BACKGROUND The liver hemodynamic changes caused by portal hypertension(PH)are closely related to various complications such as gastroesophageal varices and portosystemic shunts,which may lead to adverse clinical outco...BACKGROUND The liver hemodynamic changes caused by portal hypertension(PH)are closely related to various complications such as gastroesophageal varices and portosystemic shunts,which may lead to adverse clinical outcomes in these patients,so it is of great clinical significance to find treatment strategies with favorable clinical efficacy and low risk of complications.AIM To study the clinical efficacy of total laparoscopic splenectomy(TLS)for PH and its influence on hepatic hemodynamics and liver function.METHODS Among the 199 PH patients selected from October 2016 to October 2020,100 patients[observation group(OG)]were treated with TLS,while the remaining 99[reference group(RG)]were treated with open splenectomy(OS).We observed and compared the clinical efficacy,operation indexes[operative time(OT)and intraoperative bleeding volume],safety(intraperitoneal hemorrhage,ascitic fluid infection,eating disorders,liver insufficiency,and perioperative death),hepatic hemodynamics(diameter,velocity,and flow volume of the portal vein system),and liver function[serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),and serum total bilirubin(TBil)]of the two groups.RESULTS The OT was significantly longer and intraoperative bleeding volume was significantly lesser in the OG than in the RG.Additionally,the overall response rate,postoperative complications rate,and liver function indexes(ALT,AST,and TBil)did not differ significantly between the OG and RG.The hepatic hemodynamics statistics showed that the pre-and postoperative blood vessel diameters in the two cohorts did not differ statistically.Although the postoperative blood velocity and flow volume reduced significantly when compared with the preoperative values,there were no significant inter-group differences.CONCLUSION TLS contributes to comparable clinical efficacy,safety,hepatic hemodynamics,and liver function as those of OS in treating PH,with a longer OT but lesser intraoperative blood loss.展开更多
AIM: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma(HCC) in Chinese patients with primary biliary cirrhosis(PBC).METHODS: We reviewed the data of 52 PB Cassociated HCC pat...AIM: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma(HCC) in Chinese patients with primary biliary cirrhosis(PBC).METHODS: We reviewed the data of 52 PB Cassociated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence and characteristics between the two genders. The risk factors for PBC-associated HCC were analyzed via a case-control study comprising 20 PBC patients with HCC and 77 matched controls without HCC. The matched factors included gender, age, follow-up period and Child-Pugh scores. Conditional logistic regression was used to evaluate the odds ratios of potential risk factors for HCC development. A P < 0.05 was considered statistically significant. RESULTS: The incidence of HCC in Chinese PBC patients was 4.13%(52/1255) and was significantly higher in the males(9.52%) than in the females(3.31%). Among the 52 PBC patients with HCC, 55.76%(29/52) were diagnosed with HCC and PBC simultaneously, and 5.76%(3/52) were diagnosed with HCC before PBC. The males with PBC-associated HCCwere more likely than the females to have undergone blood transfusion(18.75% vs 8.33%, P = 0.043), consumed alcohol(31.25% vs 8.33%, P = 0.010), smoked(31.25% vs 8.33%, P = 0.010), had a family history of malignancy(25% vs 5.56%, P = 0.012), and had serious liver inflammation, as indicated by the elevated levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase(P < 0.05). Conditional logistic regression analysis revealed that body mass index(BMI) ≥ 25 [adjusted odds ratio(AOR) = 1.116, 95%CI: 1.002-1.244, P = 0.045] and history of alcohol intake(AOR = 10.294, 95%CI: 1.108-95.680, P = 0.040) were significantly associated with increased odds of HCC development in PBC patients. CONCLUSION: HCC is not rare in Chinese PBC patients. Risk factors for PBC-associated HCC include BMI ≥ 25 and a history of alcohol intake. In addition to regular monitoring, PBC patients may benefit from abstinence from alcohol and body weight control.展开更多
The corneal crosslinking （CXL） with riboflavin and ultraviolet-A （UVA） is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications ...The corneal crosslinking （CXL） with riboflavin and ultraviolet-A （UVA） is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis.展开更多
Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime...Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.展开更多
Objective:To study the effect of butyl phthalide on serum cytokines, soluble apoptosis factors and antioxidant molecules in patients with vascular dementia. Methods:86 patients with vascular dementia admitted in our h...Objective:To study the effect of butyl phthalide on serum cytokines, soluble apoptosis factors and antioxidant molecules in patients with vascular dementia. Methods:86 patients with vascular dementia admitted in our hospital between January 2014 and January 2016 were selected for retrospective study and divided into observation group and control group (n=43) according to double-blind randomized control. Observation group received butyl phthalide capsule (0.2 g/time, 3 times/d) treatment on the basis of conventional treatment, control group received conventional treatment alone, and both lasted for 24 weeks. After 24 weeks of treatment, ELISA was used to determine serum levels of vascular repair