The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration p...The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration promotion paths of EE in 284 Chinese cities during 2003‒2019 using the global super-efficiency minimum distance to strong efficient frontier(G-S-MinDS),exploratory spatial data analysis(ESDA),multiscale geographically weighted regression(MGWR),and fuzzy set qualitative comparative analysis(fsQCA)methods.The findings are:①China’s cities have an annual average EE of 0.658 with a growth rate of 0.53%,showing considerable promotion potential.②Industrial structure optimization,population agglomeration,economic development,and increased green coverage contribute positively,while government intervention and openness hinder China’s urban EE.③Four configurational promotion paths for enhancing China’s urban EE are identified,where among those paths population density is a core condition,while government intervention is not.This study provides valuable insights into substantially improving urban EE,emphasizing the need for targeted policies to address energy and environmental crises in China.展开更多
<strong>Objective:</strong> This retrospective study aims to survey the clinical outcomes of 341 consecutive patients surgically treated for and diagnosed with craniopharyngioma (CP) treated in a 10-year p...<strong>Objective:</strong> This retrospective study aims to survey the clinical outcomes of 341 consecutive patients surgically treated for and diagnosed with craniopharyngioma (CP) treated in a 10-year period in a single institution. <strong>Methods:</strong> The clinical reports of three hundred forty-one patients CP patients treated surgically between January 2006 and December 2016 were reviewed and analyzed retrospectively. <strong>Results:</strong> Our cohort consisted of 341 patients (202 male, 139 female) with a mean age of 34.9 years (range 1 - 74 years);Tumor Features: 129 patients (37.8%) had cystic tumors, 88 (23.8%) had solid tumors whereas 126 (36.4%) had heterogeneous lesions with a solid and cystic portion;calcifications were present in 139 (40.8%);Tumor Topography: Suprasellar 198 (58.1%), Intrasellar 40 (11.7%), Intra-third ventricular 103 (30.2%);Surgical approaches used among the patients included: Pterional 262 (76.8%), Transsphenoidal (TS) 42 (12.3%) Transcallosal 20 (5.9%), Transcortical 16 (4.7%) suboccipital 1 and combined approach 1;Gross total removal (GTR) was achieved in 247 patients (72.4%), Subtotal removal (STR) in 94 patients (27.6%). Good postoperative outcome at discharge was achieved in 324 (95%) patients while 17 (5%) patients had poor outcome including 5 (1.5%) perioperative deaths. Mean hospital length of stay was 21.87 (8 - 129). There were 42 (12.9%) recurrences with a mean time to recurrence of 28.36 (3 - 84) months, among which 37 (88.1%) underwent surgery for recurrence treatment. Follow-up time ranged from 3 months to 10 years. There was a statistical significance between open transcranial surgery and suprasellar tumors (p < 0.0001), TS and intrasellar tumors (p < 0.0001);postoperative diabetes inspidus and gross total resection (p < 0.0001);GTR and cystic tumors (p = 0.034) calcification and GTR (p = 0.0008). <strong>Conclusion:</strong> Good surgical outcome and long-term tumor control can be achieved through individual-based selective resection, whether total or subtotal resection. Whereas surgical prehistory of CP was found to be a significant risk factor to recurrence (p < 0.0001), the clinical risk factors of CP of recurrence are still arguable, including the presence residual tumor due to subtotal resection. More future studies are necessary.展开更多
As one of the largest global emitters of sulfur dioxide(SO_(2)),China faces increasing pressure to achieve sustainable economic and social development.Using panel data of 58 prefecture-level cities in North China betw...As one of the largest global emitters of sulfur dioxide(SO_(2)),China faces increasing pressure to achieve sustainable economic and social development.Using panel data of 58 prefecture-level cities in North China between 2003 and 2017,this paper considers the dynamic spatio-temporal characteristics of industrial SO_(2) emissions in the"2+26"in North China and extended cities in North China and decomposes the determinants of industrial SO_(2) emissions into eight effects using the Generalized Divisia Index Model(GDIM).The contributions of each effect on changes in emissions are assessed on regional,provincial,and prefectural levels,as well as according to various stages.The results indicate the following.First,industrial SO2 emissions in the"2+26"cities in North China and extended cities in North China exhibit spatial autocorrelation and agglomeration effects.Cities with high-high(HH)and low-low(LL)agglomeration patterns were concentrated in Shanxi and Henan provinces,respectively.Second,industrialization,energy consumption,and economic development were the main factors that increased industrial SO2 emissions,while technology,energy sulfur intensity,and economic sulfur intensity were the key factors that reduced them.Third,13 cities,induding Tangshan,were the most important regions where further emissions regulations need to be implemented.These cities were divided into three types and different corresponding measures for reducing their emissions are suggested.Based on the conclusions of this study,this paper puts forward some targeted policy recommendations for reducing industrial SO_(2) emissions according to different categories of cities.展开更多
