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Primary extraosseous Ewing's sarcoma of the lung in a 36-year-old female patient:clinical,imaging,and pathologic findings
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作者 Yafei Zhang Junming Feng +3 位作者 Zhiqiang Sun Jianfei Gao Bicheng Zhang zhiguo rao 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第11期555-558,共4页
Primary extraosseous Ewing's sarcoma is a very rare clinical entity. In the report, we present the case of a 36year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing's s... Primary extraosseous Ewing's sarcoma is a very rare clinical entity. In the report, we present the case of a 36year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing's sarcoma by pathological examination. The clinical, imaging, and pathologic features of the case are described and discussed. 展开更多
关键词 Ewing's sarcoma EXTRAOSSEOUS LUNG
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Holocene precipitationδ^18O as an indicator of temperature history in arid central Asia:an overview of recent advances 被引量:2
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作者 zhiguo rao YiPing Tian +4 位作者 YunXia Li HaiChun Guo XinZhu Zhang Guang Han XinPing Zhang 《Research in Cold and Arid Regions》 CSCD 2020年第6期371-379,共9页
Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ... Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ^18O(δ^18Op).Nevertheless,they have been proposed as indicators of different climatic parameters,such as wetness and temperature changes.This article summarizes previously reported records of moisture sources for the Xinjiang region and the results of modern observations conducted at an ice core site and a peat site in the Altai Mountains.The findings are used to propose that the overall positive trends in Holoceneδ^18O records from the various archives from the Xinjiang region primarily reflect the Holocene's long-term warming trend.It is concluded that more site-specific modern observations are needed to further elucidate the environmental significance of Holoceneδ^18O records from this region,especially for the separation of different seasonal temperature signals present withinδ^18O records. 展开更多
关键词 arid central Asia precipitationδ^18O Holocene temperature history ice core STALAGMITE peat
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Cisplatin sensitivity and mechanisms of anti-HPV16 E6-ribozyme on cervical carcinoma CaSKi cell line
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作者 zhiguo rao Jianfei Gao +2 位作者 Bicheng Zhang Bo Yang Jiren Zhang 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第4期237-242,共6页
Objective: The aim of this study was to study the cisplatin sensitizing effect and mechanism of anti-HPV16 E6- ribozyme on cervical carcinoma cell line. Methods: The anti-HPV16E6-ribozyme and empty eucaryotic expres... Objective: The aim of this study was to study the cisplatin sensitizing effect and mechanism of anti-HPV16 E6- ribozyme on cervical carcinoma cell line. Methods: The anti-HPV16E6-ribozyme and empty eucaryotic expressing plasmids were transfected into CaSKi cell, which named as CaSKi-R, CaSKi-P respectively. E6 mRNA, the sensitivity to cisplatin, apoptosis rates, expression of p53, Bcl-2, Bax and C-myc proteins and mRNA were examined by Northem blot, MTT colorimetric assay, PI/Annexin V stained methods, flow cytometry anslysis and RT-PCR, respectively. Results: E6 mRNA was less in CaSKi-R than in CaSKi. The sensitivity of CaSKi-R cells to cisplatin was 2.28 and 2.21 times than that of CaSKi and CaSKi-P cells. The apoptotic rates in CaSKi, CaSKi-P and CaSKi-R cells was (18.9 ± 3.5)%, (19.7 ± 4.8)% and (40.4 ± 4.5)%. The apoptotic rates was increased in CaSKi-R than that of CaSKi cells treated with cisplatin (P = 0.003). Comapred with CaSKi cell, the expression of p53 (P = 0.000), Bax protein (P = 0.002) was significantly higher and the expression of Bcl-2 protein (P = 0.005), C-myc protein (P = 0.005) was significantly lower in CaSKi-R than that of CaSKi cell treated with cisplatin. Comapred with CaSKi cell, the expression of p53, Bax mRNA in CaSKi-R cell treated with cisplatin increased, while Bcl-2, C-myc mRNA decreased. Conclusion: CaSKi-R cells transfected by anti-HPVE6-ribozyme increased the sensitivity to cisplatin. The increase of sensitivity to cisplatin in CaSKi-R cells may be associated with increasing expression of p53, Bax protein, and decreasing expression of C-myc, Bcl-2 proteins. 展开更多
关键词 RIBOZYME human papillomavirus CISPLATIN drug sensitivity cervical cancer
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黄土高原黄土地层古人类遗迹年代研究新进展 被引量:5
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作者 朱照宇 黄慰文 +11 位作者 吴翼 邱世藩 饶志国 杨石霞 侯亚梅 谢久兵 韩江伟 付淑清 欧阳婷萍 周厚云 彭莎莎 Robin Dennell 《科学通报》 EI CAS CSCD 北大核心 2019年第25期2641-2653,共13页
