Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,an...Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen(AIEgen)photosensitizer,triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt(TBPBB),that generates reactive oxygen species(ROS)when exposed to light.The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores.These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model.Furthermore,thefluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tis-sue.This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy.This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying,localizing,and visualizing the therapeutic outcomes of IBD treatments.展开更多
Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of...Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of aggregation‐induced emission(AIE)biomaterials provides an effective and promising tool for the theranostics of pathogen infections.In this review,the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized.With the excellent sensitivity and photostability,AIE biomaterials have been widely applied for precise diagnosis of pathogens.Besides,different types of anti-pathogen methods based on AIE biomaterials will be presented in detail,including chemotherapy and phototherapy.Finally,the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.展开更多
Due to their excellent stability and layer-dependent photoelectronic properties,transition metal dichalcogenides(TMDs)are one of the most extensively studied two-dimensional semiconductor materials in the postgraphene...Due to their excellent stability and layer-dependent photoelectronic properties,transition metal dichalcogenides(TMDs)are one of the most extensively studied two-dimensional semiconductor materials in the postgraphene era.However,its low luminescence quantum yield limits its application in displays,lighting,and imaging.Here,a 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile(HATCN)layer was grown on the surface of chemical vapor deposition(CVD)-grown monolayer molybdenum disulfide(MoS_(2))by vacuum evaporation,which increased the photoluminescence intensity of MoS_(2)by 15 times.The enhanced luminescence originates from the charge transfer from the conduction band of MoS_(2)to the lowest unoccupied molecular orbital(LUMO)of HATCN,which suppresses the emission of the negatively charged exciton(trion)while increasing the emission of the neutral exciton.Temperature-dependent fluorescence and Raman spectra demonstrate the feasibility of organic−inorganic hybrid heterojunctions for regulating excitons.This facile and practical organic−inorganic hybrid heterojunction can elevate TMD applications,such as light-emitting diodes.展开更多
This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://119.91.135.188:8080/)contains over 1000 entries...This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://119.91.135.188:8080/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms.展开更多
Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based o...Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images.展开更多
基金National Science Foundation of China,Grant/Award Numbers:52003228,52273197Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:DSYS20211021111400001Science Technology Innovation Commission of Shenzhen Municipality,Grant/Award Numbers:KQTD20210811090142053,JCYJ20220818103007014,JSGG20220606141800001。
文摘Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen(AIEgen)photosensitizer,triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt(TBPBB),that generates reactive oxygen species(ROS)when exposed to light.The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores.These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model.Furthermore,thefluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tis-sue.This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy.This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying,localizing,and visualizing the therapeutic outcomes of IBD treatments.
基金supported by NSFC(52003228,52273197 and 21788102)Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)the Science Technology Innovation Commission of Shenzhen Municipality(JCYJ2021324134613038,KQTD20210811090142053,JSGG20220606141800001 and GJHZ20210705141810031).
文摘Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of aggregation‐induced emission(AIE)biomaterials provides an effective and promising tool for the theranostics of pathogen infections.In this review,the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized.With the excellent sensitivity and photostability,AIE biomaterials have been widely applied for precise diagnosis of pathogens.Besides,different types of anti-pathogen methods based on AIE biomaterials will be presented in detail,including chemotherapy and phototherapy.Finally,the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
基金the National Natural Science Foundation of China(21788102),the Research Grants Council of Hong Kong(16305320 and C6014-20W)the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)+1 种基金the Science Technology Innovation Commission of Shenzhen Municipality(KQTD20210811090142053,GJHZ20210705141810031,and GJHZ20210705143204013)the Innovation and Technology Commission(ITC-CNERC14SC01).
文摘Due to their excellent stability and layer-dependent photoelectronic properties,transition metal dichalcogenides(TMDs)are one of the most extensively studied two-dimensional semiconductor materials in the postgraphene era.However,its low luminescence quantum yield limits its application in displays,lighting,and imaging.Here,a 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile(HATCN)layer was grown on the surface of chemical vapor deposition(CVD)-grown monolayer molybdenum disulfide(MoS_(2))by vacuum evaporation,which increased the photoluminescence intensity of MoS_(2)by 15 times.The enhanced luminescence originates from the charge transfer from the conduction band of MoS_(2)to the lowest unoccupied molecular orbital(LUMO)of HATCN,which suppresses the emission of the negatively charged exciton(trion)while increasing the emission of the neutral exciton.Temperature-dependent fluorescence and Raman spectra demonstrate the feasibility of organic−inorganic hybrid heterojunctions for regulating excitons.This facile and practical organic−inorganic hybrid heterojunction can elevate TMD applications,such as light-emitting diodes.
基金the National Science Foundation of China,Grant/Award Numbers:21975077,52003228,21788102Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:ZDSYS20211021111400001+1 种基金the Science and Technology Plan of Shenzhen,Grant/Award Number:JCYJ2021324134613038Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,Grant/Award Number:2019B030301003。
文摘This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://119.91.135.188:8080/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms.
基金supported by the Opening Project Fund of Shanghai Key Laboratory of Criminal Scene Evidence (201123417049)the Academician Foundation of the Ministry of Public Security of China (2011-23214203, 23215243, 23317015)+4 种基金Program for Young Innovative Research Team in China University of Political Science and Law (18CXTD09, 16CXTD05)the National Natural Science Foundation of China (21788102)the Research Grants Council of Hong Kong (16308116, C2014-15G, A-HKUST605/16, C6009-17G)the Nissan Chemical Industries Ltd., the AIEgen Biotech Co. Ltd., the Innovation and Technology Commission (ITC-CNERC14SC01)the Science and Technology Plan of Shenzhen (JCY20160229205601482)
文摘Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images.