The comprehensive use and efficient management of straw are significant for agriculture's green and low carbon transformation.This paper uses literature research and comparative analysis to systematically review t...The comprehensive use and efficient management of straw are significant for agriculture's green and low carbon transformation.This paper uses literature research and comparative analysis to systematically review the literature on comprehensive straw utilization and governance policy research in China over the past five years.The current literature has explored two major directions:regional and industrial policies and the main actors involved in the comprehensive use of straw.The research is complementary and fruitful concerning both micro and macro perspectives;however,the extant literature suffers from a lack of attention to straw intermediaries and enterprises and a lack of research across time.Therefore,this paper provides an outlook for future research.In the future,scholars should pay more attention to straw intermediaries and enterprises,conduct continuous observations of multiple regions over time to obtain panel data,and further test the heterogeneity of factors to obtain more scientific and valid results.展开更多
In medical images, exist often a lot of noise, the noise will seriously affect the accuracy of the segmentation results. The traditional standard fuzzy c-means(FCM) algorithm in image segmentation do not taken into ac...In medical images, exist often a lot of noise, the noise will seriously affect the accuracy of the segmentation results. The traditional standard fuzzy c-means(FCM) algorithm in image segmentation do not taken into account the relationship the adjacent pixels, which leads to the standard fuzzy c-means(FCM) algorithm is very sensitive to noise in the image. Proposed improvedfuzzy c-means(FCM) algorithm, taking both the local and non-local information into the standard fuzzy c-means(FCM) clustering algorithm. The ex-periment results can show that the improved algorithm can achieve better effect than other methods of brain tissue segmentation.展开更多
Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of cran...Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of craniopharyngioma and the clinical, molecular prognostic indicators of recurrence and treatment outcomes was performed retrospectively. Results: A total of 107 studies which described specific risk factors related to craniopharyngioma recurrence were identified which included but not limited to 54 retrospective case series, 7 systematic reviews, 21 laboratory reports, 13 case reports and 12 literature reviews. Conclusion: Based on the evidence identified in this review, the risk factors for recurrence in craniopharyngioma management are interrelated in a complex way, and surgery with or without adjuvant radiotherapy is reported to be of long-term benefit, but a disparity in findings suggests no definitive consensus on the risk factors of craniopharyngioma recurrence. More high-quality research is needed.展开更多
According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and na...According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.展开更多
Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic effects.The primary challenge is to integrate diverse pharmacophores within a singl...Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic effects.The primary challenge is to integrate diverse pharmacophores within a single-molecule framework.To address this,we introduced DeepSA,a novel edit-based generative framework that utilizes deep simulated annealing for the modification of articaine,a wellknown local anesthetic.DeepSA integrates deep neural networks into metaheuristics,effectively constraining molecular space during compound generation.This framework employs a sophisticated objective function that accounts for scaffold preservation,anti-inflammatory properties,and covalent constraints.Through a sequence of local editing to navigate the molecular space,DeepSA successfully identified AT-17,a derivative exhibiting potent analgesic properties and significant anti-inflammatory activity in various animal models.Mechanistic insights into AT-17 revealed its dual mode of action:selective inhibition of NaV1.7 and 1.8 channels,contributing to its prolonged local anesthetic effects,and suppression of inflammatory mediators via modulation of the NLRP3 inflammasome pathway.These findings not only highlight the efficacy of AT-17 as a multifunctional drug candidate but also highlight the potential of DeepSA in facilitating AI-enhanced drug discovery,particularly within stringent chemical constraints.展开更多
基金the financial support provided by the National Natural Science Foundation of China[Grant No.72373138 and 71973131]Major Project of National Social Science Foundation of China[Grant No.19VHQ002].
