Tabletop integral imaging display with a more realistic and immersive experience has always been a hot spot in three-dimensional imaging technology,widely used in biomedical imaging and visualization to enhance medica...Tabletop integral imaging display with a more realistic and immersive experience has always been a hot spot in three-dimensional imaging technology,widely used in biomedical imaging and visualization to enhance medical diagnosis.However,the traditional structural characteristics of integral imaging display inevitably introduce the flipping effect outside the effective viewing angle.Here,a full-parallax tabletop integral imaging display without the flipping effect based on space-multiplexed voxel screen and compound lens array is demonstrated,and two holographic functional screens with different parameters are optically designed and fabricated.To eliminate the flipping effect in the reconstruction process,the space-multiplexed voxel screen consisting of a projector array and the holographic functional screen is presented to constrain light beams passing through the corresponding lens.To greatly promote imaging quality within the viewing area,the aspherical structure of the compound lens is optimized to balance the aberrations.It cooperates with the holographic functional screen to modulate the light field spatial distribution.Compared with the simulation results,the distortion rate of the imaging display is reduced to less than 9%from more than 30%.In the experiment,the floating high-quality reconstructed three-dimensional image without the flipping effect can be observed with the correct 3D perception at 96°×96°viewing angle,where 44,100 viewpoints are employed.展开更多
Ternesite(4CaO·2SiO_(2)·CaSO_(4))-Ye’elimite(3CaO·3Al_(2)O_(3)·CaSO_(4))(simplified as TY)cement clinker was successfully prepared from steel slag at 1200℃in this study.XRD,TG/DSC and SEM were us...Ternesite(4CaO·2SiO_(2)·CaSO_(4))-Ye’elimite(3CaO·3Al_(2)O_(3)·CaSO_(4))(simplified as TY)cement clinker was successfully prepared from steel slag at 1200℃in this study.XRD,TG/DSC and SEM were used to analyze the mineral composition and hydration products of the TY clinker.The sintering process and hydration mechanism of the TY clinker were investigated.Results show that a large amount of ternesite and ye’elimite have been formed at 1200℃,while ternesite has not been decomposed.Clinker minerals include ternesite,ye’elimite,gypsum and a small amount of iron phase.Iron phase from steel slag can promote the formation of liquid phase with the presence of gypsum at 1200℃and thus lead to the coexistence of ternesite and ye’elimite.The compressive strength of TY cement cured at 28 d is 59.5 MPa,which is higher than that of P.II 42.5 cement.This research provides a sustainable and energy-effective way for the reutilization of steel slag,an otherwise valueless waste.展开更多
Stellar images will deteriorate dramatically when the sensitive elements of wide-field survey telescopes are misaligned during an observation, and active alignment is the key technology to maintain the high resolution...Stellar images will deteriorate dramatically when the sensitive elements of wide-field survey telescopes are misaligned during an observation, and active alignment is the key technology to maintain the high resolution of wide-field sky survey telescopes. Instead of traditional active alignment based on field-dependent wave front errors, this work proposes a machine learning alignment metrology based on stellar images of the scientific camera,which is more convenient and higher speed. We first theoretically confirm that the pattern of the point-spread function over the field is closely related to the misalignment status, and then the relationships are learned by twostep neural networks. After two-step active alignment, the position errors of misalignment parameters are less than5 μm for decenter and less than 5″ for tip-tilt in more than 90% of the cases. The precise alignment results indicate that this metrology provides a low-cost and high-speed solution to maintain the image quality of wide-field sky survey telescopes during observation, thus implying important significance and broad application prospects.展开更多
In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was develope...In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was developed and tested to simulate the fretting damage evolution process of cladding in the PWR environment.It can simulate the fretting wear experiment of PWR under different temperatures(maximum temperature is 350℃),displacement amplitude,vibration frequency,and normal force.The fretting wear behavior of Zr-4 alloy under different temperature environments was tested.In addition,the evolution of wear scar morphology,profile,and wear volume was studied using an optical microscope(OM),scanning electron microscopy(SEM),and a 3D white light interferometer.Results show that higher water temperature evidently decreased the cladding wear volume,the wear mechanism of Zr-4 cladding changed from abrasive wear to adhesive wear and the formation of an oxide layer on the wear scar reduced the wear volume and maximum wear depth.展开更多
