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Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma:a multicenter cohort study in China
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作者 Jian Chen Zhe Yang +13 位作者 Fengqiang Gao zhisheng zhou Junli Chen Di Lu Kai Wang Meihua Sui Zhengxin Wang Wenzhi Guo Guoyue Lyu Haizhi Qi Jinzhen Cai Jiayin Yang Shusen Zheng Xiao Xu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第4期347-362,共16页
Objective:Sex-specific differences are observed in various liver diseases,but the influence of sex on the outcomes of hepatocellular carcinoma(HCC)after liver transplantation(LT)remains to be determined.This study is ... Objective:Sex-specific differences are observed in various liver diseases,but the influence of sex on the outcomes of hepatocellular carcinoma(HCC)after liver transplantation(LT)remains to be determined.This study is the first Chinese nationwide investigation of the role of sex in post-LT outcomes in patients with HCC.Methods:Data for recipients with HCC registered in the China Liver Transplant Registry between January 2015 and December 2020 were analyzed.The associations between donor,recipient,or donor-recipient transplant patterns by sex and the post-LT outcomes were studied with propensity score matching(PSM).The survival associated with different sex-based donor-recipient transplant patterns was further studied.Results:Among 3,769 patients enrolled in this study,the 1-,3-,and 5-year overall survival(OS)rates of patients with HCC after LT were 96.1%,86.4%,and 78.5%,respectively,in female recipients,and 95.8%,79.0%,and 70.7%,respectively,in male recipients after PSM(P=0.009).However,the OS was comparable between recipients with female donors and male donors.Multivariate analysis indicated that male recipient sex was a risk factor for post-LT survival(HR=1.381,P=0.046).Among the donor-recipient transplant patterns,the male-male donor-recipient transplant pattern was associated with the poorest post-LT survival(P<0.05).Conclusions:Our findings highlighted that the post-LT outcomes of female recipients were significantly superior to those of male recipients,and the male-male donor-recipient transplant pattern was associated with the poorest post-LT survival.Livers from male donors may provide the most benefit to female recipients.Our results indicate that sex should be considered as a critical factor in organ allocation. 展开更多
关键词 SEX liver transplantation hepatocellular carcinoma OUTCOME RECIPIENT DONOR
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Progress of semitransparent emerging photovoltaics for building integrated applications
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作者 zhisheng zhou Zhangyu Yuan +3 位作者 Zhipeng Yin Qifan Xue Ning Li Fei Huang 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第6期992-1015,共24页
With the rapid development of emerging photovoltaics technology in recent years,the application of building-integrated photovoltaics(BIPVs)has attracted the research interest of photovoltaic communities.To meet the pr... With the rapid development of emerging photovoltaics technology in recent years,the application of building-integrated photovoltaics(BIPVs)has attracted the research interest of photovoltaic communities.To meet the practical application requirements of BIPVs,in addition to the evaluation indicator of power conversion efficiency(PCE),other key performance indicators such as heat-insulating ability,average visible light transmittance(AVT),color properties,and integrability are equally important.The traditional Si-based photovoltaic technology is typically limited by its opaque properties for application scenarios where transparency is required.The emerging PV technologies,such as organic and perovskite photovoltaics are promising candidates for BIPV applications,owing to their advantages such as high PCE,high AVT,and tunable properties.At present,the PCE of semitransparent perovskite solar cells(ST-PSCs)has attained 14%with AVT of 22–25%;for semitransparent organic solar cells(ST-OSCs),the PCE reached 13%with AVT of almost 40%.In this review article,we summarize recent advances in material selection,optical engineering,and device architecture design for high-performance semitransparent emerging PV devices,and discuss the application of optical modeling,as well as the challenges of commercializing these semitransparent solar cells for building-integrated applications. 展开更多
关键词 Building integrated photovoltaics Emerging photovoltaics Semitransparent solar cells Perovskite solar cells Organic solar cells
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Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation:Multicenter Propensity Score-matched Study 被引量:2