factors and soluble apoptosis factors of two groups of patients, and radioimmunoassay was used to determine serum levels of antioxidant molecules. Results:After 24 weeks of treatment, serum vascular repair factors heme oxygenase-1 (HO-1), angiogenin I (AngI) and vascular endothelial growth factor (VEGF) levels of observation group were higher than those of control group, matrix metalloproteinase-9 (MMP-9) level was lower than that of control group, and differences between groups were statistically significant (P<0.05);serum soluble factor-related apoptosis (sFas) and soluble factor-related apoptosis ligand (sFasL) levels were lower than those of control group (P<0.05);serum antioxidant molecules superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR) levels were higher than those of control group (P<0.05). Conclusions:Butyl phthalide can prompt vascular repair in patients with vascular dementia, and also inhibit apoptosis process and balance the body’s oxidation/antioxidation system function.展开更多
BACKGROUND:Several reports have inconsistently demonstrated that there is an association between hepatitis B virus(HBV)or hepatitis C virus(HCV)infections and pancreatic cancer(PC).The aim of the present meta-analysis...BACKGROUND:Several reports have inconsistently demonstrated that there is an association between hepatitis B virus(HBV)or hepatitis C virus(HCV)infections and pancreatic cancer(PC).The aim of the present meta-analysis is to assess this possible relationship.DATA SOURCES:Studies were identified by searching available database from January 2000 to July 2012.Possible associations between PC risk and hepatitis B surface antigen(HBsAg)and its antibody(HBsAb),hepatitis B e antigen(HBeAg)and its antibody(HBeAb),anti-HBcAg antibody(HBcAb),and HCV antibody(anti-HCV)were evaluated.RESULTS:Eight case-control and two cohort studies were included,and their quality scores were assessed by the modified Newcastle-Ottawa Quality Assessment Scale(NOS).We found that HBsAg and anti-HCV seropositivity significantly increased risk of PC(OR=1.28,95%CI:1.11-1.48 and OR=1.21,95%CI:1.02-1.44).The presence of HBsAb was associated with a statistically significant decrease in the risk of PC(OR=0.40,95%CI:0.20-0.79)and HBeAb(OR=0.62,95%CI:0.39-0.99).HBsAg–/HBcAb+/HBsAb–or HBsAg–/HBcAb+/HBsAb+profile was not related to PC risk(OR=1.57,95%CI:0.83-2.98 and OR=1.24,95%CI:0.72-2.14).CONCLUSIONS:HBV/HCV infection increases the risk of PC.HBsAb and HBeAb seropositivity may be the protective factors against PC.It is still uncertain whether serological pattern of past exposure to HBV with or without natural immunity is associated with an enhanced probability of this malignancy.展开更多
Aluminum is widely used in transmission lines, and the accumulation of ice on aluminum conductor may inflict serious damage such as tower collapse and power failure. In this study, super-hydrophobic surface （SHS） on...Aluminum is widely used in transmission lines, and the accumulation of ice on aluminum conductor may inflict serious damage such as tower collapse and power failure. In this study, super-hydrophobic surface （SHS） on alurninurn conductor with rnicro-nanostructure was fabricated using the preferential etching principle of crystal defects. The surface rnicrostructure and wettability were investigated by scanning electron microscope and contact angle measurement, respectively. The icing progress was observed with a self-made icing experiment platform at different environment temperature. The results showed that, due to jumping and rolling down of coalesced droplets from SHS of aluminum conductor at low temperature, the formation of icing on SHS could be delayed. Dynamic icing experiment indicated that SHS on aluminum conductor could restrain the formation of icing in certain temperature range, but could not exert influence on the accumulation of icing. This study offers new insight into understanding the anti-icing performance of actual aluminum conductor.展开更多
Muon radiography is a promising technique for imaging the internal density structures of targets such as tunnels,pyramids,and volcanoes up to a scale of a few hundred meters by measuring the flux attenuation of cosmic...Muon radiography is a promising technique for imaging the internal density structures of targets such as tunnels,pyramids,and volcanoes up to a scale of a few hundred meters by measuring the flux attenuation of cosmic ray muons after they have traveled through these targets.In this study,we conducted experimental muon radiography of one of the volcanoes in the Wudalianchi area in Northeast China to image its internal density structure.The muon detector used in this study was composed of plastic scintillators and silicon photomultipliers.After approximately one and a half months of observing the crater and conduit of the Laoheishan volcano cone in Wudalianchi from September 23^(rd) to November 10^(th) 2019,more than 3 million muon tracks fulfilling the data selection criteria were collected.Based on the muon samples and high-resolution topography obtained through aerial photogrammetry using an unmanned aerial vehicle,a density image of the Laoheishan volcano cone was constructed.The results obtained in this experiment demonstrate the feasibility of using a radiography technique based on plastic scintillator detectors.To obtain the density distribution,we performed a detailed background analysis and found that low-energy charged particles dominated the background noise.Relatively higher densities were found near the surface of the volcanic cone,whereas relatively lower densities were found near the center of the volcanic cone.The experiment in this study is the first volcano muon tomography study performed in China.Our work provides an important reference for future research.展开更多