A synergy of computer simulations, analytical formulations, and experiments proves very effective in research and development. Using nanorod growth as an example, this letter presents the synergy of the three compleme...A synergy of computer simulations, analytical formulations, and experiments proves very effective in research and development. Using nanorod growth as an example, this letter presents the synergy of the three complementary approaches in research, and demonstrates its effectiveness. Through this synergy, a theoretical framework of nanorod growth emerges; through the direction of the theories,experimental realization of smallest well-separated nanorods becomes reality; through the realization of such nanorods, metallic glue in ambient environments becomes technical reality and commercial possibility.展开更多
<div style="text-align:justify;"> This paper studies a kind of urban security risk assessment model based on multi-label learning, which is transformed into the solution of linear equations through a s...<div style="text-align:justify;"> This paper studies a kind of urban security risk assessment model based on multi-label learning, which is transformed into the solution of linear equations through a series of transformations, and then the solution of linear equations is transformed into an optimization problem. Finally, this paper uses some classical optimization algorithms to solve these optimization problems, the convergence of the algorithm is proved, and the advantages and disadvantages of several optimization methods are compared. </div>展开更多
The quadraticWasserstein metric has shown its power in comparing prob-ability densities.It is successfully applied in waveform inversion by generating ob-jective functions robust to cycle skipping and insensitive to d...The quadraticWasserstein metric has shown its power in comparing prob-ability densities.It is successfully applied in waveform inversion by generating ob-jective functions robust to cycle skipping and insensitive to data noise.As an alter-native approach that converts seismic signals to probability densities,the squaring scaling method has good convexity and thus is worth exploring.In this work,we apply the quadratic Wasserstein metric with squaring scaling to regional seismic to-mography.However,there may be interference between different seismic phases in a broad time window.The squaring scaling distorts the signal by magnifying the unbalance of the mass of different seismic phases and also breaks the linear super-position property.As a result,illegal mass transportation between different seismic phases will occur when comparing signals using the quadratic Wasserstein metric.Furthermore,it gives inaccurate Fr´echet derivative,which in turn affects the inver-sion results.By combining the prior seismic knowledge of clear seismic phase sep-aration and carefully designing the normalization method,we overcome the above problems.Therefore,we develop a robust and efficient inversion method based on optimal transport theory to reveal subsurface velocity structures.Several numerical experiments are conducted to verify our method.展开更多
The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical ...The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light.展开更多
Suppose that g(f)are bi-parameter Littlewood-Paley square functions which were introduced by H.Martikainen.It is known that the L^2(R^n×R^m)boundedness and the H1(R^n×R^m)-L1(R^n×R^m)boundedness of g(f)...Suppose that g(f)are bi-parameter Littlewood-Paley square functions which were introduced by H.Martikainen.It is known that the L^2(R^n×R^m)boundedness and the H1(R^n×R^m)-L1(R^n×R^m)boundedness of g(f)have been proved by H.Martikainen and by Z.Li and Q.Xue,respectively.In this paper,we apply the vector-valued theory,the atomic decomposition of product Hardy spaces,and Journe’s covering lemma to show that g(f)are bounded from H^p(R^n×R^m)to Lp(R^n×R^m)with p smaller than 1.展开更多
