Long-time integration technique is an effective way of improving target detection performance for unmanned aerial vehicle(UAV)in the passive bistatic radar(PBR),while range migration(RM)and Doppler frequency migration...Long-time integration technique is an effective way of improving target detection performance for unmanned aerial vehicle(UAV)in the passive bistatic radar(PBR),while range migration(RM)and Doppler frequency migration(DFM)may have a major effect due to the target maneuverability.This paper proposed an innovative long-time coherent integration approach,regarded as Continuous Radon-matched filtering process(CRMFP),for low-observable UAV target in passive bistatic radar.It not only mitigates the RM by collaborative research in range and velocity dimensions but also compensates the DFM and ensures the coherent integration through the matched filtering process(MFP).Numerical and real-life data following detailed analysis verify that the proposed method can overcome the Doppler mismatch influence and acquire comparable detection performance.展开更多
Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferropto...Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer.The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma.In this study,a combination of hydrogel-liposome nanoplatform encapsulatedwith Temozolomide and ferroptosis inducer Erastin was constructed.Theαvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy.As biocompatible drug reservoirs,cross-linked GelMA(gelatin methacrylamide)hydrogel and cRGD-coated liposome realized the sustained release of internal contents.In the modified intracranial tumor resection model,GelMA-liposome system achieved slow release of Temozolomide and Erastin in situ for more than 14 d.The results indicated that nanoplatform(T+E@LPs-cRGD+GelMA)improved glioblastoma sensitivity to chemotherapeutic temozolomide and exerted satisfactory anti-tumor effects.It was demonstrated that the induction of ferroptosis could be utilized as a therapeutic strategy to overcome drug resistance.Furthermore,transcriptome sequencing was conducted to reveal the underlying mechanism that the nanoplatform(T+E@LPs-cRGD+GelMA)implicated in.It is suggested that GelMA-liposome system participated in the immune response and immunomodulation of glioblastoma via interferon/PD-L1 pathway.Collectively,this study proposed a potential combinatory therapeutic strategy for glioblastoma treatment.展开更多
Lymphatic metastasis(LM)emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma(HSPSCC),chiefly contributing to treatment inefficacy.This study aimed to scrutinize the prognostic relevan...Lymphatic metastasis(LM)emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma(HSPSCC),chiefly contributing to treatment inefficacy.This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC.Methods:In a preceding investigation,HSP90AA1,a differential gene,was discovered through transcriptome sequencing of HPSCC tissues,considering both the presence and absence of LM.Validation of HSP90AA1 expression was accomplished via qRT-PCR,western-blotting(WB),and immunohistochemistry(IHC),while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA),log-rank test(LR),and Cox’s regression analysis(CRA).Bioinformatics techniques facilitated the prediction and analysis of its plausible mechanisms in LM,further substantiated by in vitro and in vivo experiments utilizing FaDu cell lines.Results:HSP90AA1 is substantially upregulated in HPSCC with LM and is identified as an independent prognostic risk determinant.The down-regulation of HSP90AA1 can achieve inhibition of tumor cell proliferation,migration and invasion.Both in vivo experiments and Bioinformatics exploration hint at promoting LM by Epithelial-mesenchymal transition(EMT),regulated by HSP90AA1.Conclusions:HSP90AA1,by controlling EMT,can foster LM in HPSCC.This finding sets the foundation for delving into new therapeutic targets for HPSCC.展开更多
We simulate an optomechanical system via a cavity QED scenario with a movable atom and investigate its application in the tiny mass sensing.We find that the steady-state solution of the system exhibits a multiple stab...We simulate an optomechanical system via a cavity QED scenario with a movable atom and investigate its application in the tiny mass sensing.We find that the steady-state solution of the system exhibits a multiple stability behavior,which is similar to that in the optomechanical system.We explain this phenomenon by the opto-mechanical interaction term in the effective Hamiltonian.Due to the dressed states formed by the effective coupling between the vibration degree of the atom and the optical mode in the cavity,we observe a narrow transparent window in the output field.We utilize this vibration induced transparency phenomenon to perform the tiny mass sensing.We hope our study will broaden the application of the cavity QED system to quantum technologies.展开更多
The nonlocal emitter-waveguide coupling,which gives birth to the so called giant atom,represents a new paradigm in the field of quantum optics and waveguide QED.We investigate the single-photon scattering in a one-dim...The nonlocal emitter-waveguide coupling,which gives birth to the so called giant atom,represents a new paradigm in the field of quantum optics and waveguide QED.We investigate the single-photon scattering in a one-dimensional waveguide on a two-level or three-level giant atom.Thanks to the natural interference induced by the back and forth photon transmitted/reflected between the atomwaveguide coupling points,the photon transmission can be dynamically controlled by the periodic phase modulation via adjusting the size of the giant atom.For the two-level giant-atom setup,we demonstrate the energy shift which is dependent on the atomic size.For the driven three-level giantatom setup,it is of great interest that,the Autler–Townes splitting is dramatically modulated by the giant atom,in which the width of the transmission valleys(reflection range)is tunable in terms of the atomic size.Our investigation will be beneficial to the photon or phonon control in quantum network based on mesoscopical or even macroscopical quantum nodes involving the giant atom.展开更多
基金supported by the National Natural Science Foundation of China (Nos.51975447,52275268)National Key Research and Development Program of China (No.2021YFC2203600)+2 种基金National Defense Basic Scientific Research Program of China (No.JCKY2021210B007)the Project about Building up“Scientists+Engineers”of Shaanxi Qinchuangyuan Platform (No.2022KXJ-030)Wuhu and Xidian University Special Fund for Industry University Research Cooperation (No.XWYCXY012021-012)。
文摘Long-time integration technique is an effective way of improving target detection performance for unmanned aerial vehicle(UAV)in the passive bistatic radar(PBR),while range migration(RM)and Doppler frequency migration(DFM)may have a major effect due to the target maneuverability.This paper proposed an innovative long-time coherent integration approach,regarded as Continuous Radon-matched filtering process(CRMFP),for low-observable UAV target in passive bistatic radar.It not only mitigates the RM by collaborative research in range and velocity dimensions but also compensates the DFM and ensures the coherent integration through the matched filtering process(MFP).Numerical and real-life data following detailed analysis verify that the proposed method can overcome the Doppler mismatch influence and acquire comparable detection performance.
