Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the ex...Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.展开更多
A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results show...A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent.展开更多
文摘Started from the liver targeting compounds（glycyrrhizin,glycyrrhetinicacid,bile acid）,six（amine-terminated） compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and（）1H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.
文摘A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent.
