The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a...The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a numerical calculation method is proposed,whose reliability is supported by comparison with experimental results.Through the numerical calculation,the temperature distribution,temperature change,and ignition time are acquired.The numerical results show that the ignition time is 76 s after the warhead started to burn and that the maximum temperature of the explosive’s outer surface is 238.3℃ at the ignition time.The fast cook-off experiment of the warhead is implemented so as to get the flame temperature and reaction grades that are not available through numerical calculation.The experimental results show that the overpressure fails to reach the preset minimumvalue which is equivalent to 6 kg of TNT and that the reaction grade is deflagration.The research results have reference value for the design of the warhead and the reduction of detonation risks.展开更多
Ptychography is a diffraction-based X-ray microscopy technique in which an extended sample is scanned by a coherent beam with overlapped illuminated areas and complex transmission function of the sample is obtained by...Ptychography is a diffraction-based X-ray microscopy technique in which an extended sample is scanned by a coherent beam with overlapped illuminated areas and complex transmission function of the sample is obtained by applying iterative phase retrieval algorithms to the diffraction patterns recorded at each scanned position.It permits quantitatively imaging of non-crystalline specimens at a resolution limited only by the X-ray wavelength and the maximal scattering angle detected.In this paper,the development of soft X-ray ptychography method at the BL08U1 A beamline of Shanghai Synchrotron Radiation Facility is presented.The experimental setup,experimental parameters selection criteria,and post-experimental data analyzing procedures are presented in detail with a prospect of high-resolution image reconstruction in real time.The performance of this newly implemented method is demonstrated through the measurements of a resolution test pattern and two real samples:Pt-Co alloy nanoparticles and a breast cancer cell.The results indicate that strong scattering specimens can be reconstructed to sub-20 nm resolution,while a sub-25 nm resolution for biological specimens can be achieved.展开更多
AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emissi...AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.展开更多
文摘The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a numerical calculation method is proposed,whose reliability is supported by comparison with experimental results.Through the numerical calculation,the temperature distribution,temperature change,and ignition time are acquired.The numerical results show that the ignition time is 76 s after the warhead started to burn and that the maximum temperature of the explosive’s outer surface is 238.3℃ at the ignition time.The fast cook-off experiment of the warhead is implemented so as to get the flame temperature and reaction grades that are not available through numerical calculation.The experimental results show that the overpressure fails to reach the preset minimumvalue which is equivalent to 6 kg of TNT and that the reaction grade is deflagration.The research results have reference value for the design of the warhead and the reduction of detonation risks.
基金supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.11225527,11575283,11505277)the Ministry of Science and Technology of China(2012CB825705)
文摘Ptychography is a diffraction-based X-ray microscopy technique in which an extended sample is scanned by a coherent beam with overlapped illuminated areas and complex transmission function of the sample is obtained by applying iterative phase retrieval algorithms to the diffraction patterns recorded at each scanned position.It permits quantitatively imaging of non-crystalline specimens at a resolution limited only by the X-ray wavelength and the maximal scattering angle detected.In this paper,the development of soft X-ray ptychography method at the BL08U1 A beamline of Shanghai Synchrotron Radiation Facility is presented.The experimental setup,experimental parameters selection criteria,and post-experimental data analyzing procedures are presented in detail with a prospect of high-resolution image reconstruction in real time.The performance of this newly implemented method is demonstrated through the measurements of a resolution test pattern and two real samples:Pt-Co alloy nanoparticles and a breast cancer cell.The results indicate that strong scattering specimens can be reconstructed to sub-20 nm resolution,while a sub-25 nm resolution for biological specimens can be achieved.
基金supported by the National Natural Science Foundation of China(Nos.52173137 and 51873163).
文摘AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.