文摘The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration promotion paths of EE in 284 Chinese cities during 2003‒2019 using the global super-efficiency minimum distance to strong efficient frontier(G-S-MinDS),exploratory spatial data analysis(ESDA),multiscale geographically weighted regression(MGWR),and fuzzy set qualitative comparative analysis(fsQCA)methods.The findings are:①China’s cities have an annual average EE of 0.658 with a growth rate of 0.53%,showing considerable promotion potential.②Industrial structure optimization,population agglomeration,economic development,and increased green coverage contribute positively,while government intervention and openness hinder China’s urban EE.③Four configurational promotion paths for enhancing China’s urban EE are identified,where among those paths population density is a core condition,while government intervention is not.This study provides valuable insights into substantially improving urban EE,emphasizing the need for targeted policies to address energy and environmental crises in China.
文摘<strong>Objective:</strong> This retrospective study aims to survey the clinical outcomes of 341 consecutive patients surgically treated for and diagnosed with craniopharyngioma (CP) treated in a 10-year period in a single institution. <strong>Methods:</strong> The clinical reports of three hundred forty-one patients CP patients treated surgically between January 2006 and December 2016 were reviewed and analyzed retrospectively. <strong>Results:</strong> Our cohort consisted of 341 patients (202 male, 139 female) with a mean age of 34.9 years (range 1 - 74 years);Tumor Features: 129 patients (37.8%) had cystic tumors, 88 (23.8%) had solid tumors whereas 126 (36.4%) had heterogeneous lesions with a solid and cystic portion;calcifications were present in 139 (40.8%);Tumor Topography: Suprasellar 198 (58.1%), Intrasellar 40 (11.7%), Intra-third ventricular 103 (30.2%);Surgical approaches used among the patients included: Pterional 262 (76.8%), Transsphenoidal (TS) 42 (12.3%) Transcallosal 20 (5.9%), Transcortical 16 (4.7%) suboccipital 1 and combined approach 1;Gross total removal (GTR) was achieved in 247 patients (72.4%), Subtotal removal (STR) in 94 patients (27.6%). Good postoperative outcome at discharge was achieved in 324 (95%) patients while 17 (5%) patients had poor outcome including 5 (1.5%) perioperative deaths. Mean hospital length of stay was 21.87 (8 - 129). There were 42 (12.9%) recurrences with a mean time to recurrence of 28.36 (3 - 84) months, among which 37 (88.1%) underwent surgery for recurrence treatment. Follow-up time ranged from 3 months to 10 years. There was a statistical significance between open transcranial surgery and suprasellar tumors (p < 0.0001), TS and intrasellar tumors (p < 0.0001);postoperative diabetes inspidus and gross total resection (p < 0.0001);GTR and cystic tumors (p = 0.034) calcification and GTR (p = 0.0008). <strong>Conclusion:</strong> Good surgical outcome and long-term tumor control can be achieved through individual-based selective resection, whether total or subtotal resection. Whereas surgical prehistory of CP was found to be a significant risk factor to recurrence (p < 0.0001), the clinical risk factors of CP of recurrence are still arguable, including the presence residual tumor due to subtotal resection. More future studies are necessary.
基金the financial support from the National Natural Science Foundation of China[Grant number.72074183,Grant number.71403120]the Humanities and Social Science Foundation of Chinese Ministry of Education[Grant number.20YJC630104]+1 种基金the National Social Science Foundation of China[Grant number.18ZDA052]the Fundamental Research Funds for the Central Universities[Grant number.JBK2007186].
文摘As one of the largest global emitters of sulfur dioxide(SO_(2)),China faces increasing pressure to achieve sustainable economic and social development.Using panel data of 58 prefecture-level cities in North China between 2003 and 2017,this paper considers the dynamic spatio-temporal characteristics of industrial SO_(2) emissions in the"2+26"in North China and extended cities in North China and decomposes the determinants of industrial SO_(2) emissions into eight effects using the Generalized Divisia Index Model(GDIM).The contributions of each effect on changes in emissions are assessed on regional,provincial,and prefectural levels,as well as according to various stages.The results indicate the following.First,industrial SO2 emissions in the"2+26"cities in North China and extended cities in North China exhibit spatial autocorrelation and agglomeration effects.Cities with high-high(HH)and low-low(LL)agglomeration patterns were concentrated in Shanxi and Henan provinces,respectively.Second,industrialization,energy consumption,and economic development were the main factors that increased industrial SO2 emissions,while technology,energy sulfur intensity,and economic sulfur intensity were the key factors that reduced them.Third,13 cities,induding Tangshan,were the most important regions where further emissions regulations need to be implemented.These cities were divided into three types and different corresponding measures for reducing their emissions are suggested.Based on the conclusions of this study,this paper puts forward some targeted policy recommendations for reducing industrial SO_(2) emissions according to different categories of cities.