自1920年以来,在中国黄土高原及邻近地区的黄土及河湖相地层分布区发现了大量的古人类活动遗迹地点,其中包括著名的泥河湾、水洞沟、萨拉乌苏、丁村、大荔、匼河-西侯度、庄浪、庆阳、三门峡、东秦岭地区以及蓝田地区等.在陕西蓝田的最... 自1920年以来,在中国黄土高原及邻近地区的黄土及河湖相地层分布区发现了大量的古人类活动遗迹地点,其中包括著名的泥河湾、水洞沟、萨拉乌苏、丁村、大荔、匼河-西侯度、庄浪、庆阳、三门峡、东秦岭地区以及蓝田地区等.在陕西蓝田的最新研究进展是运用第四纪地质学与古人类学和旧石器考古学交叉学科的综合研究方法,以黄土-古土壤序列和高分辨率磁性地层年代框架为依据,发现了公王岭遗址黄土地层的强烈侵蚀和多组地层缺失,确定了直立人头盖骨与伴生的古动物化石所埋藏的地层不是前人原确定的粉砂质黄土L15中部(年代为1.15 Ma),而是位于一个大侵蚀面之下的S22~S23古土壤混合层(年代为1.63 Ma).同时,在蓝田上陈一带发现了新的出露良好的连续黄土-古土壤剖面(L5~L28),并在早更新世S15~L28层段的17层黄土或古土壤层位中发现了原地埋藏的数量不等的旧石器,其年代为1.26~2.12 Ma.研究结果使蓝田地区成为迄今所知非洲以外最古老的人类活动地区之一,这不仅在人类起源和演化方面提出了新的科学思考,并拓展了'黄土石器工业'和'黄土地质考古带'的研究方向,提出了中国黄土高原高分辨率黄土-古土壤序列与多时期古人类活动序列关联研究的新设想. 展开更多
关键词 黄土-古土壤序列 古人类遗迹 年代学 黄土高原
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Lake-level records support a mid-Holocene maximum precipitation in northern China 被引量:3
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作者 Jiantao CAO zhiguo rao +2 位作者 Fuxi SHI Ergang LIAN Guodong JIA 《Science China Earth Sciences》 SCIE EI CSCD 2021年第12期2161-2171,共11页
Lake level and its inferred East Asian summer monsoon(EASM)evolution in northern boundary of EASM during the Holocene are highly debated.Here,we present a 15-ka record of glycerol dialkyl glycerol tetraethers(GDGTs)in... Lake level and its inferred East Asian summer monsoon(EASM)evolution in northern boundary of EASM during the Holocene are highly debated.Here,we present a 15-ka record of glycerol dialkyl glycerol tetraethers(GDGTs)in a closed lake in northern China to address this issue.Surface and downcore sediment data demonstrate sedimentary GDGT-0 and branched GDGTs(brGDGTs)are of aquatic production.Contents of GDGT-0 and brGDGTs increase but brGDGT-based paleo-temperature proxy decreases with water depth in surface sediments along a nearshore to offshore transect.This trend is likely due to an increasingly hypoxic condition,favored by anaerobic microbes producing these GDGT-0 and brGDGTs,in bottom water.Accordingly,brGDGT-derived water temperature and pH would reflect bottom water conditions that are largely regulated by water depth of the lake.Downcore GDGT data and their derived temperature and pH consistently reveal a gradually increasing lake level from the late Pleistocene to the early Holocene,a high level during 9.5-5 ka BP and a decreasing trend afterward.The lake-level records from independent and robust proxies in this study largely agree with pollen records in the region,supporting a mid-Holocene maximum EASM precipitation. 展开更多
关键词 Lake level membrane lipids East Asian summer monsoon HOLOCENE northern China
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Cooling or warming climatic background for the expansion of human activity in arid inland China and the Tibetan Plateau over the past~4000 years? 被引量:1
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作者 zhiguo rao Shikai Wei +2 位作者 Yunxia Li Haichun Guo Fahu Chen 《Science Bulletin》 SCIE EI CSCD 2021年第19期1936-1938,M0003,共4页
Intensified human activities during the last several thousands of years have been identified globally[1].About 4000 years ago,Chinese Neolithic cultures collapsed and were succeeded by Bronze Age culture[2],which was ... Intensified human activities during the last several thousands of years have been identified globally[1].About 4000 years ago,Chinese Neolithic cultures collapsed and were succeeded by Bronze Age culture[2],which was accompanied by a significant spatial expansion of human activities,as demonstrated by the permanent human occupation of the Tibetan Plateau(TP)since~3600 years ago[3]. 展开更多
关键词 OCCUPATION TIBETAN globally
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“North-South”dipolar mode of precipitation changes in eastern China extends to the Last Deglaciation
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作者 Jianhui Chen Zhiping Zhang +4 位作者 Jianbao Liu zhiguo rao Wei Huang Xu Zhang Shengqian Chen 《Science Bulletin》 SCIE EI CAS CSCD 2018年第24期1604-1605,共2页
Changes in the East Asian summer monsoon (EASM)are closely related to human wellbeing,and thus improving our knowledge of the evolution of the EASM is of major socioeconomic importance, as well as being of scientific ... Changes in the East Asian summer monsoon (EASM)are closely related to human wellbeing,and thus improving our knowledge of the evolution of the EASM is of major socioeconomic importance, as well as being of scientific interest.Previous studies have shown that during the Holocene (the present interglacial)a "North-South" dipolar mode of precipitation change occurred over eastern China (i.e.the so-called "northern drought-southern flood"scenario, or vice versa)on decadal [1,2],centennial [3]and millennial timescales ([4]and references therein).A recent high-resolution speleothem trace element-based precipitation record from Haozhu Cave in the Yangtze River Valley (YRV)[5],together with a pollenbased quantitative precipitation reconstruction from Lake Gonghai in North China [6],further suggests that this dipolar mode extended to the Last Deglaciation [5].This inference is based on the recorded anti-phased variation of precipitation between North China and the YRV during the Younger Dryas (YD),Bolling-Allerod (B-A),and part of Heinrich Event 1(H1)(Fig.1a,b). 展开更多
关键词 the EAST ASIAN SUMMER MONSOON closely
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