To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-typ...To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-type structure and microsphere structure is proposed in this paper. The fiber sidepolishing technique converts the coaxial dual-waveguide fiber into a D-type one, and the evanescent wave in the ring core leaks, generating a D-type sensing region;the fiber optic fused ball push technology converts the coaxial dual waveguides into microspheres, and the stimulated cladding mode evanescent wave leaks, producing the microsphere sensing region. By injecting light into the coaxial dual-waveguide middle core alone, the sensor can realize single-stage sensing in the microsphere sensing area;it can also realize dual-channel sensing in the D-type sensing area and microsphere sensing area by injecting light into the ring core. The refractive index measurement ranges for the two channels are 1.333–1.365 and 1.375–1.405, respectively, with detection sensitivities of 981.56 nm/RIU and 4138 nm/RIU. The sensor combines wavelength division multiplexing and space division multiplexing technologies, presenting a novel research concept for multi-channel fiber SPR sensors.展开更多
Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and life.At present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including th...Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and life.At present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including the tau propagation hypothesis.However,the exact ultimate pathogenic factor of AD remains unknown.Based on the current hypotheses,some anti-AD drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-D-aspartate(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is memantine.Since these drugs have undesirable side effects,it is necessary to find safer alternatives for AD treatment.Interestingly,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-AD drugs.In this study,several representatives’dietary phytochemicals with anti-AD effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside Rg1,pseudoginsenoside-F11,ginsenoside Rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.展开更多
BACKGROUND Gestational diabetes mellitus(GDM)is a concern due to its rapid increase in incidence in recent years.AIM To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PA...BACKGROUND Gestational diabetes mellitus(GDM)is a concern due to its rapid increase in incidence in recent years.AIM To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PAPP-A),triglyceride(TG),and 25-hydroxyvitamin D[25-(OH)D]with GDM in early pregnancy.METHODS A total of 99 patients in early pregnancy admitted to Peking University International Hospital from November 2015 to September 2017 were included,and underwent a fasting glucose test and oral glucose tolerance test screening at 24-28 wk of pregnancy.Of these cases with GDM,51 were assigned to group A and the remaining 48 cases without GDM were enrolled in group B.Serum PAPP-A,TG and 25-(OH)D in the two groups were compared and their correlation with blood sugar was analyzed.In addition,their diagnostic value in GDM was determined using receiver operating characteristic(ROC)curve analysis.RESULTS Group A had markedly lower serum PAPP-A and 25-(OH)D levels and a significantly higher serum TG level than group B,with statistical significance(P<0.05).Furthermore,Pearson analysis identified that PAPP-A and 25-(OH)D levels were negatively correlated with fasting blood glucose(FBG)levels(r=-0.605,P<0.001),(r=-0.597,P<0.001),while TG and FBG levels were positively correlated(r=0.628,P<0.001).The sensitivity,specificity,area under the curve(AUC)and optimal cut-off value of serum PAPP-A level in the diagnosis of GDM were 72.55%,82.35%,0.861 and 16.340,respectively,while the sensitivity of TG in diagnosing GDM was 86.27%,the specificity was 66.67%,the AUC was 0.813,with an optimal cut-off value of 1.796.The corresponding sensitivity,specificity,AUC and optimal cut-off value of serum 25-(OH)D were 64.71%,70.59%,0.721 and 23.140,respectively.Moreover,multivariate logistic regression analysis revealed that FBG,vascular endothelial growth factor,Flt-1,serum PAPP-A,TG,and 25-(OH)D were related risk factors leading to GDM in patients.CONCLUSION Serum PAPP-A,TG,and 25-(OH)D levels are all correlated with blood glucose changes in GDM,and are independent factors affecting the occurrence of GDM and have certain value in the diagnosis of GDM.展开更多
Gestational diabetes mellitus(GDM)manifests as different degrees of carbohydrate intolerance during pregnancy.According to several studies,GDM affects 4%to 25%of pregnant women.The majority of patients with GDM have v...Gestational diabetes mellitus(GDM)manifests as different degrees of carbohydrate intolerance during pregnancy.According to several studies,GDM affects 4%to 25%of pregnant women.The majority of patients with GDM have varying levels of insulin resistance and chronic low-grade inflammation,which are related to vascular injury and dysfunction and subsequent platelet activation.[1]Consequently,platelet activation may be closely related to GDM severity.The mean platelet volume(MPV)is one of the indexes used to evaluate platelet morphology and activity.An elevated MPV has been demonstrated to be related to cardiovascular diseases and other conditions,such as hypertension and nonalcoholic fatty liver disease.展开更多
Primary fallopian tube carcinoma(PFTC) is a rare malignant carcinoma among all genital tract malignancies.It occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and clinicall...Primary fallopian tube carcinoma(PFTC) is a rare malignant carcinoma among all genital tract malignancies.It occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and clinically.Because of its insidious onset and silent course,the diagnosis is made usually postoperatively.Liquid-based cytology(LBC) is a type of method for cervical cancer screening,but sometimes it may aid in making PFTC diagnosis.We report a 47-year-old woman with PFTC,whose diagnosis was made with the aid of LBC.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 61705025)the Natural Science Foundation of Chongqing (Grant Nos. cstc2019jcyjmsxm X043 and cstc2018jcyj AX0817)+2 种基金the Fund from the Science and Technology Project Affiliated to the Education Department of Chongqing Municipality (Grant Nos. KJQN201801217, KJQN202001214, KJQN201901226, and KJ1710247)the Fund from Chongqing Key Laboratory of Geological Environment Monitoring and Disaster Early-Warning in Three Gorges Reservoir Area (Grant Nos. ZD2020A0103 and ZD2020A0102)the Fundamental Research Funds for Chongqing Three Gorges University of China (Grant No. 19ZDPY08)。
文摘To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-type structure and microsphere structure is proposed in this paper. The fiber sidepolishing technique converts the coaxial dual-waveguide fiber into a D-type one, and the evanescent wave in the ring core leaks, generating a D-type sensing region;the fiber optic fused ball push technology converts the coaxial dual waveguides into microspheres, and the stimulated cladding mode evanescent wave leaks, producing the microsphere sensing region. By injecting light into the coaxial dual-waveguide middle core alone, the sensor can realize single-stage sensing in the microsphere sensing area;it can also realize dual-channel sensing in the D-type sensing area and microsphere sensing area by injecting light into the ring core. The refractive index measurement ranges for the two channels are 1.333–1.365 and 1.375–1.405, respectively, with detection sensitivities of 981.56 nm/RIU and 4138 nm/RIU. The sensor combines wavelength division multiplexing and space division multiplexing technologies, presenting a novel research concept for multi-channel fiber SPR sensors.