Background:The most common etiologies of Cushing’’s syndrome(CS)are adrenocorticotropic hormone(ACTH)-producing pituitary adenoma(pitCS)and primary adrenal gland disease(adrCS),both of which burden patients with met...Background:The most common etiologies of Cushing’’s syndrome(CS)are adrenocorticotropic hormone(ACTH)-producing pituitary adenoma(pitCS)and primary adrenal gland disease(adrCS),both of which burden patients with metabolic disturbance.The aim of this study was to compare the metabolic features of pitCS and adrCS patients.Methods:A retrospective review including 114 patients(64 adrCS and 50 pitCS)diagnosed with CS in 2009-2019 was performed.Metabolic factors were then compared between pitCS and adrCS groups.Results:Regarding sex,females suffered both adrCs(92.2%)and pitCS(88.0%)more frequently than males.Regarding age,patients with pitCS were diagnosed at a younger age(35.40±11.94 vs.39.65±11.37 years,p=0.056)than those with adrCS,although the difference was not statistically significant.Moreover,pitCS patients had much higher ACTH levels and more serious occurrences of hypercortisolemia at all time points(8 AM,4 PM,12 AM)than that in adrCS patients.Conversely,indexes,including body weight,BMI,blood pressure,serum total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides,fasting plasma glucose,and uric acid,showed no differences between adrCS and pitCS patients.Furthermore,diabetes prevalence was higher in pitCS patients than in adrCS patients;however,there were no significant differences in hypertension or dyslipidemia prevalence between the two.Conclusions:Although adrCS and pitCS had different pathogenetic mechanisms,different severities of hypercortisolemia,and different diabetes prevalences,both etiologies had similar metabolic characteristics.展开更多
Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected b...Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host cells.Herein,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was validated.According to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 proteins.The constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,respectively.Approximately 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed nanotraps.The safety of the constructed nanotraps was confirmed both in vitro and in mice.Therefore,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV.展开更多
Two-dimensional(2D)carbide Ti_(3)C_(2)was synthesized by exfoliating Ti_(3)AlC_(2)in HF solution and used for supercapacitive performance investigation in 3 M KOH electrolyte.The specific surface area(SSA)of as-synthe...Two-dimensional(2D)carbide Ti_(3)C_(2)was synthesized by exfoliating Ti_(3)AlC_(2)in HF solution and used for supercapacitive performance investigation in 3 M KOH electrolyte.The specific surface area(SSA)of as-synthesized Ti_(3)C_(2)was 22.35 m^(2)/g.Ti_(3)C_(2)-based supercapacitor electrodes exhibited good energy storage ability and had a volumetric capacitance 119.8 F/cm^(3)at the current density of 2.5 A/g.Moreover,the addition of carbon black into Ti_(3)C_(2)powders greatly improved the performance of Ti_(3)C_(2)-based capacitors because carbon black restrained the preferred orientation of 2D Ti_(3)C_(2),providing fast ion transport channels,and in turn,decreasing electrical resistance from 16.7Ωto 3.5Ω.展开更多
This paper investigated the corrosion behaviors of Ti_(3)AlC_(2) at 700℃in molten KOH with various mass ratios.If the mass ratio of KOH:Ti_(3)AlC_(2)≤2,Ti_(3)AlC_(2) can resist KOH hot corrosion in 2 h.Ti_(3)AlC_(2)...This paper investigated the corrosion behaviors of Ti_(3)AlC_(2) at 700℃in molten KOH with various mass ratios.If the mass ratio of KOH:Ti_(3)AlC_(2)≤2,Ti_(3)AlC_(2) can resist KOH hot corrosion in 2 h.Ti_(3)AlC_(2) suffered serious corrosion attack if the mass ratio≥3.The main compositions of corroded samples were amorphous graphite and potassium titanates(K_(2)O·nTiO_(2)).If the samples were washed by acid and dried,potassium titanates could decompose to K_(2)O and amorphous rutile.Based on the experimental results,a corrosion mechanism of Ti_(3)AlC_(2) in molten KOH was proposed.展开更多
Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A a...Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A at Antarctica is a promising site for planetary transit surveys,where the continuous darkness and the large clear-sky fraction in the winter months greatly enhance the detection efficiency. The Chinese Small Telescope ARray and the Antarctic Survey Telescopes are the first facilities that have been operated at Dome A for use in exoplanet surveys. To increase the sky coverage, a low-temperature-resistant wide-field robotic telescope, named the bright star survey telescope(BSST), has been developed to join the ongoing planetary transit survey in Antarctica. The BSST has an aperture size of 300 mm and is equipped with a largeframe 4K×4K CCD camera to receive starlight from a 3.°4×3.°4 field of view. The BSST was operated at Lijiang observatory in April and May 2015 for a test run.Photometric precision of 3.5 mmag was achieved for stars with V～11 mag using 75 s exposures. The transiting events of two Jupiter-size exoplanets, HAT-P-3b and HATP-12 b, were observed on May 10 and May 20, 2015,respectively.展开更多
基金The Basic Research Fund of Central-Level Nonprofit Scientific Research Institutes(No.TKS20220304)The Key Research and Development Projects of Guangxi Science and Technology Department(No.2021AB05087).
