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H型高血压患者脑卒中危险因素及CACNA1C基因多态性与血清同型半胱氨酸水平的关系研究 被引量:8
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作者 晏峰 钟益芳 +3 位作者 任振唤 戴数 周颖 胡云良 《浙江医学》 CAS 2021年第14期1494-1501,1517,共9页
目的探讨H型高血压患者脑卒中的危险因素及CACNA1C基因多态性与血清同型半胱氨酸(Hcy)之间的关系。方法选取2017年11月至2019年1月丽水市人民医院诊治的高血压患者1096例(其中H型高血压823例,单纯高血压273例)及健康体检者355例(对照组)... 目的探讨H型高血压患者脑卒中的危险因素及CACNA1C基因多态性与血清同型半胱氨酸(Hcy)之间的关系。方法选取2017年11月至2019年1月丽水市人民医院诊治的高血压患者1096例(其中H型高血压823例,单纯高血压273例)及健康体检者355例(对照组),将H型高血压患者按照是否合并发生脑卒中分为脑卒中组112例和非脑卒中组711例,分析各组患者临床基线资料与血清Hcy水平;根据血清Hcy水平将高血压患者分为A组608例(<20μmol/L)、B组147例(20-30μmol/L)和C组48例(>30μmol/L);采用质谱技术及直接测序技术检测CACNA1C的5个单核苷酸多态性(SNP)位点rs10848683、rs2299661、rs1051375、rs216008、rs215976的基因型和等位基因频率并进行比较分析。结果脑卒中组血清Hcy水平高于非脑卒中组,差异有统计学意义(P<0.05);血清Hcy水平与脑卒中患病率呈正相关(r=0.171,P<0.01)。CACNA1C基因rs2299661位点的基因型CC频率高血压各组均高于对照组(均P<0.05),脑卒中组与单纯高血压组间比较差异无统计学意义(P>0.05);C等位基因频率脑卒中组高于非脑卒中组、单纯高血压组及对照组(均P<0.05)。rs216008、rs1051375、rs10848683、rs215976的SNP位点基因型频率及等位基因频率差异均无统计学意义(均P>0.05)。脑卒中组患者的rs2299661等位基因携带者(CC+CG基因型)与非携带者(GG纯合子)相比,脂蛋白(a)和Hcy水平差异有统计学意义,C等位基因携带者的脂蛋白(a)和Hcy水平明显高于非携带者(P<0.05)。结论CACNA1C的rs2299661位点C/G多态性与H型高血压患者脑卒中的发生呈显著相关,C等位基因可能为H型高血压患者脑卒中的易感位点。 展开更多
关键词 CACNA1C基因 脑卒中 多态性 H型高血压 同型半胱氨酸
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自制眼科专用头架的应用 被引量:1
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作者 朱艳平 钟以芳 +1 位作者 叶玲 冯梅 《基层医学论坛》 2019年第15期2075-2076,共2页
目的探讨自制眼科专用头架在白内障手术中的应用效果。方法应用自制眼科专用头架前后各选取300例前来我院就医的白内障手术患者,比较应用前后患者憋闷情况、手术时间及术中体位变换情况。结果应用自制头架后,白内障手术时间、体位变换... 目的探讨自制眼科专用头架在白内障手术中的应用效果。方法应用自制眼科专用头架前后各选取300例前来我院就医的白内障手术患者,比较应用前后患者憋闷情况、手术时间及术中体位变换情况。结果应用自制头架后,白内障手术时间、体位变换次数均低于应用前,有显著性差异(P<0.05);应用自制眼科专用头架前,术中憋闷发生率为53.67%(161/300),应用后为0.00%(0/300),差异有统计学意义(P<0.05)。结论采用自制眼科头架可有效缩短白内障手术时间,患者配合较好,有利于防止术中憋闷。 展开更多
关键词 白内障手术 眼科专用头架 自制 术中憋闷
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NEW HMM ALGORITHM FOR TOPOLOGY OPTIMIZATION 被引量:4
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作者 Zuo Kongtian ZhaoYudong +2 位作者 Chen Liping zhong yifang Huang Yuying 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2005年第3期346-350,共5页
A new hybrid MMA-MGCMMA (HMM) algorithm for solving topology optimization problems is presented. This algorithm combines the method of moving asymptotes (MMA) algorithm and the modified globally convergent version... A new hybrid MMA-MGCMMA (HMM) algorithm for solving topology optimization problems is presented. This algorithm combines the method of moving asymptotes (MMA) algorithm and the modified globally convergent version of the method of moving asymptotes (MGCMMA) algorithm in the optimization process. This algorithm preserves the advantages of both MMA and MGCMMA. The optimizer is switched from MMA to MGCMMA automatically, depending on the numerical oscillation value existing in the calculation. This algorithm can improve calculation efficiency and accelerate convergence compared with simplex MMA or MGCMMA algorithms, which is proven with an example. 展开更多
关键词 Topology optimization Method of moving asymptotes (MMA) Modified globally convergent version of MMA (MGCMMA) HMM algorithm Convergence
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中医特色护理对股骨颈骨折闭合复位内固定术后疼痛及关节恢复的影响研究 被引量:6
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作者 曾连香 钟以芳 刘美华 《中国中医药现代远程教育》 2019年第23期117-119,共3页
目的分析中医特色护理对股骨颈骨折闭合复位内固定术后疼痛及关节恢复的影响。方法选取2018年2月-2019年2月收治的股骨颈骨折患者60例,按照入院单双数法分为对照组和观察组,各30例。对照组给予常规性护理,观察组予以中医特色护理。对比... 目的分析中医特色护理对股骨颈骨折闭合复位内固定术后疼痛及关节恢复的影响。方法选取2018年2月-2019年2月收治的股骨颈骨折患者60例,按照入院单双数法分为对照组和观察组,各30例。对照组给予常规性护理,观察组予以中医特色护理。对比2种护理方式对患者关节恢复情况、疼痛影响、护理满意度影响。结果观察组患者治疗后髋关节评分显著高于对照组,差异有统计学意义(P<0.05);观察组患者疼痛状况评分显著低于对照组,差异有统计学意义(P<0.05);观察组患者护理满意度100.00%显著高于对照组86.67%,差异有统计学意义(P<0.05)。结论为股骨颈骨折患者予以中医特色护理时可缓解关节疼痛、帮助关节恢复,促进护患关系,有应用价值。 展开更多
关键词 中医特色护理 股骨颈骨折 闭合复位内固定 关节恢复
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Research on Approaches of Multidisciplinary Design Optimization for Non-hierarchic Systems
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作者 Chen Baihong zhong yifang +2 位作者 Liu Jihong Xiao Renbin Zhou Ji (CAD Center of Huazhong University of Science & Technology, Wuhan 430074, PR.China) 《Computer Aided Drafting,Design and Manufacturing》 2000年第1期84-94,共11页
