Coronary atherosclerotic heart disease(CHD)is the main type of cardiovascular disease.The efficacy of Uyghur drug compound Saffron formula in CHD has been clinically proven.However,the underlying mechanism remains unc...Coronary atherosclerotic heart disease(CHD)is the main type of cardiovascular disease.The efficacy of Uyghur drug compound Saffron formula in CHD has been clinically proven.However,the underlying mechanism remains unclear.In this study,researchers investigated the active ingredients and mechanism of action of Crocus sativus and Rosa rugosa in the treatment of CHD by network pharmacology and molecular docking techniques,collected target information with the help of TCMSP,GEO,GeneCards,and other databases,constructed protein-protein interaction(PPI)network diagrams by STRING database,performed GO and KEGG pathway enrichment analysis on common targets,and finally molecularly docked the active ingredients with core targets.C.sativus-R.rugosa have a variety of polyphenol compounds,a total of 12 active ingredients,including quercetin and kaempferol,were screened.The first three targets intersected with the core targets of CHD as AKT1,TNF,and IL-1B.Enrichment results of KEGG pathway showed that C.sativus-R.rugosa against CHD involved atherosclerosis pathways.The molecular docking results showed that quercetin and kaempferol were well bound to the core targets,and it was speculated that these components might be the main active ingredients for the treatment of CHD.The potential mechanism of action of C.sativus-R.rugosa for the treatment of coronary heart disease was initially revealed.展开更多
Distributed power market trading has the characteristics of large number of participants,scattered locations,small single trading scale,and point-to-point trading.The traditional centralized power trading model has th...Distributed power market trading has the characteristics of large number of participants,scattered locations,small single trading scale,and point-to-point trading.The traditional centralized power trading model has the problems of large load,low efficiency,high cost,reliance on third parties and unreliable data.With the characteristics of decentralization and nontampering,blockchain can establish a point-to-point trusted trading environment and provide effective solutions to the above problems.Therefore,this paper proposed a distributed power market trading framework based on blockchain.In this framework,the distributed power supply characteristics and trading needs of each participant are analyzed,a complete distributed trading process based on blockchain is designed.In addition,we have studied the key technologies of distributed power market trading.With the goal of power service reputation and maximum revenue of distributed power providers,we have established a matching degree model,a distributed power market trading optimization model,and designed a smart contract-based power market trading optimization strategy and power trading settlement strategy.Finally,we designed experiments to verify the performance of the proposed framework.展开更多
基金supported by Young and Middle Aged Teachers’Career Development Support Project of Shenyang Pharmaceutical University(ZQN2019005).
文摘Coronary atherosclerotic heart disease(CHD)is the main type of cardiovascular disease.The efficacy of Uyghur drug compound Saffron formula in CHD has been clinically proven.However,the underlying mechanism remains unclear.In this study,researchers investigated the active ingredients and mechanism of action of Crocus sativus and Rosa rugosa in the treatment of CHD by network pharmacology and molecular docking techniques,collected target information with the help of TCMSP,GEO,GeneCards,and other databases,constructed protein-protein interaction(PPI)network diagrams by STRING database,performed GO and KEGG pathway enrichment analysis on common targets,and finally molecularly docked the active ingredients with core targets.C.sativus-R.rugosa have a variety of polyphenol compounds,a total of 12 active ingredients,including quercetin and kaempferol,were screened.The first three targets intersected with the core targets of CHD as AKT1,TNF,and IL-1B.Enrichment results of KEGG pathway showed that C.sativus-R.rugosa against CHD involved atherosclerosis pathways.The molecular docking results showed that quercetin and kaempferol were well bound to the core targets,and it was speculated that these components might be the main active ingredients for the treatment of CHD.The potential mechanism of action of C.sativus-R.rugosa for the treatment of coronary heart disease was initially revealed.
文摘Distributed power market trading has the characteristics of large number of participants,scattered locations,small single trading scale,and point-to-point trading.The traditional centralized power trading model has the problems of large load,low efficiency,high cost,reliance on third parties and unreliable data.With the characteristics of decentralization and nontampering,blockchain can establish a point-to-point trusted trading environment and provide effective solutions to the above problems.Therefore,this paper proposed a distributed power market trading framework based on blockchain.In this framework,the distributed power supply characteristics and trading needs of each participant are analyzed,a complete distributed trading process based on blockchain is designed.In addition,we have studied the key technologies of distributed power market trading.With the goal of power service reputation and maximum revenue of distributed power providers,we have established a matching degree model,a distributed power market trading optimization model,and designed a smart contract-based power market trading optimization strategy and power trading settlement strategy.Finally,we designed experiments to verify the performance of the proposed framework.