文摘Tabletop integral imaging display with a more realistic and immersive experience has always been a hot spot in three-dimensional imaging technology,widely used in biomedical imaging and visualization to enhance medical diagnosis.However,the traditional structural characteristics of integral imaging display inevitably introduce the flipping effect outside the effective viewing angle.Here,a full-parallax tabletop integral imaging display without the flipping effect based on space-multiplexed voxel screen and compound lens array is demonstrated,and two holographic functional screens with different parameters are optically designed and fabricated.To eliminate the flipping effect in the reconstruction process,the space-multiplexed voxel screen consisting of a projector array and the holographic functional screen is presented to constrain light beams passing through the corresponding lens.To greatly promote imaging quality within the viewing area,the aspherical structure of the compound lens is optimized to balance the aberrations.It cooperates with the holographic functional screen to modulate the light field spatial distribution.Compared with the simulation results,the distortion rate of the imaging display is reduced to less than 9%from more than 30%.In the experiment,the floating high-quality reconstructed three-dimensional image without the flipping effect can be observed with the correct 3D perception at 96°×96°viewing angle,where 44,100 viewpoints are employed.
基金the financial support of the National Natural Science Foundation of China(Grant No.51872252)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.SJCX201356).
文摘Ternesite(4CaO·2SiO_(2)·CaSO_(4))-Ye’elimite(3CaO·3Al_(2)O_(3)·CaSO_(4))(simplified as TY)cement clinker was successfully prepared from steel slag at 1200℃in this study.XRD,TG/DSC and SEM were used to analyze the mineral composition and hydration products of the TY clinker.The sintering process and hydration mechanism of the TY clinker were investigated.Results show that a large amount of ternesite and ye’elimite have been formed at 1200℃,while ternesite has not been decomposed.Clinker minerals include ternesite,ye’elimite,gypsum and a small amount of iron phase.Iron phase from steel slag can promote the formation of liquid phase with the presence of gypsum at 1200℃and thus lead to the coexistence of ternesite and ye’elimite.The compressive strength of TY cement cured at 28 d is 59.5 MPa,which is higher than that of P.II 42.5 cement.This research provides a sustainable and energy-effective way for the reutilization of steel slag,an otherwise valueless waste.
基金supported by the National Natural Science Foundation of China (Grant Nos. U1931207 and 12173062)the project of Multi-channel Photometric Survey Telescope。
文摘Stellar images will deteriorate dramatically when the sensitive elements of wide-field survey telescopes are misaligned during an observation, and active alignment is the key technology to maintain the high resolution of wide-field sky survey telescopes. Instead of traditional active alignment based on field-dependent wave front errors, this work proposes a machine learning alignment metrology based on stellar images of the scientific camera,which is more convenient and higher speed. We first theoretically confirm that the pattern of the point-spread function over the field is closely related to the misalignment status, and then the relationships are learned by twostep neural networks. After two-step active alignment, the position errors of misalignment parameters are less than5 μm for decenter and less than 5″ for tip-tilt in more than 90% of the cases. The precise alignment results indicate that this metrology provides a low-cost and high-speed solution to maintain the image quality of wide-field sky survey telescopes during observation, thus implying important significance and broad application prospects.
