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Transcriptome reveals overview of Ca^(2+) dose-dependent metabolism disorders in zebrafish larvae after Cd^(2+) exposure 被引量:1
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作者 Biran Zhu ziniu wang +3 位作者 Lei Lei Yongyong Guo Jian Han Bingsheng Zhou 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第3期480-491,共12页
Cadmium (Cd),a ubiquitous environmental hazardous heavy metal,poses a significant threat to the health of aquatic organisms,including teleosts.Although the toxic profile of Cd is well recognized,little is known regard... Cadmium (Cd),a ubiquitous environmental hazardous heavy metal,poses a significant threat to the health of aquatic organisms,including teleosts.Although the toxic profile of Cd is well recognized,little is known regarding the overall view of toxic responses to varying aquatic environmental parameters (e.g.,water hardness) at an individual level.Herein,differences in water hardness were partially mimicked by adjusting Ca^(2+)levels in E3 medium.As an in vivo model,zebrafish embryos were exposed to variable Ca^(2+)levels (NV,normal Ca^(2+);LV,low Ca^(2+);HV,high Ca^(2+)) alone or combined with 30.7μg/L Cd^(2+)(NC,LC,and HC,respectively) until 144 hr post-fertilization.The genome-wide transcriptome revealed differentially expressed genes between groups.Functional enrichment analysis found that biological processes related to metabolism,particularly lipid metabolism,were significantly disrupted in NC and LC treatments,while a remission was observed in the HC group.Biochemical assays confirmed that the decrease in Ca^(2+)enhanced synthesis,inhibited mobilization and increased the storage of lipids in Cd^(2+)treatments.This study suggests that the toxic effect of Cd on biological pathways will be influenced by Ca^(2+),which will improve the toxicological understanding and facilitate accurate assessment of Cd. 展开更多
关键词 Cadmium Calcium Zebrafish larvae TRANSCRIPTOME Metabolism disorder
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Environmental Stability and Transmissibility of Enveloped Viruses at Varied Animate and Inanimate Interfaces
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作者 Li Zeng Junya Li +9 位作者 Meilin Lv Zikang Li Linlin Yao Jie Gao Qi Wu ziniu wang Xinyue Yang Gang Tang Guangbo Qu Guibin Jiang 《Environment & Health》 2023年第1期15-31,共17页
Enveloped viruses have been the leading causative agents of viral epidemics in the past decade,including the ongoing coronavirus disease 2019 outbreak.In epidemics caused by enveloped viruses,direct contact is a commo... Enveloped viruses have been the leading causative agents of viral epidemics in the past decade,including the ongoing coronavirus disease 2019 outbreak.In epidemics caused by enveloped viruses,direct contact is a common route of infection,while indirect transmissions through the environment also contribute to the spread of the disease,although their significance remains controversial.Bridging the knowledge gap regarding the influence of interfacial interactions on the persistence of enveloped viruses in the environment reveals the transmission mechanisms when the virus undergoes mutations and prevents excessive disinfection during viral epidemics.Herein,from the perspective of the driving force,partition efficiency,and viral survivability at interfaces,we summarize the viral and environmental characteristics that affect the environmental transmission of viruses.We expect to provide insights for virus detection,environmental surveillance,and disinfection to limit the spread of severe acute respiratory syndrome coronavirus 2. 展开更多
关键词 enveloped virus environmental transmission interface SURVIVABILITY SARS-CoV-2
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