基金supported by the National Natural Science Foundation of China(21978236 and 21978229)Natural Science Basic Research Program of Shaanxi(2023-JC-JQ-17)Qin Chuangyuan cited the High-level Innovation and Entrepreneurship Talent Program(QCYRCXM-2022-129).
文摘Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and life.At present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including the tau propagation hypothesis.However,the exact ultimate pathogenic factor of AD remains unknown.Based on the current hypotheses,some anti-AD drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-D-aspartate(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is memantine.Since these drugs have undesirable side effects,it is necessary to find safer alternatives for AD treatment.Interestingly,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-AD drugs.In this study,several representatives’dietary phytochemicals with anti-AD effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside Rg1,pseudoginsenoside-F11,ginsenoside Rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.
文摘BACKGROUND Gestational diabetes mellitus(GDM)is a concern due to its rapid increase in incidence in recent years.AIM To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PAPP-A),triglyceride(TG),and 25-hydroxyvitamin D[25-(OH)D]with GDM in early pregnancy.METHODS A total of 99 patients in early pregnancy admitted to Peking University International Hospital from November 2015 to September 2017 were included,and underwent a fasting glucose test and oral glucose tolerance test screening at 24-28 wk of pregnancy.Of these cases with GDM,51 were assigned to group A and the remaining 48 cases without GDM were enrolled in group B.Serum PAPP-A,TG and 25-(OH)D in the two groups were compared and their correlation with blood sugar was analyzed.In addition,their diagnostic value in GDM was determined using receiver operating characteristic(ROC)curve analysis.RESULTS Group A had markedly lower serum PAPP-A and 25-(OH)D levels and a significantly higher serum TG level than group B,with statistical significance(P<0.05).Furthermore,Pearson analysis identified that PAPP-A and 25-(OH)D levels were negatively correlated with fasting blood glucose(FBG)levels(r=-0.605,P<0.001),(r=-0.597,P<0.001),while TG and FBG levels were positively correlated(r=0.628,P<0.001).The sensitivity,specificity,area under the curve(AUC)and optimal cut-off value of serum PAPP-A level in the diagnosis of GDM were 72.55%,82.35%,0.861 and 16.340,respectively,while the sensitivity of TG in diagnosing GDM was 86.27%,the specificity was 66.67%,the AUC was 0.813,with an optimal cut-off value of 1.796.The corresponding sensitivity,specificity,AUC and optimal cut-off value of serum 25-(OH)D were 64.71%,70.59%,0.721 and 23.140,respectively.Moreover,multivariate logistic regression analysis revealed that FBG,vascular endothelial growth factor,Flt-1,serum PAPP-A,TG,and 25-(OH)D were related risk factors leading to GDM in patients.CONCLUSION Serum PAPP-A,TG,and 25-(OH)D levels are all correlated with blood glucose changes in GDM,and are independent factors affecting the occurrence of GDM and have certain value in the diagnosis of GDM.
文摘Gestational diabetes mellitus(GDM)manifests as different degrees of carbohydrate intolerance during pregnancy.According to several studies,GDM affects 4%to 25%of pregnant women.The majority of patients with GDM have varying levels of insulin resistance and chronic low-grade inflammation,which are related to vascular injury and dysfunction and subsequent platelet activation.[1]Consequently,platelet activation may be closely related to GDM severity.The mean platelet volume(MPV)is one of the indexes used to evaluate platelet morphology and activity.An elevated MPV has been demonstrated to be related to cardiovascular diseases and other conditions,such as hypertension and nonalcoholic fatty liver disease.
文摘Primary fallopian tube carcinoma(PFTC) is a rare malignant carcinoma among all genital tract malignancies.It occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and clinically.Because of its insidious onset and silent course,the diagnosis is made usually postoperatively.Liquid-based cytology(LBC) is a type of method for cervical cancer screening,but sometimes it may aid in making PFTC diagnosis.We report a 47-year-old woman with PFTC,whose diagnosis was made with the aid of LBC.
