Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferropto...Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer.The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma.In this study,a combination of hydrogel-liposome nanoplatform encapsulatedwith Temozolomide and ferroptosis inducer Erastin was constructed.Theαvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy.As biocompatible drug reservoirs,cross-linked GelMA(gelatin methacrylamide)hydrogel and cRGD-coated liposome realized the sustained release of internal contents.In the modified intracranial tumor resection model,GelMA-liposome system achieved slow release of Temozolomide and Erastin in situ for more than 14 d.The results indicated that nanoplatform(T+E@LPs-cRGD+GelMA)improved glioblastoma sensitivity to chemotherapeutic temozolomide and exerted satisfactory anti-tumor effects.It was demonstrated that the induction of ferroptosis could be utilized as a therapeutic strategy to overcome drug resistance.Furthermore,transcriptome sequencing was conducted to reveal the underlying mechanism that the nanoplatform(T+E@LPs-cRGD+GelMA)implicated in.It is suggested that GelMA-liposome system participated in the immune response and immunomodulation of glioblastoma via interferon/PD-L1 pathway.Collectively,this study proposed a potential combinatory therapeutic strategy for glioblastoma treatment.展开更多
In this paper, a new type of ultrasonic vibration de-gluing device has been designed to remove the cured epoxy resin adhesive </span><span style="white-space:normal;font-family:"">that&...In this paper, a new type of ultrasonic vibration de-gluing device has been designed to remove the cured epoxy resin adhesive </span><span style="white-space:normal;font-family:"">that </span><span style="white-space:normal;font-family:"">overflowed from the aluminum alloy structural parts in the high-speed train carriages. At present, manual removal is used to remove the cured epoxy resin adhesive that overflows at the bonding site. This method has low removal efficiency and leads to poor surface quality of the parts. The new type of ultrasonic vibration de-gluing device can solve these problems. Modal analysis and harmonic response analysis are carried out on the ultrasonic vibration oscillator system in the ultrasonic vibration de-gluing device, and the reasonable structure parameters and resonance frequency of the ultrasonic vibration oscillator system are determined. Finally, the impedance test and de-gluing effect test are carried out on the prototype of the ultrasonic vibration de-gluing device to verify the feasibility and practicability of the new type of ultrasonic vibration de-gluing device. The results show that the ultrasonic vibration de-gluing device’s stable resonant operating frequency is 28</span><span style="white-space:normal;font-family:"">,</span><span style="white-space:normal;font-family:"">270</span><span style="white-space:normal;font-family:""> </span><span style="white-space:normal;font-family:"">Hz, and the average error between the simulation and experimental results of the resonant operating frequency is less than 3%, which validates the simulation model.展开更多
With the large-scale application of 5G technology in smart distribution networks,the operation effects of distribution networks are not clear.Herein,we propose a comprehensive evaluation model of a 5G+smart distributi...With the large-scale application of 5G technology in smart distribution networks,the operation effects of distribution networks are not clear.Herein,we propose a comprehensive evaluation model of a 5G+smart distribution network based on the combination weighting and cloud model of the improved Fuzzy Analytic Hierarchy-Entropy Weight Method(FAHP-EWM).First,we establish comprehensive evaluation indexes of a 5G+smart distribution network from five dimensions:reliable operation,economic operation,efficient interaction,technological intelligence,and green emission reduction.Second,by introducing the principle of variance minimization,we propose a combined weighting method based on the improved FAHP-EWM to calculate the comprehensive weight,so as to reduce the defects of subjective arbitrariness and promote objectivity.Finally,a comprehensive evaluation model of 5G+smart distribution network based on cloud model is proposed by considering the uncertainty of distribution network node information and equipment status information.The example analysis indicates that the overall operation of the 5G+smart distribution network project is decent,and the weight value calculated by the combined weighting method is more reasonable and accurate than that calculated by the single weighting method,which verifies the effectiveness and rationality of the proposed evaluation method.Moreover,the proposed evaluation method has a certain guiding role for the large-scale application of 5G communication technology in smart distribution networks.展开更多
