In the daily application of an iris-recognition-at-a-distance(IAAD)system,many ocular images of low quality are acquired.As the iris part of these images is often not qualified for the recognition requirements,the mor...In the daily application of an iris-recognition-at-a-distance(IAAD)system,many ocular images of low quality are acquired.As the iris part of these images is often not qualified for the recognition requirements,the more accessible periocular regions are a good complement for recognition.To further boost the performance of IAAD systems,a novel end-to-end framework for multi-modal ocular recognition is proposed.The proposed framework mainly consists of iris/periocular feature extraction and matching,unsupervised iris quality assessment,and a score-level adaptive weighted fusion strategy.First,ocular feature reconstruction(OFR)is proposed to sparsely reconstruct each probe image by high-quality gallery images based on proper feature maps.Next,a brand new unsupervised iris quality assessment method based on random multiscale embedding robustness is proposed.Different from the existing iris quality assess-ment methods,the quality of an iris image is measured by its robustness in the embedding space.At last,the fusion strategy exploits the iris quality score as the fusion weight to coalesce the complementary information from the iris and periocular regions.Extensive experi-mental results on ocular datasets prove that the proposed method is obviously better than unimodal biometrics,and the fusion strategy can significantly improve therecognition performance.展开更多
Cashmere,also known as soft gold,is produced from the secondary hair follicles(SHFs)of cashmere goats.The number of SHFs determines the yield and quality of cashmere;therefore,it is of interest to investigate the tran...Cashmere,also known as soft gold,is produced from the secondary hair follicles(SHFs)of cashmere goats.The number of SHFs determines the yield and quality of cashmere;therefore,it is of interest to investigate the transcriptional profiles present during cashmere goat hair follicle development.However,mechanisms underlying this development process remain largely unexplored,and studies regarding hair follicle development mostly use a murine research model.In this study,to provide a comprehensive understanding of cellular heterogeneity and cell fate decisions,single-cell RNA sequencing was performed on 19,705 single cells of the dorsal skin from cashmere goat fetuses at induction(embryonic day 60;E60),organogenesis(E90),and cytodifferentiation(E120)stages.For the first time,unsupervised clustering analysis identified 16 cell clusters,and their corresponding cell types were also characterized.Based on lineage inference,a detailed molecular landscape was revealed along the dermal and epidermal cell lineage developmental pathways.Notably,our current data also confirmed the heterogeneity of dermal papillae from different hair follicle types,which was further validated by immunofluorescence analysis.The current study identifies different biomarkers during cashmere goat hair follicle development and has implications for cashmere goat breeding in the future.展开更多
Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clin...Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature.展开更多
基金This work was supported by National Natural Science Foundation of China(Nos.62006225,61906199 and 62071468)the Strategic Priority Research Program of Chinese Academy of Sciences(CAS),China(No.XDA 27040700)sponsored by The Beijing Nova Program,China(Nos.Z201100006820050 and Z211100002121010).
文摘In the daily application of an iris-recognition-at-a-distance(IAAD)system,many ocular images of low quality are acquired.As the iris part of these images is often not qualified for the recognition requirements,the more accessible periocular regions are a good complement for recognition.To further boost the performance of IAAD systems,a novel end-to-end framework for multi-modal ocular recognition is proposed.The proposed framework mainly consists of iris/periocular feature extraction and matching,unsupervised iris quality assessment,and a score-level adaptive weighted fusion strategy.First,ocular feature reconstruction(OFR)is proposed to sparsely reconstruct each probe image by high-quality gallery images based on proper feature maps.Next,a brand new unsupervised iris quality assessment method based on random multiscale embedding robustness is proposed.Different from the existing iris quality assess-ment methods,the quality of an iris image is measured by its robustness in the embedding space.At last,the fusion strategy exploits the iris quality score as the fusion weight to coalesce the complementary information from the iris and periocular regions.Extensive experi-mental results on ocular datasets prove that the proposed method is obviously better than unimodal biometrics,and the fusion strategy can significantly improve therecognition performance.
基金This study was supported by the National Natural Science Foundation of China(Grant Nos.31972556 and 31772573).
文摘Cashmere,also known as soft gold,is produced from the secondary hair follicles(SHFs)of cashmere goats.The number of SHFs determines the yield and quality of cashmere;therefore,it is of interest to investigate the transcriptional profiles present during cashmere goat hair follicle development.However,mechanisms underlying this development process remain largely unexplored,and studies regarding hair follicle development mostly use a murine research model.In this study,to provide a comprehensive understanding of cellular heterogeneity and cell fate decisions,single-cell RNA sequencing was performed on 19,705 single cells of the dorsal skin from cashmere goat fetuses at induction(embryonic day 60;E60),organogenesis(E90),and cytodifferentiation(E120)stages.For the first time,unsupervised clustering analysis identified 16 cell clusters,and their corresponding cell types were also characterized.Based on lineage inference,a detailed molecular landscape was revealed along the dermal and epidermal cell lineage developmental pathways.Notably,our current data also confirmed the heterogeneity of dermal papillae from different hair follicle types,which was further validated by immunofluorescence analysis.The current study identifies different biomarkers during cashmere goat hair follicle development and has implications for cashmere goat breeding in the future.
基金funded in part by the Beijing Natural Science Foundation(JQ20032 to N.W.and to 7191007 to Z.W.)National Natural Science Foundation of China(81822030 and 82072391 to N.W.,81772299and 81930068 to Z.W.,81772301 and 81972132 to G.Q.,81672123and 81972037 to J.Z.)+7 种基金Capital's Funds for Health Improvement and Research(2020-4-40114 to N.W.)Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research ProgramNational Key Research and Development Program of China(2018YFC0910500 to N.W.and Z.W.,2016YFC0901501 to S.Z.)the PUMC Youth Fund and the Fundamental Research Funds for the Central Universities(3332019052 to Y.M.)the CAMS Initiative Fund for Medical Sciences(2016-I2M-3-003 to G.Q.and N.W.,2016-I2M-2-006 and 2017-I2M-2-001 to Z.W.)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT320025 to N.W.)sponsored by GeneScience Pharmaceuticals Co.,Ltd.(Changchun,China)funded by the United States National Institutes of Health(UM1HG006542 and K08 HG008986)。
文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature.