基金supported by Natural Science Foundation of China(Grant NO.81972340,82173140,81871196)Shandong Provincial Natural Science Foundation,China(Grant No.ZR202010300086)Academic promotion program of Shandong First Medical University(Grant NO.2019LJ005)。
文摘Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer.The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma.In this study,a combination of hydrogel-liposome nanoplatform encapsulatedwith Temozolomide and ferroptosis inducer Erastin was constructed.Theαvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy.As biocompatible drug reservoirs,cross-linked GelMA(gelatin methacrylamide)hydrogel and cRGD-coated liposome realized the sustained release of internal contents.In the modified intracranial tumor resection model,GelMA-liposome system achieved slow release of Temozolomide and Erastin in situ for more than 14 d.The results indicated that nanoplatform(T+E@LPs-cRGD+GelMA)improved glioblastoma sensitivity to chemotherapeutic temozolomide and exerted satisfactory anti-tumor effects.It was demonstrated that the induction of ferroptosis could be utilized as a therapeutic strategy to overcome drug resistance.Furthermore,transcriptome sequencing was conducted to reveal the underlying mechanism that the nanoplatform(T+E@LPs-cRGD+GelMA)implicated in.It is suggested that GelMA-liposome system participated in the immune response and immunomodulation of glioblastoma via interferon/PD-L1 pathway.Collectively,this study proposed a potential combinatory therapeutic strategy for glioblastoma treatment.
基金supported by the National Natural Science Foundation of China(Grant No.82173303)Natural Science Foundation of Chongqing,China(Grant No.cstc2021ycjh-bgzxm0149).
文摘Lymphatic metastasis(LM)emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma(HSPSCC),chiefly contributing to treatment inefficacy.This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC.Methods:In a preceding investigation,HSP90AA1,a differential gene,was discovered through transcriptome sequencing of HPSCC tissues,considering both the presence and absence of LM.Validation of HSP90AA1 expression was accomplished via qRT-PCR,western-blotting(WB),and immunohistochemistry(IHC),while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA),log-rank test(LR),and Cox’s regression analysis(CRA).Bioinformatics techniques facilitated the prediction and analysis of its plausible mechanisms in LM,further substantiated by in vitro and in vivo experiments utilizing FaDu cell lines.Results:HSP90AA1 is substantially upregulated in HPSCC with LM and is identified as an independent prognostic risk determinant.The down-regulation of HSP90AA1 can achieve inhibition of tumor cell proliferation,migration and invasion.Both in vivo experiments and Bioinformatics exploration hint at promoting LM by Epithelial-mesenchymal transition(EMT),regulated by HSP90AA1.Conclusions:HSP90AA1,by controlling EMT,can foster LM in HPSCC.This finding sets the foundation for delving into new therapeutic targets for HPSCC.
基金supported by National Key R&D Program of China(2021YFE0193500)National Natural Science Foundation of China(12105026 and 11875011).
文摘We simulate an optomechanical system via a cavity QED scenario with a movable atom and investigate its application in the tiny mass sensing.We find that the steady-state solution of the system exhibits a multiple stability behavior,which is similar to that in the optomechanical system.We explain this phenomenon by the opto-mechanical interaction term in the effective Hamiltonian.Due to the dressed states formed by the effective coupling between the vibration degree of the atom and the optical mode in the cavity,we observe a narrow transparent window in the output field.We utilize this vibration induced transparency phenomenon to perform the tiny mass sensing.We hope our study will broaden the application of the cavity QED system to quantum technologies.
文摘The nonlocal emitter-waveguide coupling,which gives birth to the so called giant atom,represents a new paradigm in the field of quantum optics and waveguide QED.We investigate the single-photon scattering in a one-dimensional waveguide on a two-level or three-level giant atom.Thanks to the natural interference induced by the back and forth photon transmitted/reflected between the atomwaveguide coupling points,the photon transmission can be dynamically controlled by the periodic phase modulation via adjusting the size of the giant atom.For the two-level giant-atom setup,we demonstrate the energy shift which is dependent on the atomic size.For the driven three-level giantatom setup,it is of great interest that,the Autler–Townes splitting is dramatically modulated by the giant atom,in which the width of the transmission valleys(reflection range)is tunable in terms of the atomic size.Our investigation will be beneficial to the photon or phonon control in quantum network based on mesoscopical or even macroscopical quantum nodes involving the giant atom.