Vector neural network(VNN)is one of the most important methods to process interval data.However,the VNN,which contains a great number of multiply-accumulate(MAC)operations,often adopts pure numerical calculation metho...Vector neural network(VNN)is one of the most important methods to process interval data.However,the VNN,which contains a great number of multiply-accumulate(MAC)operations,often adopts pure numerical calculation method,and thus is difficult to be miniaturized for the embedded applications.In this paper,we propose a memristor based vector-type backpropagation(MVTBP)architecture which utilizes memristive arrays to accelerate the MAC operations of interval data.Owing to the unique brain-like synaptic characteristics of memristive devices,e.g.,small size,low power consumption,and high integration density,the proposed architecture can be implemented with low area and power consumption cost and easily applied to embedded systems.The simulation results indicate that the proposed architecture has better identification performance and noise tolerance.When the device precision is 6 bits and the error deviation level(EDL)is 20%,the proposed architecture can achieve an identification rate,which is about 92%higher than that for interval-value testing sample and 81%higher than that for scalar-value testing sample.展开更多
Al-Si alloy was modified with Al-3P master alloy at 740℃.The effects of Si content(7,8,9,10 and 11 wt.%) and adding amount of alterant A1-3P(0,0.1,0.3,0.6,1.0 and 1.5 wt.%) on microstructures and tensile properties o...Al-Si alloy was modified with Al-3P master alloy at 740℃.The effects of Si content(7,8,9,10 and 11 wt.%) and adding amount of alterant A1-3P(0,0.1,0.3,0.6,1.0 and 1.5 wt.%) on microstructures and tensile properties of the alloy were investigated with optical microscope(OP),Image Pro Plus 6.0,scanning electron microscope(SEM) and universal testing machine.When the content of Al-3P is 0.6 wt.%,the area fraction of primary a(Al) in the Al-Si alloy increases more compared to the unmodified alloy with an increase in Si content,which could be explained by the movement of non-equilibrium eutectic point.When the Si content is constant(Al-lOSi),with the increase of Al-3P content,the increased rate in area fraction of primary a(Al) phase in the Al-lOSi alloy increases first and then decreases.And when 0.6 wt.% Al-3P is added,the increase in area fraction of primary a(Al) phase is the largest.Compared to the unmodified Al-lOSi alloy,the tensile strength and elongation of Al-lOSi alloy increase by 2.3% and 47.0%,respectively,after being modified with 0.6 wt.% Al-3P alloy.The fracture mode of the modified Al-lOSi alloy is ductile fracture.展开更多
Electronic structures and optical properties of single-layer In1-xGaxN are studied by employing Heyd-Scuseria-Ernzerh（HSE） method based on the first-principles. The band structure and density of states（DOS） of sin...Electronic structures and optical properties of single-layer In1-xGaxN are studied by employing Heyd-Scuseria-Ernzerh（HSE） method based on the first-principles. The band structure and density of states（DOS） of single-layer In1-xGaxN are calculated, and the band gap ranges from 1.8 eV to 3.8 eV as the ratio x changes, illustrating the potential for the tunability of band gap values via Ga doped. We also have investigated optical properties of single-layer In1-xGaxN such as dielectric function, refractive index and absorption coefficient, the main peak of dielectric function spectrum and the absorption edge are found to have a remarkable blue-shift as the concentration of Ga increases. Furthermore, the optical properties of single-layer In1-xGaxN are analyzed based on the band structures and DOS analysis. Such unique optical properties have profound application in nanoelectronics and optical devices.展开更多
The intrinsic stochasticity of resistance switching process is one of the holdblocks for using memristor as a fundamental element in the next-generation nonvolatile memory.However,such a weakness can be used as an ass...The intrinsic stochasticity of resistance switching process is one of the holdblocks for using memristor as a fundamental element in the next-generation nonvolatile memory.However,such a weakness can be used as an asset for generating the random bits,which is valuable in a hardware security system.In this work,a forming-free electronic bipolar Pt/Ti/Ta2O5/Pt memristor is successfully fabricated to investigate the merits of generating random bits in such a device.The resistance switching mechanism of the fabricated device is ascribed to the electric field conducted electrons trapping/de-trapping in the deep-energy-level traps produced by the"oxygen grabbing"process.The stochasticity of the electrons trapping/detrapping governs the random distribution of the set/reset switching voltages of the device,making a single memristor act as a random bit in which the resistance of the device represents information and the applied voltage pulse serves as the triggering signal.The physical implementation of such a random process provides a method of generating the random bits based on memristors in hardware security applications.展开更多
Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:...Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:30 patients with myocardial infarction(MI)who had complete clinical and imaging data from July 2016 to December 2018 after PCI were analyzed retrospectively.MR and echocardiogram were performed before and 6 months after PCI,and the parameters related to left ventricular function were measured by post-processing software of MRI workstation.The left ventricular transmural degree of CMR late gadolinium enhancement was compared with the left ventricular wall motion degree of 6-month echocardiography as a standard to judge the viable myocardium.Result:There were 193 left ventricular segmental abnormalities in 30 cases,including 121 viable myocardium and 72 non viable myocardium in CMR-LGE before operation.Six months after PCI,echocardiography showed that 125 of 193 abnormal segments of left ventricle detected by CMR-LGE before PCI were viable myocardium and 68 were non viable myocaridium.The sensitivity and specificity of CMR-LGE to determinate of viable myocardium were 92.0%and 91.1%respectively.The larger the non-viable myocardial area of the left ventricular wall,the worse the recovery of wall motion ability,and there was a negative correlation between them(r=0.416,P<0.05).The first-pass perfusion time in CMR-LEG region was significantly longer than that in normal myocardial region(4.85(+)1.51)s and(3.79(+)1.73)s,respectively.The difference was statistically significant(t=5.191,P<0.05).Conclusion:MRI can evaluate the myocardial activity of myocardial infarction,reflect the range of viable myocardium,and provide imaging basis for clinical treatment and prognosis.展开更多
In this paper a direct coupling analysis method (DCAM) of hydroelastic responses of a very large floating structures (VLFS) in complicated geographical environment is presented. In this method the three-dimensional hy...In this paper a direct coupling analysis method (DCAM) of hydroelastic responses of a very large floating structures (VLFS) in complicated geographical environment is presented. In this method the three-dimensional hydroelasticity theory of floating bodies is combined with the shallow water wave theory, to allow for proper description of the influence of uneven seabed and sheltering effect of islands on the hydroelastic responses of a VLFS deployed near island and reefs in shallow sea. This method and the numerical procedures were verified and validated by comparison-between the predictions and the model test results of a 3-module VLFS and an 8-module VLFS in two simulated shallow sea regions with different seabed topography.展开更多
Lithium-ion capacitors(LICs),consisting of a capacitor-type material and a battery-type material together with organic electrolytes,are the state-of-the-art electrochemical energy storage devices compared with superca...Lithium-ion capacitors(LICs),consisting of a capacitor-type material and a battery-type material together with organic electrolytes,are the state-of-the-art electrochemical energy storage devices compared with supercapacitors and batteries.Owing to their unique characteristics,LICs received a lot of attentions,and great progresses have been achieved,especially in the exploration of cathode and anode materials.Prelithiation techniques are regarded as indispensable procedures for LICs systems,which can compensate for the initial irreversible capacity loss,increase the Li^(+)concentration in the electrolyte,raise the working voltage and resolve the safety and cycle stability issues;however,its research progress is slow,and there is not enough attention until now.In this overview,we look into the ongoing processes on the recent development of prelithiation technologies,especially in organic electrolyte consumption-type LICs.In particular,some prelithiation strategies for LICs are summarized and discussed in detail,including the ex situ electrochemical method,in situ electrochemical method,and cathode prelithiation additives method.Moreover,we propose some unresolved challenges and prospects for prelithiation technologies from the basic research ideas and future key research directions.This work aims to bring up new insights to reassess the significance of premetallation strategies for advanced hybrid-ion capacitors based on the currently proposed prelithiation strategies.展开更多
Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treat...Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of Ml.As chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.展开更多
Quality and property control have become one of the critical problems for the metallic parts produced by selective laser melting.In this paper,the crack spontaneously formed in the Ti-6 Al-4 V alloy by selecting laser...Quality and property control have become one of the critical problems for the metallic parts produced by selective laser melting.In this paper,the crack spontaneously formed in the Ti-6 Al-4 V alloy by selecting laser melting is investigated.The crack is C-shape without branching in macro view.In micro view,the crack originates from and propagates toward the selective laser melting(SLM)processing defects.The crack surface topography shows that the crack is typical dimple cleavage.A few heads of martensiticα’laths appear at the bottom of the dimple.And the secondary crack nucleates and grows up near by the martensiticα’laths.A lot of spatters and cavities formed at the top surface of the SLM body and the residual stress accumulated in the SLM body is up to 640 MPa,which confirms that the SLM processing defects and the residual stress induced the origination and propagation of the crack.The research results indicate that preventing spatter and controlling residual stress are important to SLM processing.展开更多
基金The study was reviewed and approved by the Chinese PLA General Hospital Institutional Review Board(Approval No.2010068D).
