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ML and CFD Simulation of Flow Structure around Tandem Bridge Piers in Pressurized Flow
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作者 Aliasghar Azma Ramin Kiyanfar +4 位作者 Yakun liu Masoumeh Azma Di Zhang Ze Cao zhuoyue li 《Computers, Materials & Continua》 SCIE EI 2023年第4期1711-1733,共23页
Various regions are becoming increasingly vulnerable to the increased frequency of floods due to the recent changes in climate and precipitation patterns throughout the world.As a result,specific infrastructures,notab... Various regions are becoming increasingly vulnerable to the increased frequency of floods due to the recent changes in climate and precipitation patterns throughout the world.As a result,specific infrastructures,notably bridges,would experience significant flooding for which they were not intended and would be submerged.The flow field and shear stress distribution around tandem bridge piers under pressurized flow conditions for various bridge deck widths are examined using a series of three-dimensional(3D)simulations.It is indicated that scenarios with a deck width to pier diameter(Ld/p)ratio of 3 experience the highest levels of turbulent disturbance.In addition,maximum velocity and shear stresses occur in cases with Ld/p equal to 6.Results indicate that increasing the number of piers from 1 to 2 and 3 results in the increase of bed shear stress by 24%and 20%respectively.Finally,five machine learning algorithms,including Decision Trees(DT),Feed Forward Neural Networks(FFNN),and three Ensemble models,are implemented to estimate the flow field and the turbulent structure.Results indicated that the highest accuracy for estimation of U,and W,were obtained using AdaBoost ensemble with R2=0.946 and 0.951,respectively.Besides,the Random Forest algorithm outperformed AdaBoost slightly in the estimation of V and turbulent kinetic energy(TKE)with R2=0.894 and 0.951,respectively. 展开更多
关键词 Bridge pier scour process deck width machine learning turbulent structure
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Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response:A combination of effective photodynamic therapy,autophagy,ferroptosis,and antitumor immunity
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作者 Jingru Wang Man liu +11 位作者 Jingwen Wang zhuoyue li Zhenhan Feng Meiqi Xu Hui Wang Hui li Zhantao li Jianming Yu Junwei liu Qingchao Wei Shuang Zhang Xuan Zhang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第10期4493-4508,共16页
We prepared biocompatible and environment-friendly zinc oxide nanoparticles(ZnO NPs)with upconversion properties and catalase-like nanozyme activity.Photodynamic therapy(PDT)application is severely limited by the poor... We prepared biocompatible and environment-friendly zinc oxide nanoparticles(ZnO NPs)with upconversion properties and catalase-like nanozyme activity.Photodynamic therapy(PDT)application is severely limited by the poor penetration of UV-Visible light and a hypoxic tumor environment.Here,we used ZnO NPs as a carrier for the photosensitizer chlorin e6(Ce6)to construct zinc oxide-chlorin e6 nanoparticles(ZnO-Ce6 NPs),simultaneously addressing both problems.In terms of penetration,ZnO NPs convert 808 nm near-infrared light into 401 nm visible light to excite Ce6,achieving deep-penetrating photodynamic therapy under long-wavelength light.Interestingly,the ability to emit short-wavelength light under long-wavelength light is usually observed in upconversion nanoparticles.As nanozymes,ZnO NPs can catalyze the decomposition of hydrogen peroxide in tumors,providing oxygen for photodynamic action and relieving hypoxia.The enhanced photodynamic action produces a large amount of reactive oxygen species,which overactivate autophagy and trigger immunogenic cell death(ICD),leading to antitumor immunotherapy.In addition,even in the absence of light,ZnO and ZnO-Ce6 NPs can induce ferroptosis of tumor cells and exert antitumor effects. 展开更多
关键词 Photodynamic therapy Near-infrared light Tissue penetration Catalase-like nanozyme Ferroptosis AUTOPHAGY IMMUNITY Zinc oxide nanoparticles
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An improved wall shear stress measurement technique using sandwiched hot-film sensors 被引量:3
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作者 Xuanhe liu zhuoyue li Nan Gao 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2018年第2期137-141,共5页