To satisfy high-precision,widc-rangc,and real-time neutron flux measurement requirements by the International Thermonuclear Experimental Reactor(ITF.R),a data acquisition and control system based on fission chamber de...To satisfy high-precision,widc-rangc,and real-time neutron flux measurement requirements by the International Thermonuclear Experimental Reactor(ITF.R),a data acquisition and control system based on fission chamber detectors and fast controller technology,has been developed for neutron flux monitor in ITER Equatorial Port#7.The signal processing units which arc based on a field programmable gate array and the PXI Express platform arc designed to realize the neutron flux measurement with I ms time resolution and a fast response less than 0.2 ms,together with real-time timestamps provided by a timing hoard.The application of the wide-range algorithm allows the system to measure up to 10^10cps with a relative error of less than 5%.Furthermore,the system is managed and controlled by a software based on the Experimental Physics and Industrial Control System,compliant with COntrol.Data Access and Communication architecture.展开更多
A novel full-digital real-time neutron flux monitor(NFM) has been developed for the International Thermonuclear Experimental Reactor.A measurement range of 10~9 counts per second is achieved with 3 different sensitive...A novel full-digital real-time neutron flux monitor(NFM) has been developed for the International Thermonuclear Experimental Reactor.A measurement range of 10~9 counts per second is achieved with 3 different sensitive fission chambers.The Counting mode and Campbelling mode have been combined as a means to achieve higher measurement range.The system is based on high speed as well as parallel and pipeline processing of the field programmable gate array and has the ability to upload raw-data of analog-to-digital converter in real-time through the PXIe platform.With the advantages of the measurement range,real time performance and the ability of raw-data uploading,the digital NFM has been tested in HL-2 A experiments and reflected good experimental performance.展开更多
Premature ovarian failure refers to a disease in which women usually present with amenorrhea,infertility,decreased estrogen secretion,and increased gonadotropin before the age of 40.It seriously endangers women’s hea...Premature ovarian failure refers to a disease in which women usually present with amenorrhea,infertility,decreased estrogen secretion,and increased gonadotropin before the age of 40.It seriously endangers women’s health,making them prone to various endocrine reproductive and even systemic disorders.Its pathogenesis remains unclear;however,it may be related to genetic,immune,enzyme deficiency,iatrogenic,cyclin,psychology,and other factors.Traditional Chinese medicine believes that its etiology is related to the kidney,liver,and spleen.It can be divided into kidney deficiency and liver depression syndrome,liver and kidney Yin deficiency syndrome,spleen and kidney Yang deficiency syndrome,and so on.Traditional Chinese medicine is mainly made up of oral Chinese medicine,acupuncture,and other therapies.Through literature research,this paper discusses the etiology,pathological mechanism,and treatment of premature ovarian failure in the field of traditional Chinese medicine.展开更多
Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Emp...Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Employing accurate in vitro and in vivo models to recapitulate the complexities of brain metastasis offers the most promising approach to unravel the intricate cellular and physiological processes involved.Here,we present a comprehensive review of the currently accessible models for studying brain metastasis.We introduce a diverse array of in vitro and in vivo models,including cultured cells using the Transwell system,organoids,microfluidic models,syngeneic models,xenograft models,and genetically engineered models.We have also provided a concise summary of the merits and limitations inherent to each model while identifying the optimal contexts for their effective utilization.This review serves as a comprehensive resource,aiding researchers in making well-informed decisions regarding model selection that align with specific research questions.展开更多
Due to the abundant sodium reserves and high safety,sodium ion batteries(SIBs)are foreseen a promising future.While,hard carbon materials are very suitable for the anode of SIBs owing to their structure and cost advan...Due to the abundant sodium reserves and high safety,sodium ion batteries(SIBs)are foreseen a promising future.While,hard carbon materials are very suitable for the anode of SIBs owing to their structure and cost advantages.However,the unsatisfactory initial coulombic efficiency(ICE)is one of the crucial blemishes of hard carbon materials and the slow sodium storage kinetics also hinders their wide application.Herein,with spherical nano SiO_(2)as pore-forming agent,gelatin and polytetrafluoroethylene as carbon sources,a multi-porous carbon(MPC)material can be easily obtained via a co-pyrolysis method,by which carbonization and template removal can be achieved synchronously without the assistance of strong acids or strong bases.As a result,the MPC anode exhibited remarkable ICE of 83%and a high rate capability(208 m Ah/g at 5 A/g)when used in sodium-ion half cells.Additionally,coupling with Na3V2(PO4)3as the cathode to assemble full cells,the as-fabricated MPC//NVP full cell delivered a good rate capability(146 m Ah/g at 5 A/g)as well,implying a good application prospect the MPC anode has.展开更多
基金supported by Natural Science Foundation of China(Grant NO.81972340,82173140,81871196)Shandong Provincial Natural Science Foundation,China(Grant No.ZR202010300086)Academic promotion program of Shandong First Medical University(Grant NO.2019LJ005)。