文摘BACKGROUND The liver hemodynamic changes caused by portal hypertension(PH)are closely related to various complications such as gastroesophageal varices and portosystemic shunts,which may lead to adverse clinical outcomes in these patients,so it is of great clinical significance to find treatment strategies with favorable clinical efficacy and low risk of complications.AIM To study the clinical efficacy of total laparoscopic splenectomy(TLS)for PH and its influence on hepatic hemodynamics and liver function.METHODS Among the 199 PH patients selected from October 2016 to October 2020,100 patients[observation group(OG)]were treated with TLS,while the remaining 99[reference group(RG)]were treated with open splenectomy(OS).We observed and compared the clinical efficacy,operation indexes[operative time(OT)and intraoperative bleeding volume],safety(intraperitoneal hemorrhage,ascitic fluid infection,eating disorders,liver insufficiency,and perioperative death),hepatic hemodynamics(diameter,velocity,and flow volume of the portal vein system),and liver function[serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),and serum total bilirubin(TBil)]of the two groups.RESULTS The OT was significantly longer and intraoperative bleeding volume was significantly lesser in the OG than in the RG.Additionally,the overall response rate,postoperative complications rate,and liver function indexes(ALT,AST,and TBil)did not differ significantly between the OG and RG.The hepatic hemodynamics statistics showed that the pre-and postoperative blood vessel diameters in the two cohorts did not differ statistically.Although the postoperative blood velocity and flow volume reduced significantly when compared with the preoperative values,there were no significant inter-group differences.CONCLUSION TLS contributes to comparable clinical efficacy,safety,hepatic hemodynamics,and liver function as those of OS in treating PH,with a longer OT but lesser intraoperative blood loss.
基金Supported by National Natural Science Foundation of China,No.81470837,No.81101589 and No.81302593
文摘AIM: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma(HCC) in Chinese patients with primary biliary cirrhosis(PBC).METHODS: We reviewed the data of 52 PB Cassociated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence and characteristics between the two genders. The risk factors for PBC-associated HCC were analyzed via a case-control study comprising 20 PBC patients with HCC and 77 matched controls without HCC. The matched factors included gender, age, follow-up period and Child-Pugh scores. Conditional logistic regression was used to evaluate the odds ratios of potential risk factors for HCC development. A P < 0.05 was considered statistically significant. RESULTS: The incidence of HCC in Chinese PBC patients was 4.13%(52/1255) and was significantly higher in the males(9.52%) than in the females(3.31%). Among the 52 PBC patients with HCC, 55.76%(29/52) were diagnosed with HCC and PBC simultaneously, and 5.76%(3/52) were diagnosed with HCC before PBC. The males with PBC-associated HCCwere more likely than the females to have undergone blood transfusion(18.75% vs 8.33%, P = 0.043), consumed alcohol(31.25% vs 8.33%, P = 0.010), smoked(31.25% vs 8.33%, P = 0.010), had a family history of malignancy(25% vs 5.56%, P = 0.012), and had serious liver inflammation, as indicated by the elevated levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase(P < 0.05). Conditional logistic regression analysis revealed that body mass index(BMI) ≥ 25 [adjusted odds ratio(AOR) = 1.116, 95%CI: 1.002-1.244, P = 0.045] and history of alcohol intake(AOR = 10.294, 95%CI: 1.108-95.680, P = 0.040) were significantly associated with increased odds of HCC development in PBC patients. CONCLUSION: HCC is not rare in Chinese PBC patients. Risk factors for PBC-associated HCC include BMI ≥ 25 and a history of alcohol intake. In addition to regular monitoring, PBC patients may benefit from abstinence from alcohol and body weight control.
文摘The corneal crosslinking （CXL） with riboflavin and ultraviolet-A （UVA） is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis.
文摘Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.
文摘Objective:To study the effect of butyl phthalide on serum cytokines, soluble apoptosis factors and antioxidant molecules in patients with vascular dementia. Methods:86 patients with vascular dementia admitted in our hospital between January 2014 and January 2016 were selected for retrospective study and divided into observation group and control group (n=43) according to double-blind randomized control. Observation group received butyl phthalide capsule (0.2 g/time, 3 times/d) treatment on the basis of conventional treatment, control group received conventional treatment alone, and both lasted for 24 weeks. After 24 weeks of treatment, ELISA was used to determine serum levels of vascular repair factors and soluble apoptosis factors of two groups of patients, and radioimmunoassay was used to determine serum levels of antioxidant molecules. Results:After 24 weeks of treatment, serum vascular repair factors heme oxygenase-1 (HO-1), angiogenin I (AngI) and vascular endothelial growth factor (VEGF) levels of observation group were higher than those of control group, matrix metalloproteinase-9 (MMP-9) level was lower than that of control group, and differences between groups were statistically significant (P<0.05);serum soluble factor-related apoptosis (sFas) and soluble factor-related apoptosis ligand (sFasL) levels were lower than those of control group (P<0.05);serum antioxidant molecules superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR) levels were higher than those of control group (P<0.05). Conclusions:Butyl phthalide can prompt vascular repair in patients with vascular dementia, and also inhibit apoptosis process and balance the body’s oxidation/antioxidation system function.