In this letter we present a novel wall shear stress measurement technique for a turbulent boundary layer using sandwiched hot-film sensors. Under certain conditions, satisfactory results can be obtained using only the... In this letter we present a novel wall shear stress measurement technique for a turbulent boundary layer using sandwiched hot-film sensors. Under certain conditions, satisfactory results can be obtained using only the heat generated by one of the hot-film and a calibration of the sensors is not required. Two thin Nickel films with the same size were used in this study, separated by an electrical insulating layer. The upper film served as a sensor and the bottom one served as a guard heater. The two Nickel films were operated at a same temperature, so that the Joule heat flux generated by the sensor film transferred to the air with a minimum loss or gain depending on the uncertainties in the film temperature measurements. Analytical solution of the shear stress based on the aforementioned heat flux was obtained. The preliminary results were promising and the estimated wall shear stresses agreed reasonablywell with the directly measured values (with errors less than 20%) in a fully developed turbulent pipe flow. The proposed technique can be improved to further increase precisions. 展开更多
关键词 Wall shear stress Skin friction Hot-film MEMS Calibration-free
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Response of turbulent fluctuations to the periodic perturbations in a flow over a backward facing step 被引量:2
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作者 zhuoyue li Honglei Bai Nan Gao 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2015年第5期191-195,共5页
The flow structures in a separated shear layer actuated by a synthetic jet actuator were studied using experimental methods. When forced at a frequency much lower than the natural shedding frequency (fH/U = 0.042 orf... The flow structures in a separated shear layer actuated by a synthetic jet actuator were studied using experimental methods. When forced at a frequency much lower than the natural shedding frequency (fH/U = 0.042 orfXr/U = 0.24), the vertical flapping motion of the shear layer downstream of the separation point became prominent. The size of the peak in the pressure spectra at the forcing frequency (Sta = fAH//U) measured near the separation point (x/H = 1) increased linearly with the forcing ampli- tude (u'/U) suggesting a linear response of the pressure fluctuations to the forcing by the synthetic jet. The linear response did not hold for the pressure fluctuations away from the jet exit as the magnitude of the peak for StA measured at x/H = 3 soon saturated when the forcing amplitude became larger than 0.3. 展开更多
关键词 Active flow controlSynthetic jetBackward facing step
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Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer 被引量:4
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作者 Jianhua DAI Xiu HE +8 位作者 zhuoyue li Kang li Tingting YANG Zengling RAN lijian YIN Yao CHEN Xiang ZOU Dianchun FANG Guiyong PENG 《Photonic Sensors》 SCIE EI CAS CSCD 2019年第1期53-59,共7页
A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large c... A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large core fibers and a focus lens,and a highly sensitive spectrum meter.The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality.A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed,based on the differences in half-height width(HHW)in 1200cm^-1 to 1400cm^-1 frequency band and the ratios of the spectral integral energy between 1600cm^-1-1700cm^-1 and 1500cm^-1- 1600cm^-1 band.It shows a high specificity and effectivity for the diagnosis of esophageal cancer. 展开更多
关键词 Fiber-optic RAMAN SPECTRUM ESOPHAGEAL CANCER
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Microstructures and Phase Transition in Omphacite: Constraints on the P-T Path of Shuanghe Eclogite (Dabie Orogen) 被引量:2
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作者 Zhanjun Xie Xiangwen liu +1 位作者 Zhenmin Jin zhuoyue li 《Journal of Earth Science》 SCIE CAS CSCD 2020年第2期254-261,共8页
Omphacite microstructures are important to decipher the metamorphic pressuretemperature(P-T)conditions of eclogite during subduction and exhumation processes.Here we present a systematic microstructural investigation ... Omphacite microstructures are important to decipher the metamorphic pressuretemperature(P-T)conditions of eclogite during subduction and exhumation processes.Here we present a systematic microstructural investigation of omphacite using transmission electron microscopy(TEM)in an ultrahigh-pressure(UHP)eclogite sample from Shuanghe,Dabie orogen,China.The omphacite can be divided into two phases:(1)Omp-1,exhibits as the main part of omphacite with P2/n space group containing small amount of dislocations and numerous antiphase domains(APDs).