.2Ce and Mg–1.5Zn–0.2Y alloys,resulting from the less and smaller second phase of MgZnGd.
基金Supported by the National Natural Science Foundation of China,No. 30772860
文摘BACKGROUND:Gastrointestinal motility dysfunction in multiple organ dysfunction syndrome(MODS) has been reported to be related to damage to interstitial cells of Cajal(ICC).In the enteric nervous system,ICC and smooth muscle cells are connected in a network to form a special functional unit.Many gastrointestinal motility dysfunction diseases are associated with damage to this network.OBJECTIVE:To investigate the morphological changes of intestinal ICC,and to explore the mechanisms underlying gastrointestinal motility dysfunction in rats with MODS.DESIGN,TIME AND SETTING:The randomized,controlled,experiment was performed at the Central Laboratory of the First Affiliated Hospital of Dalian Medical University of China between June 2007 and March 2009.MATERIALS:Escherichia coli(E.coli strain O127 H6) and bovine serum albumin were purchased from Sigma,USA.METHODS:A total of 40 Wistar rats were equally and randomly divided into MODS group and control group.Suspension of E.coli strain O127 H6 containing BaSO4 and saline were sterilely injected into the abdominal cavity of rats in the MODS and control groups,respectively.MAIN OUTCOME MEASURES:Immunohistochemical double-staining and confocal laser scanning microscopy were used to observe the morphological changes in intestinal cholinergic nerves and ICC in the deep muscular plexus network.Electron microscopy was employed to evaluate the ultrastructural features of ICC in the deep muscular plexus of rats with MODS.RESULTS:Compared with the control group,the distributions and densities of cholinergic/nitrergic nerves and ICC in the deep muscular plexus were significantly decreased in the MODS group(P < 0.01).The enteric nerve-ICC network were disrupted.CONCLUSION:There is ultrastructural injury in the ICC in the deep muscular plexus and enteric nerves of the intestine in rats with MODS,which may be associated with the dysmotility of the gastrointestinal tract in MODS.
基金the National Natural Scientific Foundation of China(Grant Nos.22222501,21975021,21975020,21875019,22105019,and 22175023)supported by Beijing National Laboratory for Molecular Sciences(BNLMS202007)the BIT Research and Innovation Promoting Project(2022YCXZ035).
文摘Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve the penetration depth for bioimaging.However,the design of red persistent RTP materials is still challenging.In this study,a fused-ring structure has been proposed to effectively decrease the triplet energy level,thus extending the emission wavelength of phosphorescence.In addition,the fused-ring structure exhibits a high molar extinction coefficient(ɛ)and high luminescence efficiency due to the rigid structure.A new class of crystalline hosts(iminodibenzyl,IDB)are developed to stabilize the triplet excitons that are generated from the fused-ring molecules.The maximum RTP wavelength of doping materials can reach 635 nm with a lifetime of 9.35 ms.Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging,which eliminates the background fluorescence interference from biological tissues.These reveal a delicate design strategy for the construction of long-wavelength emissive RTP materials for high-resolution bioimaging.
基金National Natural Scientific Foundation of China,Grant/Award Numbers:21975021,21975020,21875019,21871119,22105019,22175023Beijing National Laboratory for Molecular Sciences,Grant/Award Number:BNLMS192007BIT Research and Innovation Promoting Project,Grant/Award Number:2022YCXZ035。
文摘Buckybowl structures as non-uniform electrostatic potential distributions of poly-cyclic aromatic materials show a unique photoelectric performance.In this work,OTC was utilized for dynamic modulation of triplet exciton transition processes.Five host molecules with different functional units were selected,thus providing dif-ferent intermolecular interactions in the host/guest systems.Therefore,the delayed emissions were regulated from 536 to 624 nm via the tuning of the triplet exciton transition processes of OTC in different hosts.Experimental data and theoretical calculations revealed that the varied triplet transition behaviors resulted from the competition between the intersystem crossing(ISC)process of OTC-monomer and the reverse intersystem crossing(RISC)process of OTC-aggregates.This work proves the superior structure of buckybowl-based luminophore for controlling triplet exciton transition processes and supplies a new perspective for persistent afterglow luminophore design.
基金financially supported by the National Natural Science Foundation of China(21875019,21803007,21975020,51803009)the National Key Research and Development Program of China(2018YFA0901800)+1 种基金the Department of Science and Technology of Guangdong Province(2019ZT08Y191)the Shenzhen Science and Technology Program(JSGG20200225151916021)。
文摘Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency.Aiming to address this challenge,we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers.Among these multi-arylpyrrole derivatives,MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%)when they are encapsulated by an amphiphilic polymer.As a result,the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic signals.The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.
基金supported by the National Natural Scientific Foundation of China(grant nos.21975021,51803009,21905021,51673024,21975020,and 21875019)supported by Beijing National Laboratory for Molecular Sciences(no.BNLMS202007),China Postdoctoral Science Foundation 2019TQ0034.
文摘Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we report red-emissive RTP materials via integration of the ring-fusing effect and host–guest interaction.
基金supported by the National Natural Science Foundation of China (51673024, 21875019, 21490574, 51803009)Beijing Institute of Technology Research Fund Program for Young Scholars
文摘Organic dyes with conformational sensitivity can be used to probe weak interactions at the molecular level.Here,three molecules based on tetraphenyl-1,3-butadienes(TPBs)were synthesized and studied with respect to their synthesis,structural characterization and potential application.All TPBs showed aggregation-induced emission(AIE)characteristics and sensitive conformational properties,in which the emission wavelengths could be changed in different states.The TPBs single crystals revealed that the phenyl groups at the 4-position of the 1,3-butadienes contributed to their conformational sensitivity.Furthermore,the potential application for monitoring the interactions among polyelectrolyte complexes and metal ions was explored,and the results showed that TPBs could be used for sensitively probing some weak interactions by changing the emission wavelengths due to their conformation-sensitive properties.TPBs may become a new star in AIE research fields.
基金The present research was financially supported by Chinese Academy of Sciences,NSFC(No.21372226)and State Key Basic Research Program.
文摘In this paper,we report the design,synthesis and semiconducting behavior of two conjugated D-A polymers BPDDTE and BPDBDTE which entail BPD,a Pechmann dye framework,as electron accepting moieties and(E)-1,2-di(thiophen-2-yl)ethane with and without alkyl chains as electron donating moieties.They both show very narrow bandgaps below 1.3 eV.Based on the characterization of the field-effect transistors,thin film of BPDDT exhibits ambipolar semiconducting properties with hole and electron mobilities reaching 0.245 and 0.095 cm^(2)•V^(−1)•s^(−1),respectively,after thermal annealing.Similarly,BPDBDTE with more alkylchains shows ambipolar semiconducting behavior with hole mobility and electron mobilities reaching 0.109 and 0.081 cm^(2)•V^(−1)•s^(−1).Furthermore,BPDBDTE shows good solubilities in several common organic solvents and thus is easily solution-processible.Thus,BPDBDTE is potentially processible with inkjet printing and roll-to-roll printing techniques.