文摘BACKGROUND:Several reports have inconsistently demonstrated that there is an association between hepatitis B virus(HBV)or hepatitis C virus(HCV)infections and pancreatic cancer(PC).The aim of the present meta-analysis is to assess this possible relationship.DATA SOURCES:Studies were identified by searching available database from January 2000 to July 2012.Possible associations between PC risk and hepatitis B surface antigen(HBsAg)and its antibody(HBsAb),hepatitis B e antigen(HBeAg)and its antibody(HBeAb),anti-HBcAg antibody(HBcAb),and HCV antibody(anti-HCV)were evaluated.RESULTS:Eight case-control and two cohort studies were included,and their quality scores were assessed by the modified Newcastle-Ottawa Quality Assessment Scale(NOS).We found that HBsAg and anti-HCV seropositivity significantly increased risk of PC(OR=1.28,95%CI:1.11-1.48 and OR=1.21,95%CI:1.02-1.44).The presence of HBsAb was associated with a statistically significant decrease in the risk of PC(OR=0.40,95%CI:0.20-0.79)and HBeAb(OR=0.62,95%CI:0.39-0.99).HBsAg–/HBcAb+/HBsAb–or HBsAg–/HBcAb+/HBsAb+profile was not related to PC risk(OR=1.57,95%CI:0.83-2.98 and OR=1.24,95%CI:0.72-2.14).CONCLUSIONS:HBV/HCV infection increases the risk of PC.HBsAb and HBeAb seropositivity may be the protective factors against PC.It is still uncertain whether serological pattern of past exposure to HBV with or without natural immunity is associated with an enhanced probability of this malignancy.
基金supported by the National Natural Science Foundation of China (No.51272208)
文摘Aluminum is widely used in transmission lines, and the accumulation of ice on aluminum conductor may inflict serious damage such as tower collapse and power failure. In this study, super-hydrophobic surface （SHS） on alurninurn conductor with rnicro-nanostructure was fabricated using the preferential etching principle of crystal defects. The surface rnicrostructure and wettability were investigated by scanning electron microscope and contact angle measurement, respectively. The icing progress was observed with a self-made icing experiment platform at different environment temperature. The results showed that, due to jumping and rolling down of coalesced droplets from SHS of aluminum conductor at low temperature, the formation of icing on SHS could be delayed. Dynamic icing experiment indicated that SHS on aluminum conductor could restrain the formation of icing in certain temperature range, but could not exert influence on the accumulation of icing. This study offers new insight into understanding the anti-icing performance of actual aluminum conductor.
基金supported by the National Natural Science Foundation of China(Nos.41974064,42174076 and U1865206)Young Elite Scientists Sponsorship Program by CAST(No.2019QNRC001).
文摘Muon radiography is a promising technique for imaging the internal density structures of targets such as tunnels,pyramids,and volcanoes up to a scale of a few hundred meters by measuring the flux attenuation of cosmic ray muons after they have traveled through these targets.In this study,we conducted experimental muon radiography of one of the volcanoes in the Wudalianchi area in Northeast China to image its internal density structure.The muon detector used in this study was composed of plastic scintillators and silicon photomultipliers.After approximately one and a half months of observing the crater and conduit of the Laoheishan volcano cone in Wudalianchi from September 23^(rd) to November 10^(th) 2019,more than 3 million muon tracks fulfilling the data selection criteria were collected.Based on the muon samples and high-resolution topography obtained through aerial photogrammetry using an unmanned aerial vehicle,a density image of the Laoheishan volcano cone was constructed.The results obtained in this experiment demonstrate the feasibility of using a radiography technique based on plastic scintillator detectors.To obtain the density distribution,we performed a detailed background analysis and found that low-energy charged particles dominated the background noise.Relatively higher densities were found near the surface of the volcanic cone,whereas relatively lower densities were found near the center of the volcanic cone.The experiment in this study is the first volcano muon tomography study performed in China.Our work provides an important reference for future research.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61471377,61804181,61604177,and 61704191).