基金the financial support from the National Natural Science Foundation of China[Grant number.72074183]the Humanities and Social Science Foundation of Chinese Ministry of Education[Grant number.20YJC630104]the National Social Science Foundation of China[Grant number.18ZDA052].
文摘The comprehensive use and efficient management of straw are significant for agriculture's green and low carbon transformation.This paper uses literature research and comparative analysis to systematically review the literature on comprehensive straw utilization and governance policy research in China over the past five years.The current literature has explored two major directions:regional and industrial policies and the main actors involved in the comprehensive use of straw.The research is complementary and fruitful concerning both micro and macro perspectives;however,the extant literature suffers from a lack of attention to straw intermediaries and enterprises and a lack of research across time.Therefore,this paper provides an outlook for future research.In the future,scholars should pay more attention to straw intermediaries and enterprises,conduct continuous observations of multiple regions over time to obtain panel data,and further test the heterogeneity of factors to obtain more scientific and valid results.
文摘In medical images, exist often a lot of noise, the noise will seriously affect the accuracy of the segmentation results. The traditional standard fuzzy c-means(FCM) algorithm in image segmentation do not taken into account the relationship the adjacent pixels, which leads to the standard fuzzy c-means(FCM) algorithm is very sensitive to noise in the image. Proposed improvedfuzzy c-means(FCM) algorithm, taking both the local and non-local information into the standard fuzzy c-means(FCM) clustering algorithm. The ex-periment results can show that the improved algorithm can achieve better effect than other methods of brain tissue segmentation.
文摘Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of craniopharyngioma and the clinical, molecular prognostic indicators of recurrence and treatment outcomes was performed retrospectively. Results: A total of 107 studies which described specific risk factors related to craniopharyngioma recurrence were identified which included but not limited to 54 retrospective case series, 7 systematic reviews, 21 laboratory reports, 13 case reports and 12 literature reviews. Conclusion: Based on the evidence identified in this review, the risk factors for recurrence in craniopharyngioma management are interrelated in a complex way, and surgery with or without adjuvant radiotherapy is reported to be of long-term benefit, but a disparity in findings suggests no definitive consensus on the risk factors of craniopharyngioma recurrence. More high-quality research is needed.
基金supported by grants from the National Key R&D Program of China(Nos.2021YFA1101300,2021YFA1101800,and 2020YFA0112503)Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303,China)+3 种基金National Natural Science Foundation of China(Nos.82101228,82030029,81970882,and 92149304)Science and Technology Department of Sichuan Province(No.2021YFS0371,China)Shenzhen Science and Technology Program(JCYJ20190814093401920 and JCYJ20210324125608022,China)Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(No.SKLGE-2104,China).
文摘According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.
基金supported by the National Natural Science Foundation of China(82273784,China)the Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202004,China)+3 种基金the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYYC 21002,ZYGD23025,China)the Clinical Research Innovation Project,West China Hospital,Sichuan University(2019 HXCX006,China)the Science and Technology Major Project of Tibetan Autonomous Region of China(XZ202201ZD0001G,China)the Sichuan Science and Technology Program(2023 ZYD0168,China).
文摘Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic effects.The primary challenge is to integrate diverse pharmacophores within a single-molecule framework.To address this,we introduced DeepSA,a novel edit-based generative framework that utilizes deep simulated annealing for the modification of articaine,a wellknown local anesthetic.DeepSA integrates deep neural networks into metaheuristics,effectively constraining molecular space during compound generation.This framework employs a sophisticated objective function that accounts for scaffold preservation,anti-inflammatory properties,and covalent constraints.Through a sequence of local editing to navigate the molecular space,DeepSA successfully identified AT-17,a derivative exhibiting potent analgesic properties and significant anti-inflammatory activity in various animal models.Mechanistic insights into AT-17 revealed its dual mode of action:selective inhibition of NaV1.7 and 1.8 channels,contributing to its prolonged local anesthetic effects,and suppression of inflammatory mediators via modulation of the NLRP3 inflammasome pathway.These findings not only highlight the efficacy of AT-17 as a multifunctional drug candidate but also highlight the potential of DeepSA in facilitating AI-enhanced drug discovery,particularly within stringent chemical constraints.
