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A DNA-based nanocarrier for efficient cancer therapy
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作者 Muhammad Abbas Mirza Muhammad Faran Ashraf Baig +5 位作者 Yaliang Zhang Yu-Shun Yang Songyu Wu Yiqiao Hu zhong-chang wang Hai-Liang Zhu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第3期330-339,共10页
The study aimed to achieve enhanced targeted cytotoxicity and cell-internalization of cisplatin-loaded deoxyribonucleic acid-nanothread(CPT-DNA-NT),mediated by scavenger receptors into HeLa cells.DNA-NT was developed ... The study aimed to achieve enhanced targeted cytotoxicity and cell-internalization of cisplatin-loaded deoxyribonucleic acid-nanothread(CPT-DNA-NT),mediated by scavenger receptors into HeLa cells.DNA-NT was developed with stiff-topology utilizing circular-scaffold to encapsulate CPT.Atomic force microscopy(AFM)characterization of the DNA-NT showed uniformity in the structure with a diameter of 50-150 nm and length of 300-600 nm.The successful fabrication of the DNA-NT was confirmed through native-polyacrylamide gel electrophoresis analysis,as large the molecular-weight(polymeric)DNA-NT did not split into constituting strands under applied current and voltage.The results of cell viability confirmed that blank DNA-NT had the least cytotoxicity at the highest concentration(512 nM)with a viability of 92%as evidence of its biocompatibility for drug delivery.MTT assay showed superior cytotoxicity of CPT-DNA-NT than that of the free CPT due to the depot release of CPT after DNA-NT internalization.The DNA-NT exhibited targeted cell internalizations with the controlled intracellular release of CPT(from DNA-NT),as illustrated in confocal images.Therefore,in vitro cytotoxicity assessment through flow cytometry showed enhanced apoptosis(72.7%)with CPT-DNA-NT(compared to free CPT;64.4%).CPT-DNA-NT,being poly-anionic,showed enhanced endocytosis via scavenger receptors. 展开更多
关键词 DNA-nanothread CISPLATIN Drug delivery Scavenger receptors CAVEOLAE HeLa cell line
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Microstructure and Mechanical Properties of AZ31 Mg Alloy Fabricated by Pre-compression and Frustum Shearing Extrusion 被引量:3
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作者 Kun Sheng Li-Wei Lu +2 位作者 Yao Xiang Min Ma zhong-chang wang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2019年第2期235-244,共10页
The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically inve... The AZ31 Mg alloys were processed by 6% pre-compression and frustum shearing extrusion at various temperatures, and the microstructure, texture and mechanical properties of the resulting alloys are systematically investigated. The results show that the grain size monotonically increases from 6.4 to 12.6 lm and the texture intensity increases from 6.7 to 9.6with the increase in the extrusion temperature. The combining effect of the pre-twinning and the frustum shearing deformation is found to contribute to the development of the weak basal texture in Mg alloys. The Mg alloy sheet produced at the extrusion temperature of 563 K exhibits excellent mechanical properties. The yield strength, ultimate tensile strength and elongation for the extruded alloys are 189.6 MPa, 288.4 MPa and 24.9%, respectively. Such improved mechanical properties are comparable or even superior to those of the alloys subjected to other deformation techniques, rendering the pre-compression and frustum shearing extrusion a promising way for further tailoring properties of Mg alloys. 展开更多
关键词 AZ31 MAGNESIUM alloy Frustum SHEARING EXTRUSION Microstructure Mechanical property Dynamic RECRYSTALLIZATION
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Three-dimensional graphene and its composite for gas sensors 被引量:4
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作者 Meng Hao Wen Zeng +1 位作者 Yan-Qiong Li zhong-chang wang 《Rare Metals》 SCIE EI CAS CSCD 2021年第6期1494-1514,共21页
As a two-dimensional(2D)material,graphene shows excellent advantages in the field of gas sensors due to its inherent large specific surface area and unique electrical properties.However,in the practical application of... As a two-dimensional(2D)material,graphene shows excellent advantages in the field of gas sensors due to its inherent large specific surface area and unique electrical properties.However,in the practical application of gas detection,graphene sheet is easy to form irreversible agglomeration and has some limitations such as low sensitivity,long response time and slow recovery speed,which greatly reduce its gas sensing performance.As a gas sensing material,three-dimensional(3D)porous graphene has been extensively studied in recent years owing to its larger specific surface area and stable structure.In order to synthesize graphene with different three-dimensional structures,many methods have been developed.Herein,the synthesis and assembly of three-dimensional graphene and its composites were reviewed,with emphasis on the application of three-dimensional graphene and its composites in the field of gas sensors.The challenges and development prospects of three-dimensional graphene materials in the application of gas sensors were briefly described. 展开更多
关键词 Three-dimensional graphene Gas sensor Sensitivity Composites material
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