文摘Vector neural network(VNN)is one of the most important methods to process interval data.However,the VNN,which contains a great number of multiply-accumulate(MAC)operations,often adopts pure numerical calculation method,and thus is difficult to be miniaturized for the embedded applications.In this paper,we propose a memristor based vector-type backpropagation(MVTBP)architecture which utilizes memristive arrays to accelerate the MAC operations of interval data.Owing to the unique brain-like synaptic characteristics of memristive devices,e.g.,small size,low power consumption,and high integration density,the proposed architecture can be implemented with low area and power consumption cost and easily applied to embedded systems.The simulation results indicate that the proposed architecture has better identification performance and noise tolerance.When the device precision is 6 bits and the error deviation level(EDL)is 20%,the proposed architecture can achieve an identification rate,which is about 92%higher than that for interval-value testing sample and 81%higher than that for scalar-value testing sample.
基金Projects(51571039,51671037)supported by the National Natural Science Foundation of ChinaProject(KYCX18-0820)supported by Postgraduate Research and Practice Innovation Program of Jiangsu Province,ChinaProject supported by Qing Lan Program of Education Department of Jiangsu Province,China
文摘Al-Si alloy was modified with Al-3P master alloy at 740℃.The effects of Si content(7,8,9,10 and 11 wt.%) and adding amount of alterant A1-3P(0,0.1,0.3,0.6,1.0 and 1.5 wt.%) on microstructures and tensile properties of the alloy were investigated with optical microscope(OP),Image Pro Plus 6.0,scanning electron microscope(SEM) and universal testing machine.When the content of Al-3P is 0.6 wt.%,the area fraction of primary a(Al) in the Al-Si alloy increases more compared to the unmodified alloy with an increase in Si content,which could be explained by the movement of non-equilibrium eutectic point.When the Si content is constant(Al-lOSi),with the increase of Al-3P content,the increased rate in area fraction of primary a(Al) phase in the Al-lOSi alloy increases first and then decreases.And when 0.6 wt.% Al-3P is added,the increase in area fraction of primary a(Al) phase is the largest.Compared to the unmodified Al-lOSi alloy,the tensile strength and elongation of Al-lOSi alloy increase by 2.3% and 47.0%,respectively,after being modified with 0.6 wt.% Al-3P alloy.The fracture mode of the modified Al-lOSi alloy is ductile fracture.
基金supported by the National Natural Science Foundation of China (No.11404230)Foundation of Science and Technology Bureau of Sichuan Province (No.2013JY0085)
文摘Electronic structures and optical properties of single-layer In1-xGaxN are studied by employing Heyd-Scuseria-Ernzerh（HSE） method based on the first-principles. The band structure and density of states（DOS） of single-layer In1-xGaxN are calculated, and the band gap ranges from 1.8 eV to 3.8 eV as the ratio x changes, illustrating the potential for the tunability of band gap values via Ga doped. We also have investigated optical properties of single-layer In1-xGaxN such as dielectric function, refractive index and absorption coefficient, the main peak of dielectric function spectrum and the absorption edge are found to have a remarkable blue-shift as the concentration of Ga increases. Furthermore, the optical properties of single-layer In1-xGaxN are analyzed based on the band structures and DOS analysis. Such unique optical properties have profound application in nanoelectronics and optical devices.
基金Project supported by the National Natural Science Foundation of China(Grant No.61832007)the National Key Research and Development Program of China(Grant No.2018YFB1003304)。
文摘The intrinsic stochasticity of resistance switching process is one of the holdblocks for using memristor as a fundamental element in the next-generation nonvolatile memory.However,such a weakness can be used as an asset for generating the random bits,which is valuable in a hardware security system.In this work,a forming-free electronic bipolar Pt/Ti/Ta2O5/Pt memristor is successfully fabricated to investigate the merits of generating random bits in such a device.The resistance switching mechanism of the fabricated device is ascribed to the electric field conducted electrons trapping/de-trapping in the deep-energy-level traps produced by the"oxygen grabbing"process.The stochasticity of the electrons trapping/detrapping governs the random distribution of the set/reset switching voltages of the device,making a single memristor act as a random bit in which the resistance of the device represents information and the applied voltage pulse serves as the triggering signal.The physical implementation of such a random process provides a method of generating the random bits based on memristors in hardware security applications.
