Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells（SCs） and human embryonic nerve stem cells（NSCs） on macaque Parkinson’s disease（PD）.Methods: Macaque autologous SCs and h...Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells（SCs） and human embryonic nerve stem cells（NSCs） on macaque Parkinson’s disease（PD）.Methods: Macaque autologous SCs and human embryonic NSCs were adopled for the treatment of macaque PD.Results:Six months after transplantation,positron emission computerized tomography showed that <sup>18</sup>F-FP-β-CIT was significantly concentrated in the injured striatum in the cotransplanted group.Immunohistoehemieal staining of transplanted area tissue showed migration of tyrosine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.Conclusions:Co-transplantation of SCs and NSCs could effectively cure PD in macaques.SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems,so it is expected to be applied clinically.展开更多
基金supported by the Hainan Natural Science Foundation, NO.310147
文摘Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells（SCs） and human embryonic nerve stem cells（NSCs） on macaque Parkinson’s disease（PD）.Methods: Macaque autologous SCs and human embryonic NSCs were adopled for the treatment of macaque PD.Results:Six months after transplantation,positron emission computerized tomography showed that <sup>18</sup>F-FP-β-CIT was significantly concentrated in the injured striatum in the cotransplanted group.Immunohistoehemieal staining of transplanted area tissue showed migration of tyrosine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.Conclusions:Co-transplantation of SCs and NSCs could effectively cure PD in macaques.SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems,so it is expected to be applied clinically.