基金Supported by National Key R&D Program of China(Grant No.2022YFB3401901)Key Program of National Natural Science Foundation of China(Grant No.U2067221)+2 种基金Sichuan Provincial Science and Technology Planning Project(Grant Nos.2022JDJQ0019 and 2022ZYD0029)Funds for China Postdoctoral Science Foundation(Grant No.2022M713008)Sichuan Provincial Innovative Talent Funding Project for Postdoctoral Fellows(Grant No.BX202225).
文摘In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was developed and tested to simulate the fretting damage evolution process of cladding in the PWR environment.It can simulate the fretting wear experiment of PWR under different temperatures(maximum temperature is 350℃),displacement amplitude,vibration frequency,and normal force.The fretting wear behavior of Zr-4 alloy under different temperature environments was tested.In addition,the evolution of wear scar morphology,profile,and wear volume was studied using an optical microscope(OM),scanning electron microscopy(SEM),and a 3D white light interferometer.Results show that higher water temperature evidently decreased the cladding wear volume,the wear mechanism of Zr-4 cladding changed from abrasive wear to adhesive wear and the formation of an oxide layer on the wear scar reduced the wear volume and maximum wear depth.
基金the sponsorship of the US Department of Energy Office of Basic Energy Science (DE-SC0014035)the US National Science Foundation (NSF 1506966)
文摘A synergy of computer simulations, analytical formulations, and experiments proves very effective in research and development. Using nanorod growth as an example, this letter presents the synergy of the three complementary approaches in research, and demonstrates its effectiveness. Through this synergy, a theoretical framework of nanorod growth emerges; through the direction of the theories,experimental realization of smallest well-separated nanorods becomes reality; through the realization of such nanorods, metallic glue in ambient environments becomes technical reality and commercial possibility.
文摘<div style="text-align:justify;"> This paper studies a kind of urban security risk assessment model based on multi-label learning, which is transformed into the solution of linear equations through a series of transformations, and then the solution of linear equations is transformed into an optimization problem. Finally, this paper uses some classical optimization algorithms to solve these optimization problems, the convergence of the algorithm is proved, and the advantages and disadvantages of several optimization methods are compared. </div>
基金supported by the National Natural Science Foundation of China(Grant No.12271289).
文摘The quadraticWasserstein metric has shown its power in comparing prob-ability densities.It is successfully applied in waveform inversion by generating ob-jective functions robust to cycle skipping and insensitive to data noise.As an alter-native approach that converts seismic signals to probability densities,the squaring scaling method has good convexity and thus is worth exploring.In this work,we apply the quadratic Wasserstein metric with squaring scaling to regional seismic to-mography.However,there may be interference between different seismic phases in a broad time window.The squaring scaling distorts the signal by magnifying the unbalance of the mass of different seismic phases and also breaks the linear super-position property.As a result,illegal mass transportation between different seismic phases will occur when comparing signals using the quadratic Wasserstein metric.Furthermore,it gives inaccurate Fr´echet derivative,which in turn affects the inver-sion results.By combining the prior seismic knowledge of clear seismic phase sep-aration and carefully designing the normalization method,we overcome the above problems.Therefore,we develop a robust and efficient inversion method based on optimal transport theory to reveal subsurface velocity structures.Several numerical experiments are conducted to verify our method.
基金supported by the National Basic Research Program(973 Program)of China(2013CB834900)the Chinese Polar Environment Comprehensive Investigation&Assessment Program(CHINARE2016-02-03)+21 种基金the National Natural Science Foundation of China(11573014,11673068,11325313,11633002,11433009,11725314)the Key Research Program of Frontier Sciences(QYZDY-SSW-SLH010,QYZDB-SSW-SYS005)the Strategic Priority Research Program"multi-waveband gravitational wave Universe”(XDB23040000)the Youth Innovation Promotion Association(2011231)of Chinese Academy of Sciencesfunds from Tsinghua UniversityNanjing UniversityBeijing Normal UniversityUniversity of New South WalesTexas A&M Universitythe Australian Antarctic Divisionthe National Collaborative Research Infrastructure Strategy(NCRIS)of Australiafunding from the Chinese Academy of Sciences through the Center for Astronomical Mega-Science and National Astronomical Observatory of China(NAOC)made possible through the use of the AAVSO Photometric All-Sky Survey(APASS)funded by the Robert Martin Ayers Sciences Fundfunded by the Australian Research Council(ARC)Centre of Excellence for Gravitational Wave Discovery(OzGrav),CE170100004the ARC Centre of Excellence for All-sky Astrophysics(CAASTRO),CE110001020the Centre of Excellence for All-sky Astrophysics in 3-Dimensions(ASTRO-3D),CE170100013provided by the Australian Astronomical Observatory(AAO)the ARC Future Fellowship grant,FT130101219supported by the National Basic Research Program(Project 973)of China(2014CB845800)the National Natural Science Foundation of China(11633001 and 11373014)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB23000000)
文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.11901495,11771345)the Hunan Provincial Natural Science Foundation(2019JJ50573)the Hunan Education Department Project(18C0109).
