In-situ ceramics particle reinforced aluminum matrix composites are favored in the aerospace industry due to excellent properties.However,the hard ceramic particles as the reinforcement phase bring challenges to machi...In-situ ceramics particle reinforced aluminum matrix composites are favored in the aerospace industry due to excellent properties.However,the hard ceramic particles as the reinforcement phase bring challenges to machining.To study the effect of in-situ TiB_(2)particles on machinability and surface integrity of TiB_(2)/2024 composite and TiB_(2)/7075 composite,milling experiments were performed,and compared with conventional 2024 and 7075 aluminum alloys.In-situ TiB_(2)particles clustered at the grain boundaries and dispersed inside the matrix alloy grains hinder the dislocation movement of the matrix alloy.Therefore,the milling force and temperature of the composites are higher than those of the aluminum alloys due to the increase of the strength and the decrease of the plasticity.In the milling of composites,abrasive wear is the main wear form of carbide tools,due to the scratching of hard nano-TiB_(2)particles.The composites containing in-situ TiB_(2)particles have machining defects such as smearing,micro-scratches,micro-pits and tail on the machined surface.However,in-situ TiB_(2)particles impede the plastic deformation of the composites,which greatly reduces cutting edge marks on the machined surface.Therefore,under the same milling parameters,the surface roughness of TiB_(2)/2024 composite and TiB_(2)/7075 composite is much less than that of2024 and 7075 aluminum alloy respectively.Under the milling conditions of this experiment,the machined subsurface has no metamorphic layer,and the microhardness of the machined surface is almost the same as that of the material.Besides,compared with 2024 and 7075 aluminum alloy,machined surfaces of TiB_(2)/2024 composite and TiB_(2)/7075 composite both show tensile residual stress or low magnitude of compressive residual stress.展开更多
Human embryonic stem cells （hESCs） can self-renew indefinitely and differentiate into all cell types in the human body. Therefore, they are valuable in regenerative medicine, human developmental biology and drug dis...Human embryonic stem cells （hESCs） can self-renew indefinitely and differentiate into all cell types in the human body. Therefore, they are valuable in regenerative medicine, human developmental biology and drug discovery. A number of hESC lines have been derived from the Chinese population, but limited of them are available for research purposes. Here we report the derivation and characterization of two hESC lines derived from human blastocysts of Chinese origin. These hESCs express alkaline phosphatase and hESC-specific markers, including Oct4, Nanog, SSEA-3, SSEA-4, TRA- 1-60 and TRA-1-81. They also have high levels of telomerase activity and normal karyotypes. These ceils can form embryoid body in vitro and can be differentiated into all three germ layers in vivo by teratoma formation. The newly established hESCs will be distributed for research purposes. The availability of hESC lines from the Chinese population will facilitate studies on the differences in hESCs from different ethnic groups.展开更多
基金the National Natural Science Foundation of China(No.51875356)。
文摘In-situ ceramics particle reinforced aluminum matrix composites are favored in the aerospace industry due to excellent properties.However,the hard ceramic particles as the reinforcement phase bring challenges to machining.To study the effect of in-situ TiB_(2)particles on machinability and surface integrity of TiB_(2)/2024 composite and TiB_(2)/7075 composite,milling experiments were performed,and compared with conventional 2024 and 7075 aluminum alloys.In-situ TiB_(2)particles clustered at the grain boundaries and dispersed inside the matrix alloy grains hinder the dislocation movement of the matrix alloy.Therefore,the milling force and temperature of the composites are higher than those of the aluminum alloys due to the increase of the strength and the decrease of the plasticity.In the milling of composites,abrasive wear is the main wear form of carbide tools,due to the scratching of hard nano-TiB_(2)particles.The composites containing in-situ TiB_(2)particles have machining defects such as smearing,micro-scratches,micro-pits and tail on the machined surface.However,in-situ TiB_(2)particles impede the plastic deformation of the composites,which greatly reduces cutting edge marks on the machined surface.Therefore,under the same milling parameters,the surface roughness of TiB_(2)/2024 composite and TiB_(2)/7075 composite is much less than that of2024 and 7075 aluminum alloy respectively.Under the milling conditions of this experiment,the machined subsurface has no metamorphic layer,and the microhardness of the machined surface is almost the same as that of the material.Besides,compared with 2024 and 7075 aluminum alloy,machined surfaces of TiB_(2)/2024 composite and TiB_(2)/7075 composite both show tensile residual stress or low magnitude of compressive residual stress.
基金This work was partially supported by grants from the National Key Basic Research and Development Program of China(Nos.2007CB948003,2009CB940900,2009CB941000, 2009CB941100,2006CB943901,2007CB947902 and 2011 CB965101)the National Natural Science Foundation of China (Nos.30621091 and 31025016)+3 种基金the Chinese Academy of Sciences Knowledge Creation Program(No.KSCX1-YW-R- 54,KSCX1-YW-R-46)the Shanghai Science & Technology Developmental Foundation(No.08DJ1400500)the National High Technology Research and Development Program(863 program) of China(No.2010AA100504)the Shanghai Institutes for Biological Sciences(No.2007KIP401)
文摘Human embryonic stem cells （hESCs） can self-renew indefinitely and differentiate into all cell types in the human body. Therefore, they are valuable in regenerative medicine, human developmental biology and drug discovery. A number of hESC lines have been derived from the Chinese population, but limited of them are available for research purposes. Here we report the derivation and characterization of two hESC lines derived from human blastocysts of Chinese origin. These hESCs express alkaline phosphatase and hESC-specific markers, including Oct4, Nanog, SSEA-3, SSEA-4, TRA- 1-60 and TRA-1-81. They also have high levels of telomerase activity and normal karyotypes. These ceils can form embryoid body in vitro and can be differentiated into all three germ layers in vivo by teratoma formation. The newly established hESCs will be distributed for research purposes. The availability of hESC lines from the Chinese population will facilitate studies on the differences in hESCs from different ethnic groups.