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作者 Mengfan Yang Xuyong Wei +12 位作者 Abdul Rehman Khan Qiang Wei Rui Wang Binhua Pan Kun Wang zhisheng zhou Di Lu Beini Cen Shuijun Zhang Wenzhi Guo Shusen Zheng Yang Yang Xiao Xu 《Journal of Clinical and Translational Hepatology》 SCIE 2023年第4期827-838,共12页
Background and Aims:Liver transplantation(LT)using ABO-incompatible(ABOi)grafts can extend the donor pool to a certain extent and hence reduce the waiting time for transplantation.However,concerns of the impending pro... Background and Aims:Liver transplantation(LT)using ABO-incompatible(ABOi)grafts can extend the donor pool to a certain extent and hence reduce the waiting time for transplantation.However,concerns of the impending prognosis associated with this option,especially for patients with liver failure and higher model for end-stage liver disease(MELD)scores,who tend to be more fragile during the waiting period before LT.Methods:Recipients undergoing LT for acute-onchronic liver failure or acute liver failure were retrospectively enrolled at four institutions.Overall survival was compared and a Cox regression analysis was performed.Propensity score matching was performed for further comparison.Patients were stratified by MELD score and cold ischemia time(CIT)to determine the subgroups with survival benefits.Results:Two hundred ten recipients who underwent ABOi LT and 1,829 who underwent ABO compatible(ABOc)LT were enrolled.The 5-year overall survival rate was significantly inferior in the ABOi group compared with the ABOc group after matching(50.6%vs.75.7%,p<0.05).For patients with MELD scores≤30,using ABOi grafts achieved a comparable overall survival rate as using ABOc grafts(p>0.05).Comparison of the survival rates revealed no statistically significant difference for patients with MELD scores≥40(p>0.05).For patients with MELD scores of 31-39,the overall survival rate was significantly inferior in the ABOi group compared with the ABOc group(p<0.001);however,the rate was increased when the liver graft CIT was<8 h.Conclusions:For recipients with MELD scores≤30,ABOi LT had a prognosis comparable to that of ABOc LT and can be regarded as a feasible option.For recipients with MELD scores≥40,ABOi should be adopted with caution in emergency cases.For recipients with MELD scores of 31-39,the ABOi LT prognosis was worse.However,those patients benefited from receiving ABOi grafts with a CIT of<8 h. 展开更多
关键词 Liver transplantation ABO-INCOMPATIBLE Model for end-stage liver disease score Cold ischemia time Propensity score matching
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Highly efficient perovskite solar cells by building 2D/3D perovskite heterojuction in situ for interfacial passivation and energy level adjustment
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作者 Yaoyao Huang Zhangyu Yuan +9 位作者 Jia Yang Shungao Yin Aihui Liang Gang Xie Chuizheng Feng zhisheng zhou Qifan Xue Yang Pan Fei Huang Yiwang Chen 《Science China Chemistry》 SCIE EI CAS CSCD 2023年第2期449-458,共10页
Passivating the interfacial defects and reducing the interfacial non-radiative recombination losses are the keys to improving the photovoltaic performance of three-dimensional(3D)perovskite solar cells(PVSCs).Stacking... Passivating the interfacial defects and reducing the interfacial non-radiative recombination losses are the keys to improving the photovoltaic performance of three-dimensional(3D)perovskite solar cells(PVSCs).Stacking two dimensional(2D)perovskites on 3D perovskite is a promising method for interfacial treatment that improves the stability and efficiency of PVSCs.Herein,we developed conjugated fluorinated benzimidazolium cation(FBIm+)which can be inserted between 3D perovskite and holetransporting layer(HTL)to form 2D perovskite in situ.The 2D single crystal structures of(FBIm)_(2)Pb I4and(FBIm)_(2)Pb Br_(4)were achieved and confirmed by single-crystal X-ray diffraction(XRD),while few single crystals of 2D perovskite based on imidazolium or benzimidazolium anchors have been reported.The 2D perovskite can passivate the interfacial defects,induce better crystallinity and orientation,conduct lower trap density and extend carrier lifetime.Furthermore,the energy level arrangement can be regulated by changing the counterion from iodide to bromide,which can efficiently improve the hole extraction and device performances.As a consequence,the best efficiency of 23.00%for FBIm Br-incorporated devices was achieved,while only 20.72%for the control device.Meanwhile,the PVSCs modified by FBIm Br displayed excellent environmental stability due to the constructed hydrophobic 2D perovskite layer which can effectively block moisture permeation.This work develops a new path to design novel conjugated organic passivants to form 2D/3D perovskite structures. 展开更多
关键词 organic-inorganic halide perovskites solar cells passivation engineering 2D/3D perovskites
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