(2)Omp-2,shows as banded subgrains with C2/c space group containing large amount of dislocations.These two phases of omphacite have almost the same crystallography orientation and bounded by dislocation walls.Along these dislocation walls,we found some barroisite and albite microcrystals.The barroisite microcrystals contain large amount of dislocations and show a topological relation with host omphacite.While the albite microcrystals contain small amount of dislocations and does not show topological relation with host.These microstructures could give us the following metamorphic information to constrain the P-T path of eclogite:Firstly,this two omphacite space groups should be evolved from the same precursor C2/c omphacite,which had been underwent strongly plastic deformation during the syn-to late-peak metamorphic stage.Secondly,the precursor C2/c omphacite began to be retrograded and altered by small amount of barroisite microcrystals along its dislocation walls under the P-T condition of 2.2–2.6 GPa and 650–700℃ at the early amphibole eclogite stage.Thirdly,large amount of Na and other elements were exsolved from some precursor C2/c omphacite subgrains and crystallized numerous albite microcrystals at their boundaries,which is the necessary for the space group of C2/c surviving under the lower P-T conditions(1.7–1.9 GPa and 630–690 C)during the middle amphibole eclogite stage.Lastly,the rest of precursor C2/c omphacite subgrains were transformed into P2/n polymorph and formed the APDs structures under the P-T condition of^1.5 GPa and 650–680℃ during the late amphibole eclogite stage. 展开更多
关键词 microstructure OMPHACITE ECLOGITE TEM P-T PATH
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Preparation and characterization of pH-sensitive calcium carbonate-chlorin e6 nanoparticles for photodynamic therapy 被引量:1
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作者 Jingru Wang Shuang Zhang +3 位作者 zhuoyue li Meiqi Xu Guangxue Wang Xuan Zhang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2021年第11期904-911,共8页
In the present study,we combined CaCO_(3)NPs and Ce6 to construct CaCO_(3)-Ce6 nanoparticles (NPs).CaCO_(3)-Ce6 NPs were characterized in terms of particle size,zeta potential,UV-Vis absorption spectrum,fluorescence s... In the present study,we combined CaCO_(3)NPs and Ce6 to construct CaCO_(3)-Ce6 nanoparticles (NPs).CaCO_(3)-Ce6 NPs were characterized in terms of particle size,zeta potential,UV-Vis absorption spectrum,fluorescence spectrum,FTIR spectrum,and pH-responsive behavior.The reactive oxygen species (ROS) generation in vitro was measured in 4T1 cells.The results showed that CaCO_(3)-Ce6 NPs were uniform-sized NPs with excellent fluorescence properties and pH-responsive behavior.The ability of ROS generation by CaCO_(3)-Ce6 NPs was stronger compared with Ce6 in 4T1 cells because Ca;could enhance the ROS generation,which could contribute to a stronger anti-tumor effect. 展开更多
关键词 Calcium carbonate nanoparticles Chlorin e6 Photodynamic therapy Reactive oxygen species PH-RESPONSIVE
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Preparation and characterization of zinc oxide nanoparticles 被引量:1
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作者 Man liu Shuang Zhang +3 位作者 zhuoyue li Guangxue Wang Jingru Wang Xuan Zhang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2020年第9期617-625,共9页
In the present study, the zinc oxide nanoparticles(ZnO NPs) were prepared by using a sol-gel method. The characterization of ZnO NPs, such as particle size, morphology, crystal form, optical properties and p H-respons... In the present study, the zinc oxide nanoparticles(ZnO NPs) were prepared by using a sol-gel method. The characterization of ZnO NPs, such as particle size, morphology, crystal form, optical properties and p H-responsive behavior, was carried out. The in vitro anti-tumor activity of ZnO NPs was evaluated on PC-3M and 4T1 cell lines. The results indicated that ZnO NPs were spherical NPs with uniform particle size, excellent fluorescence properties, and p H-responsive behavior. The in vitro anti-tumor activity of ZnO NPs was observed on PC-3M and 4T1 cell lines. Considering to above characteristics, Zn O NPs could be used as drug delivery carries for loading active compound performing therapeutic and diagnostic effect. 展开更多
关键词 Zinc oxide nanoparticles Sol-gel method Size and morphology Optical properties In vitro anti-tumor activity
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Study of the Sensing Characteristics of Irradiated Fiber Bragg Gratings and Fabry-Perot Interferometers Under Gamma Radiation 被引量:1
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作者 zhuoyue li Zengling RAN +7 位作者 Xianguo QING Zhengxi HE Yaqin XIAO Tingting YANG Xiu HE Jialiang ZHU Peng HE Sijie XU 《Photonic Sensors》 SCIE EI CSCD 2022年第1期91-98,共8页