文摘Suppose that g(f)are bi-parameter Littlewood-Paley square functions which were introduced by H.Martikainen.It is known that the L^2(R^n×R^m)boundedness and the H1(R^n×R^m)-L1(R^n×R^m)boundedness of g(f)have been proved by H.Martikainen and by Z.Li and Q.Xue,respectively.In this paper,we apply the vector-valued theory,the atomic decomposition of product Hardy spaces,and Journe’s covering lemma to show that g(f)are bounded from H^p(R^n×R^m)to Lp(R^n×R^m)with p smaller than 1.
基金National Natural Science Foundation(81922016,81870607)Shandong Provincial Natural Science Foundation(ZR2019JQ25)National Key R&D Program of China(2017YFC0908900)。
文摘Background:The most common etiologies of Cushing’’s syndrome(CS)are adrenocorticotropic hormone(ACTH)-producing pituitary adenoma(pitCS)and primary adrenal gland disease(adrCS),both of which burden patients with metabolic disturbance.The aim of this study was to compare the metabolic features of pitCS and adrCS patients.Methods:A retrospective review including 114 patients(64 adrCS and 50 pitCS)diagnosed with CS in 2009-2019 was performed.Metabolic factors were then compared between pitCS and adrCS groups.Results:Regarding sex,females suffered both adrCs(92.2%)and pitCS(88.0%)more frequently than males.Regarding age,patients with pitCS were diagnosed at a younger age(35.40±11.94 vs.39.65±11.37 years,p=0.056)than those with adrCS,although the difference was not statistically significant.Moreover,pitCS patients had much higher ACTH levels and more serious occurrences of hypercortisolemia at all time points(8 AM,4 PM,12 AM)than that in adrCS patients.Conversely,indexes,including body weight,BMI,blood pressure,serum total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides,fasting plasma glucose,and uric acid,showed no differences between adrCS and pitCS patients.Furthermore,diabetes prevalence was higher in pitCS patients than in adrCS patients;however,there were no significant differences in hypertension or dyslipidemia prevalence between the two.Conclusions:Although adrCS and pitCS had different pathogenetic mechanisms,different severities of hypercortisolemia,and different diabetes prevalences,both etiologies had similar metabolic characteristics.
基金supported by the National Key Research and Development Program of China(2019YFA0705400)the National Natural Science Foundation of China(12172176,52002175,and 11802121)+5 种基金the Joint Fund of Advanced Aerospace Manufacturing Technology Research(U1937601)the Natural Science Foundation of Jiangsu Province(BK20211191 and BK20212008)the Research Fund of State Key Laboratory of Mechanics and Control of Mechanical Structures(MCMS-I-0421G01 and MCMS-I-0421K01)China Postdoctoral Science Foundation(2018T110494,2020TQ0146,2021M701703,and 2021M701705)the Fundamental Research Funds for the Central Universities(NE2020001,NJ2020003,NZ2020001,and NS2021042)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
基金The current work was supported by the National Natural Science Foundation of China(No.81502675).
文摘Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host cells.Herein,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was validated.According to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 proteins.The constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,respectively.Approximately 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed nanotraps.The safety of the constructed nanotraps was confirmed both in vitro and in mice.Therefore,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV.