In complex engineering optimization, multilevel or two-level approaches are often applied. These approaches are carried out in assumption that there are no connections among sub problems at the same level. But it is d... In complex engineering optimization, multilevel or two-level approaches are often applied. These approaches are carried out in assumption that there are no connections among sub problems at the same level. But it is difficult to construct the models that suit to this assumption. In recent years, the complexity of engineering systems has led to the rapid development in the field of Multidisciplinary Design Optimization (MDO). In MDO, two kinds of coupled factors, coupled variables (or functions) and system (or global) variables, always exist among all disciplines. These variable5 or functions make it disordered to solve the whole system. So, how to handle these variables is one of important studies in MDO. In this paper two approaches are discussed for handling these coupled factors in non-hierarchic system in MDO. And a test engineering example gives a demonstration about the implemeniation of these approaches. 展开更多
关键词 coupled factors two-level technique collaborative optimization MDO
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An Automatic Generation System of Reinforcement Detail Drawings for Hydraulic Structures
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作者 Qian Yusen Chen Liping +3 位作者 zhong yifang Zhou Ji (National CAD Sopport Software Engineering Research Center (Wuhan) Huazhong University of Science and Technology, Wuhan P. r. China, 430074) Niu Xinqiang Yang Xinjun Yang Benxin (Changjiang Water Resource C 《Computer Aided Drafting,Design and Manufacturing》 2000年第1期41-49,共9页
Reinforcement detail drawings are one important part of the design of hydraulic structures and the important basis of construction and management. However, the efficiency of the traditional creation of engineering dra... Reinforcement detail drawings are one important part of the design of hydraulic structures and the important basis of construction and management. However, the efficiency of the traditional creation of engineering drawings is very low and the workload is heavy. There is no satisfactory software for hydraulic engineering because of the irregularity and diversity of hydraulic structures' shape. An automatic generation system of reinforcement detail drawings for hydraulic structures is introduced. Its functions and modules are introduced first. The related technologies such as automatic driensioning are discussed in detail. At the end of the paper, an example is given. 展开更多
关键词 reinforcement detail drawings automatic dimensioning collision checking engineering drawings
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A Mechanism for Dynamic and Consistent Product Information Association
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作者 Zhang Tianbing Wu Junjun +1 位作者 zhong yifang Zhou Ji (CAD Center Huazhong University of Science and Technology, Wu Han 430074) 《Computer Aided Drafting,Design and Manufacturing》 2000年第1期50-56,共7页
The dynamic and consistent information association among vtrious application activities in the full life cycle of a product is a key to the assurance of the cooperation among different application domains. In order to... The dynamic and consistent information association among vtrious application activities in the full life cycle of a product is a key to the assurance of the cooperation among different application domains. In order to establish and maintain the association, a design-process-based product association model was proposed. This model takes advantage of the generic naming mechanism, the private protocol for history-based form feature modeling, on which the Data Association Protocol is built. Hence the model can provide the way of constructing and maintaining the information linkage among different product developing stages naturally and dynamically while keeping the privacy of the feature coding. A case study illustrates the utilities of the model in the data linking between design model and process planning model. 展开更多
关键词 product data association feature coding design process CAD
全文增补中
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