The sensing characteristics of irradiated fiber Bragg gratings(FBGs)and Fabry-Perot interferometers(FPIs)were investigated under a 2MGy dose of gamma radiation.The study found that the pressure sensitivity of FP senso... The sensing characteristics of irradiated fiber Bragg gratings(FBGs)and Fabry-Perot interferometers(FPIs)were investigated under a 2MGy dose of gamma radiation.The study found that the pressure sensitivity of FP sensors after irradiation was stable,while the temperature sensitivity of FBG sensors was unstable,and both wavelengths displayed a shift.These findings offer the possibility for the application of FP pressure sensors in the gamma radiation environments,and FBG sensors require further research to be suitable for application in the nuclear radiation environments. 展开更多
关键词 Fiber Bragg gratings Fabry-Perot interferometers gamma radiation
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Synthesis of poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine) and preparation of its hydrogel solution containing doxorubicin
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作者 Zhantao li Ai liao +14 位作者 Man liu Shuang Zhang Zhenhan Feng Guangxue Wang Jingru Wang Meiqi Xu zhuoyue li Xiaochuan Duan Yanli Hao Xiuchai Zheng Hui li Qin Na Hua Zhang Bilin liu Xuan Zhang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2019年第5期316-328,共13页
Many pH-and temperature-responsive polymers have been designed for preparing hydrogel.In the present study,in order to decrease the pH sensitivity of reported poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA... Many pH-and temperature-responsive polymers have been designed for preparing hydrogel.In the present study,in order to decrease the pH sensitivity of reported poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA1580-PEG4600-PAA1580),we designed and synthesized poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA-PEG-PAA)with shorter length of PAA chain by decreasing reaction temperature for preparing PAA-PEG-PAA hydrogel solution containing doxorubicin(DOX).The PAA-PEG-PAA was synthesized via the Michael-addition polymerization.The characteristic of PAA-PEG-PAA was evaluated.The PAA-PEG-PAA hydrogel solution was prepared and investigated.DOX-loaded PAA-PEG-PAA hydrogel solution was prepared,and its in vitro DOX release and in vitro anti-tumor activity were evaluated.Our results indicated that the viscosity of PAA-PEG-PAA hydrogel solution was concentration-and temperature-dependent.The sol-gel transition temperature of PAA-PEG-PAA hydrogel solution(12%,w/w)ranged from 35 to 29℃,and its pH ranged from 6.0 to 7.4.The released DOX from DOX-loaded PAA-PEG-PAA hydrogel showed sustained release characteristics.The in vitro anti-tumor activity of DOX-loaded PAA-PEG-PAA hydrogel was confirmed in B16 F10 cell line.Considering the acidic tumor microenvironment,this DOX-loaded PAA-PEG-PAA hydrogel solution would be easy in situ administration for intra-tumor injection or para-tumor injection forming hydrogel at body temperature.We suggested that this DOX-loaded PAA-PEG-PAAhydrogel solution,if containing photothermal conversion agents,would have a potential further use for photothermal therapy. 展开更多
关键词 Poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA-PEG-PAA) pH-and temperature-responsive polymer HYDROGEL Doxorubicin(DOX) B16F10 cells
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Design of an All-Fiber Fabry-Perot Sensor for Strain Measurement in Radiative Environment
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作者 Tingting YANG Zengling RAN +6 位作者 Xiu HE Lupeng GAN Zhengxi HE Jialiang ZHU Peng HE zhuoyue li Dong SUN 《Photonic Sensors》 SCIE EI CSCD 2022年第4期81-90,共10页
A length-matched micro Fabry-Perot(FP)interferometer is proposed for strain measurement under irradiation environment.Theoretical simulation shows that a well length-matched FP sensor can achieve a very low drift of t... A length-matched micro Fabry-Perot(FP)interferometer is proposed for strain measurement under irradiation environment.Theoretical simulation shows that a well length-matched FP sensor can achieve a very low drift of the cavity length and strain sensitivity in irradiation environment.In experiment,such an FP cavity is realized by laser micromachining.It shows a low cavity length drift of−0.037μm and a strain sensitivity deviation of 0.52%,respectively,under gamma irradiation.Meanwhile,the intensity of interference fringes is also stable.As a result,such a length-matched FP cavity is a very promising candidate for strain sensing in radiative environments. 展开更多
关键词 Gamma radiation Fabry-Perot sensor radiation-induced compaction strain sensing
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