基金supported by National Nature Science Foundation of China(51472075,51205111)Plan for Scientific Innovation Talent of Henan Province(134100510008)+2 种基金Program for Innovative Research Team of Henan Polytechnic University(T2013-4)State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(KF201313)Opening Project of Henan Key Discipline Open Laboratory of Mining Engineering Materials(MEM12-11).
文摘Two-dimensional(2D)carbide Ti_(3)C_(2)was synthesized by exfoliating Ti_(3)AlC_(2)in HF solution and used for supercapacitive performance investigation in 3 M KOH electrolyte.The specific surface area(SSA)of as-synthesized Ti_(3)C_(2)was 22.35 m^(2)/g.Ti_(3)C_(2)-based supercapacitor electrodes exhibited good energy storage ability and had a volumetric capacitance 119.8 F/cm^(3)at the current density of 2.5 A/g.Moreover,the addition of carbon black into Ti_(3)C_(2)powders greatly improved the performance of Ti_(3)C_(2)-based capacitors because carbon black restrained the preferred orientation of 2D Ti_(3)C_(2),providing fast ion transport channels,and in turn,decreasing electrical resistance from 16.7Ωto 3.5Ω.
基金This work was supported by the National Nature Science Foundation of China(Grant Nos.51002045,51205111)Program for Innovative Research Team of Henan Polytechnic University(T2013-4)Opening Project of Henan Key Discipline Open Laboratory of Mining Engineering Materials(MEM12-5).
文摘This paper investigated the corrosion behaviors of Ti_(3)AlC_(2) at 700℃in molten KOH with various mass ratios.If the mass ratio of KOH:Ti_(3)AlC_(2)≤2,Ti_(3)AlC_(2) can resist KOH hot corrosion in 2 h.Ti_(3)AlC_(2) suffered serious corrosion attack if the mass ratio≥3.The main compositions of corroded samples were amorphous graphite and potassium titanates(K_(2)O·nTiO_(2)).If the samples were washed by acid and dried,potassium titanates could decompose to K_(2)O and amorphous rutile.Based on the experimental results,a corrosion mechanism of Ti_(3)AlC_(2) in molten KOH was proposed.
基金supported by the Astronomical Project for the Chinese Antarctic Inland Stationthe SOC Program(CHINARE2012-02-03+12 种基金CHINARE2013-02-03CHINARE2014-02-03and CHINARE2015-02-03)the National Basic Research Program of China(2013CB834905 and 2015CB857005)Q.Tian is supported by the National Natural Science Foundation of China(11503023)the Natural Science Foundation of Shanghai(14ZR1444100)the Polar Science Innovation Fund for Young Scientists of Polar Research Institute of China(CX20130201)P.Jiang is supported by the National Natural Science Foundation of China(11233002 and11203022)H.Zhou is supported by the National Natural Science Foundation of China(1147302511421303 and 11033007)S.Zhang is supported by the National Natural Science Foundation of China(11573024)T.Ji is supported by the National Natural Science Foundation of China(11503022)the Natural Science Foundation of Shanghai(15ZR1444200)
文摘Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A at Antarctica is a promising site for planetary transit surveys,where the continuous darkness and the large clear-sky fraction in the winter months greatly enhance the detection efficiency. The Chinese Small Telescope ARray and the Antarctic Survey Telescopes are the first facilities that have been operated at Dome A for use in exoplanet surveys. To increase the sky coverage, a low-temperature-resistant wide-field robotic telescope, named the bright star survey telescope(BSST), has been developed to join the ongoing planetary transit survey in Antarctica. The BSST has an aperture size of 300 mm and is equipped with a largeframe 4K×4K CCD camera to receive starlight from a 3.°4×3.°4 field of view. The BSST was operated at Lijiang observatory in April and May 2015 for a test run.Photometric precision of 3.5 mmag was achieved for stars with V～11 mag using 75 s exposures. The transiting events of two Jupiter-size exoplanets, HAT-P-3b and HATP-12 b, were observed on May 10 and May 20, 2015,respectively.