文摘Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer.The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma.In this study,a combination of hydrogel-liposome nanoplatform encapsulatedwith Temozolomide and ferroptosis inducer Erastin was constructed.Theαvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy.As biocompatible drug reservoirs,cross-linked GelMA(gelatin methacrylamide)hydrogel and cRGD-coated liposome realized the sustained release of internal contents.In the modified intracranial tumor resection model,GelMA-liposome system achieved slow release of Temozolomide and Erastin in situ for more than 14 d.The results indicated that nanoplatform(T+E@LPs-cRGD+GelMA)improved glioblastoma sensitivity to chemotherapeutic temozolomide and exerted satisfactory anti-tumor effects.It was demonstrated that the induction of ferroptosis could be utilized as a therapeutic strategy to overcome drug resistance.Furthermore,transcriptome sequencing was conducted to reveal the underlying mechanism that the nanoplatform(T+E@LPs-cRGD+GelMA)implicated in.It is suggested that GelMA-liposome system participated in the immune response and immunomodulation of glioblastoma via interferon/PD-L1 pathway.Collectively,this study proposed a potential combinatory therapeutic strategy for glioblastoma treatment.
文摘In this paper, a new type of ultrasonic vibration de-gluing device has been designed to remove the cured epoxy resin adhesive </span><span style="white-space:normal;font-family:"">that </span><span style="white-space:normal;font-family:"">overflowed from the aluminum alloy structural parts in the high-speed train carriages. At present, manual removal is used to remove the cured epoxy resin adhesive that overflows at the bonding site. This method has low removal efficiency and leads to poor surface quality of the parts. The new type of ultrasonic vibration de-gluing device can solve these problems. Modal analysis and harmonic response analysis are carried out on the ultrasonic vibration oscillator system in the ultrasonic vibration de-gluing device, and the reasonable structure parameters and resonance frequency of the ultrasonic vibration oscillator system are determined. Finally, the impedance test and de-gluing effect test are carried out on the prototype of the ultrasonic vibration de-gluing device to verify the feasibility and practicability of the new type of ultrasonic vibration de-gluing device. The results show that the ultrasonic vibration de-gluing device’s stable resonant operating frequency is 28</span><span style="white-space:normal;font-family:"">,</span><span style="white-space:normal;font-family:"">270</span><span style="white-space:normal;font-family:""> </span><span style="white-space:normal;font-family:"">Hz, and the average error between the simulation and experimental results of the resonant operating frequency is less than 3%, which validates the simulation model.
基金supported by the State Grid Corporation of China(KJ21-1-56).
文摘With the large-scale application of 5G technology in smart distribution networks,the operation effects of distribution networks are not clear.Herein,we propose a comprehensive evaluation model of a 5G+smart distribution network based on the combination weighting and cloud model of the improved Fuzzy Analytic Hierarchy-Entropy Weight Method(FAHP-EWM).First,we establish comprehensive evaluation indexes of a 5G+smart distribution network from five dimensions:reliable operation,economic operation,efficient interaction,technological intelligence,and green emission reduction.Second,by introducing the principle of variance minimization,we propose a combined weighting method based on the improved FAHP-EWM to calculate the comprehensive weight,so as to reduce the defects of subjective arbitrariness and promote objectivity.Finally,a comprehensive evaluation model of 5G+smart distribution network based on cloud model is proposed by considering the uncertainty of distribution network node information and equipment status information.The example analysis indicates that the overall operation of the 5G+smart distribution network project is decent,and the weight value calculated by the combined weighting method is more reasonable and accurate than that calculated by the single weighting method,which verifies the effectiveness and rationality of the proposed evaluation method.Moreover,the proposed evaluation method has a certain guiding role for the large-scale application of 5G communication technology in smart distribution networks.
文摘To satisfy high-precision,widc-rangc,and real-time neutron flux measurement requirements by the International Thermonuclear Experimental Reactor(ITF.R),a data acquisition and control system based on fission chamber detectors and fast controller technology,has been developed for neutron flux monitor in ITER Equatorial Port#7.The signal processing units which arc based on a field programmable gate array and the PXI Express platform arc designed to realize the neutron flux measurement with I ms time resolution and a fast response less than 0.2 ms,together with real-time timestamps provided by a timing hoard.The application of the wide-range algorithm allows the system to measure up to 10^10cps with a relative error of less than 5%.Furthermore,the system is managed and controlled by a software based on the Experimental Physics and Industrial Control System,compliant with COntrol.Data Access and Communication architecture.