基金Hainan key research and development plan science and technology project funding(No.ZDYF2018166)Hainan key science and technology project Sanya supporting fund project support(No.2019PT107)Sanya medical science and technology innovation project(No.2019YW01)
文摘Objective:To investigate the correlation of cardiac magnetic resonance imaging(MRI)in the assessment of myocardial activity in patients with myocardial infarction and the outcome of cardiac function after PCI.Methods:30 patients with myocardial infarction(MI)who had complete clinical and imaging data from July 2016 to December 2018 after PCI were analyzed retrospectively.MR and echocardiogram were performed before and 6 months after PCI,and the parameters related to left ventricular function were measured by post-processing software of MRI workstation.The left ventricular transmural degree of CMR late gadolinium enhancement was compared with the left ventricular wall motion degree of 6-month echocardiography as a standard to judge the viable myocardium.Result:There were 193 left ventricular segmental abnormalities in 30 cases,including 121 viable myocardium and 72 non viable myocardium in CMR-LGE before operation.Six months after PCI,echocardiography showed that 125 of 193 abnormal segments of left ventricle detected by CMR-LGE before PCI were viable myocardium and 68 were non viable myocaridium.The sensitivity and specificity of CMR-LGE to determinate of viable myocardium were 92.0%and 91.1%respectively.The larger the non-viable myocardial area of the left ventricular wall,the worse the recovery of wall motion ability,and there was a negative correlation between them(r=0.416,P<0.05).The first-pass perfusion time in CMR-LEG region was significantly longer than that in normal myocardial region(4.85(+)1.51)s and(3.79(+)1.73)s,respectively.The difference was statistically significant(t=5.191,P<0.05).Conclusion:MRI can evaluate the myocardial activity of myocardial infarction,reflect the range of viable myocardium,and provide imaging basis for clinical treatment and prognosis.
文摘In this paper a direct coupling analysis method (DCAM) of hydroelastic responses of a very large floating structures (VLFS) in complicated geographical environment is presented. In this method the three-dimensional hydroelasticity theory of floating bodies is combined with the shallow water wave theory, to allow for proper description of the influence of uneven seabed and sheltering effect of islands on the hydroelastic responses of a VLFS deployed near island and reefs in shallow sea. This method and the numerical procedures were verified and validated by comparison-between the predictions and the model test results of a 3-module VLFS and an 8-module VLFS in two simulated shallow sea regions with different seabed topography.
基金financially supported by the National Natural Science Foundation of China(Nos.U1802256,21975283,21773118 and 21875107)the Key Research and Development Program in Jiangsu Province(No.BE2018122)+1 种基金the general research Project of Jiangsu Key Laboratory of Coal-based Greenhouse Gas Control and Utilization(No.2022KF03)the Fundamental Research Funds for the Central Universities(No.2022QN1088)。
文摘Lithium-ion capacitors(LICs),consisting of a capacitor-type material and a battery-type material together with organic electrolytes,are the state-of-the-art electrochemical energy storage devices compared with supercapacitors and batteries.Owing to their unique characteristics,LICs received a lot of attentions,and great progresses have been achieved,especially in the exploration of cathode and anode materials.Prelithiation techniques are regarded as indispensable procedures for LICs systems,which can compensate for the initial irreversible capacity loss,increase the Li^(+)concentration in the electrolyte,raise the working voltage and resolve the safety and cycle stability issues;however,its research progress is slow,and there is not enough attention until now.In this overview,we look into the ongoing processes on the recent development of prelithiation technologies,especially in organic electrolyte consumption-type LICs.In particular,some prelithiation strategies for LICs are summarized and discussed in detail,including the ex situ electrochemical method,in situ electrochemical method,and cathode prelithiation additives method.Moreover,we propose some unresolved challenges and prospects for prelithiation technologies from the basic research ideas and future key research directions.This work aims to bring up new insights to reassess the significance of premetallation strategies for advanced hybrid-ion capacitors based on the currently proposed prelithiation strategies.
基金This study was supported by the National Key R&D Program of China(No.2019YFC1709001)the National Natural Science Foundation of China(No.81774434)+2 种基金the National Natural Science Foundation of China(No.81704187)the Department of Science and Technology of Sichuan Province(China)(No.2019YJ0587)the Department of Science and Technology of Sichuan Province(No.2018JY0482).
文摘Myocardial ischemia(Ml)is a common disease with high mortality and morbidity worldwide.Since the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of Ml.As chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.
基金financially supported by the Science and Technology Commission of Shanghai Municipality(Grant Nos.17JC1400600,and 17JC1400601)the National Natural Science Foundation of China(Grant No.51471105)
文摘Quality and property control have become one of the critical problems for the metallic parts produced by selective laser melting.In this paper,the crack spontaneously formed in the Ti-6 Al-4 V alloy by selecting laser melting is investigated.The crack is C-shape without branching in macro view.In micro view,the crack originates from and propagates toward the selective laser melting(SLM)processing defects.The crack surface topography shows that the crack is typical dimple cleavage.A few heads of martensiticα’laths appear at the bottom of the dimple.And the secondary crack nucleates and grows up near by the martensiticα’laths.A lot of spatters and cavities formed at the top surface of the SLM body and the residual stress accumulated in the SLM body is up to 640 MPa,which confirms that the SLM processing defects and the residual stress induced the origination and propagation of the crack.The research results indicate that preventing spatter and controlling residual stress are important to SLM processing.