基金supported by National Natural Science Foundation of China (Nos.11375195,11575184)the National Magnetic Confinement Fusion Energy Development Research of China (No.2013GB104003)
文摘A novel full-digital real-time neutron flux monitor(NFM) has been developed for the International Thermonuclear Experimental Reactor.A measurement range of 10~9 counts per second is achieved with 3 different sensitive fission chambers.The Counting mode and Campbelling mode have been combined as a means to achieve higher measurement range.The system is based on high speed as well as parallel and pipeline processing of the field programmable gate array and has the ability to upload raw-data of analog-to-digital converter in real-time through the PXIe platform.With the advantages of the measurement range,real time performance and the ability of raw-data uploading,the digital NFM has been tested in HL-2 A experiments and reflected good experimental performance.
文摘Premature ovarian failure refers to a disease in which women usually present with amenorrhea,infertility,decreased estrogen secretion,and increased gonadotropin before the age of 40.It seriously endangers women’s health,making them prone to various endocrine reproductive and even systemic disorders.Its pathogenesis remains unclear;however,it may be related to genetic,immune,enzyme deficiency,iatrogenic,cyclin,psychology,and other factors.Traditional Chinese medicine believes that its etiology is related to the kidney,liver,and spleen.It can be divided into kidney deficiency and liver depression syndrome,liver and kidney Yin deficiency syndrome,spleen and kidney Yang deficiency syndrome,and so on.Traditional Chinese medicine is mainly made up of oral Chinese medicine,acupuncture,and other therapies.Through literature research,this paper discusses the etiology,pathological mechanism,and treatment of premature ovarian failure in the field of traditional Chinese medicine.
基金This work was supported by the National Natural Science Foundation of China(No.82072787)the Department of Science and Technology of Guangdong Province International Cooperation Project(No.2022A0505050012)+1 种基金the Tertiary Education Scientific Research Project of Guangzhou Municipal Education Bureau(No.202235421)the Guangzhou Basic and Applied Basic Research Scheme(No.G23151016).
文摘Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Employing accurate in vitro and in vivo models to recapitulate the complexities of brain metastasis offers the most promising approach to unravel the intricate cellular and physiological processes involved.Here,we present a comprehensive review of the currently accessible models for studying brain metastasis.We introduce a diverse array of in vitro and in vivo models,including cultured cells using the Transwell system,organoids,microfluidic models,syngeneic models,xenograft models,and genetically engineered models.We have also provided a concise summary of the merits and limitations inherent to each model while identifying the optimal contexts for their effective utilization.This review serves as a comprehensive resource,aiding researchers in making well-informed decisions regarding model selection that align with specific research questions.
基金financially supported by the Start-up Funding of Jinan University(No.88016105)the Discipline Construction Outstanding Young Backbone Project(No.12819023)+3 种基金the Fundamental Research Funds for the Central Universities(No.21620317)the Guangdong Basic and Applied Basic Research Foundation(Nos.2020A1515110611 and 2021A1515010362)the Guangzhou Basic and Applied Basic Research Foundation(No.202102020995)supported by the Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications(No.2020B121201005)。
文摘Due to the abundant sodium reserves and high safety,sodium ion batteries(SIBs)are foreseen a promising future.While,hard carbon materials are very suitable for the anode of SIBs owing to their structure and cost advantages.However,the unsatisfactory initial coulombic efficiency(ICE)is one of the crucial blemishes of hard carbon materials and the slow sodium storage kinetics also hinders their wide application.Herein,with spherical nano SiO_(2)as pore-forming agent,gelatin and polytetrafluoroethylene as carbon sources,a multi-porous carbon(MPC)material can be easily obtained via a co-pyrolysis method,by which carbonization and template removal can be achieved synchronously without the assistance of strong acids or strong bases.As a result,the MPC anode exhibited remarkable ICE of 83%and a high rate capability(208 m Ah/g at 5 A/g)when used in sodium-ion half cells.Additionally,coupling with Na3V2(PO4)3as the cathode to assemble full cells,the as-fabricated MPC//NVP full cell delivered a good rate capability(146 m Ah/g at 5 A/g)as well,implying a good application prospect the MPC anode has.
